메뉴 건너뛰기




Volumn 15, Issue 5, 2011, Pages 1271-1284

Alterations to the blood-retinal barrier in diabetes: Cytokines and reactive oxygen species

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CYTOKINE; GROWTH FACTOR; PIGMENT EPITHELIUM DERIVED FACTOR; POLYOL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STEROID; TRANSCRIPTION FACTOR NRF2; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; XANTHINE OXIDASE;

EID: 79960772833     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2011.3906     Document Type: Review
Times cited : (114)

References (123)
  • 1
    • 0025073693 scopus 로고
    • A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy
    • Sorbinil Retinopathy Trial Research Group
    • A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Sorbinil Retinopathy Trial Research Group. Arch Ophthalmol 108: 1234-1244, 1990.
    • (1990) Arch Ophthalmol , vol.108 , pp. 1234-1244
  • 7
    • 0033551811 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    • Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, and Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 274: 23463-23467, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 23463-23467
    • Antonetti, D.A.1    Barber, A.J.2    Hollinger, L.A.3    Wolpert, E.B.4    Gardner, T.W.5
  • 8
    • 0031737671 scopus 로고    scopus 로고
    • Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content. Vascular endothelial growth factor decreases occludin in retinal endothelial cells
    • Antonetti DA, Barber AJ, Khin S, Lieth E, Tarbell JM, and Gardner TW. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: Vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes 47: 1953-1959, 1998. (Pubitemid 28549205)
    • (1998) Diabetes , vol.47 , Issue.12 , pp. 1953-1959
    • Antonetti, D.A.1    Barber, A.J.2    Khin, S.3    Lieth, E.4    Tarbell, J.M.5    Gardner, T.W.6
  • 9
    • 0037317423 scopus 로고    scopus 로고
    • A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat
    • DOI 10.2337/diabetes.52.2.506
    • Asnaghi V, Gerhardinger C, Hoehn T, Adeboje A, and Lorenzi M. A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat. Diabetes 52: 506-511, 2003. (Pubitemid 36173210)
    • (2003) Diabetes , vol.52 , Issue.2 , pp. 506-511
    • Asnaghi, V.1    Gerhardinger, C.2    Hoehn, T.3    Adeboje, A.4    Lorenzi, M.5
  • 10
    • 78049280268 scopus 로고    scopus 로고
    • TNF-a signals through PKCf/NF-jB to alter the tight junction complex and increase retinal endothelial cell permeability
    • Aveleira CA, Lin CM, Abcouwer SF, Ambrosio AF, and Antonetti DA. TNF-a signals through PKCf/NF-jB to alter the tight junction complex and increase retinal endothelial cell permeability. Diabetes 59: 2872-2882, 2010.
    • (2010) Diabetes , vol.59 , pp. 2872-2882
    • Aveleira, C.A.1    Lin, C.M.2    Abcouwer, S.F.3    Ambrosio, A.F.4    Antonetti, D.A.5
  • 11
    • 0033771018 scopus 로고    scopus 로고
    • Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes
    • The Penn State Retina Research Group
    • Barber AJ, Antonetti DA, and Gardner TW. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. Invest Ophthalmol Vis Sci 41: 3561-3568, 2000.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3561-3568
    • Barber, A.J.1    Antonetti, D.A.2    Gardner, T.W.3
  • 12
    • 0344851507 scopus 로고    scopus 로고
    • Mapping the Blood Vessels with Paracellular Permeability in the Retinas of Diabetic Rats
    • DOI 10.1167/iovs.03-0244
    • Barber AJ and Antonetti DA. Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. Invest Ophthalmol Vis Sci 44: 5410-5416, 2003. (Pubitemid 37475417)
    • (2003) Investigative Ophthalmology and Visual Science , vol.44 , Issue.12 , pp. 5410-5416
    • Barber, A.J.1    Antonetti, D.A.2
  • 13
    • 0022450293 scopus 로고
    • The effect of oxidation on sorbitol pathway kinetics
    • Barnett PA, Gonzalez RG, Chylack LT, Jr., and Cheng HM. The effect of oxidation on sorbitol pathway kinetics. Diabetes 35: 426-432, 1986. (Pubitemid 16078454)
    • (1986) Diabetes , vol.35 , Issue.4 , pp. 426-432
    • Barnett, P.A.1    Gonzalez, R.G.2    Chylack Jr., L.T.3    Cheng, H.-M.4
  • 15
    • 79960756426 scopus 로고    scopus 로고
    • Pathobiology of junctional adhesion molecules
    • Bazzoni G. Pathobiology of junctional adhesion molecules. Antioxid Redox Signal 15: 1221-1234, 2011.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1221-1234
    • Bazzoni, G.1
  • 16
    • 43449109783 scopus 로고    scopus 로고
    • Diabetes-enhanced tumor necrosis factor-α production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy
    • DOI 10.2353/ajpath.2008.071070
    • Behl Y, Krothapalli P, Desta T, DiPiazza A, Roy S, and Graves DT. Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy. Am J Pathol 172: 1411-1418, 2008. (Pubitemid 351671553)
    • (2008) American Journal of Pathology , vol.172 , Issue.5 , pp. 1411-1418
    • Behl, Y.1    Krothapalli, P.2    Desta, T.3    DiPiazza, A.4    Roy, S.5    Graves, D.T.6
  • 17
    • 1642484244 scopus 로고    scopus 로고
    • Xanthine oxidoreductase and cardiovascular disease: Molecular mechanisms and pathophysiological implications
    • DOI 10.1113/jphysiol.2003.055913
    • Berry CE and Hare JM. Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications. J Physiol 555(Pt 3):589-606, 2004. (Pubitemid 38404582)
    • (2004) Journal of Physiology , vol.555 , Issue.3 , pp. 589-606
    • Berry, C.E.1    Hare, J.M.2
  • 19
    • 0037627630 scopus 로고    scopus 로고
    • Low content of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor predicts progression of diabetic retinopathy
    • Boehm BO, Lang G, Volpert O, Jehle PM, Kurkhaus A, Rosinger S, Lang GK, and Bouck N. Low content of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor predicts progression of diabetic retinopathy. Diabetologia 46: 394-400, 2003. (Pubitemid 36547595)
    • (2003) Diabetologia , vol.46 , Issue.3 , pp. 394-400
    • Boehm, B.O.1    Lang, G.2    Volpert, O.3    Jehle, P.M.4    Kurkhaus, A.5    Rosinger, S.6    Lang, G.K.7    Bouck, N.8
  • 20
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • DOI 10.1038/414813a
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001. (Pubitemid 34000785)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 21
    • 48249091745 scopus 로고    scopus 로고
    • Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators
    • Busik JV, Mohr S and Grant MB. Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. Diabetes 57: 1952-1965, 2008.
