메뉴 건너뛰기




Volumn 8, Issue 11, 2009, Pages 3117-3129

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CYCLOOXYGENASE 2; PROSTAGLANDIN E2;

EID: 70949091684     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0448     Document Type: Article
Times cited : (194)

References (48)
  • 2
    • 25144522831 scopus 로고    scopus 로고
    • A systematic review of taxane-containing regimens for metastatic breast cancer
    • Ghersi D, Wilcken N, Simes RJ. A systematic review of taxane-containing regimens for metastatic breast cancer. Br J Cancer 2005;93:293-301.
    • (2005) Br J Cancer , vol.93 , pp. 293-301
    • Ghersi, D.1    Wilcken, N.2    Simes, R.J.3
  • 3
    • 0032720340 scopus 로고    scopus 로고
    • Recent advances in breast cancer biology
    • Schultz LB, Weber BL. Recent advances in breast cancer biology. Curr Opin Oncol 1999;11:429-434
    • (1999) Curr Opin Oncol , vol.11 , pp. 429-434
    • Schultz, L.B.1    Weber, B.L.2
  • 4
    • 0034079089 scopus 로고    scopus 로고
    • Systematic reviews of chemotherapy and endocrine therapy in metastatic breast cancer
    • Stockler M, Wilcken NR, Ghersi D, Simes RJ. Systematic reviews of chemotherapy and endocrine therapy in metastatic breast cancer. Cancer Treat Rev 2000;26:151-168
    • (2000) Cancer Treat Rev , vol.26 , pp. 151-168
    • Stockler, M.1    Wilcken, N.R.2    Ghersi, D.3    Simes, R.J.4
  • 6
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990;346:561-564
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 7
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993;365:61-65
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 8
    • 33845627660 scopus 로고    scopus 로고
    • Cannabinoid receptors as novel targets for the treatment of melanoma
    • Blazquez C, Carracedo A, Barrado L, et al. Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J 2006;20:2633-2635
    • (2006) FASEB J , vol.20 , pp. 2633-2635
    • Blazquez, C.1    Carracedo, A.2    Barrado, L.3
  • 9
    • 33845973763 scopus 로고    scopus 로고
    • Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest
    • Sarfaraz S, Afaq F, Adhami VM, Malik A, Mukhtar H. Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest. J Biol Chem 2006;281:39480-39491
    • (2006) J Biol Chem , vol.281 , pp. 39480-39491
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Malik, A.4    Mukhtar, H.5
  • 10
    • 33750298256 scopus 로고    scopus 로고
    • Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma
    • DOI 10.1016/j.cancergencyto.2006.06.014, PII S0165460806004110
    • Xu X, Liu Y, Huang S, et al. Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma. Cancer Genet Cytogenet 2006;171:31-38 (Pubitemid 44635750)
    • (2006) Cancer Genetics and Cytogenetics , vol.171 , Issue.1 , pp. 31-38
    • Xu, X.1    Liu, Y.2    Huang, S.3    Liu, G.4    Xie, C.5    Zhou, J.6    Fan, W.7    Li, Q.8    Wang, Q.9    Zhong, D.10    Miao, X.11
  • 11
    • 33746138649 scopus 로고    scopus 로고
    • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    • DOI 10.1158/0008-5472.CAN-06-0169
    • Carracedo A, Gironella M, Lorente M, et al. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 2006;66:6748-6755 (Pubitemid 44085633)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6748-6755
