Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase

Journal of Medicinal Chemistry

Volumn 58, Issue 12, 2015, Pages 4984-4997

  Sugawara, Akihiro ^a   Maita, Nobuo ^b,d   Gouda, Hiroaki ^a   Yamamoto, Tsuyoshi ^a   Hirose, Tomoyasu ^a   Kimura, Saori ^a   Saito, Yoshifumi ^a   Nakano, Hayato ^a   Kasai, Takako ^a   Nakano, Hirofumi ^a   Shiomi, Kazuro ^a   Hirono, Shuichi ^a   Watanabe, Takeshi ^c   Taniguchi, Hisaaki ^b   Omura, Satoshi ^a   Sunazuka, Toshiaki ^a  

^a KITASATO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

^d SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONE; ALLOSAMIDIN; ANTIINFECTIVE AGENT; ARGIFIN; CHITINASE; MACROLIDE; PENTAPEPTIDE; UNCLASSIFIED DRUG; CYCLOPEPTIDE; ENZYME INHIBITOR;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PROTEIN FAMILY; QUANTUM YIELD; SERRATIA MARCESCENS; ANTAGONISTS AND INHIBITORS; BACTERIAL INFECTIONS; BACTERIUM; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGY; SERRATIA INFECTIONS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BACTERIA; BACTERIAL INFECTIONS; CHITINASE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MACROLIDES; MODELS, MOLECULAR; PEPTIDES, CYCLIC; SERRATIA INFECTIONS; SERRATIA MARCESCENS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84933056587     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00175     Document Type: Article

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