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Volumn 1319, Issue , 2015, Pages 95-141

T cell receptor engineering and analysis using the yeast display platform

Author keywords

Affinity maturation; Intracellular antigens; Major histocompatibility complex; Peptide antigens; Singlechain T cell receptors; T cell receptors; Yeast display

Indexed keywords

ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR; ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE LIBRARY; PROTEIN BINDING;

EID: 84931265899     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-2748-7_6     Document Type: Article
Times cited : (17)

References (57)
  • 1
    • 17344362313 scopus 로고    scopus 로고
    • Ligand recognition by alpha beta T cell receptors
    • Davis MM, Boniface JJ, Reich Z et al (1998) Ligand recognition by alpha beta T cell receptors. Annu Rev Immunol 16:523–544
    • (1998) Annu Rev Immunol , vol.16 , pp. 523-544
    • Davis, M.M.1    Boniface, J.J.2    Reich, Z.3
  • 2
    • 0043268924 scopus 로고    scopus 로고
    • Dynamics of cell surface molecules during T cell recognition
    • Davis MM, Krogsgaard M, Huppa JB et al (2003) Dynamics of cell surface molecules during T cell recognition. Annu Rev Biochem 72:717–742
    • (2003) Annu Rev Biochem , vol.72 , pp. 717-742
    • Davis, M.M.1    Krogsgaard, M.2    Huppa, J.B.3
  • 3
    • 0042971650 scopus 로고    scopus 로고
    • Molecular interactions mediating T cell antigen recognition
    • van der Merwe PA, Davis SJ (2003) Molecular interactions mediating T cell antigen recognition. Annu Rev Immunol 21:659–684
    • (2003) Annu Rev Immunol , vol.21 , pp. 659-684
    • Van Der Merwe, P.A.1    Davis, S.J.2
  • 4
    • 34247847666 scopus 로고    scopus 로고
    • T cells as a self-referential, sensory organ
    • Davis MM, Krogsgaard M, Huse M et al (2007) T cells as a self-referential, sensory organ. Annu Rev Immunol 25:681–695. doi: 10.1146/annurev.immunol.24.021605.090600
    • (2007) Annu Rev Immunol , vol.25 , pp. 681-695
    • Davis, M.M.1    Krogsgaard, M.2    Huse, M.3
  • 6
    • 42649112362 scopus 로고    scopus 로고
    • Evolutionarily conserved amino acids that control TCR-MHC interaction
    • Marrack P, Scott-Browne JP, Dai S et al (2008) Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol 26:171–203
    • (2008) Annu Rev Immunol , vol.26 , pp. 171-203
    • Marrack, P.1    Scott-Browne, J.P.2    Dai, S.3
  • 7
    • 84884248064 scopus 로고    scopus 로고
    • Lck availability during thymic selection determines the recognition specificity of the T cell repertoire
    • Van Laethem F, Tikhonova AN, Pobezinsky LA et al (2013) Lck availability during thymic selection determines the recognition specificity of the T cell repertoire. Cell 154:1326–1341. doi: 10.1016/j.cell.2013.08.009,S0092-8674(13)01003-9 [pii]
    • (2013) Cell , vol.154 , pp. 1326-1341
    • Van Laethem, F.1    Tikhonova, A.N.2    Pobezinsky, L.A.3
  • 8
    • 84883725376 scopus 로고    scopus 로고
    • Structural and biophysical insights into the role of CD4 and CD8 in T cell activation
    • Li Y, Yin Y, Mariuzza RA (2013) Structural and biophysical insights into the role of CD4 and CD8 in T cell activation. Front Immunol 4:206. doi: 10.3389/fimmu.2013.00206
    • (2013) Front Immunol , vol.4 , pp. 206
    • Li, Y.1    Yin, Y.2    Mariuzza, R.A.3
  • 9
    • 58649114309 scopus 로고    scopus 로고
    • The molecular basis of TCR germline bias for MHC is surprisingly simple
    • Garcia KC, Adams JJ, Feng D et al (2009) The molecular basis of TCR germline bias for MHC is surprisingly simple. Nat Immunol 10:143–147. doi:10.1038/ni.f.219,ni.f.219 [pii]
    • (2009) Nat Immunol , vol.10 , pp. 143-147
    • Garcia, K.C.1    Adams, J.J.2    Feng, D.3
  • 10
    • 84931272779 scopus 로고    scopus 로고