    • (2008) Diabetes , vol.57 , pp. 1952-1965
    • Busik, J.V.1    Mohr, S.2    Grant, M.B.3
  • 22
    • 0024438305 scopus 로고
    • Effect of aldose reductase inhibition and insulin treatment on retinal capillary basement membrane thickening in BB rats
    • Chakrabarti S and Sima AA. Effect of aldose reductase inhibition and insulin treatment on retinal capillary basement membrane thickening in BB rats. Diabetes 38: 1181-1186, 1989. (Pubitemid 19250406)
    • (1989) Diabetes , vol.38 , Issue.9 , pp. 1181-1186
    • Chakrabarti, S.1    Sima, A.A.F.2
  • 25
    • 33644663628 scopus 로고    scopus 로고
    • Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice
    • DOI 10.2337/diabetes.54.11.3119
    • Cheung AK, Fung MK, Lo AC, Lam TT, So KF, Chung SS, and Chung SK. Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice. Diabetes 54: 3119-3125, 2005. (Pubitemid 43334364)
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3119-3125
    • Cheung, A.K.H.1    Fung, M.K.L.2    Lo, A.C.Y.3    Lam, T.T.L.4    Kwok, F.S.5    Chung, S.S.M.6    Chung, S.K.7
  • 26
    • 79960755029 scopus 로고    scopus 로고
    • Tight junctions in brain barriers during CNS inflammation
    • Coisne C and Engelhardt B. Tight junctions in brain barriers during CNS inflammation. Antioxid Redox Signal 15: 1285-1303, 2011.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1285-1303
    • Coisne, C.1    Engelhardt, B.2
  • 27
    • 33748194692 scopus 로고    scopus 로고
    • Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: The role of reactive oxygen species in diabetic retinopathy
    • DOI 10.1016/j.exer.2006.03.024, PII S0014483506002089
    • Cui Y, Xu X, Bi H, Zhu Q, Wu J, Xia X, Qiushi R, and Ho PC. Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: the role of reactive oxygen species in diabetic retinopathy. Exp Eye Res 83: 807-816, 2006. (Pubitemid 44308613)
    • (2006) Experimental Eye Research , vol.83 , Issue.4 , pp. 807-816
    • Cui, Y.1    Xu, X.2    Bi, H.3    Zhu, Q.4    Wu, J.5    Xia, X.6    Qiushi Ren7    Ho, P.C.P.8
  • 28
    • 4344658774 scopus 로고    scopus 로고
    • Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy
    • DOI 10.2337/diabetes.53.9.2404
    • Dagher Z, Park YS, Asnaghi V, Hoehn T, Gerhardinger C, and Lorenzi M. Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy. Diabetes 53: 2404-2411, 2004. (Pubitemid 39145596)
    • (2004) Diabetes , vol.53 , Issue.9 , pp. 2404-2411
    • Dagher, Z.1    Park, Y.S.2    Asnaghi, V.3    Hoehn, T.4    Gerhardinger, C.5    Lorenzi, M.6
  • 29
    • 0033538517 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor: A potent inhibitor of angiogenesis
    • DOI 10.1126/science.285.5425.245
    • Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, and Bouck NP. Pigment epithelium-derived factor: A potent inhibitor of angiogenesis. Science 285: 245-248, 1999. (Pubitemid 29329995)
    • (1999) Science , vol.285 , Issue.5425 , pp. 245-248
    • Dawson, D.W.1    Volpert, O.V.2    Gillis, P.3    Crawford, S.E.4    Xu, H.-J.5    Benedict, W.6    Bouck, N.P.7
  • 30
    • 14244265356 scopus 로고    scopus 로고
    • VEGF increases paracellular transport without altering the solvent-drag reflection coefficient
    • DOI 10.1016/j.mvr.2004.06.007
    • DeMaio L, Antonetti DA, Scaduto RC, Jr., Gardner TW, and Tarbell JM. VEGF increases paracellular transport without altering the solvent-drag reflection coefficient. Microvasc Res 68: 295-302, 2004. (Pubitemid 40288126)
    • (2004) Microvascular Research , vol.68 , Issue.3 , pp. 295-302
    • DeMaio, L.1    Antonetti, D.A.2    Scaduto Jr., R.C.3    Gardner, T.W.4    Tarbell, J.M.5
  • 31
    • 33845546564 scopus 로고    scopus 로고
    • Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy
    • DOI 10.1038/sj.eye.6702138, PII 6702138
    • Demircan N, Safran BG, Soylu M, Ozcan AA, and Sizmaz S. Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye (Lond) 20: 1366-1369, 2006. (Pubitemid 44921137)
    • (2006) Eye , vol.20 , Issue.12 , pp. 1366-1369
    • Demircan, N.1    Safran, B.G.2    Soylu, M.3    Ozcan, A.A.4    Sizmaz, S.5
  • 33
    • 0035180299 scopus 로고    scopus 로고
    • Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
    • DOI 10.1172/JCI200111235
    • Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, and Brownlee M. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 108: 1341-1348, 2001. (Pubitemid 33107762)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.9 , pp. 1341-1348
