Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 52, 2009, Pages 22468-22473

  Tsai, Shang Yi ^a   Hayashi, Teruo ^a   Harvey, Brandon K ^a   Wang, Yun ^a   Wu, Wells W ^b   Shen, Rong Fong ^b   Zhang, Yongqing ^b   Becker, Kevin G ^b   Hoffer, Barry J ^a   Su, Tsung Ping ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Caspase 3; Learning and memory; Mitochondria; N acetyl cyteine; ROS

Indexed keywords

ACETYLCYSTEINE; CALCIUM; CASPASE 3; CYTOCHROME C; FREE RADICAL; GUANOSINE TRIPHOSPHATE; RAC1 PROTEIN; SIGMA 1 OPIATE RECEPTOR; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CONTROLLED STUDY; DENDRITIC SPINE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; HIPPOCAMPUS; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CALCIUM SIGNALING; CASPASE 3; CELLS, CULTURED; DENDRITIC SPINES; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; FREE RADICAL SCAVENGERS; FREE RADICALS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE TRIPHOSPHATE; HIPPOCAMPUS; LEARNING; MEMORY; MITOCHONDRIA; NEOPLASM PROTEINS; NEURONAL PLASTICITY; RAC1 GTP-BINDING PROTEIN; RATS; RECEPTORS, SIGMA; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL; TRANSFECTION;

RATTUS;

EID: 76049121038     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909089106     Document Type: Article

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