Accelerated retinal ganglion cell death in mice deficient in the sigma-1 receptor

Molecular Vision

Volumn 17, Issue , 2011, Pages 1034-1044

  Mavlyutov, Timur A ^a   Nickells, Robert W ^a   Guo, Lian Wang ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIGMA 1 OPIATE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; CELL COUNT; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; FROZEN SECTION; IMMUNOFLUORESCENCE TEST; KNOCKOUT MOUSE; LIVER LEVEL; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NISSL STAINING; NONHUMAN; OPTIC NERVE INJURY; PHOTOAFFINITY LABELING; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; RECEPTOR OCCUPANCY; RETINA DEGENERATION; RETINA GANGLION CELL; WILD TYPE;

ANIMALS; AUTORADIOGRAPHY; CELL COUNT; DISEASE MODELS, ANIMAL; GLAUCOMA; MICE; MICE, KNOCKOUT; NERVE CRUSH; NEURODEGENERATIVE DISEASES; OPTIC NERVE; PHOTORECEPTOR CELLS; RADIOLIGAND ASSAY; RECEPTORS, SIGMA; RETINAL DEGENERATION; RETINAL GANGLION CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 79955642334     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Hanner M, Moebius FF, Flandorfer A, Knaus HG, Striessnig J, Kempner E, Glossmann H. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA 1996; 93:8072-8077. [PMID: 8755605]
2. Su TP, Hayashi T, Maurice T, Buch S, Ruoho AE. The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol Sci 2010; 31:557-566. [PMID: 20869780]
3. Alonso G, Phan V, Guillemain I, Saunier M, Legrand A, Anoal M, Maurice T. Immunocytochemical localization of the sigma [1] receptor in the adult rat central nervous system. Neuroscience 2000; 97:155-170. [PMID: 10771347]
4. Ola MS, Moore P, El-Sherbeny A, Roon P, Agarwal N, Sarthy VP, Casellas P, Ganapathy V, Smith SB. Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina. Brain Res Mol Brain Res 2001; 95:86-95. [PMID: 11687279]
5. Liu LL, Wang L, Zhong YM, Yang XL. Expression of sigma receptor 1 mRNA and protein in rat retina. Neuroscience 2010; 167:1151-1159. [PMID: 20223280]
6. Mavlyutov TA, Epstein ML, Andersen KA, Ziskind-Conhaim L, Ruoho AE. The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study. Neuroscience 2010; 167:247-255. [PMID: 20167253]
7. Hellewell SB, Bruce A, Feinstein G, Orringer J, Williams W, Bowen WD. Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling. Eur J Pharmacol 1994; 268:9-18. [PMID: 7925616]
8. Hayashi T, Su TP. Sigma-1 receptor chaperones at the ER mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell 2007; 131:596-610. [PMID: 17981125]
9. Meunier J, Ieni J, Maurice T. The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor. Br J Pharmacol 2006; 149:998-1012. [PMID: 17057756]
10. Katnik C, Guerrero WR, Pennypacker KR, Herrera Y, Cuevas J. Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. J Pharmacol Exp Ther 2006; 319:1355-1365. [PMID: 16988055]
11. Nishimura T, Ishima T, Iyo M, Hashimoto K. Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways. PLoS ONE 2008; 3:e2558. [PMID: 18596927]
12. Guzmán-Lenis MS, Navarro X, Casas C. Selective Sigma Receptor Agonist PRE084 Promotes Neuroprotection and Neurite Elongation Through PKC Signaling on Motoneurons. Neuroscience 2009; 162:31-38. [PMID: 19345724]
13. Ola MS, Moore P, Maddox D, El-Sherbeny A, Huang W, Roon P, Agarwal N, Ganapathy V, Smith SB. Analysis of sigmareceptor (sigmaR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabeticmice. Brain Res Mol Brain Res 2002; 107:97-107. [PMID:12425939]
14. Senda T, Matsuno K, Mita S. The presence of sigma receptor subtypes in bovine retinal membranes. Exp Eye Res 1997; 64:857-860. [PMID: 9245918]