    • Du, X.L.1    Edelstein, D.2    Dimmeler, S.3    Ju, Q.4    Sui, C.5    Brownlee, M.6
  • 34
    • 0034710891 scopus 로고    scopus 로고
    • Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
    • Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, Wu J, and Brownlee M. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci USA 97: 12222-12226, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12222-12226
    • Du, X.L.1    Edelstein, D.2    Rossetti, L.3    Fantus, I.G.4    Goldberg, H.5    Ziyadeh, F.6    Wu, J.7    Brownlee, M.8
  • 35
    • 0036319333 scopus 로고    scopus 로고
    • Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine
    • DOI 10.1046/j.0022-3042.2001.00737.x
    • Du Y, Smith MA, Miller CM, and Kern TS. Diabetesinduced nitrative stress in the retina, and correction by aminoguanidine. J Neurochem 80: 771-779, 2002. (Pubitemid 34809229)
    • (2002) Journal of Neurochemistry , vol.80 , Issue.5 , pp. 771-779
    • Du, Y.1    Smith, M.A.2    Miller, C.M.3    Kern, T.S.4
  • 39
    • 0037562523 scopus 로고    scopus 로고
    • High glucose-induced tyrosine nitration in endothelial cells: Role of eNOS uncoupling and aldose reductase activation
    • DOI 10.1167/iovs.02-1022
    • El-Remessy AB, Abou-Mohamed G, Caldwell RW, and Caldwell RB. High glucose-induced tyrosine nitration in endothelial cells: Role of eNOS uncoupling and aldose reductase activation. Invest Ophthalmol Vis Sci 44: 3135-3143, 2003. (Pubitemid 36759784)
    • (2003) Investigative Ophthalmology and Visual Science , vol.44 , Issue.7 , pp. 3135-3143
    • El-Remessy, A.B.1    Abou-Mohamed, G.2    Caldwell, R.W.3    Caldwell, R.B.4
  • 40
  • 41
    • 0038243821 scopus 로고    scopus 로고
    • Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor
    • El-Remessy AB, Behzadian MA, Abou-Mohamed G, Franklin T, Caldwell RW, and Caldwell RB. Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor. Am J Pathol 162: 1995-2004, 2003. (Pubitemid 36613056)
    • (2003) American Journal of Pathology , vol.162 , Issue.6 , pp. 1995-2004
    • El-Remessy, A.B.1    Ali Behzadian, M.2    Abou-Mohamed, G.3    Franklin, T.4    Caldwell, R.W.5    Caldwell, R.B.6
  • 42
    • 14044265526 scopus 로고    scopus 로고
    • Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration
    • DOI 10.1242/jcs.01612
    • El-Remessy AB, Bartoli M, Platt DH, Fulton D, and Caldwell RB. Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration. J Cell Sci 118: 243-252, 2005. (Pubitemid 40277119)
    • (2005) Journal of Cell Science , vol.118 , Issue.1 , pp. 243-252
    • El-Remessy, A.B.1    Bartoli, M.2    Platt, D.H.3    Fulton, D.4    Caldwell, R.B.5
  • 44
    • 0033621686 scopus 로고    scopus 로고
    • 2, vascular endothelial growth factor and receptors in the retina of the BBZ/WOR diabetic rat
    • DOI 10.1016/S0891-5849(99)00216-6, PII S0891584999002166
    • Ellis EA, Guberski DL, Somogyi-Mann M, and Grant MB. Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat. Free Radic Biol Med 28: 91-101, 2000. (Pubitemid 30045577)
    • (2000) Free Radical Biology and Medicine , vol.28 , Issue.1 , pp. 91-101
    • Ellis, E.A.1    Guberski, D.L.2    Somogyi-Mann, M.3    Grant, M.B.4
  • 46
    • 33947308813 scopus 로고    scopus 로고
    • Vascular permeability in ocular disease and the role of tight junctions
    • DOI 10.1007/s10456-007-9067-z
    • Erickson KK, Sundstrom JM, and Antonetti DA. Vascular permeability in ocular disease and the role of tight junctions. Angiogenesis 10: 103-117, 2007. (Pubitemid 46440630)
    • (2007) Angiogenesis , vol.10 , Issue.2 , pp. 103-117
    • Erickson, K.K.1    Sundstrom, J.M.2    Antonetti, D.A.3
  • 47
    • 60749137151 scopus 로고    scopus 로고
    • NADPH oxidasedependent signaling in endothelial cells: Role in physiology and pathophysiology
    • Frey RS, Ushio-Fukai M, and Malik AB. NADPH oxidasedependent signaling in endothelial cells: Role in physiology and pathophysiology. Antioxid Redox Signal 11: 791-810, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 791-810
    • Frey, R.S.1    Ushio-Fukai, M.2    Malik, A.B.3
  • 48
    • 62349116866 scopus 로고    scopus 로고
    • H oxidase activation in diabetes: A double-edged sword in redox signalling
    • Gao L and Mann GE. Vascular NAD(P)H oxidase activation in diabetes: A double-edged sword in redox signalling. Cardiovasc Res 82: 9-20, 2009.
