Sigma receptor ligands protect human retinal cells against oxidative stress

NeuroReport

Volumn 17, Issue 3, 2006, Pages 287-291

  Bucolo, Claudio ^a   Drago, Filippo ^a   Lin, Li Ren ^b   Reddy, Venkat N ^b  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

receptors; Human retinal pigment epithelial cells; Oxidative stress

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; CELL DNA; N [2 (2,3 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; N [2 (3,4 DICHLOROPHENYL)ETHYL] N METHYL 2 (DIMETHYLAMINO)ETHYLAMINE; OPIATE AGONIST; OPIATE ANTAGONIST; SIGMA 1 OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL SURVIVAL; CELL VIABILITY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENTIATION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA CELL;

ANISOLES; CELL SURVIVAL; CELLS, CULTURED; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EPITHELIAL CELLS; ETHYLENEDIAMINES; HUMANS; HYDROGEN PEROXIDE; MORPHOLINES; OXIDATIVE STRESS; PROPYLAMINES; RECEPTORS, SIGMA; RETINA;

EID: 33644560336     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnr.0000199469.21734.e1     Document Type: Article

References (24)

1. Quirion R, Bowen WD, Itzhak Y, Junien JL, Musacchio JM, Rothman RB, et al. A proposal for the classification of sigma binding sites. Trends Pharmacol Sci 1992; 13:85-86.
2. 2 binding in rat brain. Eur J Pharmacol 1994; 259:65-69.
3. DeCosta BR, He XS. Structure-activity relationships and evolution of sigma receptor ligands. In: Ytzhak Y, editor. The sigma receptors, neuroscience perspective series. London: Academic Press; 1994. pp. 45-111.
4. Schoenwald RD, Barfknecht CF, Xia E, Newton RE. The presence of σ-receptors in the lacrimal gland. J Ocular Pharmacol 1993; 9:125-139.
5. Senda T, Matsuno K, Mita S. The presence of σ receptor subtype in bovine retinal membranes. Exp Eye Res 1997; 64:857-860.
6. 1-site agonists lower intraocular pressure. J Pharmacol Exp Ther 1999; 289:1362-1369.
7. Shamsul Ola M, Moore P, El-Sherbeny A, Roon P, Agarwal N, Sarthy VP, et al. Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina. Mol Brain Res 2002; 95:86-95.
8. 1 receptors in eyes by ex vivo autoradiography and in vivo positron emission tomography. Exp Eye Res 2002; 75:723-730.
9. 2 sites. Neurosci Res Commun 1994; 14:43-51.
10. Pauwels PJ, Van Assouw HP, Peeters L, Moeremans M, Leysen JE. Chronic treatment with sabeluzole protects cultured rat brain neurons from the neurotoxic effects of excitatory amino acids. Synapse 1992; 12:271-280.
11. Martin PM, Shamsul Ola M, Agarwal N, Ganapathy V, Smith SB. The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate. Mol Brain Res 2004; 123:66-75.
12. Miceli MV, Liles MR, Newsome DA. Evaluation of oxidative process in human pigment epithelial cells associated with retinal outer segment phagocytosis. Exp Cell Res 1994; 214:242-249.
13. 2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 1995; 36:1271-1279.
14. Ballinger SW, Van Houten B, Jin GF, Conklin CA, Godley BF. Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells. Exp Eye Res 1999; 68:765-772.
15. Jin GF, Hurst JS, Godley BF. Hydrogen peroxide stimulates apoptosis in cultured human retinal epithelial cells. Curr Eye Res 2001; 22:165-173.
16. McCracken KA, Bowen WD, De Costa BR, Matsumoto RR. Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity. Eur J Pharmacol 1999; 370:225-232.
17. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175:184-191.
18. Cai J, Nelson KC, Wu M, Sternberg P Jr, Jones DP. Oxidative damage and protection of the RPE. Prog Retin Eye Res 2000; 19:205-221.
19. 1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res 2004; 64:4875-4886.
20. Crawford KW, Bowen WD. Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. Cancer Res 2002; 62:313-322.
21. 1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures. Neurochem Int 1998; 32:337-343.
22. 1 receptor agonist glutamate neurotoxicity in cultured rat retinal neurons. Eur J Pharmacol 1998; 342:105-111.
23. 1 recognition sites. Eur J Pharmacol 2004; 498:111-114.
24. Bucolo C, Drago F, Lin LR, Reddy VN. Neuroactive steroids protect retinal pigment epithelium against oxidative stress. Neuroreport 2005; 16:1203-1207.