메뉴 건너뛰기




Volumn 171, Issue 19, 2014, Pages 4464-4477

Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANNEXIN; CANNABIDIOL; CANNABINOID; DICHLORODIHYDROFLUORESCEIN; INHIBITOR OF DIFFERENTIATION 1; O 1663; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; RESORCINOL DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CANNABINOID 2 RECEPTOR; ID1 PROTEIN, HUMAN;

EID: 84927667530     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12803     Document Type: Article
Times cited : (74)

References (48)
  • 2
    • 40949083594 scopus 로고    scopus 로고
    • Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
    • Blazquez C, Salazar M, Carracedo A, Lorente M, Egia A, Gonzalez-Feria L, et al. (2008). Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res 68: 1945-1952.
    • (2008) Cancer Res , vol.68 , pp. 1945-1952
    • Blazquez, C.1    Salazar, M.2    Carracedo, A.3    Lorente, M.4    Egia, A.5    Gonzalez-Feria, L.6
  • 4
    • 33746138649 scopus 로고    scopus 로고
    • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    • Carracedo A, Gironella M, Lorente M, Garcia S, Guzman M, Velasco G, et al. (2006a). Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 66: 6748-6755.
    • (2006) Cancer Res , vol.66 , pp. 6748-6755
    • Carracedo, A.1    Gironella, M.2    Lorente, M.3    Garcia, S.4    Guzman, M.5    Velasco, G.6
  • 5
    • 33645763253 scopus 로고    scopus 로고
    • The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    • Carracedo A, Lorente M, Egia A, Blazquez C, Garcia S, Giroux V, et al. (2006b). The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 9: 301-312.
    • (2006) Cancer Cell , vol.9 , pp. 301-312
    • Carracedo, A.1    Lorente, M.2    Egia, A.3    Blazquez, C.4    Garcia, S.5    Giroux, V.6
  • 6
    • 79952432817 scopus 로고    scopus 로고
    • Cancer drugs: Remedy required
    • Editorial
    • Editorial (2011). Cancer drugs: remedy required. Nat Med 17: 231.
    • (2011) Nat Med , vol.17 , pp. 231
  • 7
    • 0029118444 scopus 로고
    • Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
    • Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, et al. (1995). Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48: 443-450.
    • (1995) Mol Pharmacol , vol.48 , pp. 443-450
    • Felder, C.C.1    Joyce, K.E.2    Briley, E.M.3    Mansouri, J.4    Mackie, K.5    Blond, O.6
  • 8
    • 0345686714 scopus 로고    scopus 로고
    • Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
    • Fong S, Itahana Y, Sumida T, Singh J, Coppe JP, Liu Y, et al. (2003). Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci U S A 100: 13543-13548.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13543-13548
    • Fong, S.1    Itahana, Y.2    Sumida, T.3    Singh, J.4    Coppe, J.P.5    Liu, Y.6
  • 10
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson AJ, Grimaldi M, Axelrod J, Wink D, (1998). Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A 95: 8268-8273.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 11
    • 67449088929 scopus 로고    scopus 로고
    • The role of Id-1 in chemosensitivity and epirubicin-induced apoptosis in bladder cancer cells
    • Hu H, Han HY, Wang YL, Zhang XP, Chua CW, Wong YC, et al. (2009). The role of Id-1 in chemosensitivity and epirubicin-induced apoptosis in bladder cancer cells. Oncol Rep 21: 1053-1059.
    • (2009) Oncol Rep , vol.21 , pp. 1053-1059
    • Hu, H.1    Han, H.Y.2    Wang, Y.L.3    Zhang, X.P.4    Chua, C.W.5    Wong, Y.C.6
  • 12
    • 0242526142 scopus 로고    scopus 로고
    • Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells
    • Itahana Y, Singh J, Sumida T, Coppe JP, Parrinello S, Bennington JL, et al. (2003). Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells. Cancer Res 63: 7098-7105.
