-
1
-
-
0019855492
-
Interactions of delta 1-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentography
-
COI: 1:CAS:528:DyaL38XhvF0%3D, PID: 6273208
-
Agurell S, Carlsson S, Lindgren JE, Ohlsson A, Gillespie H, Hollister LE (1981) Interactions of delta 1-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentography. Experientia 37:1090–1092
-
(1981)
Experientia
, vol.37
, pp. 1090-1092
-
-
Agurell, S.1
Carlsson, S.2
Lindgren, J.E.3
Ohlsson, A.4
Gillespie, H.5
Hollister, L.E.6
-
2
-
-
0028970609
-
Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
-
COI: 1:CAS:528:DyaK2MXos1ehsrs%3D, PID: 7559524
-
Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, Pestell RG (1995) Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem 270:23589–23597
-
(1995)
J Biol Chem
, vol.270
, pp. 23589-23597
-
-
Albanese, C.1
Johnson, J.2
Watanabe, G.3
Eklund, N.4
Vu, D.5
Arnold, A.6
Pestell, R.G.7
-
3
-
-
0018981254
-
3H-delta 9-Tetrahydrocannabinol, 3H-cannabinol and 3H-cannabidiol: penetration and regional distribution in rat brain
-
COI: 1:CAS:528:DyaL3cXks1Sru74%3D, PID: 6246544
-
Alozie SO, Martin BR, Harris LS, Dewey WL (1980) 3H-delta 9-Tetrahydrocannabinol, 3H-cannabinol and 3H-cannabidiol: penetration and regional distribution in rat brain. Pharmacol Biochem Behav 12:217–218
-
(1980)
Pharmacol Biochem Behav
, vol.12
, pp. 217-218
-
-
Alozie, S.O.1
Martin, B.R.2
Harris, L.S.3
Dewey, W.L.4
-
4
-
-
84938096558
-
-
Velasco G and Lovat PE: Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death. J Invest Dermatol
-
Armstrong JL, Hill DS, McKee CS, Hernandez-Tiedra S, Lorente M, Lopez-Valero I, Eleni Anagnostou M, Babatunde F, Corazzari M, Redfern CP, Velasco G and Lovat PE (2015) Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death. J Invest Dermatol
-
(2015)
Redfern CP
-
-
Armstrong, J.L.1
Hill, D.S.2
McKee, C.S.3
Hernandez-Tiedra, S.4
Lorente, M.5
Lopez-Valero, I.6
Eleni Anagnostou, M.7
Babatunde, F.8
Corazzari, M.9
-
5
-
-
0028227013
-
Structure and function of receptors coupled to G proteins
-
Baldwin JM (1994) Structure and function of receptors coupled to G proteins. Curr Opin Cell Biol 6
-
(1994)
Curr Opin Cell Biol
, pp. 6
-
-
Baldwin, J.M.1
-
6
-
-
0036278032
-
Targeting the endocannabinoid system in cancer therapy: a call for further research
-
COI: 1:CAS:528:DC%2BD38XktVyisbs%3D, PID: 12042794
-
Bifulco M, Di Marzo V (2002) Targeting the endocannabinoid system in cancer therapy: a call for further research. Nat Med 8:547–550
-
(2002)
Nat Med
, vol.8
, pp. 547-550
-
-
Bifulco, M.1
Di Marzo, V.2
-
7
-
-
0031773166
-
Characterization of cytochrome P450 3A inactivation by cannabidiol: possible involvement of cannabidiol-hydroxyquinone as a P450 inactivator
-
COI: 1:CAS:528:DyaK1cXmtV2gtL8%3D, PID: 9778318
-
Bornheim LM, Grillo MP (1998) Characterization of cytochrome P450 3A inactivation by cannabidiol: possible involvement of cannabidiol-hydroxyquinone as a P450 inactivator. Chem Res Toxicol 11:1209–1216
-
(1998)
Chem Res Toxicol
, vol.11
, pp. 1209-1216
-
-
Bornheim, L.M.1
Grillo, M.P.2
-
8
-
-
0019126986
-
The effects of delta 9-tetrahydrocannabinol alone and in combination with cannabidiol on fixed-interval performance in rhesus monkeys
-
COI: 1:CAS:528:DyaL3MXlvVeitA%3D%3D, PID: 6258188
-
Brady KT, Balster RL (1980) The effects of delta 9-tetrahydrocannabinol alone and in combination with cannabidiol on fixed-interval performance in rhesus monkeys. Psychopharmacology 72:21–26
-
(1980)
Psychopharmacology
, vol.72
, pp. 21-26
-
-
Brady, K.T.1
Balster, R.L.2
-
9
-
-
77954789824
-
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
-
PID: 20649976
-
Caffarel MM, Andradas C, Mira E, Perez-Gomez E, Cerutti C, Moreno-Bueno G, Flores JM, Garcia-Real I, Palacios J, Manes S, Guzman M, Sanchez C (2010) Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition. Mol Cancer 9:196
-
(2010)
Mol Cancer
, vol.9
, pp. 196
-
-
Caffarel, M.M.1
Andradas, C.2
Mira, E.3
Perez-Gomez, E.4
Cerutti, C.5
Moreno-Bueno, G.6
Flores, J.M.7
Garcia-Real, I.8
Palacios, J.9
Manes, S.10
Guzman, M.11
Sanchez, C.12
-
10
-
-
84862849835
-
Redox implications of AMPK-mediated signal transduction beyond energetic clues
-
COI: 1:CAS:528:DC%2BC38XhtVGltr7L, PID: 22619229
-
Cardaci S, Filomeni G, Ciriolo MR (2012) Redox implications of AMPK-mediated signal transduction beyond energetic clues. J Cell Sci 125:2115–2125
-
(2012)
J Cell Sci
, vol.125
, pp. 2115-2125
-
-
Cardaci, S.1
Filomeni, G.2
Ciriolo, M.R.3
-
11
-
-
33746138649
-
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
-
COI: 1:CAS:528:DC%2BD28XmsValsrw%3D, PID: 16818650
-
Carracedo A, Gironella M, Lorente M, Garcia S, Guzman M, Velasco G, Iovanna JL (2006a) Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 66:6748–6755
-
(2006)
Cancer Res
, vol.66
, pp. 6748-6755
-
-
Carracedo, A.1
Gironella, M.2
Lorente, M.3
Garcia, S.4
Guzman, M.5
Velasco, G.6
Iovanna, J.L.7
-
12
-
-
33645763253
-
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
-
COI: 1:CAS:528:DC%2BD28XjvFeiurs%3D, PID: 16616335
-
Carracedo A, Lorente M, Egia A, Blazquez C, Garcia S, Giroux V, Malicet C, Villuendas R, Gironella M, Gonzalez-Feria L, Piris MA, Iovanna JL, Guzman M, Velasco G (2006b) The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 9:301–312
-
(2006)
Cancer Cell
, vol.9
, pp. 301-312
-
-
Carracedo, A.1
Lorente, M.2
Egia, A.3
Blazquez, C.4
Garcia, S.5
Giroux, V.6
Malicet, C.7
Villuendas, R.8
Gironella, M.9
Gonzalez-Feria, L.10
Piris, M.A.11
Iovanna, J.L.12
Guzman, M.13
Velasco, G.14
-
13
-
-
0017227448
-
Influence of cannabidiol on delta-9-tetrahydrocannabinol effects
-
COI: 1:CAS:528:DyaE28XhsVCqu7g%3D, PID: 770048
-
Dalton WS, Martz R, Lemberger L, Rodda BE, Forney RB (1976) Influence of cannabidiol on delta-9-tetrahydrocannabinol effects. Clin Pharmacol Ther 19:300–309