    • (2009) Cardiovasc Res , vol.82 , pp. 9-20
    • Gao, L.1    Mann, G.E.2    Nad, V.3
  • 49
    • 52649142151 scopus 로고    scopus 로고
    • Novel potential mechanisms for diabetic macular edema: Leveraging new investigational approaches
    • Gardner TW and Antonetti DA. Novel potential mechanisms for diabetic macular edema: Leveraging new investigational approaches. Curr Diab Rep 8: 263-269, 2008.
    • (2008) Curr Diab Rep , vol.8 , pp. 263-269
    • Gardner, T.W.1    Antonetti, D.A.2
  • 50
    • 72349083592 scopus 로고    scopus 로고
    • Diabetic macular oedema and visual loss: Relationship to location, severity and duration
    • Gardner TW, Larsen M, Girach A, and Zhi X. Diabetic macular oedema and visual loss: relationship to location, severity and duration. Acta Ophthalmol 87: 709-713, 2009.
    • (2009) Acta Ophthalmol , vol.87 , pp. 709-713
    • Gardner, T.W.1    Larsen, M.2    Girach, A.3    Zhi, X.4
  • 53
    • 0030009314 scopus 로고    scopus 로고
    • BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells
    • Giardino I, Edelstein D, and Brownlee M. BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells. J Clin Invest 97: 1422-1428, 1996. (Pubitemid 26097031)
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.6 , pp. 1422-1428
    • Giardino, I.1    Edelstein, D.2    Brownlee, M.3
  • 56
    • 42549108719 scopus 로고    scopus 로고
    • TNF-alpha is an independent serum marker for proliferative retinopathy in type 1 diabetic patients
    • Gustavsson C, Agardh E, Bengtsson B, and Agardh CD. TNF-alpha is an independent serum marker for proliferative retinopathy in type 1 diabetic patients. J Diabetes Complications 22: 309-316, 2008.
    • (2008) J Diabetes Complications , vol.22 , pp. 309-316
    • Gustavsson, C.1    Agardh, E.2    Bengtsson, B.3    Agardh, C.D.4
  • 57
    • 0037046214 scopus 로고    scopus 로고
    • Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase
    • DOI 10.1161/01.CIR.0000012748.58444.08
    • Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, and Channon KM. Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 105: 1656-1662, 2002. (Pubitemid 34298608)
    • (2002) Circulation , vol.105 , Issue.14 , pp. 1656-1662
    • Guzik, T.J.1    Mussa, S.2    Gastaldi, D.3    Sadowski, J.4    Ratnatunga, C.5    Pillai, R.6    Channon, K.M.7
  • 59
    • 0029347181 scopus 로고
    • Flavoprotein structure and mechanism Xanthine oxidase and xanthine dehydrogenase
    • Hille R and Nishino T. Flavoprotein structure and mechanism. Xanthine oxidase and xanthine dehydrogenase. FASEB J 9: 995-1003, 1995.
    • (1995) FASEB J , vol.9 , pp. 995-1003
    • Hille, R.1    Nishino, T.2
  • 60
    • 33947253955 scopus 로고    scopus 로고
    • Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular function in diabetic rats
    • DOI 10.1016/j.ejphar.2006.12.029, PII S0014299907000507
    • Inkster ME, Cotter MA, and Cameron NE. Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular function in diabetic rats. Eur J Pharmacol 561: 63-71, 2007. (Pubitemid 46435845)
    • (2007) European Journal of Pharmacology , vol.561 , Issue.1-3 , pp. 63-71
    • Inkster, M.E.1    Cotter, M.A.2    Cameron, N.E.3
  • 61
    • 0033765672 scopus 로고    scopus 로고
    • High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
    • Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, and Nawata H. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49: 1939-1945, 2000.
    • (2000) Diabetes , vol.49 , pp. 1939-1945
    • Inoguchi, T.1    Li, P.2    Umeda, F.3    Yu, H.Y.4    Kakimoto, M.5    Imamura, M.6    Aoki, T.7    Etoh, T.8    Hashimoto, T.9    Naruse, M.10    Sano, H.11    Utsumi, H.12    Nawata, H.13
  • 62
    • 0019414648 scopus 로고
    • Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium
    • Jarasch ED, Grund C, Bruder G, Heid HW, Keenan TW, and Franke WW. Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium. Cell 25: 67-82, 1981. (Pubitemid 11087436)
    • (1981) Cell , vol.25 , Issue.1 , pp. 67-82
    • Jarasch, E.D.1    Grund, C.2    Bruder, G.3
  • 63
    • 77951199503 scopus 로고    scopus 로고
    • The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy
    • Jiang T, Huang Z, Lin Y, Zhang Z, Fang D, and Zhang DD. The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes 59: 850-860, 2010.
