Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 11, 2013, Pages 3214-3220

  Wakasugi, Masaki ^a   Gouda, Hiroaki ^a   Hirose, Tomoyasu ^a   Sugawara, Akihiro ^a   Yamamoto, Tsuyoshi ^a   Shiomi, Kazuro ^a   Sunazuka, Toshiaki ^a   Omura, Satoshi ^a   Hirono, Shuichi ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Asthma medications; Chitinase; In silico screening; Inhibitor; Structure based drug design

Indexed keywords

ACIDIC MAMMALIAN CHITINASE; ACIDIC MAMMALIAN CHITINASE INHIBITOR; ANTIASTHMATIC AGENT; CHITINASE; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; DATA BASE; DRUG DESIGN; DRUG SCREENING; DRUG TARGETING; ENZYME BINDING; ENZYME INHIBITION; HUMAN; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; PROTEIN DATABASE; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANTI-ASTHMATIC AGENTS; BINDING SITES; CHITINASE; COMPUTER SIMULATION; DATABASES, CHEMICAL; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR DOCKING SIMULATION; PEPTIDES, CYCLIC; PROTEIN BINDING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 84877816554     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.047     Document Type: Article

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