-
(1976)
Clin Pharmacol Ther
, vol.19
, pp. 300-309
-
-
Dalton, W.S.1
Martz, R.2
Lemberger, L.3
Rodda, B.E.4
Forney, R.B.5
-
14
-
-
84879666294
-
Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells
-
COI: 1:CAS:528:DC%2BC3sXhtVyrsLvK, PID: 23764845
-
Dando I, Donadelli M, Costanzo C, Dalla Pozza E, D’Alessandro A, Zolla L, Palmieri M (2013) Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells. Cell Death Dis 4:e664
-
(2013)
Cell Death Dis
, vol.4
, pp. e664
-
-
Dando, I.1
Donadelli, M.2
Costanzo, C.3
Dalla Pozza, E.4
D’Alessandro, A.5
Zolla, L.6
Palmieri, M.7
-
15
-
-
0020699799
-
Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol
-
COI: 1:CAS:528:DyaL3sXitV2mu7o%3D, PID: 6301931
-
Davis WM, Hatoum NS (1983) Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol. Gen Pharmacol 14:247–252
-
(1983)
Gen Pharmacol
, vol.14
, pp. 247-252
-
-
Davis, W.M.1
Hatoum, N.S.2
-
16
-
-
84872555149
-
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
-
PID: 22594963
-
De Petrocellis L, Ligresti A, Schiano Moriello A, Iappelli M, Verde R, Stott CG, Cristino L, Orlando P, Di Marzo V (2013) Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms. Br J Pharmacol 168:79–102
-
(2013)
Br J Pharmacol
, vol.168
, pp. 79-102
-
-
De Petrocellis, L.1
Ligresti, A.2
Schiano Moriello, A.3
Iappelli, M.4
Verde, R.5
Stott, C.G.6
Cristino, L.7
Orlando, P.8
Di Marzo, V.9
-
17
-
-
79959956124
-
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
-
COI: 1:STN:280:DC%2BC3Mvnt1GktA%3D%3D, PID: 21525939
-
Donadelli M, Dando I, Zaniboni T, Costanzo C, Dalla Pozza E, Scupoli MT, Scarpa A, Zappavigna S, Marra M, Abbruzzese A, Bifulco M, Caraglia M, Palmieri M (2011) Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis 2:e152
-
(2011)
Cell Death Dis
, vol.2
, pp. e152
-
-
Donadelli, M.1
Dando, I.2
Zaniboni, T.3
Costanzo, C.4
Dalla Pozza, E.5
Scupoli, M.T.6
Scarpa, A.7
Zappavigna, S.8
Marra, M.9
Abbruzzese, A.10
Bifulco, M.11
Caraglia, M.12
Palmieri, M.13
-
19
-
-
84926410281
-
-
Novel anti-tumor mechanisms of Cannabidiol in breast cancer, Mol Oncol
-
Elbaz M, Nasser MW, Ravi J, Wani NA, Ahirwar DK, Zhao H, Oghumu S, Satoskar AR, Shilo K, Carson WE, 3rd and Ganju RK (2015) Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti-tumor mechanisms of Cannabidiol in breast cancer. Mol Oncol
-
(2015)
Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway
-
-
Elbaz, M.1
Nasser, M.W.2
Ravi, J.3
Wani, N.A.4
Ahirwar, D.K.5
Zhao, H.6
Oghumu, S.7
Satoskar, A.R.8
Shilo, K.9
Carson, W.E.10
Ganju, R.K.11
-
20
-
-
84893147489
-
Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells
-
PID: 24259678
-
Emery SM, Alotaibi MR, Tao Q, Selley DE, Lichtman AH, Gewirtz DA (2014) Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. J Pharmacol Exp Ther 348:293–302
-
(2014)
J Pharmacol Exp Ther
, vol.348
, pp. 293-302
-
-
Emery, S.M.1
Alotaibi, M.R.2
Tao, Q.3
Selley, D.E.4
Lichtman, A.H.5
Gewirtz, D.A.6
-
21
-
-
43049127845
-
The endocannabinoid system in cancer-potential therapeutic target?
-
COI: 1:CAS:528:DC%2BD1cXlslGis7w%3D, PID: 18249558
-
Flygare J, Sander B (2008) The endocannabinoid system in cancer-potential therapeutic target? Semin Cancer Biol 18:176–189
-
(2008)
Semin Cancer Biol
, vol.18
, pp. 176-189
-
-
Flygare, J.1
Sander, B.2
-
22
-
-
0345686714
-
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
-
COI: 1:CAS:528:DC%2BD3sXptFOit7g%3D, PID: 14578451
-
Fong S, Itahana Y, Sumida T, Singh J, Coppe JP, Liu Y, Richards PC, Bennington JL, Lee NM, Debs RJ, Desprez PY (2003) Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci U S A 100:13543–13548
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 13543-13548
-
-
Fong, S.1
Itahana, Y.2
Sumida, T.3
Singh, J.4
Coppe, J.P.5
Liu, Y.6
Richards, P.C.7
Bennington, J.L.8
Lee, N.M.9
Debs, R.J.10
Desprez, P.Y.11
-
23
-
-
76749083341
-
Antitumorigenic effects of cannabinoids beyond apoptosis
-
COI: 1:CAS:528:DC%2BC3cXltVCksLY%3D, PID: 19889794
-
Freimuth N, Ramer R, Hinz B (2010) Antitumorigenic effects of cannabinoids beyond apoptosis. J Pharmacol Exp Ther 332:336–344
-
(2010)
J Pharmacol Exp Ther
, vol.332
, pp. 336-344
-
-
Freimuth, N.1
Ramer, R.2
Hinz, B.3
-
24
-
-
17344380844
-
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
-
COI: 1:CAS:528:DC%2BD3cXhslygs7w%3D, PID: 10700234
-
Galve-Roperh I, Sanchez C, Cortes ML, del Pulgar TG, Izquierdo M, Guzman M (2000) Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 6:313–319
-
(2000)
Nat Med
, vol.6
, pp. 313-319
-
-
Galve-Roperh, I.1
Sanchez, C.2
Cortes, M.L.3
del Pulgar, T.G.4
Izquierdo, M.5
Guzman, M.6
-
25
-
-
0028089295
-
Anxiolytic effect of cannabidiol derivatives in the elevated plus-maze
-
COI: 1:CAS:528:DyaK2cXis1WjtrY%3D, PID: 7913072
-
Guimaraes FS, de Aguiar JC, Mechoulam R, Breuer A (1994) Anxiolytic effect of cannabidiol derivatives in the elevated plus-maze. Gen Pharmacol 25:161–164
-
(1994)
Gen Pharmacol
, vol.25
, pp. 161-164
-
-
Guimaraes, F.S.1
de Aguiar, J.C.2
Mechoulam, R.3
Breuer, A.4
-
26
-
-
79960336157
-
The endocannabinoid system and cancer: therapeutic implication
-
COI: 1:CAS:528:DC%2BC3MXps1Sju7g%3D, PID: 21410463
-
Guindon J, Hohmann AG (2011) The endocannabinoid system and cancer: therapeutic implication. Br J Pharmacol 163:1447–1463
-
(2011)
Br J Pharmacol
, vol.163
, pp. 1447-1463
-
-
Guindon, J.1
Hohmann, A.G.2
-
27
-
-
37649001973
-
ID genes mediate tumor reinitiation during breast cancer lung metastasis
-
COI: 1:CAS:528:DC%2BD1cXisVOgsw%3D%3D, PID: 18048329
-
Gupta GP, Perk J, Acharyya S, de Candia P, Mittal V, Todorova-Manova K, Gerald WL, Brogi E, Benezra R, Massague J (2007) ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A 104:19506–19511
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19506-19511