    • (2010) Diabetes , vol.59 , pp. 850-860
    • Jiang, T.1    Huang, Z.2    Lin, Y.3    Zhang, Z.4    Fang, D.5    Zhang, D.D.6
  • 64
    • 79960772834 scopus 로고    scopus 로고
    • Epithelial barriers in intestinal inflammation
    • John LJ, Fromm M, and Schulzke JD. Epithelial barriers in intestinal inflammation. Antioxid Redox Signal 15: 1255-1270, 2011.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1255-1270
    • John, L.J.1    Fromm, M.2    Schulzke, J.D.3
  • 66
  • 67
    • 34648825492 scopus 로고    scopus 로고
    • Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase
    • DOI 10.1167/iovs.06-1280
    • Kanwar M, Chan PS, Kern TS, and Kowluru RA. Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci 48: 3805-3811, 2007. (Pubitemid 351261121)
    • (2007) Investigative Ophthalmology and Visual Science , vol.48 , Issue.8 , pp. 3805-3811
    • Kanwar, M.1    Chan, P.-S.2    Kern, T.S.3    Kowluru, R.A.4
  • 68
    • 0142138124 scopus 로고    scopus 로고
    • Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats
    • DOI 10.1016/S1056-8727(02)00193-9
    • Kato N, Yashima S, Suzuki T, Nakayama Y, and Jomori T. Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats. J Diabetes Complications 17: 374-379, 2003. (Pubitemid 37315949)
    • (2003) Journal of Diabetes and its Complications , vol.17 , Issue.6 , pp. 374-379
    • Kato, N.1    Yashima, S.2    Suzuki, T.3    Nakayama, Y.4    Jomori, T.5
  • 69
    • 0036062227 scopus 로고    scopus 로고
    • Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes
    • Kim YK, Lee MS, Son SM, Kim IJ, Lee WS, Rhim BY, Hong KW, and Kim CD. Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. Diabetes 51: 522-527, 2002. (Pubitemid 34764812)
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 522-527
    • Kim, Y.K.1    Lee, M.-S.2    Son, S.M.3    Kim, I.J.4    Lee, W.S.5    Rhim, B.Y.6    Hong, K.W.7    Kim, C.D.8
  • 70
    • 33645964980 scopus 로고    scopus 로고
    • Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy
    • DOI 10.1167/iovs.05-1276
    • Kowluru RA, Atasi L, and Ho YS. Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci 47: 1594-1599, 2006. (Pubitemid 46780770)
    • (2006) Investigative Ophthalmology and Visual Science , vol.47 , Issue.4 , pp. 1594-1599
    • Kowluru, R.A.1    Atasi, L.2    Ho, Y.-S.3
  • 71
    • 0034493893 scopus 로고    scopus 로고
    • Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine
    • DOI 10.1076/ceyr.21.4.814.5545
    • Kowluru RA, Engerman RL, and Kern TS. Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine. Curr Eye Res 21: 814-819, 2000. (Pubitemid 32099432)
    • (2000) Current Eye Research , vol.21 , Issue.4 , pp. 814-819
    • Kowluru, R.A.1    Engerman, R.L.2    Kern, T.S.3
  • 72
    • 33749070956 scopus 로고    scopus 로고
    • Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress
    • DOI 10.1016/j.freeradbiomed.2006.01.012, PII S0891584906000396
    • Kowluru RA, Kowluru V, Xiong Y, and Ho YS. Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Free Radic Biol Med 41: 1191-1196, 2006. (Pubitemid 44466317)
    • (2006) Free Radical Biology and Medicine , vol.41 , Issue.8 , pp. 1191-1196
    • Kowluru, R.A.1    Kowluru, V.2    Xiong, Y.3    Ho, Y.-S.4
  • 73
    • 9444224415 scopus 로고    scopus 로고
    • Effect of long-term administration of α-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats
    • DOI 10.2337/diabetes.53.12.3233
    • Kowluru RA and Odenbach S. Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes 53: 3233-3238, 2004. (Pubitemid 39564500)
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3233-3238
    • Kowluru, R.A.1    Odenbach, S.2
  • 74
    • 6944233576 scopus 로고    scopus 로고
    • Role of interleukin-1β in the development of retinopathy in rats: Effect of antioxidants
    • DOI 10.1167/iovs.04-0633
    • Kowluru RA and Odenbach S. Role of interleukin-1beta in the development of retinopathy in rats: Effect of antioxidants. Invest Ophthalmol Vis Sci 45: 4161-4166, 2004. (Pubitemid 39411175)
    • (2004) Investigative Ophthalmology and Visual Science , vol.45 , Issue.11 , pp. 4161-4166
    • Kowluru, R.A.1    Odenbach, S.2
  • 75
    • 4744347272 scopus 로고    scopus 로고
    • Role of interleukin-1β in the pathogenesis of diabetic retinopathy
    • DOI 10.1136/bjo.2003.038133
    • Kowluru RA and Odenbach S. Role of interleukin-1beta in the pathogenesis of diabetic retinopathy. Br J Ophthalmol 88: 1343-1347, 2004. (Pubitemid 39312984)
    • (2004) British Journal of Ophthalmology , vol.88 , Issue.10 , pp. 1343-1347
    • Kowluru, R.A.1    Odenbach, S.2
  • 78
    • 77953200258 scopus 로고    scopus 로고
    • Inhibition of reactive oxygen species by lovastatin downregulates VEGF expression and ameliorates blood-retinal barrier breakdown in db/db mice: Role of NADPH oxidase
    • Li J, Wang JJ, Yu Q, Chen K, Mahadev K, and Zhang SX. Inhibition of reactive oxygen species by lovastatin downregulates VEGF expression and ameliorates blood-retinal barrier breakdown in db/db mice: Role of NADPH oxidase Diabetes 59: 1528-1538, 2010.
    • (2010) Diabetes , vol.59 , pp. 1528-1538
    • Li, J.1    Wang, J.J.2    Yu, Q.3    Chen, K.4    Mahadev, K.5    Zhang, S.X.6
  • 80
    • 79953291729 scopus 로고    scopus 로고
    • A three-pore model describes transport properties of bovine retinal endothelial cells in normal and elevated glucose
    • Lopez-Quintero SU, Ji XY, Antonetti DA, Tarbell JM. A three-pore model describes transport properties of bovine retinal endothelial cells in normal and elevated glucose. Invest Opthalmol Vis Sci 52: 1171-1180.
