MHC-class I-restricted CD4 T cells: A nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

Cancer Immunology, Immunotherapy

Volumn 62, Issue 2, 2013, Pages 359-369

  Soto, Carolina M ^a   Stone, Jennifer D ^b   Chervin, Adam S ^b   Engels, Boris ^c   Schreiber, Hans ^c   Roy, Edward J ^a   Kranz, David M ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Adoptive T cell therapy; Cancer immunotherapy; Melanoma; TCR; Tumor targeting

Indexed keywords

ALBUMIN CR 51; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; IMMUNE RESPONSE; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE TRANSFER; MELANOMA; MEMORY T LYMPHOCYTE; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; T LYMPHOCYTE RECEPTOR GENE; VIRAL GENE DELIVERY SYSTEM; WILD TYPE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL SURVIVAL; GENES, MHC CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS I; INTERFERON-GAMMA; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; SKIN NEOPLASMS;

EID: 84874106326     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-012-1336-z     Document Type: Article

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