    • (2003) Cancer Res , vol.63 , pp. 7098-7105
    • Itahana, Y.1    Singh, J.2    Sumida, T.3    Coppe, J.P.4    Parrinello, S.5    Bennington, J.L.6
  • 13
    • 0038845604 scopus 로고    scopus 로고
    • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
    • Jarai Z, Wagner JA, Varga K, Lake KD, Compton DR, Martin BR, et al. (1999). Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci U S A 96: 14136-14141.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14136-14141
    • Jarai, Z.1    Wagner, J.A.2    Varga, K.3    Lake, K.D.4    Compton, D.R.5    Martin, B.R.6
  • 14
    • 50549105058 scopus 로고    scopus 로고
    • The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT)
    • Kaplan BL, Springs AE, Kaminski NE, (2008). The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT). Biochem Pharmacol 76: 726-737.
    • (2008) Biochem Pharmacol , vol.76 , pp. 726-737
    • Kaplan, B.L.1    Springs, A.E.2    Kaminski, N.E.3
  • 17
    • 33747624175 scopus 로고    scopus 로고
    • Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
    • Ligresti A, Moriello AS, Starowicz K, Matias I, Pisanti S, De Petrocellis L, et al. (2006). Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 318: 1375-1387.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1375-1387
    • Ligresti, A.1    Moriello, A.S.2    Starowicz, K.3    Matias, I.4    Pisanti, S.5    De Petrocellis, L.6
  • 18
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
    • Malfait AM, Gallily R, Sumariwalla PF, Malik AS, Andreakos E, Mechoulam R, et al. (2000). The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A 97: 9561-9566.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9561-9566
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3    Malik, A.S.4    Andreakos, E.5    Mechoulam, R.6
  • 19
    • 73949139182 scopus 로고    scopus 로고
    • Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
    • Marcu JP, Christian RT, Lau D, Zielinski AJ, Horowitz MP, Lee J, et al. (2010). Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Mol Cancer Ther 9: 180-189.
    • (2010) Mol Cancer Ther , vol.9 , pp. 180-189
    • Marcu, J.P.1    Christian, R.T.2    Lau, D.3    Zielinski, A.J.4    Horowitz, M.P.5    Lee, J.6
  • 21
    • 33748492117 scopus 로고    scopus 로고
    • The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
    • Massi P, Vaccani A, Bianchessi S, Costa B, Macchi P, Parolaro D, (2006). The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci 63: 2057-2066.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2057-2066
    • Massi, P.1    Vaccani, A.2    Bianchessi, S.3    Costa, B.4    Macchi, P.5    Parolaro, D.6
  • 22
    • 38449109178 scopus 로고    scopus 로고
    • 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
    • Massi P, Valenti M, Vaccani A, Gasperi V, Perletti G, Marras E, et al. (2008). 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 104: 1091-1100.
    • (2008) J Neurochem , vol.104 , pp. 1091-1100
    • Massi, P.1    Valenti, M.2    Vaccani, A.3    Gasperi, V.4    Perletti, G.5    Marras, E.6
  • 23
    • 78349265651 scopus 로고    scopus 로고
    • Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes
    • Mato S, Victoria Sanchez-Gomez M, Matute C, (2010). Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes. Glia 58: 1739-1747.
    • (2010) Glia , vol.58 , pp. 1739-1747
    • Mato, S.1    Victoria Sanchez-Gomez, M.2    Matute, C.3
  • 25
    • 0242522905 scopus 로고    scopus 로고
    • An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region
    • McAllister SD, Rizvi G, Anavi-Goffer S, Hurst DP, Barnett-Norris J, Lynch DL, et al. (2003). An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region. J Med Chem 46: 5139-5152.
    • (2003) J Med Chem , vol.46 , pp. 5139-5152
    • McAllister, S.D.1    Rizvi, G.2    Anavi-Goffer, S.3    Hurst, D.P.4    Barnett-Norris, J.5    Lynch, D.L.6
  • 26
  • 27
    • 79960835512 scopus 로고    scopus 로고
    • Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
    • McAllister SD, Murase R, Christian RT, Lau D, Zielinski AJ, Allison J, et al. (2011). Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat 129: 37-47.
    • (2011) Breast Cancer Res Treat , vol.129 , pp. 37-47
    • McAllister, S.D.1    Murase, R.2    Christian, R.T.3    Lau, D.4    Zielinski, A.J.5    Allison, J.6
  • 29
    • 33747592582 scopus 로고    scopus 로고
    • Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
    • McKallip RJ, Jia W, Schlomer J, Warren JW, Nagarkatti PS, Nagarkatti M, (2006). Cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression. Mol Pharmacol 70: 897-908.
