Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc-, the Na+-independent glutamate-cystine exchanger

Free Radical Biology and Medicine

Volumn 86, Issue , 2015, Pages 25-36

  Wang, Jing ^a   Shanmugam, Arul ^a   Markand, Shanu ^a   Zorrilla, Eric ^b   Ganapathy, Vadivel ^a   Smith, Sylvia B ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Free radicals; Mouse; Nrf2; Retina; Retinal M ller glial cells; Sigma 1 receptor; System xc ; xCT

Indexed keywords

CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SIGMA 1 OPIATE RECEPTOR; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; AMINO ACID TRANSPORTER; CYTOSKELETON PROTEIN; KEAP1 PROTEIN, MOUSE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; NFE2L2 PROTEIN, MOUSE; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SLC7A11 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALASE GENE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; FEMALE; GENE; GENE EXPRESSION; GLIA CELL; GPX1 GENE; GSTM6 GENE; HMOX1 GENE; KNOCKOUT MOUSE; MOUSE; MUELLER CELL; NEUROPROTECTION; NONHUMAN; NQO1 GENE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA NERVE CELL; SIGNAL TRANSDUCTION; SOD1 GENE; TRANSACTIVATION ASSAY; WILD TYPE; 129 MOUSE; ANIMAL; ANTIOXIDANT RESPONSIVE ELEMENT; C57BL MOUSE; CELL CULTURE; MACROGLIA; METABOLISM; PHYSIOLOGY; PRIMARY CELL CULTURE; TRANSCRIPTION INITIATION;

MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; CELLS, CULTURED; CYTOSKELETAL PROTEINS; EPENDYMOGLIAL CELLS; FEMALE; GLUTATHIONE; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PRIMARY CELL CULTURE; REACTIVE OXYGEN SPECIES; RECEPTORS, SIGMA; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 84931265794     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.04.009     Document Type: Article

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