    • Two mechanisms that account for major histocompatibility complex restriction of T cells
    • Kranz DM (2009) Two mechanisms that account for major histocompatibility complex restriction of T cells. F1000 Biol Rep 1:55–58
    • (2009) F1000 Biol Rep , vol.1 , pp. 55-58
    • Kranz, D.M.1
  • 11
    • 0034624983 scopus 로고    scopus 로고
    • In vitro evolution of a T cell receptor with high affinity for peptide/MHC
    • Holler PD, Holman PO, Shusta EV et al (2000) In vitro evolution of a T cell receptor with high affinity for peptide/MHC. Proc Natl Acad Sci U S A 97:5387–5392
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5387-5392
    • Holler, P.D.1    Holman, P.O.2    Shusta, E.V.3
  • 12
    • 0037234768 scopus 로고    scopus 로고
    • TCRs with high affinity for foreign pMHC show self-reactivity
    • Holler PD, Chlewicki LK, Kranz DM (2003) TCRs with high affinity for foreign pMHC show self-reactivity. Nat Immunol 4:55–62
    • (2003) Nat Immunol , vol.4 , pp. 55-62
    • Holler, P.D.1    Chlewicki, L.K.2    Kranz, D.M.3
  • 13
    • 30044449525 scopus 로고    scopus 로고
    • Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function
    • Weber KS, Donermeyer DL, Allen PM et al (2005) Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proc Natl Acad Sci U S A 102:19033–19038
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 19033-19038
    • Weber, K.S.1    Donermeyer, D.L.2    Allen, P.M.3
  • 14
    • 21444445173 scopus 로고    scopus 로고
    • Directed evolution of human T-cell receptors with picomolar affi nities by phage display
    • Li Y, Moysey R, Molloy PE et al (2005) Directed evolution of human T-cell receptors with picomolar affi nities by phage display. Nat Biotechnol 23:349–354
    • (2005) Nat Biotechnol , vol.23 , pp. 349-354
    • Li, Y.1    Moysey, R.2    Molloy, P.E.3
  • 15
    • 84862025335 scopus 로고    scopus 로고
    • Monoclonal TCR-redirected tumor cell killing
    • Liddy N, Bossi G, Adams KJ et al (2012) Monoclonal TCR-redirected tumor cell killing. Nat Med 18:980–987. doi: 10.1038/nm.2764,nm.2764 [pii]
    • (2012) Nat Med , vol.18 , pp. 980-987
    • Liddy, N.1    Bossi, G.2    Adams, K.J.3
  • 16
    • 0037100289 scopus 로고    scopus 로고
    • TCR-like human antibodies expressed on human CTLs mediate antibody affinitydependent cytolytic activity
    • Chames P, Willemsen RA, Rojas G et al (2002) TCR-like human antibodies expressed on human CTLs mediate antibody affinitydependent cytolytic activity. J Immunol 169:1110–1118
    • (2002) J Immunol , vol.169 , pp. 1110-1118
    • Chames, P.1    Willemsen, R.A.2    Rojas, G.3
  • 17
    • 0037446653 scopus 로고    scopus 로고
    • Direct phenotypic analysis of human MHC class I antigen presentation: Visualization, quantitation, and in situ detection of human viral epitopes using peptide-specific, MHCrestricted human recombinant antibodies
    • Cohen CJ, Sarig O, Yamano Y et al (2003) Direct phenotypic analysis of human MHC class I antigen presentation: visualization, quantitation, and in situ detection of human viral epitopes using peptide-specific, MHCrestricted human recombinant antibodies. J Immunol 170:4349–4361
    • (2003) J Immunol , vol.170 , pp. 4349-4361
    • Cohen, C.J.1    Sarig, O.2    Yamano, Y.3
  • 18
    • 43649088780 scopus 로고    scopus 로고
    • Phage display-derived recombinant antibodies with TCR-like specificity against alpha- galactosylceramide and its analogues in complex with human CD1d molecules
    • Denkberg G, Stronge VS, Zahavi E et al (2008) Phage display-derived recombinant antibodies with TCR-like specificity against alpha- galactosylceramide and its analogues in complex with human CD1d molecules. Eur J Immunol 38:829–840. doi: 10.1002/eji.200737518
    • (2008) Eur J Immunol , vol.38 , pp. 829-840
