Critical requirement for cell cycle inhibitors in sustaining nonproliferative states

Journal of Cell Biology

Volumn 176, Issue 6, 2007, Pages 807-818

  Pajalunga, Deborah ^a   Mazzola, Alessia ^a   Salzano, Anna Maria ^a   Biferi, Maria Grazia ^a   De Luca, Gabriele ^a   Crescenzi, Marco ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; KIDNEY CELL; MITOSIS; MOUSE; MUSCLE CELL; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SKELETAL MUSCLE; TISSUE REPAIR;

ANIMALS; CELL AGING; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; CYCLINS; DNA REPLICATION; HUMANS; MICE; MUSCLE FIBERS; RNA INTERFERENCE;

VERTEBRATA;

EID: 33947271294     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200608109     Document Type: Article

References (61)

1. Bader, D., T. Masaki, and D.A. Fischman. 1982. Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro. J. Cell Biol. 95:763-770.
2. Baldin, V., J. Lukas, M.J. Marcote, M. Pagano, and G. Draetta. 1993. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 7:812-821.
3. Bagui, T.K., S. Mohapatra, E. Haura, and W.J. Pledger. 2003. p27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes. Mol. Cell. Biol. 23:7285-7290.
4. Beausejour, C.M., A. Krtolica, F. Galimi, M. Narita, S.W. Lowe, P. Yaswen, and J. Campisi. 2003. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 22:4212-4222.
5. Bischoff, F.Z., S.O. Yim, S. Pathak, G. Grant, M.J. Siciliano, B.C. Giovanella, L.C. Strong, and M.A. Tainsky. 1990. Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization. Cancer Res. 50:7979-7984.
6. Blau, H.M., G.K. Pavlath, E.C. Hardeman, C.-P. Chiu, L. Silberstein, S.G. Webster, S.C. Miller, and C. Webster. 1985. Plasticity of the differentiated state. Science. 230:758-766.
7. Bodnar, A.G., M. Ouellette, M. Frolkis, S.E. Holt, C.-P. Chiu, G.B. Morin, C.B. Harley, J.W. Shay, S. Lichtsteiner, and W.E. Wright. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science. 279:349-352.
8. Bringold, F., and M. Serrano. 2000. Tumor suppressors and oncogenes in cellular senescence. Exp. Gerontol. 35:317-329.
9. Brown, J.P., W. Wei, and J.M. Sedivy. 1997. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science. 277:831-834.
10. Camarda, G., F. Siepi, D. Pajalunga, C. Bernardini, R. Rossi, A. Montecucco, E. Meccia, and M. Crescenzi. 2004. A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells. J. Cell Biol. 167:417-423.
11. Cenciarelli, C., F. De Santa, P.L. Puri, E. Mattei, L. Ricci, F. Bucci, A. Felsani, and M. Caruso. 1999. Critical role played by cyclin D3 in the MyoD-mediated arrest of cell cycle during myoblast differentiation. Mol. Cell Biol. 19:5203-5217.
12. Coller, H.A., L. Sang, and J.M. Roberts. 2006. A new description of cellular quiescence. PLoS Biol. 4:e83.
13. Connell-Crowley, L., S.J. Elledge, and J.W. Harper. 1998. G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts. Curr. Biol. 8:65-68.
14. Counter, C.M., A.A. Avilion, C.E. LeFeuvre, N.G. Stewart, C.W. Greider, C.B. Harley, and S. Bacchetti. 1992. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1921-1929.
15. Crescenzi, M., S. Soddu, and F. Tato. 1995. Mitotic cycle reactivation in terminally differentiated cells by adenovirus infection. J. Cell. Physiol. 162:26-35.
16. Dimri, G.P., X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E.E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, M. Peacocke, and J. Campisi. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA. 92:9363-9367.
17. 1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc. Natl. Acad. Sci. USA. 90:11034-11038.
18. Ekholm, S.V., and S.I. Reed. 2000. Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle. Curr. Opin. Cell Biol. 12:676-684.
19. Figliola, R., and R. Maione. 2004. MyoD induces the expression of p57Kip2 in cells lacking p21Cip1/Waf1: overlapping and distinct functions of the two cdk inhibitors. J. Cell. Physiol. 200:468-475.
20. Gill, R.M., R. Slack, M. Kiess, and P.A. Hamel. 1998. Regulation of expression and activity of distinct pRB, E2F, D-type cyclin, and CKI family members during terminal differentiation of P19 cells. Exp. Cell Res. 244:157-170.
21. Gire, V., and D. Wynford-Thomas. 1998. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol. Cell. Biol. 18:1611-1621.
22. Halevy, O., B.G. Novitch, D.B. Spicer, S.X. Skapek, J. Rhee, G.J. Hannon, D. Beach, and A.B. Lassar. 1995. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science. 267:1018-1021.
23. Harper, J.W. 1997. Cyclin dependent kinase inhibitors. Cancer Surv. 29:91-107.
24. Hayflick, L., and P.S. Moorhead. 1961. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:585-621.
25. Herbig, U., and J.M. Sedivy. 2006. Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech. Ageing Dev. 127:16-24.
26. Huh, M.S., M.H. Parker, A. Scime, R. Parks, and M.A. Rudnicki. 2004. Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J. Cell Biol. 166:865-876.