    • Invest Opthalmol Vis Sci , vol.52 , pp. 1171-1180
    • Lopez-Quintero, S.U.1    Ji, X.Y.2    Antonetti, D.A.3    Tarbell, J.M.4
  • 81
    • 0029739621 scopus 로고    scopus 로고
    • Localization of vascular endothelial growth factor in human retina and choroid
    • Lutty GA, McLeod DS, Merges C, Diggs A, and Plouet J. Localization of vascular endothelial growth factor in human retina and choroid. Arch Ophthalmol 114: 971-977, 1996. (Pubitemid 26271463)
    • (1996) Archives of Ophthalmology , vol.114 , Issue.8 , pp. 971-977
    • Lutty, G.A.1    McLeod, D.S.2    Merges, C.3    Diggs, A.4    Plouet, J.5
  • 82
    • 0027962667 scopus 로고
    • Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy
    • Malecaze F, Clamens S, Simorre-Pinatel V, Mathis A, Chollet P, Favard C, Bayard F, and Plouet J. Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch Ophthalmol 112: 1476-1482, 1994. (Pubitemid 24350514)
    • (1994) Archives of Ophthalmology , vol.112 , Issue.11 , pp. 1476-1482
    • Malecaze, F.1    Clamens, S.2    Simorre-Pinatel, V.3    Mathis, A.4    Chollet, P.5    Favard, C.6    Bayard, F.7    Plouet, J.8
  • 86
    • 1542603184 scopus 로고    scopus 로고
    • Potential new strategies to prevent the development of diabetic retinopathy
    • DOI 10.1517/13543784.13.3.189
    • Mohr S. Potential new strategies to prevent the development of diabetic retinopathy. Expert Opin Investig Drugs 13: 189-198, 2004. (Pubitemid 38351341)
    • (2004) Expert Opinion on Investigational Drugs , vol.13 , Issue.3 , pp. 189-198
    • Mohr, S.1
  • 87
    • 0036224782 scopus 로고    scopus 로고
    • Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients
    • Mohr S, Xi X, Tang J, and Kern TS. Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes 51: 1172-1179, 2002. (Pubitemid 34438365)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 1172-1179
    • Mohr, S.1    Xi, A.2    Tang, J.3    Kern, T.S.4
  • 88
    • 0031807908 scopus 로고    scopus 로고
    • The 14-year incidence of visual loss in a diabetic population
    • DOI 10.1016/S0161-6420(98)96025-0
    • Moss SE, Klein R, and Klein BE. The 14-year incidence of visual loss in a diabetic population. Ophthalmology 105: 998-1003, 1998. (Pubitemid 28268322)
    • (1998) Ophthalmology , vol.105 , Issue.6 , pp. 998-1003
    • Moss, S.E.1    Klein, R.2    Klein, B.E.K.3
  • 89
    • 68949129005 scopus 로고    scopus 로고
    • Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability
    • Murakami T, Felinski EA, and Antonetti DA. Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem 284: 21036-21046, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 21036-21046
    • Murakami, T.1    Felinski, E.A.2    Antonetti, D.A.3
  • 90
    • 0033857531 scopus 로고    scopus 로고
    • The missing link: A single unifying mechanism for diabetic complications
    • Nishikawa T, Edelstein D, and Brownlee M. The missing link: A single unifying mechanism for diabetic complications. Kidney Int Suppl 77: S26-30, 2000.
    • (2000) Kidney Int Suppl , vol.77
    • Nishikawa, T.1    Edelstein, D.2    Brownlee, M.3
  • 91
    • 7044229733 scopus 로고    scopus 로고
    • Interactions between hyperglycemia and hypoxia: Implications for diabetic retinopathy
    • DOI 10.2337/diabetes.53.11.2931
    • Nyengaard JR, Ido Y, Kilo C, and Williamson JR. Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes 53: 2931-2938, 2004. (Pubitemid 39425919)
    • (2004) Diabetes , vol.53 , Issue.11 , pp. 2931-2938
    • Nyengaard, J.R.1    Ido, Y.2    Kilo, C.3    Williamson, J.R.4
  • 92
    • 0344837811 scopus 로고    scopus 로고
    • Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    • DOI 10.2337/diabetes.52.3.864
    • Obrosova IG, Minchenko AG, Vasupuram R, White L, Abatan OI, Kumagai AK, Frank RN, and Stevens MJ. Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. Diabetes 52: 864-871, 2003. (Pubitemid 36323597)
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 864-871
    • Obrosova, I.G.1    Minchenko, A.G.2    Vasupuram, R.3    White, L.4    Abatan, O.I.5    Kumagai, A.K.6    Frank, R.N.7    Stevens, M.J.8
  • 93
    • 0036742063 scopus 로고    scopus 로고
    • Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy
    • Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, and Matsumura M. Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am J Ophthalmol 134: 348-353, 2002.
    • (2002) Am J Ophthalmol , vol.134 , pp. 348-353
    • Ogata, N.1    Nishikawa, M.2    Nishimura, T.3    Mitsuma, Y.4    Matsumura, M.5
  • 94
    • 0034832184 scopus 로고    scopus 로고
    • Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury
    • DOI 10.1076/ceyr.22.4.245.5506
    • Ogata N, Wang L, Jo N, Tombran-Tink J, Takahashi K, Mrazek D, and Matsumura M. Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury. Curr Eye Res 22: 245-252, 2001. (Pubitemid 32881412)
    • (2001) Current Eye Research , vol.22 , Issue.4 , pp. 245-252
    • Ogata, N.1    Wang, L.2    Jo, N.3    Tombran-Tink, J.4    Takahashi, K.5    Mrazek, D.6    Matsumura, M.7
  • 96
    • 79960830822 scopus 로고    scopus 로고
    • Claudins: Control of barrier function and regulation in response to oxidant stress
    • Overgaard CE, Daugherty BL, Mitchell LA, and Koval M. Claudins: control of barrier function and regulation in response to oxidant stress. Antioxid Redox Signal 15: 1179-1193, 2011.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1179-1193
    • Overgaard, C.E.1    Daugherty, B.L.2    Mitchell, L.A.3    Koval, M.4
  • 98
    • 58149269716 scopus 로고    scopus 로고
    • Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States 2005-2050
    • Saaddine JB, Honeycutt AA, Narayan KM, Zhang X, Klein R, and Boyle JP. Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005-2050. Arch Ophthalmol 126: 1740-1747, 2008.