    • Denkberg, G.1    Stronge, V.S.2    Zahavi, E.3
  • 19
    • 77949895698 scopus 로고    scopus 로고
    • TCR mimic monoclonal antibody targets a specific peptide/HLA class I complex and significantly impedes tumor growth in vivo using breast cancer models
    • Verma B, Neethling FA, Caseltine S et al (2010) TCR mimic monoclonal antibody targets a specific peptide/HLA class I complex and significantly impedes tumor growth in vivo using breast cancer models. J Immunol 184:2156–2165. doi: 10.4049/jimmunol.0902414,jimmunol.0902414 [pii]
    • (2010) J Immunol , vol.184 , pp. 2156-2165
    • Verma, B.1    Neethling, F.A.2    Caseltine, S.3
  • 20
    • 57649165426 scopus 로고    scopus 로고
    • How a T cell receptor-like antibody recognizes major histocompatibility complexbound peptide
    • Mareeva T, Martinez-Hackert E, Sykulev Y (2008) How a T cell receptor-like antibody recognizes major histocompatibility complexbound peptide. J Biol Chem 283:29053–29059. doi: 10.1074/jbc.M804996200,M804996200 [pii]
    • (2008) J Biol Chem , vol.283 , pp. 29053-29059
    • Mareeva, T.1    Martinez-Hackert, E.2    Sykulev, Y.3
  • 21
    • 34548592046 scopus 로고    scopus 로고
    • Display, engineering, and applications of antigen-specific T cell receptors
    • Richman SA, Kranz DM (2007) Display, engineering, and applications of antigen-specific T cell receptors. Biomol Eng 24:361–373
    • (2007) Biomol Eng , vol.24 , pp. 361-373
    • Richman, S.A.1    Kranz, D.M.2
  • 22
    • 84855584055 scopus 로고    scopus 로고
    • T cell receptor engineering
    • Stone JD, Chervin AS, Aggen DH et al (2012) T cell receptor engineering. Methods Enzymol 503:189–222. doi: 10.1016/B978-0-12-396962-0.00008-2,B978-0-12-396962-0.00008-2 [pii]
    • (2012) Methods Enzymol , vol.503 , pp. 189-222
    • Stone, J.D.1    Chervin, A.S.2    Aggen, D.H.3
  • 23
    • 84886945598 scopus 로고    scopus 로고
    • ImmTACs: Novel bi-specific agents for targeted cancer therapy
    • Oates J, Jakobsen BK (2013) ImmTACs: novel bi-specific agents for targeted cancer therapy. Oncoimmunology 2:e22891. doi: 10.4161/onci.22891,2012ONCOIMM0357 [pii]
    • (2013) Oncoimmunology , vol.2 , pp. e22891
    • Oates, J.1    Jakobsen, B.K.2
  • 24
    • 84931283954 scopus 로고    scopus 로고
    • Engineering high-affinity T cell receptor/ cytokine fusions for therapeutic targeting
    • In Kaumaya P (ed), 978-953-51-0037-9, InTech
    • Stone JD, Yin Y, Mo M et al (2012) Engineering high-affinity T cell receptor/ cytokine fusions for therapeutic targeting. In Kaumaya P (ed) Protein engineering, ISBN: 978-953-51-0037-9, InTech
    • (2012) Protein Engineering, ISBN
    • Stone, J.D.1    Yin, Y.2    Mo, M.3
  • 25
    • 84872399679 scopus 로고    scopus 로고
    • Design and characterization of a protein superagonist of IL-15 fused with IL-15Ralpha and a high-affinity T cell receptor
    • Stone JD, Chervin AS, Schreiber H et al (2012) Design and characterization of a protein superagonist of IL-15 fused with IL-15Ralpha and a high-affinity T cell receptor. Biotechnol Prog 28:1588–1597. doi: 10.1002/btpr.1631
    • (2012) Biotechnol Prog , vol.28 , pp. 1588-1597
    • Stone, J.D.1    Chervin, A.S.2    Schreiber, H.3
  • 26
    • 84874106326 scopus 로고    scopus 로고
    • MHC-class I-restricted CD4 T cells: A nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR
    • Soto CM, Stone JD, Chervin AS et al (2013) MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR. Cancer Immunol Immunother 62:359–369. doi: 10.1007/s00262-012-1336-z
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 359-369
    • Soto, C.M.1    Stone, J.D.2    Chervin, A.S.3
  • 27
    • 84883705209 scopus 로고    scopus 로고
    • Role of T cell receptor affinity in the efficacy and specifi city of adoptive T cell therapies