-
-
Gupta, G.P.1
Perk, J.2
Acharyya, S.3
de Candia, P.4
Mittal, V.5
Todorova-Manova, K.6
Gerald, W.L.7
Brogi, E.8
Benezra, R.9
Massague, J.10
-
28
-
-
0032493197
-
Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
-
COI: 1:CAS:528:DyaK1cXks1SltL0%3D, PID: 9653176
-
Hampson AJ, Grimaldi M, Axelrod J, Wink D (1998) Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A 95:8268–8273
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 8268-8273
-
-
Hampson, A.J.1
Grimaldi, M.2
Axelrod, J.3
Wink, D.4
-
29
-
-
0024159898
-
Cannabinol and cannabidiol in combination: temperature, open-field activity, and vocalization
-
COI: 1:CAS:528:DyaL1cXlt1ansb8%3D, PID: 3211977
-
Hiltunen AJ, Jarbe TU, Wangdahl K (1988) Cannabinol and cannabidiol in combination: temperature, open-field activity, and vocalization. Pharmacol Biochem Behav 30:675–678
-
(1988)
Pharmacol Biochem Behav
, vol.30
, pp. 675-678
-
-
Hiltunen, A.J.1
Jarbe, T.U.2
Wangdahl, K.3
-
30
-
-
0024502485
-
Behaviour in rats maintained by low differential reinforcement rate: effects of delta 1-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination
-
COI: 1:CAS:528:DyaL1MXhsVOktrw%3D, PID: 2541367
-
Hiltunen AJ, Jarbe TU, Kamkar MR, Archer T (1989) Behaviour in rats maintained by low differential reinforcement rate: effects of delta 1-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination. Neuropharmacology 28:183–189
-
(1989)
Neuropharmacology
, vol.28
, pp. 183-189
-
-
Hiltunen, A.J.1
Jarbe, T.U.2
Kamkar, M.R.3
Archer, T.4
-
31
-
-
33644828740
-
The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells
-
COI: 1:CAS:528:DC%2BD28Xit1ynurc%3D, PID: 16458258
-
Holland ML, Panetta JA, Hoskins JM, Bebawy M, Roufogalis BD, Allen JD, Arnold JC (2006) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochem Pharmacol 71:1146–1154
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1146-1154
-
-
Holland, M.L.1
Panetta, J.A.2
Hoskins, J.M.3
Bebawy, M.4
Roufogalis, B.D.5
Allen, J.D.6
Arnold, J.C.7
-
32
-
-
35648948415
-
The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids
-
COI: 1:CAS:528:DC%2BD2sXht1ejt7%2FE, PID: 17906686
-
Holland ML, Lau DT, Allen JD, Arnold JC (2007) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Br J Pharmacol 152:815–824
-
(2007)
Br J Pharmacol
, vol.152
, pp. 815-824
-
-
Holland, M.L.1
Lau, D.T.2
Allen, J.D.3
Arnold, J.C.4
-
33
-
-
0016524399
-
Interactions in man of delta-9-tetrahydrocannabinol. II. Cannabinol and cannabidiol
-
COI: 1:CAS:528:DyaE2MXlsVajtb4%3D, PID: 1097148
-
Hollister LE, Gillespie H (1975) Interactions in man of delta-9-tetrahydrocannabinol. II. Cannabinol and cannabidiol. Clin Pharmacol Ther 18:80–83
-
(1975)
Clin Pharmacol Ther
, vol.18
, pp. 80-83
-
-
Hollister, L.E.1
Gillespie, H.2
-
34
-
-
0023197826
-
Cannabinoid inhibition of adenylate cyclase: relative activity of the constituents and metabolites of marijuana
-
COI: 1:CAS:528:DyaL2sXktlejur4%3D, PID: 3601007
-
Howlett AC (1987) Cannabinoid inhibition of adenylate cyclase: relative activity of the constituents and metabolites of marijuana. Neuropharmacology 26:507–512
-
(1987)
Neuropharmacology
, vol.26
, pp. 507-512
-
-
Howlett, A.C.1
-
35
-
-
67449088929
-
The role of Id-1 in chemosensitivity and epirubicin-induced apoptosis in bladder cancer cells
-
COI: 1:CAS:528:DC%2BD1MXksVSrtLs%3D, PID: 19288008
-
Hu H, Han HY, Wang YL, Zhang XP, Chua CW, Wong YC, Wang XF, Ling MT, Xu KX (2009) The role of Id-1 in chemosensitivity and epirubicin-induced apoptosis in bladder cancer cells. Oncol Rep 21:1053–1059
-
(2009)
Oncol Rep
, vol.21
, pp. 1053-1059
-
-
Hu, H.1
Han, H.Y.2
Wang, Y.L.3
Zhang, X.P.4
Chua, C.W.5
Wong, Y.C.6
Wang, X.F.7
Ling, M.T.8
Xu, K.X.9
-
36
-
-
0029846519
-
Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor
-
COI: 1:CAS:528:DyaK28XlsVCisLg%3D, PID: 8831752
-
Huffman JW, Shu Y, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett DR, Reggio PH (1996) Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. J Med Chem 39:3875–3877
-
(1996)
J Med Chem
, vol.39
, pp. 3875-3877
-
-
Huffman, J.W.1
Shu, Y.2
Showalter, V.3
Abood, M.E.4
Wiley, J.L.5
Compton, D.R.6
Martin, B.R.7
Bramblett, D.R.8
Reggio, P.H.9
-
37
-
-
0019821033
-
Evidence that cannabidiol does not significantly alter the pharmacokinetics of tetrahydrocannabinol in man
-
COI: 1:CAS:528:DyaL3MXlvFOksLo%3D, PID: 6270295
-
Hunt CA, Jones RT, Herning RI, Bachman J (1981) Evidence that cannabidiol does not significantly alter the pharmacokinetics of tetrahydrocannabinol in man. J Pharmacokinet Biopharm 9:245–260
-
(1981)
J Pharmacokinet Biopharm
, vol.9
, pp. 245-260
-
-
Hunt, C.A.1
Jones, R.T.2
Herning, R.I.3
Bachman, J.4
-
38
-
-
0034672605
-
Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability
-
COI: 1:CAS:528:DC%2BD3cXosFCit7w%3D, PID: 11108795
-
Jacobsson SO, Rongard E, Stridh M, Tiger G, Fowler CJ (2000) Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability. Biochem Pharmacol 60:1807–1813
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1807-1813
-
-
Jacobsson, S.O.1
Rongard, E.2
Stridh, M.3
Tiger, G.4
Fowler, C.J.5
-
39
-
-
0029917596
-
Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes
-
COI: 1:CAS:528:DyaK28XitFKisLw%3D, PID: 8730919
-
Jaeger W, Benet LZ, Bornheim LM (1996) Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica 26:275–284
-
(1996)
Xenobiotica
, vol.26
, pp. 275-284
-
-
Jaeger, W.1
Benet, L.Z.2
Bornheim, L.M.3
-
40
-
-
0023157571
-
Cannabimimetic activity of cannabinol in rats and pigeons
-
COI: 1:STN:280:DyaL2s3ivFekug%3D%3D, PID: 3035413
-
Jarbe TU, Hiltunen AJ (1987) Cannabimimetic activity of cannabinol in rats and pigeons. Neuropharmacology 26:219–228
-
(1987)
Neuropharmacology
, vol.26
, pp. 219-228
-
-
Jarbe, T.U.1
Hiltunen, A.J.2