    • (2008) Arch Ophthalmol , vol.126 , pp. 1740-1747
    • Saaddine, J.B.1    Honeycutt, A.A.2    Narayan, K.M.3    Zhang, X.4    Klein, R.5    Boyle, J.P.6
  • 100
    • 0035140932 scopus 로고    scopus 로고
    • Diabetic macular edema: Passive and active transport of fluorescein through the blood-retina barrier
    • Sander B, Larsen M, Moldow B, and Lund-Andersen H. Diabetic macular edema: passive and active transport of fluorescein through the blood-retina barrier. Invest Ophthalmol Vis Sci 42: 433-438, 2001. (Pubitemid 32121476)
    • (2001) Investigative Ophthalmology and Visual Science , vol.42 , Issue.2 , pp. 433-438
    • Sander, B.1    Larsen, M.2    Moldow, B.3    Lund-Andersen, H.4
  • 101
    • 17444405235 scopus 로고    scopus 로고
    • Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes - The EURODIAB Prospective Complications Study
    • DOI 10.1007/s00125-004-1628-8
    • Schram MT, Chaturvedi N, Schalkwijk CG, Fuller JH, and Stehouwer CD.Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes. The EURODIAB Prospective Complications Study. Diabetologia 48: 370-378, 2005. (Pubitemid 40543311)
    • (2005) Diabetologia , vol.48 , Issue.2 , pp. 370-378
    • Schram, M.T.1    Chaturvedi, N.2    Schalkwijk, C.G.3    Fuller, J.H.4    Stehouwer, C.D.A.5
  • 102
    • 77956374138 scopus 로고    scopus 로고
    • Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture
    • Schrufer TL, Antonetti DA, Sonenberg N, Kimball SR, Gardner TW, and Jefferson LS. Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes 59: 2107-2116, 2010.
    • (2010) Diabetes , vol.59 , pp. 2107-2116
    • Schrufer, T.L.1    Antonetti, D.A.2    Sonenberg, N.3    Kimball, S.R.4    Gardner, T.W.5    Jefferson, L.S.6
  • 103
    • 70449479010 scopus 로고    scopus 로고
    • Mechanisms and functional implications of intestinal barrier defects
    • Shen L, Su L and Turner JR. Mechanisms and functional implications of intestinal barrier defects. Dig Dis 27: 443-449, 2009.
    • (2009) Dig Dis , vol.27 , pp. 443-449
    • Shen, L.1    Su, L.2    Turner, J.R.3
  • 104
    • 2942562273 scopus 로고    scopus 로고
    • Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity
    • DOI 10.1016/j.freeradbiomed.2004.04.001, PII S0891584904003041
    • Sonta T, Inoguchi T, Tsubouchi H, Sekiguchi N, Kobayashi K, Matsumoto S, Utsumi H, and Nawata H. Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity. Free Radic Biol Med 37: 115-123, 2004. (Pubitemid 38746655)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.1 , pp. 115-123
    • Sonta, T.1    Inoguchi, T.2    Tsubouchi, H.3    Sekiguchi, N.4    Kobayashi, K.5    Matsumoto, S.6    Utsumi, H.7    Nawata, H.8
  • 106
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, and Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62: 5196-5203, 2002. (Pubitemid 35033454)
    • (2002) Cancer Research , vol.62 , Issue.18 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 107
    • 77953240236 scopus 로고    scopus 로고
    • Blood-retinal barrier glycerol permeability in diabetic macular edema and healthy eyes: Estimations from macular volume changes after peroral glycerol
    • Thornit DN, Vinten CM, Sander B, Lund-Andersen H, and la Cour M. Blood-retinal barrier glycerol permeability in diabetic macular edema and healthy eyes: Estimations from macular volume changes after peroral glycerol. Invest Ophthalmol Vis Sci 51: 2827-2834, 2009.
    • (2009) Invest Ophthalmol Vis Sci , vol.51 , pp. 2827-2834
    • Thornit, D.N.1    Vinten, C.M.2    Sander, B.3    Lund-Andersen, H.4    La Cour, M.5
  • 108
    • 0024457571 scopus 로고
    • Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors
    • Tilton RG, Chang K, Pugliese G, Eades DM, Province MA, Sherman WR, Kilo C, and Williamson JR. Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors. Diabetes 38: 1258-1270, 1989. (Pubitemid 19247421)
    • (1989) Diabetes , vol.38 , Issue.10 , pp. 1258-1270
    • Tilton, R.G.1    Chang, K.2    Pugliese, G.3    Eades, D.M.4    Province, M.A.5    Sherman, W.R.6    Kilo, C.7    Williamson, J.R.8
  • 109
    • 0025772716 scopus 로고
    • PEDF: A pigment epithelium-derived factor with potent neuronal differentiative activity
    • Tombran-Tink J, Chader GG, and Johnson LV. PEDF: A pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res 53: 411-414, 1991.