    • Carracedo, A.1    Gironella, M.2    Lorente, M.3    Garcia, S.4    Guzman, M.5    Velasco, G.6    Iovanna, J.L.7
  • 13
    • 17344380844 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
    • DOI 10.1038/73171
    • Galve-Roperh I, Sanchez C, Cortes ML, Gomez del Pulgar T, Izquierdo M, Guzman M. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000;6:313-319 (Pubitemid 30148624)
    • (2000) Nature Medicine , vol.6 , Issue.3 , pp. 313-319
    • Galve-Roperh, I.1    Sanchez, C.2    Cortes, M.L.3    Del Pulgar, T.G.4    Izquierdo, M.5    Guzman, M.6
  • 14
    • 0035422139 scopus 로고    scopus 로고
    • Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
    • Sanchez C, de Ceballos ML, Gomez del Pulgar T, et al. Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 2001;61:5784-5789
    • (2001) Cancer Res , vol.61 , pp. 5784-5789
    • Sanchez, C.1    De Ceballos, M.L.2    Gomez Del Pulgar, T.3
  • 15
    • 2242448020 scopus 로고    scopus 로고
    • The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway
    • DOI 10.1074/jbc.M206590200
    • Rueda D, Navarro B, Martinez-Serrano A, Guzman M, Galve-Roperh I. The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway. J Biol Chem 2002;277:46645-46650 (Pubitemid 35417665)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.48 , pp. 46645-46650
    • Rueda, D.1    Navarro, B.2    Martinez-Serrano, A.3    Guzman, M.4    Galve-Roperh, I.5
  • 16
    • 35348910284 scopus 로고    scopus 로고
    • The cannabinoid Δ(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
    • Greenhough A, Patsos HA, Williams AC, Paraskeva C. The cannabinoid Δ(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. Int J Cancer 2007;121:2172-2180
    • (2007) Int J Cancer , vol.121 , pp. 2172-2180
    • Greenhough, A.1    Patsos, H.A.2    Williams, A.C.3    Paraskeva, C.4
  • 17
    • 0035147072 scopus 로고    scopus 로고
    • Ceramide: A new second messenger of cannabinoid action
    • DOI 10.1016/S0165-6147(00)01586-8, PII S0165614700015868
    • Guzman M, Galve-Roperh I, Sanchez C. Ceramide: a new second messenger of cannabinoid action. Trends Pharmacol Sci 2001;22:19-22. (Pubitemid 32126281)
    • (2001) Trends in Pharmacological Sciences , vol.22 , Issue.1 , pp. 19-22
    • Guzman, M.1    Galve-Roperh, I.2    Sanchez, C.3
  • 19
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: A molecular target for colorectal cancer prevention
    • DOI 10.1200/JCO.2005.09.051
    • Brown JR, DuBois RN. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol 2005;23:2840-2855 (Pubitemid 46179475)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.12 , pp. 2840-2855
    • Brown, J.R.1    Dubois, R.N.2
  • 20
    • 34249890767 scopus 로고    scopus 로고
    • The anti-cancer effect of COX-2 inhibitors on gastric cancer cells
    • DOI 10.1007/s10620-007-9787-3
    • Cho SJ, Kim N, Kim JS, Jung HC, Song IS. The anti-cancer effect of COX-2 inhibitors on gastric cancer cells. Dig Dis Sci 2007;52:1713-1721 (Pubitemid 46870572)
    • (2007) Digestive Diseases and Sciences , vol.52 , Issue.7 , pp. 1713-1721
    • Cho, S.-J.1    Kim, N.2    Kim, J.S.3    Jung, H.C.4    Song, I.S.5
  • 21
    • 40349113534 scopus 로고    scopus 로고
    • Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer
    • Howe LR. Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer. Breast Cancer Res 2007;9:210.
