Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice

Experimental Neurology

Volumn 237, Issue 2, 2012, Pages 388-395

  Griesmaier, E ^a   Posod, A ^a   Gross, M ^a   Neubauer, V ^a   Wegleiter, K ^a   Hermann, M ^a   Urbanek, M ^a   Keller, M ^a,b   Kiechl Kohlendorfer, U ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b Childrend s Hospital Passau Dritter Orden   (Germany)

Author keywords

Excitotoxicity; Neonatal brain injury; PRE 084; Sigma 1 receptor agonist

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; CASPASE 3; GLUTAMIC ACID; IBOTENIC ACID; ISOLECTIN B4; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SIGMA 1 OPIATE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN INJURY; CELL ACTIVATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG DOSE COMPARISON; DRUG MEGADOSE; EMBRYO; EXCITOTOXICITY; GENE EXPRESSION; GRAY MATTER; HIPPOCAMPUS; IN VITRO STUDY; LOW DRUG DOSE; MALE; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NICK END LABELING; NONHUMAN; PERINATAL BRAIN INJURY; PRIORITY JOURNAL; SIGMA 1 RECEPTOR GENE;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BRAIN INJURIES; EXCITATORY AMINO ACIDS; GLUTAMIC ACID; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LIGANDS; MICE; MICROSCOPY, CONFOCAL; MORPHOLINES; NEURONS; NEUROPROTECTIVE AGENTS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, SIGMA;

EID: 84864939857     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.06.030     Document Type: Article

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