Obserèation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 40, 2013, Pages 15892-15897

  Hirose, Tomoyasu ^a   Maita, Nobuo ^a   Gouda, Hiroaki ^b   Koseki, Jun ^b   Yamamoto, Tsuyoshi ^a   Sugawara, Akihiro ^a   Nakano, Hirofumi ^a   Hirono, Shuichi ^b   Shiomi, Kazuro ^a   Watanabe, Takeshi ^c   Taniguchi, Hisaaki ^a   Sharpless, K Barry ^d   Omura, Satoshi ^a   Sunazuka, Toshiaki ^a  

^a KITASATO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Argifin; Cocrystal structure; Molding effect; Target guided synthesis

Indexed keywords

CHITINASE; CHITINASE INHIBITOR; ENZYME INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; AZIDE; OXIME;

ARTICLE; CLICK CHEMISTRY; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYCLOADDITION; DENSITY FUNCTIONAL THEORY; HYDROLYSIS; IC 50; LIGAND BINDING; MOLECULAR MECHANICS; PRIORITY JOURNAL; QUANTUM MECHANICS; X RAY ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; METABOLISM; PROCEDURES; QUANTUM THEORY; SERRATIA MARCESCENS; ARGIFIN; COCRYSTAL STRUCTURE; DRUG ANTAGONISM; METHODOLOGY; MOLDING EFFECT; TARGET-GUIDED SYNTHESIS;

AZIDES; CHITINASE; CLICK CHEMISTRY; CRYSTALLIZATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIMES; QUANTUM THEORY; SERRATIA MARCESCENS; TRIAZOLES;

ARGIFIN; COCRYSTAL STRUCTURE; MOLDING EFFECT; TARGET-GUIDED SYNTHESIS;

EID: 84885052005     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1315049110     Document Type: Article

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