27. Itahana, K., Y. Zou, Y. Itahana, J.L. Martinez, C. Beausejour, J.J. Jacobs, M. Van Lohuizen, V. Band, J. Campisi, and G.P. Dimri. 2003. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell. Biol. 23:389-401.
28. Kerkhoff, E., and U.R. Rapp. 1997. Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1. Mol. Cell. Biol. 17:2576-2586.
29. Kiyono, T., S.A. Foster, J.I. Koop, J.K. McDougall, D.A. Galloway, and A.J. Klingelhutz. 1998. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature. 396:84-88.
30. LaBaer, J., M.D. Garrett, L.F. Stevenson, J.M. Slingerland, C. Sandhu, H.S. Chou, A. Fattaey, and E. Harlow. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847-862.
31. Latella, L., A. Sacchi, and M. Crescenzi. 2000. Long-term fate of terminally differentiated skeletal muscle cells following E1A-initiated cell cycle reactivation. Cell Death Differ. 7:145-154.
32. Latella, L., A. Sacco, D. Pajalunga, M. Tiainen, D. Macera, M. D'Angelo, A. Felici, A. Sacchi, and M. Crescenzi. 2001. Reconstitution of cyclin D1-associated kinase activity drives terminally differentiated cells into the cell cycle. Mol. Cell. Biol. 21:5631-5643.
33. Lukas, J., T. Herzinger, K. Hansen, M.C. Moroni, D. Resnitzky, K. Helin, S.I. Reed, and J. Bartek. 1997. Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev. 11:1479-1492.
34. Mal, A., D. Chattopadhyay, M.K. Ghosh, R.Y. Poon, T. Hunter, and M.L. Harter. 2000. p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells. J. Cell Biol. 149:281-292.
35. Messina, G., C. Blasi, S.A. La Rocca, M. Pompili, A. Calconi, and M. Grossi. 2005. p27Kip1 acts downstream of N-cadherin-mediated cell adhesion to promote myogenesis beyond cell cycle regulation. Mol. Biol. Cell. 16:1469-1480.
36. Missero, C., E. Calautti, R. Eckner, J. Chin, L.H. Tsai, D.M. Livingston, and G.P. Dotto. 1995. Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc. Natl. Acad. Sci. USA. 92:5451-5455.
37. Murray, A.W. 2004. Recycling the cell cycle: cyclins revisited. Cell. 116:221-234.
38. Myers, T.K., S.E. Andreuzza, and D.S. Franklin. 2004. p18(INK4c) and p27(KIP1) are required for cell cycle arrest of differentiated myotubes. Exp. Cell Res. 300:365-378.
39. Sdi1 antisense RNA. Proc. Natl. Acad. Sci. USA. 92:4352-4356.
40. Ohkubo, Y., T. Kishimoto, T. Nakata, H. Yasuda, and T. Endo. 1994. SV40 large T antigen reduces the cell cycle in terminally differentiated myotubes through inducing Cdk2, Cdc2, and their partner cyclins. Exp. Cell Res. 214:270-278.
41. Pajalunga, D., and M. Crescenzi. 2004. Regulation of cyclin E protein levels through E2F-mediated inhibition of degradation. Cell Cycle. 3:1572-1578.
42. Cip1 in muscle and other terminally differentiated cells. Science. 267:1024-1027.
43. Parrinello, S., E. Samper, A. Krtolica, J. Goldstein, S. Melov, and J. Campisi. 2003. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat. Cell Biol. 5:741-747.
44. Rando, T.A., and H.M. Blau. 1994. Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy. J. Cell Biol. 125:1275-1287.
45. Ren, S., and B.J. Rollins. 2004. Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell. 117:239-251.
46. Sage, J., G.J. Mulligan, L.D. Attardi, A. Miller, S. Chen, B. Williams, E. Theodorou, and T. Jacks. 2000. Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev. 14:3037-3050.
47. Sage, J., A.L. Miller, P.A. Perez-Mancera, J.M. Wysocki, and T. Jacks. 2003. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 424:223-228.
48. -/- muscle cells. Science. 264:1467-1471.
49. Shay, J.W., O.M. Pereira-Smith, and W.E. Wright. 1991. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196:33-39.
50. Sherr, C.J. 1994. G1 phase progression: cycling on cue. Cell. 79:551-555.
51. Sherr, C.J. 1995. D-type cyclins. Trends Biochem. Sci. 20:187-190.
52. Sherr, C.J., and J.M. Roberts. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501-1512.
53. Sherr, C.J., and J.M. Roberts. 2004. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18:2699-2711.
54. Shevchenko, A., M. Wilm, O. Vorm, and M. Mann. 1996. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68:850-858.
55. 1 upon growth factor stimulation. Cell Growth Differ. 7:1039-1050.
56. Tiainen, M., D. Spitkovsky, P. Jansen-Dürr, A. Sacchi, and M. Crescenzi. 1996b. Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms. Mol. Cell. Biol. 16:5302-5312.
57. Vaccarello, G., R. Figliola, S. Cramerotti, F. Novelli, and R. Maione. 2006. p57Kip2 is induced by MyoD through a p73-dependent pathway. J. Mol. Biol. 356:578-588.
58. Wang, J., and K. Walsh. 1996. Inhibition of retinoblastoma protein phosphorylation by myogenesis-induced changes in the subunit composition of the cyclin-dependent kinase 4 complex. Cell Growth Differ. 7:1471-1478.
59. Weinberg, R.A. 1995. The retinoblastoma protein and cell cycle control. Cell. 81:323-330.
60. Kip1 is expressed transiently in developing myotomes and enhances myogenesis. Cell Growth Differ. 9:1-11.
61. Zhang, P., C. Wong, D. Liu, M. Finegold, J.W. Harper, and S.J. Elledge. 1999. p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev. 13:213-224.