    • Stone JD, Kranz DM (2013) Role of T cell receptor affinity in the efficacy and specifi city of adoptive T cell therapies. Front Immunol 2444:. doi: 10.3389/fimmu.2013.00244
    • (2013) Front Immunol , vol.4 , pp. 244
    • Stone, J.D.1    Kranz, D.M.2
  • 28
    • 38449104431 scopus 로고    scopus 로고
    • High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines
    • Zhao Y, Bennett AD, Zheng Z et al (2007) High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines. J Immunol 179:5845–5854
    • (2007) J Immunol , vol.179 , pp. 5845-5854
    • Zhao, Y.1    Bennett, A.D.2    Zheng, Z.3
  • 29
    • 70249091519 scopus 로고    scopus 로고
    • The impact of TCR-binding properties and antigen presentation format on T cell responsiveness
    • Chervin AS, Stone JD, Holler PD et al (2009) The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. J Immunol 183:1166–1178. doi: 10.4049/jimmunol.0900054,jimmunol.0900054 [pii]
    • (2009) J Immunol , vol.183 , pp. 1166-1178
    • Chervin, A.S.1    Stone, J.D.2    Holler, P.D.3
  • 30
    • 0033545862 scopus 로고    scopus 로고
    • Selection of functional T cell receptor mutants from a yeast surface- display library
    • Kieke MC, Shusta EV, Boder ET et al (1999) Selection of functional T cell receptor mutants from a yeast surface- display library. Proc Natl Acad Sci U S A 96:5651–5656
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5651-5656
    • Kieke, M.C.1    Shusta, E.V.2    Boder, E.T.3
  • 31
    • 59249094502 scopus 로고    scopus 로고
    • Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments
    • Richman SA, Aggen DH, Dossett ML et al (2009) Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments. Mol Immunol 46:902–916. doi: 10.1016/j.molimm.2008.09.021,S0161-5890(08)00665-2 [pii]
    • (2009) Mol Immunol , vol.46 , pp. 902-916
    • Richman, S.A.1    Aggen, D.H.2    Dossett, M.L.3
  • 32
    • 79952654605 scopus 로고    scopus 로고
    • Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors
    • Aggen DH, Chervin AS, Insaidoo FK et al (2011) Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors. Protein Eng Des Sel 24:361–372
    • (2011) Protein Eng Des Sel , vol.24 , pp. 361-372
    • Aggen, D.H.1    Chervin, A.S.2    Insaidoo, F.K.3
  • 33
    • 84886728346 scopus 로고    scopus 로고
    • Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes
    • Smith SN, Sommermeyer D, Piepenbrink KH et al (2013) Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J Mol Biol. doi: 10.1016/j.jmb.2013.08.007,S0022-2836(13)00510-X [pii]
    • (2013) J Mol Biol
    • Smith, S.N.1    Sommermeyer, D.2    Piepenbrink, K.H.3
  • 34
    • 0030994634 scopus 로고    scopus 로고
    • Yeast surface display for screening combinatorial polypeptide libraries
    • Boder ET, Wittrup KD (1997) Yeast surface display for screening combinatorial polypeptide libraries. Nat Biotechnol 15:553–557
    • (1997) Nat Biotechnol , vol.15 , pp. 553-557
    • Boder, E.T.1    Wittrup, K.D.2
  • 35
    • 0033536626 scopus 로고    scopus 로고
    • Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency
    • Shusta EV, Kieke MC, Parke E et al (1999) Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency. J Mol Biol 292:949–956
    • (1999) J Mol Biol , vol.292 , pp. 949-956
    • Shusta, E.V.1    Kieke, M.C.2    Parke, E.3
  • 36
    • 0033926329 scopus 로고    scopus 로고
    • Directed evolution of a stable scaffold for T-cell receptor engineering
    • Shusta EV, Holler PD, Kieke MC et al (2000) Directed evolution of a stable scaffold for T-cell receptor engineering. Nat Biotechnol 18:754–759
    • (2000) Nat Biotechnol , vol.18 , pp. 754-759
    • Shusta, E.V.1    Holler, P.D.2    Kieke, M.C.3
  • 37
    • 0033748716 scopus 로고    scopus 로고
    • Yeast surface display for directed evolution of protein expression, affi nity, and stability