15. Bucolo C, Drago F. Effects of neurosteroids on ischemiareperfusion injury in the rat retina: role of sigma1 recognition sites. Eur J Pharmacol 2004; 498:111-114. [PMID: 15363983]
16. Cantarella G, Bucolo C, Di Benedetto G, Pezzino S, Lempereur L, Calvagna R, Clementi S, Pavone P, Fiore L, Bernardini R. Protective effects of the sigma agonist Pre-084 in the rat retina. Br J Ophthalmol 2007; 91:1382-1384. [PMID: 17522150]
17. Dun Y, Thangaraju M, Prasad P, Ganapathy V, Smith SB. Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligand. Invest Ophthalmol Vis Sci 2007; 48:4785-4794. [PMID: 17898305]
18. Martin PM, Ola MS, Agarwal N, Ganapathy V, Smith SB. The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate. Brain Res Mol Brain Res 2004; 123:66-75.[PMID: 15046867]
19. Tchedre KT, Yorio T. sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation. Invest Ophthalmol Vis Sci 2008; 49:2577-2588. [PMID: 18296662]
20. Smith SB, Duplantier J, Dun Y, Mysona B, Roon P, Martin PM, Ganapathy V. In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine. Invest Ophthalmol Vis Sci 2008; 49:4154-4161.[PMID: 18469181]
21. Maurice T, Su TP. The pharmacology of sigma-1 receptors. Pharmacol Ther 2009; 124:195-206. [PMID: 19619582
22. Cobos EJ, Entrena JM, Nieto FR, Cendan CM, Del Pozo E. Pharmacology and therapeutic potential of sigma [1] receptorligands. Curr Neuropharmacol 2008; 6:344-366. [PMID: 19587856]
23. Fontanilla D, Johannessen M, Hajipour AR, Cozzi NV, Jackson MB, Ruoho AE. The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 2009; 323:934-937. [PMID: 19213917]
24. Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL. Predicting new molecular targets for known drugs. Nature 2009; 462:175-181. [PMID: 19881490]
25. Langa F, Codony X, Tovar V, Lavado A, Giménez E, Cozar P, Cantero M, Dordal A, Hernández E, Pérez R, Monroy X, Zamanillo D, Guitart X, Montoliu L. Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice. Eur J Neurosci 2003; 18:2188-196. [PMID: 14622179]
26. McKinnon SJ, Schlamp CL, Nickells RW. Mouse models of retinal ganglion cell death and glaucoma. Exp Eye Res 2009; 88:816-824. [PMID: 19105954]
27. Li Y, Schlamp CL, Nickells RW. Experimental induction of retinal ganglion cell death in adult mice. Invest Ophthalmol Vis Sci 1999; 40:1004-1008. [PMID: 10102300]
28. Li Y, Semaan SJ, Schlamp CL, Nickells RW. Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice. BMC Neurosci 2007; 8:19. [PMID: 17338819]
29. Ferreira PA. Characterization of RanBP2-associated molecular components in neuroretina. Methods Enzymol 2000; 315:455-468. [PMID: 10736720]
30. Pal A, Hajipour AR, Fontanilla D, Ramachandran S, Chu UB, Mavlyutov T, Ruoho AE. Identification of regions of the sigma-1 receptor ligand binding site using a novel photoprobe. Mol Pharmacol 2007; 72:921-933. [PMID: 17622576]
31. Mavlyutov TA, Cai Y, Ferreira PA. Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. Traffic 2002; 3:630-640. [PMID: 12191015]
32. Bucolo C, Marrazzo A, Ronsisvalle S, Ronsisvalle G, Cuzzocrea S, Mazzon E, Caputi A, Drago F. A novel adamantane derivative attenuates retinal ischemiareperfusion damage in the rat retina through sigma1 receptors. Eur J Pharmacol 2006; 536:200-203. [PMID: 16580663]
33. Libby RT, Li Y, Savinova OV, Barter J, Smith RS, Nickells RW, John SW. Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet 2005; 1:17-26. [PMID: 16103918]
34. Zhang XJ, Liu LL, Jiang SX, Zhong YM, Yang XL. Activation of the Sigma Receptor 1 Suppresses NMDA Responses in Rat Retinal Ganglion Cells. Neuroscience 2011; 177:12-22.[PMID: 21211548]