    • (1991) Exp Eye Res , vol.53 , pp. 411-414
    • Tombran-Tink, J.1    Chader, G.G.2    Johnson, L.V.3
  • 110
    • 0029032001 scopus 로고
    • Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy
    • Van den Enden MK, Nyengaard JR, Ostrow E, Burgan JH, and Williamson JR. Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy. Invest Ophthalmol Vis Sci 36: 1675-1685, 1995.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 1675-1685
    • Van Den Enden, M.K.1    Nyengaard, J.R.2    Ostrow, E.3    Burgan, J.H.4    Williamson, J.R.5
  • 111
    • 33847048626 scopus 로고    scopus 로고
    • Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia
    • Vincent JA and Mohr S. Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes 56: 224-230, 2007.
    • (2007) Diabetes , vol.56 , pp. 224-230
    • Vincent, J.A.1    Mohr, S.2
  • 112
    • 62649094525 scopus 로고    scopus 로고
    • Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation
    • Warboys CM, Toh HB, and Fraser PA. Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation. Invest Ophthalmol Vis Sci 50: 1319-1328, 2009.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1319-1328
    • Warboys, C.M.1    Toh, H.B.2    Fraser, P.A.3
  • 113
    • 2342466734 scopus 로고    scopus 로고
    • Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
    • DOI 10.2337/diacare.27.5.1047
    • Wild S, Roglic G, Green A, Sicree R, and King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047-1053, 2004. (Pubitemid 38579764)
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 115
    • 0031015865 scopus 로고    scopus 로고
    • Glucose dependence of glycolysis, hexose monophosphate shunt activity, energy status, and the polyol pathway in retinas isolated from normal (nondiabetic) rats
    • Winkler BS, Arnold MJ, Brassell MA, and Sliter DR. Glucose dependence of glycolysis, hexose monophosphate shunt activity, energy status, and the polyol pathway in retinas isolated from normal (nondiabetic) rats. Invest Ophthalmol Vis Sci 38: 62-71, 1997. (Pubitemid 27051525)
    • (1997) Investigative Ophthalmology and Visual Science , vol.38 , Issue.1 , pp. 62-71
    • Winkler, B.S.1    Arnold, M.J.2    Brassell, M.A.3    Sliter, D.F.L.4
  • 116
    • 53149131731 scopus 로고    scopus 로고
    • Mitochondrial DNA oxidative damage triggering mitochondrial dysfunction and apoptosis in high glucose-induced HRECs
    • Xie L, Zhu X, Hu Y, Li T, Gao Y, Shi Y, and Tang S. Mitochondrial DNA oxidative damage triggering mitochondrial dysfunction and apoptosis in high glucose-induced HRECs. Invest Ophthalmol Vis Sci 49: 4203-4209, 2008.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 4203-4209
    • Xie, L.1    Zhu, X.2    Hu, Y.3    Li, T.4    Gao, Y.5    Shi, Y.6    Tang, S.7
  • 117
    • 32144437485 scopus 로고    scopus 로고
    • Potential utility of statins, 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in diabetic retinopathy
    • DOI 10.1016/j.mehy.2005.08.023, PII S0306987705004275
    • Yamagishi S, Nakamura K, Matsui T, Sato T, and Takeuchi M. Potential utility of statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in diabetic retinopathy. Med Hypotheses 66: 1019-1021, 2006. (Pubitemid 43207665)
    • (2006) Medical Hypotheses , vol.66 , Issue.5 , pp. 1019-1021
    • Yamagishi, S.1    Nakamura, K.2    Matsui, T.3    Sato, T.4    Takeuchi, M.5
  • 120
    • 0028220322 scopus 로고
    • Scanning electron-microscopic study of corrosion casts on retinal and choroidal angioarchitecture in man and animals
    • DOI 10.1016/1350-9462(94)90012-4
    • Zhang H. Scanning electron-microscopic study of corrosion casts on retinal and choroidal angioarchitecture in man and animals. Prog Ret Eye Res 13: 243-270, 1994. (Pubitemid 24086382)
    • (1994) Progress in Retinal and Eye Research , vol.13 , Issue.1 , pp. 243-270
    • Zhang, H.R.1
  • 121
    • 64649091717 scopus 로고    scopus 로고
    • Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: Involvement of a mitochondria-reactive oxygen species pathway
    • Zheng Z, Chen H, Ke G, Fan Y, Zou H, Sun X, Gu Q, Xu X, and Ho PC. Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: Involvement of a mitochondria-reactive oxygen species pathway. Diabetes 58: 954-964, 2009.
    • (2009) Diabetes , vol.58 , pp. 954-964
    • Zheng, Z.1    Chen, H.2    Ke, G.3    Fan, Y.4    Zou, H.5    Sun, X.6    Gu, Q.7    Xu, X.8    Ho, P.C.9
  • 122
    • 75749084898 scopus 로고    scopus 로고
    • Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro
    • Zheng Z, Chen H, Zhao H, Liu K, Luo D, Chen Y, Yang X, Gu Q, and Xu X. Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro. Invest Ophthalmol Vis Sci 51: 64-71, 2010.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 64-71
    • Zheng, Z.1    Chen, H.2    Zhao, H.3    Liu, K.4    Luo, D.5    Chen, Y.6    Yang, X.7    Gu, Q.8    Xu, X.9
  • 123
    • 77951709095 scopus 로고    scopus 로고
    • Pleiotropic effects of statins Basic research and clinical perspectives
    • Zhou Q and Liao JK. Pleiotropic effects of statins. Basic research and clinical perspectives. Circ J 74: 818-826, 2010.
    • (2010) Circ J , vol.74 , pp. 818-826
    • Zhou, Q.1    Liao, J.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.