    • Boder ET, Wittrup KD (2000) Yeast surface display for directed evolution of protein expression, affi nity, and stability. Methods Enzymol 328:430–444
    • (2000) Methods Enzymol , vol.328 , pp. 430-444
    • Boder, E.T.1    Wittrup, K.D.2
  • 38
    • 0037318058 scopus 로고    scopus 로고
    • Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library
    • Feldhaus M, Siegel R, Opresko L et al (2003) Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library. Nat Biotechnol 21: 163–170
    • (2003) Nat Biotechnol , vol.21 , pp. 163-170
    • Feldhaus, M.1    Siegel, R.2    Opresko, L.3
  • 39
    • 34648832245 scopus 로고    scopus 로고
    • Yeast surface display for protein engineering and characterization
    • Gai SA, Wittrup KD (2007) Yeast surface display for protein engineering and characterization. Curr Opin Struct Biol 17:467–473. doi: 10.1016/j.sbi.2007.08.012,S0959-440X(07)00119-4 [pii]
    • (2007) Curr Opin Struct Biol , vol.17 , pp. 467-473
    • Gai, S.A.1    Wittrup, K.D.2
  • 40
    • 34247176809 scopus 로고    scopus 로고
    • Isolating and engineering human antibodies using yeast surface display
    • Chao G, Lau WL, Hackel BJ et al (2006) Isolating and engineering human antibodies using yeast surface display. Nat Protoc 1: 755–768. doi: 10.1038/nprot.2006.94,nprot.2006.94 [pii]
    • (2006) Nat Protoc , vol.1 , pp. 755-768
    • Chao, G.1    Lau, W.L.2    Hackel, B.J.3
  • 41
    • 77954656041 scopus 로고    scopus 로고
    • An improved yeast transformation method for the generation of very large human antibody libraries
    • Benatuil L, Perez JM, Belk J et al (2010) An improved yeast transformation method for the generation of very large human antibody libraries. Protein Eng Des Sel 23:155–159. doi: 10.1093/protein/gzq002,gzq002 [pii]
    • (2010) Protein Eng Des Sel , vol.23 , pp. 155-159
    • Benatuil, L.1    Perez, J.M.2    Belk, J.3
  • 42
    • 0026606072 scopus 로고
    • Characterization of a single-chain T cell receptor expressed in E
    • Soo Hoo WF, Lacy MJ, Denzin LK et al (1992) Characterization of a single-chain T cell receptor expressed in E. Coli.Proc Natl Acad Sci 89:4759–4763
    • (1992) Coli.Proc Natl Acad Sci , vol.89 , pp. 4759-4763
    • Soo Hoo, W.F.1    Lacy, M.J.2    Denzin, L.K.3
  • 43
    • 0028954118 scopus 로고
    • Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure
    • Gietz RD, Schiestl RH, Willems A et al (1995) Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast 11:355–360
    • (1995) Yeast , vol.11 , pp. 355-360
    • Gietz, R.D.1    Schiestl, R.H.2    Willems, A.3
  • 44
    • 62449313699 scopus 로고    scopus 로고
    • Biosensor detection systems: Engineering stable, high-affinity bioreceptors by yeast surface display
    • Richman SA, Kranz DM, Stone JD (2009) Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display. Methods Mol Biol 504:323–350. doi: 10.1007/978-1-60327-569-9_19
    • (2009) Methods Mol Biol , vol.504 , pp. 323-350
    • Richman, S.A.1    Kranz, D.M.2    Stone, J.D.3
  • 45
    • 0027301982 scopus 로고
    • A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations
    • Dal Porto J, Johansen TE, Catipovic B et al (1993) A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations. Proc Natl Acad Sci U S A 90:6671–6675
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6671-6675
    • Dal Porto, J.1    Johansen, T.E.2    Catipovic, B.3
  • 46
    • 0029743737 scopus 로고    scopus 로고
    • Phenotypic analysis of antigen-specific T lymphocytes
    • Altman JD, Moss PAH, Goulder PJR et al (1996) Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94–96
    • (1996) Science , vol.274 , pp. 94-96
    • Altman, J.D.1    Moss, P.2    Goulder, P.3
  • 47
    • 83755178630 scopus 로고    scopus 로고
