D-ring modified novel isosteviol derivatives: Design, synthesis and cytotoxic activity evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5827-5832

  Zhang, Tao ^a   Lu, Li Hui ^a   Liu, Hao ^a   Wang, Jun Wei ^a   Wang, Rui Xue ^a   Zhang, Yun Xiao ^a   Tao, Jing Chao ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Amino alcohol; Antitumor activity; Isosteviol; Tetracyclic diterpenoids

Indexed keywords

15 ALPHA AMINOMETHYL 16 BETA HYDROXYL ISOSTEVIOL; AMINOALCOHOL; ANTINEOPLASTIC AGENT; CISPLATIN; DITERPENOID; ISOSTEVIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ESOPHAGUS CARCINOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; PROSTATE CARCINOMA; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES, KAURANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865512422     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.083     Document Type: Article

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