-
41
-
-
84908759476
-
Cannabis and epilepsy
-
Nahas GG, Paton WDM, (eds), Pergamon Press, Oxford
-
Karler R, Turkanis SA (1979) Cannabis and epilepsy. In: Nahas GG, Paton WDM (eds) Marihuana: biological effects, analysis, metabolism, cellular responses, reproduction and brain. Pergamon Press, Oxford, pp 619–641
-
(1979)
Marihuana: biological effects, analysis, metabolism, cellular responses, reproduction and brain
, pp. 619-641
-
-
Karler, R.1
Turkanis, S.A.2
-
42
-
-
18844400058
-
Cannabinoid-based drugs as anti-inflammatory therapeutics
-
COI: 1:CAS:528:DC%2BD2MXjs1Okurg%3D, PID: 15864274
-
Klein TW (2005) Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 5:400–411
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 400-411
-
-
Klein, T.W.1
-
43
-
-
3142618434
-
Synthesis and antitumor activity of quinonoid derivatives of cannabinoids
-
COI: 1:CAS:528:DC%2BD2cXks1Gisbk%3D, PID: 15239658
-
Kogan NM, Rabinowitz R, Levi P, Gibson D, Sandor P, Schlesinger M, Mechoulam R (2004) Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. J Med Chem 47:3800–3806
-
(2004)
J Med Chem
, vol.47
, pp. 3800-3806
-
-
Kogan, N.M.1
Rabinowitz, R.2
Levi, P.3
Gibson, D.4
Sandor, P.5
Schlesinger, M.6
Mechoulam, R.7
-
44
-
-
33846840690
-
HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor
-
COI: 1:CAS:528:DC%2BD2sXmsVamtg%3D%3D, PID: 17237277
-
Kogan NM, Schlesinger M, Priel E, Rabinowitz R, Berenshtein E, Chevion M, Mechoulam R (2007) HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor. Mol Cancer Ther 6:173–183
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 173-183
-
-
Kogan, N.M.1
Schlesinger, M.2
Priel, E.3
Rabinowitz, R.4
Berenshtein, E.5
Chevion, M.6
Mechoulam, R.7
-
45
-
-
20844447150
-
Controlling tumor growth by modulating endogenous production of reactive oxygen species
-
COI: 1:CAS:528:DC%2BD2MXhtVWntb4%3D, PID: 15705895
-
Laurent A, Nicco C, Chereau C, Goulvestre C, Alexandre J, Alves A, Levy E, Goldwasser F, Panis Y, Soubrane O, Weill B, Batteux F (2005) Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 65:948–956
-
(2005)
Cancer Res
, vol.65
, pp. 948-956
-
-
Laurent, A.1
Nicco, C.2
Chereau, C.3
Goulvestre, C.4
Alexandre, J.5
Alves, A.6
Levy, E.7
Goldwasser, F.8
Panis, Y.9
Soubrane, O.10
Weill, B.11
Batteux, F.12
-
46
-
-
33747624175
-
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
-
COI: 1:CAS:528:DC%2BD28XovFygtLY%3D, PID: 16728591
-
Ligresti A, Moriello AS, Starowicz K, Matias I, Pisanti S, De Petrocellis L, Laezza C, Portella G, Bifulco M, Di Marzo V (2006) Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 318:1375–1387
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 1375-1387
-
-
Ligresti, A.1
Moriello, A.S.2
Starowicz, K.3
Matias, I.4
Pisanti, S.5
De Petrocellis, L.6
Laezza, C.7
Portella, G.8
Bifulco, M.9
Di Marzo, V.10
-
47
-
-
0034662868
-
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
-
COI: 1:CAS:528:DC%2BD3cXmtVensbs%3D, PID: 10920191
-
Malfait AM, Gallily R, Sumariwalla PF, Malik AS, Andreakos E, Mechoulam R, Feldmann M (2000) The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A 97:9561–9566
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 9561-9566
-
-
Malfait, A.M.1
Gallily, R.2
Sumariwalla, P.F.3
Malik, A.S.4
Andreakos, E.5
Mechoulam, R.6
Feldmann, M.7
-
48
-
-
84878151308
-
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
-
COI: 1:CAS:528:DC%2BC3sXhtFSjsbzE, PID: 23650391
-
Mao P, Joshi K, Li J, Kim SH, Li P, Santana-Santos L, Luthra S, Chandran UR, Benos PV, Smith L, Wang M, Hu B, Cheng SY, Sobol RW, Nakano I (2013) Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3. Proc Natl Acad Sci U S A 110:8644–8649
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 8644-8649
-
-
Mao, P.1
Joshi, K.2
Li, J.3
Kim, S.H.4
Li, P.5
Santana-Santos, L.6
Luthra, S.7
Chandran, U.R.8
Benos, P.V.9
Smith, L.10
Wang, M.11
Hu, B.12
Cheng, S.Y.13
Sobol, R.W.14
Nakano, I.15
-
49
-
-
73949139182
-
Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
-
COI: 1:CAS:528:DC%2BC3cXktVOitA%3D%3D, PID: 20053780
-
Marcu JP, Christian RT, Lau D, Zielinski AJ, Horowitz MP, Lee J, Pakdel A, Allison J, Limbad C, Moore DH, Yount GL, Desprez PY, McAllister SD (2010) Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Mol Cancer Ther 9:180–189
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 180-189
-
-
Marcu, J.P.1
Christian, R.T.2
Lau, D.3
Zielinski, A.J.4
Horowitz, M.P.5
Lee, J.6
Pakdel, A.7
Allison, J.8
Limbad, C.9
Moore, D.H.10
Yount, G.L.11
Desprez, P.Y.12
McAllister, S.D.13
-
50
-
-
1342280974
-
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines
-
COI: 1:CAS:528:DC%2BD2cXhvVWnt7g%3D, PID: 14617682
-
Massi P, Vaccani A, Ceruti S, Colombo A, Abbracchio MP, Parolaro D (2004) Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. J Pharmacol Exp Ther 308:838–845
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 838-845
-
-
Massi, P.1
Vaccani, A.2
Ceruti, S.3
Colombo, A.4
Abbracchio, M.P.5
Parolaro, D.6
-
51
-
-
33748492117
-
The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
-
COI: 1:CAS:528:DC%2BD28XhtVCjt7%2FI, PID: 16909207
-
Massi P, Vaccani A, Bianchessi S, Costa B, Macchi P, Parolaro D (2006) The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci 63:2057–2066
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 2057-2066
-
-
Massi, P.1
Vaccani, A.2
Bianchessi, S.3
Costa, B.4
Macchi, P.5
Parolaro, D.6
-
52
-
-
38449109178
-
Maccarrone M and Parolaro D (2008) 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
-
Massi P, Valenti M, Vaccani A, Gasperi V, Perletti G, Marras E, Fezza F, Maccarrone M and Parolaro D (2008) 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 104:1091–1100
-
J Neurochem
, vol.104
, pp. 1091-1100
-
-
Massi, P.1
Valenti, M.2
Vaccani, A.3
Gasperi, V.4