    • (2007) Breast Cancer Res , vol.9 , pp. 210
    • Howe, L.R.1
  • 22
    • 0034646688 scopus 로고    scopus 로고
    • The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2
    • DOI 10.1074/jbc.275.15.11397
    • Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM, Chen CS. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J Biol Chem 2000;275:11397-11403 (Pubitemid 30212792)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.15 , pp. 11397-11403
    • Hsu, A.-L.1    Ching, T.-T.2    Wang, D.-S.3    Song, X.4    Rangnekar, V.M.5    Chen, C.-S.6
  • 23
  • 24
    • 34147220392 scopus 로고    scopus 로고
    • Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
    • Gupta GP, Nguyen DX, Chiang AC, et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 2007;446: 765-770
    • (2007) Nature , vol.446 , pp. 765-770
    • Gupta, G.P.1    Nguyen, D.X.2    Chiang, A.C.3
  • 25
    • 27144523271 scopus 로고    scopus 로고
    • Nitric oxide upregulates the cyclooxygenase-2 expression through the cAMP-response element in its promoter in several cancer cell lines
    • DOI 10.1038/sj.onc.1208816, PII 1208816
    • Park SW, Sung MW, Heo DS, Inoue H, Shim SH, Kim KH. Nitric oxide upregulates the cyclooxygenase-2 expression through the cAMP-response element in its promoter in several cancer cell lines. Oncogene 2005;24: 6689-6698 (Pubitemid 41486799)
    • (2005) Oncogene , vol.24 , Issue.44 , pp. 6689-6698
    • Park, S.-W.1    Sung, M.-W.2    Heo, D.-S.3    Inoue, H.4    Shim, S.-H.5    Kim, K.-H.6
  • 26
    • 41849150053 scopus 로고    scopus 로고
    • 15-Deoxy-Δ12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: A potential role of ROS
    • Kim EH, Na HK, Kim DH, et al. 15-Deoxy-Δ12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. Carcinogenesis 2008;29: 688-695
    • (2008) Carcinogenesis , vol.29 , pp. 688-695
    • Kim, E.H.1    Na, H.K.2    Kim, D.H.3
  • 28
    • 55549115695 scopus 로고    scopus 로고
    • Slit-2 induces a tumor- suppressive effect by regulating β-catenin in breast cancer cells
    • Prasad A, Paruchuri V, Preet A, Latif F, Ganju RK. Slit-2 induces a tumor- suppressive effect by regulating β-catenin in breast cancer cells. J Biol Chem 2008;283:26624-26633
    • (2008) J Biol Chem , vol.283 , pp. 26624-26633
    • Prasad, A.1    Paruchuri, V.2    Preet, A.3    Latif, F.4    Ganju, R.K.5
  • 29
    • 38049143945 scopus 로고    scopus 로고
    • Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
    • Preet A, Ganju RK, Groopman JE. Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 2008;27:339-346
    • (2008) Oncogene , vol.27 , pp. 339-346
    • Preet, A.1    Ganju, R.K.2    Groopman, J.E.3
  • 32
    • 15744382273 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium
    • DOI 10.1016/j.mvr.2005.02.001
    • Chen P, Hu S, Yao J, Moore SA, Spector AA, Fang X. Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium. Microvasc Res 2005;69:28-35. (Pubitemid 40416723)
    • (2005) Microvascular Research , vol.69 , Issue.1-2 , pp. 28-35
    • Chen, P.1    Hu, S.2    Yao, J.3    Moore, S.A.4    Spector, A.A.5    Fang, X.6
  • 33
    • 33745013193 scopus 로고    scopus 로고
    • Cannabinoids and cancer: Pros and cons of an antitumour strategy
    • DOI 10.1038/sj.bjp.0706632, PII 0706632
    • Bifulco M, Laezza C, Pisanti S, Gazzerro P. Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 2006;148: 123-135 (Pubitemid 43873031)
    • (2006) British Journal of Pharmacology , vol.148 , Issue.2 , pp. 123-135
    • Bifulco, M.1    Laezza, C.2    Pisanti, S.3    Gazzerro, P.4
  • 34
    • 33746125474 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation
    • DOI 10.1158/0008-5472.CAN-05-4566
    • Caffarel MM, Sarrio D, Palacios J, Guzman M, Sanchez C. Δ9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res 2006;66:6615-6621 (Pubitemid 44085617)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6615-6621
    • Caffarel, M.M.1    Sarrio, D.2    Palacios, J.3    Guzman, M.4    Sanchez, C.5
  • 35
    • 0142166330 scopus 로고    scopus 로고
    • Cannabinoids: Potential anticancer agents
    • Guzman M. Cannabinoids: potential anticancer agents. Nat Rev Cancer 2003;3:745-755
    • (2003) Nat Rev Cancer , vol.3 , pp. 745-755
    • Guzman, M.1
  • 37
    • 1542510624 scopus 로고    scopus 로고
    • Cannabinoids induce cancer cell proliferation via tumor necrosis factor α-converting enzyme (TACE/ADAM17)- mediated transactivation of the epidermal growth factor receptor
    • Hart S, Fischer OM, Ullrich A. Cannabinoids induce cancer cell proliferation via tumor necrosis factor α-converting enzyme (TACE/ADAM17)- mediated transactivation of the epidermal growth factor receptor. Cancer Res 2004;64:1943-1950.
