VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis

Gastroenterology

Volumn 149, Issue 1, 2015, Pages 177-189.e10

  Foersch, Sebastian ^a   Sperka, Tobias ^b   Lindner, Christina ^a   Taut, Astrid ^a   Rudolph, Karl L ^b   Breier, Georg ^c   Boxberger, Frank ^a   Rau, Tilman T ^a   Hartmann, Arndt ^a   Stürzl, Michael ^a   Wittkopf, Nadine ^a   Haep, Lisa ^a   Wirtz, Stefan ^a   Neurath, Markus F ^a   Waldner, Maximilian J ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Angiogenesis; Colon Cancer; Inflammation; Mouse Model

Indexed keywords

AZOXYMETHANE; BEVACIZUMAB; CRE RECOMBINASE; DEXTRAN SULFATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; PROTEIN P21; REACTIVE OXYGEN METABOLITE; VASCULOTROPIN RECEPTOR 2; MONOCLONAL ANTIBODY;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CELL AGING; CLINICAL ARTICLE; COLITIS; COLON CARCINOGENESIS; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; ENDOSCOPY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; MALE; MIDDLE AGED; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN DEPLETION; PROTEIN MODIFICATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR VOLUME; WESTERN BLOTTING; ANIMAL; CELL PROLIFERATION; COLORECTAL NEOPLASMS; COMPLICATION; DISEASE FREE SURVIVAL; DISEASE MODEL; DRUG EFFECTS; GENETICS; HCT116 CELL LINE; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; CD8-POSITIVE T-LYMPHOCYTES; CELL AGING; CELL PROLIFERATION; COLITIS; COLORECTAL NEOPLASMS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; DISEASE-FREE SURVIVAL; FEMALE; HCT116 CELLS; HUMANS; MALE; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-AKT; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84931460607     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.03.016     Document Type: Article

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