Perletti, G.5
Marras, E.6
Fezza, F.7
-
54
-
-
78349265651
-
Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes
-
Mato S, Victoria Sanchez-Gomez M, Matute C (2010) Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes. Glia 58:1739–1747
-
(2010)
Glia
, vol.58
, pp. 1739-1747
-
-
Mato, S.1
Victoria Sanchez-Gomez, M.2
Matute, C.3
-
55
-
-
36749015683
-
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
-
COI: 1:CAS:528:DC%2BD2sXhtlWkt7bN, PID: 18025276
-
McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez PY (2007) Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Mol Cancer Ther 6:2921–2927
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2921-2927
-
-
McAllister, S.D.1
Christian, R.T.2
Horowitz, M.P.3
Garcia, A.4
Desprez, P.Y.5
-
56
-
-
79960835512
-
Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
-
PID: 20859676
-
McAllister SD, Murase R, Christian RT, Lau D, Zielinski AJ, Allison J, Almanza C, Pakdel A, Lee J, Limbad C, Liu Y, Debs RJ, Moore DH, Desprez PY (2010) Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat 129:37–47
-
(2010)
Breast Cancer Res Treat
, vol.129
, pp. 37-47
-
-
McAllister, S.D.1
Murase, R.2
Christian, R.T.3
Lau, D.4
Zielinski, A.J.5
Allison, J.6
Almanza, C.7
Pakdel, A.8
Lee, J.9
Limbad, C.10
Liu, Y.11
Debs, R.J.12
Moore, D.H.13
Desprez, P.Y.14
-
57
-
-
33747592582
-
Cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression
-
COI: 1:CAS:528:DC%2BD28Xps1SmsLg%3D, PID: 16754784
-
McKallip RJ, Jia W, Schlomer J, Warren JW, Nagarkatti PS, Nagarkatti M (2006) Cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression. Mol Pharmacol 70:897–908
-
(2006)
Mol Pharmacol
, vol.70
, pp. 897-908
-
-
McKallip, R.J.1
Jia, W.2
Schlomer, J.3
Warren, J.W.4
Nagarkatti, P.S.5
Nagarkatti, M.6
-
58
-
-
85071447718
-
Cannabis and cannabis extract: greater than the sum of the parts?
-
COI: 1:CAS:528:DC%2BD3MXoslSrt7g%3D
-
McPartland JM, Russo EB (2001) Cannabis and cannabis extract: greater than the sum of the parts? J Cannabis Therapeut 1:103–132
-
(2001)
J Cannabis Therapeut
, vol.1
, pp. 103-132
-
-
McPartland, J.M.1
Russo, E.B.2
-
59
-
-
0029012014
-
Identification of a 2-mono-glyceride, present in canine gut, that biinds to cannabinoid receptors
-
COI: 1:CAS:528:DyaK2MXmsl2ks7Y%3D, PID: 7605349
-
Mechoulam R, Ben-Shabat S, Hanus S, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almong S, Martin BR, Compton DR, Pertwee RG, Griffin G, Bayewitch M, Barg J, Vogel Z (1995) Identification of a 2-mono-glyceride, present in canine gut, that biinds to cannabinoid receptors. Biochem Pharmacol 50:83–90
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 83-90
-
-
Mechoulam, R.1
Ben-Shabat, S.2
Hanus, S.3
Ligumsky, M.4
Kaminski, N.E.5
Schatz, A.R.6
Gopher, A.7
Almong, S.8
Martin, B.R.9
Compton, D.R.10
Pertwee, R.G.11
Griffin, G.12
Bayewitch, M.13
Barg, J.14
Vogel, Z.15
-
60
-
-
23144461051
-
Genes that mediate breast cancer metastasis to lung
-
COI: 1:CAS:528:DC%2BD2MXmsFCgs7o%3D, PID: 16049480
-
Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL, Massague J (2005) Genes that mediate breast cancer metastasis to lung. Nature 436:518–524
-
(2005)
Nature
, vol.436
, pp. 518-524
-
-
Minn, A.J.1
Gupta, G.P.2
Siegel, P.M.3
Bos, P.D.4
Shu, W.5
Giri, D.D.6
Viale, A.7
Olshen, A.B.8
Gerald, W.L.9
Massague, J.10
-
61
-
-
84927667530
-
Targeting multiple cannabinoid antitumor pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
-
COI: 1:CAS:528:DC%2BC2cXhsFymtbfF, PID: 24910342
-
Murase R, Kawamura R, Singer E, Pakdel A, Sarma P, Judkins J, Elwakeel E, Dayal S, Martinez-Martinez E, Amere M, Gujjar R, Mahadevan A, Desprez PY, McAllister SD (2014) Targeting multiple cannabinoid antitumor pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol 171:4464–4477
-
(2014)
Br J Pharmacol
, vol.171
, pp. 4464-4477
-
-
Murase, R.1
Kawamura, R.2
Singer, E.3
Pakdel, A.4
Sarma, P.5
Judkins, J.6
Elwakeel, E.7
Dayal, S.8
Martinez-Martinez, E.9
Amere, M.10
Gujjar, R.11
Mahadevan, A.12
Desprez, P.Y.13
McAllister, S.D.14
-
62
-
-
80052532033
-
Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion
-
COI: 1:CAS:528:DC%2BC3MXht1ChsLnE, PID: 21915267
-
Nasser MW, Qamri Z, Deol YS, Smith D, Shilo K, Zou X, Ganju RK (2011) Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. PLoS One 6:e23901
-
(2011)
PLoS One
, vol.6
, pp. e23901
-
-
Nasser, M.W.1
Qamri, Z.2
Deol, Y.S.3
Smith, D.4
Shilo, K.5
Zou, X.6
Ganju, R.K.7
-
63
-
-
0018963804
-
Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking
-
COI: 1:CAS:528:DyaL3cXlvFOnu70%3D, PID: 6250760
-
Ohlsson A, Lindgren JE, Wahlen A, Agurell S, Hollister LE, Gillespie HK (1980) Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking. Clin Pharmacol Ther 28:409–416
-
(1980)
Clin Pharmacol Ther
, vol.28
, pp. 409-416
-
-
Ohlsson, A.1
Lindgren, J.E.2
Wahlen, A.3
Agurell, S.4
Hollister, L.E.5
Gillespie, H.K.6
-
64
-
-
0015909841
-
A comparison of the pharmacological activity in man of intraveneously administered D9-tetrahydrocannabinol, cannabinol, and cannabidiol
-
COI: 1:CAS:528:DyaE2cXkt1Wisbw%3D, PID: 4761242
-
Perez-Reyes M, Timmons MC, Davis KH, Wall EM (1973) A comparison of the pharmacological activity in man of intraveneously administered D9-tetrahydrocannabinol, cannabinol, and cannabidiol. Experientia 29:1368–1369
-
(1973)
Experientia
, vol.29
, pp. 1368-1369
-
-
Perez-Reyes, M.1
Timmons, M.C.2
Davis, K.H.3
Wall, E.M.4
-
65
-
-
0030611978
-
Pharmacology of cannabinoid CB1 and CB2 receptors
-
COI: 1:CAS:528:DyaK2sXkvFChsL0%3D, PID: 9336020
-
Pertwee RG (1997) Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 74:129–180
-
(1997)
Pharmacol Ther
, vol.74
, pp. 129-180
-
-
Pertwee, R.G.1
-
66
-
-
30444457225
-
Cannabinoid pharmacology: the first 66 years
-
