The cyclic dipeptide CI-4 [cyclo-(L-Arg-D-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate

Biochemical Journal

Volumn 368, Issue 1, 2002, Pages 23-27

  Houston, Douglas R ^a   Eggleston, Ian ^a   Synstad, Bjørnar ^b   Eijsink, Vincent G H ^b   Van Aalten, Daan M F ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

Allosamidin; Candida albicans; Glycoside hydrolase; Plasmodium falciparum; X ray crystallography

Indexed keywords

CHEMOTHERAPY; CRYSTAL STRUCTURE; ENZYMES; FUNGI; OPTIMIZATION; POLYPEPTIDES;

STRUCTURAL MIMICRY;

BIOCHEMISTRY;

CHITINASE; CYCLO(ARGININE DEXTRO PROLINE); DIPEPTIDE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACETYLGLUCOSAMINE; BINDING SITES; CHITINASE; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; PEPTIDES, CYCLIC; PLANT PROTEINS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SERRATIA MARCESCENS; TRISACCHARIDES; X-RAY DIFFRACTION;

CANDIDA; CANDIDA ALBICANS; FUNGI; HEXAPODA; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0037113166     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021034     Document Type: Article

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