Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3914-3918

  Semenova, Marina N ^a,b   Tsyganov, Dmitry V ^c   Malyshev, Oleg R ^c   Ershov, Oleg V ^d   Bardasov, Ivan N ^d   Semenov, Roman V ^c   Kiselyov, Alex S ^e   Semenov, Victor V ^b,c  

^a KOL TSOV INSTITUTE OF DEVELOPMENTAL BIOLOGY   (Russian Federation)

^b Chemical Block Ltd   (Cyprus)

^c N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^d CHUVASH STATE UNIVERSITY   (Russian Federation)

^e MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY   (Russian Federation)

Author keywords

4H Chromenes; Cytotoxicity; Microtubule destabilizing agents; Oxa podophyllotoxins; Sea urchin embryo

Indexed keywords

ANTINEOPLASTIC AGENT; BENZOPYRAN DERIVATIVE; PODOPHYLLOTOXIN;

ANALOGS AND DERIVATIVES; ANIMAL; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; EMBRYOLOGY; HUMAN; METABOLISM; MICROTUBULE; PHENOTYPE; SEA URCHIN; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOPYRANS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROTUBULES; MOLECULAR STRUCTURE; PHENOTYPE; PODOPHYLLOTOXIN; SEA URCHINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905907269     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.06.043     Document Type: Article

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