35. Kahoun JR, Ruoho AE. (125I)iodoazidococaine, a photoaffinity label for the haloperidol-sensitive sigma receptor. Proc Natl Acad Sci USA 1992; 89:1393-1397. [PMID: 1311097]
36. Chen Y, Hajipour AR, Sievert MK, Arbabian M, Ruoho AE. Characterization of the cocaine binding site on the sigma-1 receptor. Biochemistry 2007; 46:3532-3542. [PMID: 17315983]
37. Gebreselassie D, Bowen WD. Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes. Eur J Pharmacol 2004; 493:19-28. [PMID: 15189760]
38. Ramachandran S, Lu H, Prabhu U, Ruoho AE. Purification and characterization of the guinea pig sigma-1 receptor functionally expressed in Escherichia coli. Protein Expr Purif 2007; 51:283-92. [PMID: 16962337]
39. Jiang G, Mysona B, Dun Y, Gnana-Prakasam JP, Pabla N, Li W, Dong Z, Ganapathy V, Smith SB. Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells. Invest Ophthalmol Vis Sci 2006; 47:5576-5582. [PMID:17122151]
40. Dräger UC, Olsen JF. Ganglion cell distribution in the retina of the mouse. Invest Ophthalmol Vis Sci 1981; 20:285-293.[PMID: 6162818]
41. Jeon CJ, Strettoi E, Masland RH. The major cell populations of the mouse retina. J Neurosci 1998; 18:8936-8946. [PMID: 9786999]
42. Su TP, Hayashi T, Vaupel DB. When the endogenous hallucinogenic trace amine N,N-dimethyl tryptamine meets the sigma-1 receptor. Sci Signal 2009; 2:pe12. [PMID: 19278957]
43. Aydar E, Palmer CP, Klyachko VA, Jackson MB. The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 2002; 34:399-410. [PMID: 11988171]
44. Tchedre KT, Huang RQ, Dibas A, Krishnamoorthy RR, Dillon GH, Yorio T. Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction. Invest Ophthalmol Vis Sci 2008; 49:4993-5002. [PMID: 18641291]
45. Mavlyutov TA, Ruoho AE. Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells. J Mol Signal 2007; 2:8. [PMID: 17883859]
46. Hayashi T, Su TP. Sigma-1 receptors (sigma [1] binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export. J Pharmacol Exp Ther 2003; 306:718-725. [PMID: 12730355]
47. Yao H, Yang Y, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP, Wang JQ, Buch S. Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood 2010; 115:4951-4962. [PMID: 20354174]
48. Navarro G, Moreno E, Aymerich M, Marcellino D, McCormick PJ, Mallol J, Cortés A, Casadó V, Canela EI, Ortiz J, Fuxe K, Lluís C, Ferré S, Franco R. Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine. Proc Natl Acad Sci USA 2010; 107:18676-1881.[PMID: 20956312]
49. Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res 2006; 25:490-513. [PMID: 16962364]
50. Bucolo C, Drago F, Lin LR, Reddy VN. Sigma receptor ligands protect human retinal cells against oxidative stress. Neuroreport 2006; 17:287-291. [PMID: 16462599]
51. Li Y, Schlamp CL, Poulsen KP, Nickells RW. Bax-dependent and independent pathways of retinal ganglion cell death induced by different damaging stimuli. Exp Eye Res 2000; 71:209-213. [PMID: 10930325]
52. Meunier J, Hayashi T. Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB. J Pharmacol Exp Ther 2010; 332:388-397. [PMID: 19855099]
53. Nickells RW. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Exp Eye Res 2010; 91:2-8. [PMID: 20230818]
54. Levin LA, Schlamp CL, Spieldoch RL, Geszvain KM, Nickells RW. Identification of the bcl-2 family of genes in the rat retina. Invest Ophthalmol Vis Sci 1997; 38:2545-2553. [PMID: 9375574]
55. Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet 2006; 368:1795-1809. [PMID: 17113430]
56. Ramachandran S, Chu UB, Mavlyutov TA, Pal A, Pyne S, Ruoho AE. The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids. Eur J Pharmacol 2009; 609:19-26. [PMID: 19285059]