The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

Nature Immunology

Volumn 14, Issue 5, 2013, Pages 446-453

  Gatto, Dominique ^a,b   Wood, Katherine ^a   Caminschi, Irina ^c   Murphy Durland, Danielle ^a   Schofield, Peter ^a   Christ, Daniel ^a,b   Karupiah, Gunasegaran ^d   Brink, Robert ^a,b  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c BURNET INSTITUTE   (Australia)

^d Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; G PROTEIN COUPLED RECEPTOR; LIGAND; PROTEIN EBI2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL MIGRATION; CELL SUBPOPULATION; CELL SURVIVAL; CHEMOTAXIS; CONTROLLED STUDY; DENDRITIC CELL; HOMEOSTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODY FORMATION; ANTIGEN PRESENTATION; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS; DENDRITIC CELLS; HOMEOSTASIS; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, G-PROTEIN-COUPLED; SPLEEN;

EID: 84876545322     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2555     Document Type: Article

References (47)

1. Shortman, K. & Liu, Y.J. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2, 151-161 (2002).
2. Villadangos, J.A. & Schnorrer, P. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat. Rev. Immunol. 7, 543-555 (2007).
3. Satpathy, A.T., Wu, X., Albring, J.C. & Murphy, K.M. Re(de)fning the dendritic cell lineage. Nat. Immunol. 13, 1145-1154 (2012).
4. Pulendran, B., Tang, H. & Denning, T.L. Division of labor, plasticity, and crosstalk between dendritic cell subsets. Curr. Opin. Immunol. 20, 61-67 (2008).
5. Vremec, D., Pooley, J., Hochrein, H., Wu, L. & Shortman, K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 164, 2978-2986 (2000).
6. Dudziak, D. et al. Differential antigen processing by dendritic cell subsets in vivo. Science 315, 107-111 (2007).
7. Luber, C.A. et al. Quantitative proteomics reveals subset-specifc viral recognition in dendritic cells. Immunity 32, 279-289 (2010).
8. + T cells after viral stimulation. PLoS One 3, e1691 (2008).
9. - dendritic cells in vivo. J. Exp. Med. 196, 817-827 (2002).
10. + dendritic cells. J. Immunol. 166, 5327-5330 (2001).
11. Chappell, C.P., Draves, K.E., Giltiay, N.V. & Clark, E.A. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J. Exp. Med. 209, 1825-1840 (2012).
12. - dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 192, 1685-1696 (2000).
13. + dendritic cells in cross-presentation is not dictated by antigen capture. Proc. Natl. Acad. Sci. USA 103, 10729-10734 (2006).
14. Caminschi, I. et al. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood 112, 3264-3273 (2008).
15. Sancho, D. et al. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J. Clin. Invest. 118, 2098-2110 (2008).
16. Kabashima, K. et al. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 22, 439-450 (2005).
17. Naik, S.H. et al. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat. Immunol. 7, 663-671 (2006).
18. Diao, J. et al. In situ replication of immediate dendritic cell (DC) precursors contributes to conventional DC homeostasis in lymphoid tissue. J. Immunol. 176, 7196-7206 (2006).
19. Liu, K. et al. Origin of dendritic cells in peripheral lymphoid organs of mice. Nat. Immunol. 8, 578-583 (2007).
20. Belz, G.T. & Nutt, S.L. Transcriptional programming of the dendritic cell network. Nat. Rev. Immunol. 12, 101-113 (2012).
21. Gunn, M.D. et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451-460 (1999).
22. Reis e Sousa, C. et al. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186, 1819-1829 (1997).
23. Ohl, L. et al. CCR7 governs skin dendritic cell migration under infammatory and steady-state conditions. Immunity 21, 279-288 (2004).
24. Czeloth, N. et al. Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen. J. Immunol. 179, 5855-5863 (2007).
25. Hannedouche, S. et al. Oxysterols direct immune cell migration via EBI2. Nature 475, 524-527 (2011).
26. Liu, C. et al. Oxysterols direct B-cell migration through EBI2. Nature 475, 519-523 (2011).
27. Yi, T. et al. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity 37, 535-548 (2012).
28. Gatto, D., Paus, D., Basten, A., Mackay, C.R. & Brink, R. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 31, 259-269 (2009).
29. Pereira, J.P., Kelly, L.M., Xu, Y. & Cyster, J.G. EBI2 mediates B cell segregation between the outer and centre follicle. Nature 460, 1122-1126 (2009).
30. Gatto, D., Wood, K. & Brink, R. EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center. J. Immunol. 187, 4621-4628 (2011).
31. Kelly, L.M., Pereira, J.P., Yi, T., Xu, Y. & Cyster, J.G. EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J. Immunol. 187, 3026-3032 (2011).
32. Shortman, K. & Naik, S.H. Steady-state and infammatory dendritic-cell development. Nat. Rev. Immunol. 7, 19-30 (2007).
33. Kamath, A.T. et al. The development, maturation, and turnover rate of mouse spleen dendritic cell populations. J. Immunol. 165, 6762-6770 (2000).
34. Türeci, O. et al. Cascades of transcriptional induction during dendritic cell maturation revealed by genome-wide expression analysis. FASEB J. 17, 836-847 (2003).
35. Paus, D. et al. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J. Exp. Med. 203, 1081-1091 (2006).
36. Brink, R., Phan, T.G., Paus, D. & Chan, T.D. Visualizing the effects of antigen affnity on T-dependent B-cell differentiation. Immunol. Cell Biol. 86, 31-39 (2008).
37. - dendritic cells. J. Immunol. 177, 372-382 (2006).
38. Garciá De Vinuesa, C. et al. Dendritic cells associated with plasmablast survival. Eur. J. Immunol. 29, 3712-3721 (1999).
39. Ansel, K.M. et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406, 309-314 (2000).
40. Lahoud, M.H. et al. The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. J. Immunol. 182, 7587-7594 (2009).
41. Rosenkilde, M.M. et al. Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity. J. Biol. Chem. 281, 13199-13208 (2006).
42. Phan, T.G. et al. B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells. J. Exp. Med. 197, 845-860 (2003).
43. Barnden, M.J., Allison, J., Heath, W.R. & Carbone, F.R. Defective TCR expression in transgenic mice constructed using cDNA-based α-and β-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76, 34-40 (1998).
44. - dendritic cells in the spleen. J. Exp. Med. 204, 1653-1664 (2007).
45. Bauman, D.R. et al. 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. Proc. Natl. Acad. Sci. USA 106, 16764-16769 (2009).
46. Phan, T.G., Gardam, S., Basten, A. & Brink, R. Altered migration, recruitment, and somatic hypermutation in the early response of marginal zone B cells to T cell-dependent antigen. J. Immunol. 174, 4567-4578 (2005).
47. Allen, C.D. et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat. Immunol. 5, 943-952 (2004).