COI: 1:CAS:528:DC%2BD28XisVCntQ%3D%3D, PID: 16402100
-
Pertwee RG (2006) Cannabinoid pharmacology: the first 66 years. Br J Pharmacol 147(Suppl 1):S163–S171
-
(2006)
Br J Pharmacol
, vol.147
, pp. S163-S171
-
-
Pertwee, R.G.1
-
67
-
-
0242268553
-
The molecular logic of endocannabinoid signalling
-
COI: 1:CAS:528:DC%2BD3sXosFOktrY%3D, PID: 14595399
-
Piomelli D (2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873–884
-
(2003)
Nat Rev Neurosci
, vol.4
, pp. 873-884
-
-
Piomelli, D.1
-
68
-
-
79959246435
-
Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance
-
COI: 1:CAS:528:DC%2BC3MXnsFKns70%3D, PID: 21540238
-
Ponz-Sarvise M, Nguewa PA, Pajares MJ, Agorreta J, Lozano MD, Redrado M, Pio R, Behrens C, Wistuba II, Garcia-Franco CE, Garcia-Foncillas J, Montuenga LM, Calvo A, Gil-Bazo I (2011) Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance. Clin Cancer Res 17:4155–4166
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4155-4166
-
-
Ponz-Sarvise, M.1
Nguewa, P.A.2
Pajares, M.J.3
Agorreta, J.4
Lozano, M.D.5
Redrado, M.6
Pio, R.7
Behrens, C.8
Wistuba, I.I.9
Garcia-Franco, C.E.10
Garcia-Foncillas, J.11
Montuenga, L.M.12
Calvo, A.13
Gil-Bazo, I.14
-
69
-
-
78650808693
-
Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis
-
COI: 1:CAS:528:DC%2BC3MXhvVyqtbY%3D
-
Preet A, Qamri Z, Nasser MW, Prasad A, Shilo K, Zou X, Groopman JE, Ganju RK (2011) Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer Prev Res (Phila) 4:65–75
-
(2011)
Cancer Prev Res (Phila)
, vol.4
, pp. 65-75
-
-
Preet, A.1
Qamri, Z.2
Nasser, M.W.3
Prasad, A.4
Shilo, K.5
Zou, X.6
Groopman, J.E.7
Ganju, R.K.8
-
70
-
-
70949091684
-
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
-
COI: 1:CAS:528:DC%2BD1MXhtlyrt7%2FE, PID: 19887554
-
Qamri Z, Preet A, Nasser MW, Bass CE, Leone G, Barsky SH, Ganju RK (2009) Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. Mol Cancer Ther 8:3117–3129
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 3117-3129
-
-
Qamri, Z.1
Preet, A.2
Nasser, M.W.3
Bass, C.E.4
Leone, G.5
Barsky, S.H.6
Ganju, R.K.7
-
71
-
-
38049185265
-
Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1
-
COI: 1:CAS:528:DC%2BD1cXit1Cku7g%3D, PID: 18159069
-
Ramer R, Hinz B (2008) Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 100:59–69
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 59-69
-
-
Ramer, R.1
Hinz, B.2
-
72
-
-
77449127143
-
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
-
COI: 1:CAS:528:DC%2BC3cXhtlaisb0%3D, PID: 19914218
-
Ramer R, Merkord J, Rohde H, Hinz B (2010a) Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Biochem Pharmacol 79:955–966
-
(2010)
Biochem Pharmacol
, vol.79
, pp. 955-966
-
-
Ramer, R.1
Merkord, J.2
Rohde, H.3
Hinz, B.4
-
73
-
-
77957369035
-
Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells
-
COI: 1:CAS:528:DC%2BC3cXpsVKis74%3D, PID: 20668920
-
Ramer R, Rohde A, Merkord J, Rohde H, Hinz B (2010b) Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res 27:2162–2174
-
(2010)
Pharm Res
, vol.27
, pp. 2162-2174
-
-
Ramer, R.1
Rohde, A.2
Merkord, J.3
Rohde, H.4
Hinz, B.5
-
74
-
-
84860895849
-
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
-
PID: 22198381
-
Ramer R, Bublitz K, Freimuth N, Merkord J, Rohde H, Haustein M, Borchert P, Schmuhl E, Linnebacher M, Hinz B (2011) Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J 26:1535–1548
-
(2011)
FASEB J
, vol.26
, pp. 1535-1548
-
-
Ramer, R.1
Bublitz, K.2
Freimuth, N.3
Merkord, J.4
Rohde, H.5
Haustein, M.6
Borchert, P.7
Schmuhl, E.8
Linnebacher, M.9
Hinz, B.10
-
75
-
-
84872524524
-
COX-2 and PPAR-gamma confer cannabidiol-induced apoptosis of human lung cancer cells
-
COI: 1:CAS:528:DC%2BC3sXntVarsw%3D%3D, PID: 23220503
-
Ramer R, Heinemann K, Merkord J, Rohde H, Salamon A, Linnebacher M, Hinz B (2013) COX-2 and PPAR-gamma confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther 12:69–82
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 69-82
-
-
Ramer, R.1
Heinemann, K.2
Merkord, J.3
Rohde, H.4
Salamon, A.5
Linnebacher, M.6
Hinz, B.7
-
76
-
-
84891802683
-
Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death
-
COI: 1:CAS:528:DC%2BC3sXhvFCqtrvN, PID: 24309936
-
Rimmerman N, Ben-Hail D, Porat Z, Juknat A, Kozela E, Daniels MP, Connelly PS, Leishman E, Bradshaw HB, Shoshan-Barmatz V, Vogel Z (2013) Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death. Cell Death Dis 4:e949
-
(2013)
Cell Death Dis
, vol.4
, pp. e949
-
-
Rimmerman, N.1
Ben-Hail, D.2
Porat, Z.3
Juknat, A.4
Kozela, E.5
Daniels, M.P.6
Connelly, P.S.7
Leishman, E.8
Bradshaw, H.B.9
Shoshan-Barmatz, V.10
Vogel, Z.11
-
77
-
-
60849124534
-
Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels
-
COI: 1:CAS:528:DC%2BD1MXisV2hurw%3D, PID: 19228959
-
Ryan D, Drysdale AJ, Lafourcade C, Pertwee RG, Platt B (2009) Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels. J Neurosci 29:2053–2063
-
(2009)
J Neurosci
, vol.29
, pp. 2053-2063
-
-
Ryan, D.1
Drysdale, A.J.2
Lafourcade, C.3
Pertwee, R.G.4
Platt, B.5
-
78
-
-
66449115318
-
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
-
COI: 1:CAS:528:DC%2BD1MXlsFyrtrc%3D, PID: 19425170
-
Salazar M, Carracedo A, Salanueva IJ, Hernandez-Tiedra S, Lorente M, Egia A, Vazquez P, Blazquez C, Torres S, Garcia S, Nowak J, Fimia GM, Piacentini M, Cecconi F, Pandolfi PP, Gonzalez-Feria L, Iovanna JL, Guzman M, Boya P, Velasco G (2009) Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 119:1359–1372
-
(2009)
J Clin Invest
, vol.119
, pp. 1359-1372
-
-
Salazar, M.1
Carracedo, A.2
Salanueva, I.J.3
Hernandez-Tiedra, S.4
Lorente, M.5
Egia, A.6
Vazquez, P.7
Blazquez, C.8
Torres, S.9
Garcia, S.10
Nowak, J.11
Fimia, G.M.12
Piacentini, M.13
Cecconi, F.14
Pandolfi, P.P.15
Gonzalez-Feria, L.16
Iovanna, J.L.17
Guzman, M.18
Boya, P.19
Velasco, G.20
more..
