Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

Oncotarget

Volumn 6, Issue 14, 2015, Pages 11806-11819

  Bianchi, Giovanna ^a   Martella, Roberto ^a   Ravera, Silvia ^b   Marini, Cecilia ^c   Capitanio, Selene ^d   Orengo, Annamaria ^d   Emionite, Laura ^d   Lavarello, Chiara ^a   Amaro, Adriana ^d   Petretto, Andrea ^a   Pfeffer, Ulrich ^d   Sambuceti, Gianmario ^d   Pistoia, Vito ^a   Raffaghello, Lizzia ^a   Longo, Valter D ^e,f,g  

^a G GASLINI INSTITUTE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

Colon cancer; Fasting; Glucose uptake; Oxidative phosphorylation; Warburg effect

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; LACTATE DEHYDROGENASE; OXALIPLATIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; PYRUVATE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTI WARBURG EFFECT; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL VIABILITY; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME SYNTHESIS; FEMALE; GLUCOSE INTAKE; GLUCOSE TRANSPORT; GLYCOLYSIS; IN VITRO STUDY; IN VIVO STUDY; KWASHIORKOR; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEOMICS; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL PROLIFERATION; CELL RESPIRATION; CELL SURVIVAL; COLON TUMOR; DIET RESTRICTION; DISEASE MODEL; DNA MICROARRAY; DRUG RESISTANCE; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE; WESTERN BLOTTING; XENOGRAFT;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL RESPIRATION; CELL SURVIVAL; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, NEOPLASM; FASTING; FLUORESCENT ANTIBODY TECHNIQUE; HETEROGRAFTS; HUMANS; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 84931388298     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3688     Document Type: Article

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