    • Interaction of streptavidin-based peptide- MHC oligomers (Tetramers) with cellsurface TCRs
    • Stone JD, Artyomov MN, Chervin AS et al (2011) Interaction of streptavidin-based peptide- MHC oligomers (tetramers) with cellsurface TCRs. J Immunol 187:6281–6290. doi: 10.4049/jimmunol.1101734,jimmunol.1101734 [pii]
    • (2011) J Immunol , vol.187 , pp. 6281-6290
    • Stone, J.D.1    Artyomov, M.N.2    Chervin, A.S.3
  • 48
    • 0029855347 scopus 로고    scopus 로고
    • Structure of the complex between human T-cell receptor, viral peptide and HLA-A 2
    • Garboczi DN, Ghosh P, Utz U et al (1996) Structure of the complex between human T-cell receptor, viral peptide and HLA-A 2. Nature 384:134–141
    • (1996) Nature , vol.384 , pp. 134-141
    • Garboczi, D.N.1    Ghosh, P.2    Utz, U.3
  • 49
    • 0030589221 scopus 로고    scopus 로고
    • Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLAA 2
    • Garboczi DN, Utz U, Ghosh P et al (1996) Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLAA 2. J Immunol 157:5403–5410
    • (1996) J Immunol , vol.157 , pp. 5403-5410
    • Garboczi, D.N.1    Utz, U.2    Ghosh, P.3
  • 50
    • 32244442535 scopus 로고    scopus 로고
    • Design and use of conditional MHC class I ligands
    • Toebes M, Coccoris M, Bins A et al (2006) Design and use of conditional MHC class I ligands. Nat Med 12:246–251. doi: 10.1038/nm1360,nm1360 [pii]
    • (2006) Nat Med , vol.12 , pp. 246-251
    • Toebes, M.1    Coccoris, M.2    Bins, A.3
  • 51
    • 58149280299 scopus 로고    scopus 로고
    • T-cell receptor binding affi nities and kinetics: Impact on T-cell activity and specificity
    • Stone JD, Chervin AS, Kranz DM (2009) T-cell receptor binding affi nities and kinetics: impact on T-cell activity and specificity. Immunology 126:165–176. doi: 10.1111/j.1365-2567.2008.03015.x,IMM3015 [pii]
    • (2009) Immunology , vol.126 , pp. 165-176
    • Stone, J.D.1    Chervin, A.S.2    Kranz, D.M.3
  • 53
    • 12344322695 scopus 로고    scopus 로고
    • High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR 3
    • Chlewicki LK, Holler PD, Monti BC et al (2005) High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR 3. J Mol Biol 346:223–239
    • (2005) J Mol Biol , vol.346 , pp. 223-239
    • Chlewicki, L.K.1    Holler, P.D.2    Monti, B.C.3
  • 54
    • 33645498495 scopus 로고    scopus 로고
    • Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity
    • Dunn SM, Rizkallah PJ, Baston E et al (2006) Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein Sci 15:710–721
    • (2006) Protein Sci , vol.15 , pp. 710-721
    • Dunn, S.M.1    Rizkallah, P.J.2    Baston, E.3
  • 55
    • 0025326334 scopus 로고
    • Gene splicing by overlap extension: Tailormade genes using the polymerase chain reaction
    • Horton RM, Cai ZL, Ho SN et al (1990) Gene splicing by overlap extension: tailormade genes using the polymerase chain reaction. Biotechniques 8:528–535
    • (1990) Biotechniques , vol.8 , pp. 528-535
    • Horton, R.M.1    Cai, Z.L.2    Ho, S.N.3
  • 56
    • 84882276058 scopus 로고    scopus 로고
    • Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses
    • Chervin AS, Stone JD, Soto CM et al (2013) Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses. Gene Ther 20(6):634–644. doi: 10.1038/gt.2012.80
    • (2013) Gene Ther , vol.20 , Issue.6 , pp. 634-644
    • Chervin, A.S.1    Stone, J.D.2    Soto, C.M.3
  • 57
    • 0037359054 scopus 로고    scopus 로고
    • Rapid method for measuring ScFv thermal stability by yeast surface display
    • Orr BA, Carr LM, Wittrup KD et al (2003) Rapid method for measuring ScFv thermal stability by yeast surface display. Biotechnol Prog 19:631–638
    • (2003) Biotechnol Prog , vol.19 , pp. 631-638
    • Orr, B.A.1    Carr, L.M.2    Wittrup, K.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.