-
79
-
-
33845973763
-
Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest
-
COI: 1:CAS:528:DC%2BD28XhtlagsLfI, PID: 17068343
-
Sarfaraz S, Afaq F, Adhami VM, Malik A, Mukhtar H (2006) Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest. J Biol Chem 281:39480–39491
-
(2006)
J Biol Chem
, vol.281
, pp. 39480-39491
-
-
Sarfaraz, S.1
Afaq, F.2
Adhami, V.M.3
Malik, A.4
Mukhtar, H.5
-
80
-
-
39049104489
-
Cannabinoids for cancer treatment: progress and promise
-
COI: 1:CAS:528:DC%2BD1cXmt1OgsA%3D%3D, PID: 18199524
-
Sarfaraz S, Adhami VM, Syed DN, Afaq F, Mukhtar H (2008) Cannabinoids for cancer treatment: progress and promise. Cancer Res 68:339–342
-
(2008)
Cancer Res
, vol.68
, pp. 339-342
-
-
Sarfaraz, S.1
Adhami, V.M.2
Syed, D.N.3
Afaq, F.4
Mukhtar, H.5
-
81
-
-
0038723739
-
Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts
-
COI: 1:CAS:528:DC%2BD3sXls1Wqsrk%3D, PID: 12861385
-
Sarker KP, Maruyama I (2003) Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. Cell Mol Life Sci 60:1200–1208
-
(2003)
Cell Mol Life Sci
, vol.60
, pp. 1200-1208
-
-
Sarker, K.P.1
Maruyama, I.2
-
82
-
-
84917737275
-
The combination of cannabidiol and Delta9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model
-
COI: 1:CAS:528:DC%2BC2cXitVCju7jP, PID: 25398831
-
Scott KA, Dalgleish AG, Liu WM (2014) The combination of cannabidiol and Delta9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model. Mol Cancer Ther 13:2955–2967
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2955-2967
-
-
Scott, K.A.1
Dalgleish, A.G.2
Liu, W.M.3
-
83
-
-
79960115996
-
Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
-
COI: 1:CAS:528:DC%2BC3MXos1Sitb4%3D, PID: 21566064
-
Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A (2011) Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther 10:1161–1172
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1161-1172
-
-
Shrivastava, A.1
Kuzontkoski, P.M.2
Groopman, J.E.3
Prasad, A.4
-
84
-
-
84925593582
-
Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma
-
COI: 1:CAS:528:DC%2BC2MXhtFGrur4%3D, PID: 25590811
-
Singer E, Judkins J, Salomonis N, Matlaf L, Soteropoulos P, McAllister S, Soroceanu L (2015) Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma. Cell Death Dis 6:e1601
-
(2015)
Cell Death Dis
, vol.6
, pp. e1601
-
-
Singer, E.1
Judkins, J.2
Salomonis, N.3
Matlaf, L.4
Soteropoulos, P.5
McAllister, S.6
Soroceanu, L.7
-
85
-
-
84867803387
-
Cannabidiol inhibits angiogenesis by multiple mechanisms
-
COI: 1:CAS:528:DC%2BC38XhsFKktL7O, PID: 22624859
-
Solinas M, Massi P, Cantelmo AR, Cattaneo MG, Cammarota R, Bartolini D, Cinquina V, Valenti M, Vicentini LM, Noonan DM, Albini A, Parolaro D (2012) Cannabidiol inhibits angiogenesis by multiple mechanisms. Br J Pharmacol 167:1218–1231
-
(2012)
Br J Pharmacol
, vol.167
, pp. 1218-1231
-
-
Solinas, M.1
Massi, P.2
Cantelmo, A.R.3
Cattaneo, M.G.4
Cammarota, R.5
Bartolini, D.6
Cinquina, V.7
Valenti, M.8
Vicentini, L.M.9
Noonan, D.M.10
Albini, A.11
Parolaro, D.12
-
86
-
-
84874840668
-
Id-1 is a Key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
-
Soroceanu L, Murase R, Limbad C, Singer EL, Allison J, Adrados I, Kawamura R, Pakdel A, Fukuyo Y, Nguyen D, Khan S, Arauz R, Yount GL, Moore D, Desprez PY, McAllister SD (2013) Id-1 is a Key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target. Cancer Res 73:1559–1569
-
(2013)
Cancer Res
, vol.73
, pp. 1559-1569
-
-
Soroceanu, L.1
Murase, R.2
Limbad, C.3
Singer, E.L.4
Allison, J.5
Adrados, I.6
Kawamura, R.7
Pakdel, A.8
Fukuyo, Y.9
Nguyen, D.10
Khan, S.11
Arauz, R.12
Yount, G.L.13
Moore, D.14
Desprez, P.Y.15
McAllister, S.D.16
-
87
-
-
0031593692
-
Delta9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells
-
COI: 1:CAS:528:DyaK1cXntVyhu78%3D, PID: 9858061
-
Srivastava MD, Srivastava BI, Brouhard B (1998) Delta9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells. Immunopharmacology 40:179–185
-
(1998)
Immunopharmacology
, vol.40
, pp. 179-185
-
-
Srivastava, M.D.1
Srivastava, B.I.2
Brouhard, B.3
-
88
-
-
0028970517
-
2-Arachidonoylglycerol: a possible cannabinoid receptor ligand in the brain
-
COI: 1:CAS:528:DyaK2MXosVyqtLk%3D, PID: 7575630
-
Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K, Yamashita A, Waku K (1995) 2-Arachidonoylglycerol: a possible cannabinoid receptor ligand in the brain. Biochem Biophys Res Commun 215:89–97
-
(1995)
Biochem Biophys Res Commun
, vol.215
, pp. 89-97
-
-
Sugiura, T.1
Kondo, S.2
Sukagawa, A.3
Nakane, S.4
Shinoda, A.5
Itoh, K.6
Yamashita, A.7
Waku, K.8
-
89
-
-
84887437596
-
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
-
COI: 1:CAS:528:DC%2BC3sXhs1SksbjL, PID: 24113172
-
Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, Han W, Lou F, Yang J, Zhang Q, Wang X, He C, Pan H (2013) Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis 4:e838
-
(2013)
Cell Death Dis
, vol.4
, pp. e838
-
-
Sui, X.1
Chen, R.2
Wang, Z.3
Huang, Z.4
Kong, N.5
Zhang, M.6
Han, W.7
Lou, F.8
Yang, J.9
Zhang, Q.10
Wang, X.11
He, C.12
Pan, H.13
-
90
-
-
44449084242
-
Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response
-
COI: 1:CAS:528:DC%2BD1cXkslSnsL8%3D, PID: 18378907
-
Swarbrick A, Roy E, Allen T, Bishop JM (2008) Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. Proc Natl Acad Sci U S A 105:5402–5407
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 5402-5407
-