    • (2004) Cancer Res , vol.64 , pp. 1943-1950
    • Hart, S.1    Fischer, O.M.2    Ullrich, A.3
  • 38
    • 33748417610 scopus 로고    scopus 로고
    • δ9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of bad to mitochondria
    • DOI 10.1158/1541-7786.MCR-05-0193
    • Jia W, Hegde VL, Singh NP, et al. Δ9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria. Mol Cancer Res 2006;4:549-562 (Pubitemid 44341365)
    • (2006) Molecular Cancer Research , vol.4 , Issue.8 , pp. 549-562
    • Jia, W.1    Hegde, V.L.2    Singh, N.P.3    Sisco, D.4    Grant, S.5    Nagarkatti, M.6    Nagarkatti, P.S.7
  • 41
    • 16444375370 scopus 로고    scopus 로고
    • Cannabinoid receptor as a novel target for the treatment of prostate cancer
    • DOI 10.1158/0008-5472.CAN-04-3410
    • Sarfaraz S, Afaq F, Adhami VM, Mukhtar H. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 2005;65: 1635-1641 (Pubitemid 40478586)
    • (2005) Cancer Research , vol.65 , Issue.5 , pp. 1635-1641
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4
  • 42
    • 14844362003 scopus 로고    scopus 로고
    • Δ-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response
    • McKallip RJ, Nagarkatti M, Nagarkatti PS. Δ-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J Immunol 2005;174:3281-3289
    • (2005) J Immunol , vol.174 , pp. 3281-3289
    • McKallip, R.J.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 43
    • 33751198532 scopus 로고    scopus 로고
    • Cannabinoid receptor- mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
    • Gustafsson K, Christensson B, Sander B, Flygare J. Cannabinoid receptor- mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma. Mol Pharmacol 2006;70:1612-1620
    • (2006) Mol Pharmacol , vol.70 , pp. 1612-1620
    • Gustafsson, K.1    Christensson, B.2    Sander, B.3    Flygare, J.4
  • 44
    • 33747624175 scopus 로고    scopus 로고
    • Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
    • Ligresti A, Moriello AS, Starowicz K, et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 2006;318:1375-1387
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1375-1387
    • Ligresti, A.1    Moriello, A.S.2    Starowicz, K.3
  • 45
    • 4644226099 scopus 로고    scopus 로고
    • Cannabinoids downregulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein
    • Ellert-Miklaszewska A, Kaminska B, Konarska L. Cannabinoids downregulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein. Cell Signal 2005;17:25-37.
    • (2005) Cell Signal , vol.17 , pp. 25-37
    • Ellert-Miklaszewska, A.1    Kaminska, B.2    Konarska, L.3
  • 46
    • 29144447456 scopus 로고    scopus 로고
    • Anandamide inhibits adhesion and migration of breast cancer cells
    • Grimaldi C, Pisanti S, Laezza C, et al. Anandamide inhibits adhesion and migration of breast cancer cells. Exp Cell Res 2006;312:363-373
    • (2006) Exp Cell Res , vol.312 , pp. 363-373
    • Grimaldi, C.1    Pisanti, S.2    Laezza, C.3
  • 47
    • 0642273057 scopus 로고    scopus 로고
    • Methanandamide increases COX-2 expression and tumor growth in murine lung cancer
    • Gardner B, Zhu LX, Sharma S, Tashkin DP, Dubinett SM. Methanandamide increases COX-2 expression and tumor growth in murine lung cancer. FASEB J 2003;17:2157-2159
    • (2003) FASEB J , vol.17 , pp. 2157-2159
    • Gardner, B.1    Zhu, L.X.2    Sharma, S.3    Tashkin, D.P.4    Dubinett, S.M.5
  • 48
    • 34547578958 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer
    • Harris RE. Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer. Subcell Biochem 2007;42:93-126.
    • (2007) Subcell Biochem , vol.42 , pp. 93-126
    • Harris, R.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.