-
Swarbrick, A.1
Roy, E.2
Allen, T.3
Bishop, J.M.4
-
91
-
-
84885378901
-
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target
-
COI: 1:CAS:528:DC%2BC3sXhsFOltbvM, PID: 24094812
-
Timmerman LA, Holton T, Yuneva M, Louie RJ, Padro M, Daemen A, Hu M, Chan DA, Ethier SP, van’t Veer LJ, Polyak K, McCormick F, Gray JW (2013) Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell 24:450–465
-
(2013)
Cancer Cell
, vol.24
, pp. 450-465
-
-
Timmerman, L.A.1
Holton, T.2
Yuneva, M.3
Louie, R.J.4
Padro, M.5
Daemen, A.6
Hu, M.7
Chan, D.A.8
Ethier, S.P.9
van’t Veer, L.J.10
Polyak, K.11
McCormick, F.12
Gray, J.W.13
-
92
-
-
78751527443
-
A combined preclinical therapy of cannabinoids and temozolomide against glioma
-
COI: 1:CAS:528:DC%2BC3MXjtFertw%3D%3D, PID: 21220494
-
Torres S, Lorente M, Rodriguez-Fornes F, Hernandez-Tiedra S, Salazar M, Garcia-Taboada E, Barcia J, Guzman M, Velasco G (2011) A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther 10:90–103
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 90-103
-
-
Torres, S.1
Lorente, M.2
Rodriguez-Fornes, F.3
Hernandez-Tiedra, S.4
Salazar, M.5
Garcia-Taboada, E.6
Barcia, J.7
Guzman, M.8
Velasco, G.9
-
93
-
-
0016744453
-
Influence of anticonvulsant cannabinoids on posttetanic potentiation at isolated bullfrog ganglia
-
COI: 1:CAS:528:DyaE2MXlvVyhtbs%3D, PID: 1081172
-
Turkanis SA, Karler R (1975) Influence of anticonvulsant cannabinoids on posttetanic potentiation at isolated bullfrog ganglia. Life Sci 17:569–578
-
(1975)
Life Sci
, vol.17
, pp. 569-578
-
-
Turkanis, S.A.1
Karler, R.2
-
94
-
-
0019308268
-
Constituents of Cannabis sativa L. XVII. A review of the natural constituents
-
COI: 1:CAS:528:DyaL3cXitFWktL0%3D, PID: 6991645
-
Turner CE, Elsohly MA, Boeren EG (1980) Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod 43:169–234
-
(1980)
J Nat Prod
, vol.43
, pp. 169-234
-
-
Turner, C.E.1
Elsohly, M.A.2
Boeren, E.G.3
-
95
-
-
17844388088
-
Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
-
COI: 1:CAS:528:DC%2BD2MXjtlaksr4%3D, PID: 15700028
-
Vaccani A, Massi P, Colombo A, Rubino T, Parolaro D (2005) Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 144:1032–1036
-
(2005)
Br J Pharmacol
, vol.144
, pp. 1032-1036
-
-
Vaccani, A.1
Massi, P.2
Colombo, A.3
Rubino, T.4
Parolaro, D.5
-
96
-
-
3242738471
-
Hypothesis: cannabinoid therapy for the treatment of gliomas?
-
COI: 1:CAS:528:DC%2BD2cXmtVCjtLk%3D, PID: 15275820
-
Velasco G, Galve-Roperh I, Sanchez C, Blazquez C, Guzman M (2004) Hypothesis: cannabinoid therapy for the treatment of gliomas? Neuropharmacology 47:315–323
-
(2004)
Neuropharmacology
, vol.47
, pp. 315-323
-
-
Velasco, G.1
Galve-Roperh, I.2
Sanchez, C.3
Blazquez, C.4
Guzman, M.5
-
97
-
-
84861530762
-
Towards the use of cannabinoids as antitumour agents
-
COI: 1:CAS:528:DC%2BC38XmsFCgs70%3D, PID: 22555283
-
Velasco G, Sanchez C, Guzman M (2012) Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 12:436–444
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 436-444
-
-
Velasco, G.1
Sanchez, C.2
Guzman, M.3
-
98
-
-
84892409960
-
Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy
-
COI: 1:CAS:528:DC%2BC2cXlvFWruw%3D%3D, PID: 24117398
-
Ward SJ, McAllister SD, Kawamura R, Murase R, Neelakantan H, Walker EA (2014) Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy. Br J Pharmacol 171:636–645
-
(2014)
Br J Pharmacol
, vol.171
, pp. 636-645
-
-
Ward, S.J.1
McAllister, S.D.2
Kawamura, R.3
Murase, R.4
Neelakantan, H.5
Walker, E.A.6
-
99
-
-
0037177601
-
Endocannabinoid signaling in the brain
-
COI: 1:CAS:528:DC%2BD38XjtlOhtb4%3D, PID: 11976437
-
Wilson RI, Nicoll RA (2002) Endocannabinoid signaling in the brain. Science 296:678–682
-
(2002)
Science
, vol.296
, pp. 678-682
-
-
Wilson, R.I.1
Nicoll, R.A.2
-
100
-
-
70449107252
-
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
-
COI: 1:CAS:528:DC%2BD1MXhsVGlt7jF, PID: 19496700
-
Wondrak GT (2009) Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid Redox Signal 11:3013–3069
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 3013-3069
-
-
Wondrak, G.T.1
-
101
-
-
84875454018
-
xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma
-
COI: 1:CAS:528:DC%2BC3sXktVGisL0%3D, PID: 23319806
-
Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O (2013) xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma. Cancer Res 73:1855–1866
-
(2013)
Cancer Res
, vol.73
, pp. 1855-1866
-
-
Yoshikawa, M.1
Tsuchihashi, K.2
Ishimoto, T.3
Yae, T.4
Motohara, T.5
Sugihara, E.6
Onishi, N.7
Masuko, T.8
Yoshizawa, K.9
Kawashiri, S.10
Mukai, M.11
Asoda, S.12
Kawana, H.13
Nakagawa, T.14
Saya, H.15
Nagano, O.16
-
102
-
-
33645841349
-
Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana
-
COI: 1:CAS:528:DC%2BD28XktFalsro%3D, PID: 16439618
-
Zhu HJ, Wang JS, Markowitz JS, Donovan JL, Gibson BB, Gefroh HA, Devane CL (2006) Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana. J Pharmacol Exp Ther 317:850–857
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 850-857
-
-
Zhu, H.J.1
Wang, J.S.2
Markowitz, J.S.3
Donovan, J.L.4
Gibson, B.B.5
Gefroh, H.A.6
Devane, C.L.7
-
103
-
-
54249156391
-
Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
-
PID: 18833429
-
Zuardi AW (2008) Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Rev Bras Psiquiatr 30:271–280
-
(2008)
Rev Bras Psiquiatr
, vol.30
, pp. 271-280
-
-
Zuardi, A.W.1
|