    • (2006) Mol Pharmacol , vol.70 , pp. 897-908
    • McKallip, R.J.1    Jia, W.2    Schlomer, J.3    Warren, J.W.4    Nagarkatti, P.S.5    Nagarkatti, M.6
  • 30
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, et al. (2005). Genes that mediate breast cancer metastasis to lung. Nature 436 (7050): 518-524.
    • (2005) Nature , vol.436 , Issue.7050 , pp. 518-524
    • Minn, A.J.1    Gupta, G.P.2    Siegel, P.M.3    Bos, P.D.4    Shu, W.5    Giri, D.D.6
  • 31
    • 18244396915 scopus 로고    scopus 로고
    • Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
    • Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K, et al. (2005). Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke 36: 1077-1082.
    • (2005) Stroke , vol.36 , pp. 1077-1082
    • Mishima, K.1    Hayakawa, K.2    Abe, K.3    Ikeda, T.4    Egashira, N.5    Iwasaki, K.6
  • 32
    • 1942420338 scopus 로고    scopus 로고
    • Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1
    • Mo FM, Offertaler L, Kunos G, (2004). Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. Eur J Pharmacol 489: 21-27.
    • (2004) Eur J Pharmacol , vol.489 , pp. 21-27
    • Mo, F.M.1    Offertaler, L.2    Kunos, G.3
  • 33
    • 84891791940 scopus 로고    scopus 로고
    • The IUPHAR/BPS Guide to PHARMACOLOGY: An expert-driven knowledgebase of drug targets and their ligands
    • NC-IUPHAR
    • Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al.; NC-IUPHAR (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucl Acids Res 42 (Database Issue): D1098-D1106.
    • (2014) Nucl Acids Res , vol.42 , pp. D1098-D1106
    • Pawson, A.J.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Alexander, S.P.5    Buneman, O.P.6
  • 34
    • 30444457225 scopus 로고    scopus 로고
    • Cannabinoid pharmacology: The first 66 years
    • Pertwee RG, (2006). Cannabinoid pharmacology: the first 66 years. Br J Pharmacol 147 (Suppl. 1): S163-S171.
    • (2006) Br J Pharmacol , vol.147 , pp. S163-S171
    • Pertwee, R.G.1
  • 35
    • 79959246435 scopus 로고    scopus 로고
    • Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance
    • Ponz-Sarvise M, Nguewa PA, Pajares MJ, Agorreta J, Lozano MD, Redrado M, et al. (2011). Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance. Clin Cancer Res 17: 4155-4166.
    • (2011) Clin Cancer Res , vol.17 , pp. 4155-4166
    • Ponz-Sarvise, M.1    Nguewa, P.A.2    Pajares, M.J.3    Agorreta, J.4    Lozano, M.D.5    Redrado, M.6
  • 36
    • 77449127143 scopus 로고    scopus 로고
    • Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
    • Ramer R, Merkord J, Rohde H, Hinz B, (2010). Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Biochem Pharmacol 79: 955-966.
    • (2010) Biochem Pharmacol , vol.79 , pp. 955-966
    • Ramer, R.1    Merkord, J.2    Rohde, H.3    Hinz, B.4
  • 37
    • 84860895849 scopus 로고    scopus 로고
    • Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
    • Ramer R, Bublitz K, Freimuth N, Merkord J, Rohde H, Haustein M, et al. (2012). Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J 26: 1535-1548.
    • (2012) FASEB J , vol.26 , pp. 1535-1548
    • Ramer, R.1    Bublitz, K.2    Freimuth, N.3    Merkord, J.4    Rohde, H.5    Haustein, M.6
  • 38
    • 41549121013 scopus 로고    scopus 로고
    • Cannabinoids in the management of difficult to treat pain
    • Russo EB, (2008). Cannabinoids in the management of difficult to treat pain. Ther Clin Risk Manag 4: 245-259.
    • (2008) Ther Clin Risk Manag , vol.4 , pp. 245-259
    • Russo, E.B.1
  • 40
    • 66449115318 scopus 로고    scopus 로고
    • Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    • Salazar M, Carracedo A, Salanueva IJ, Hernandez-Tiedra S, Lorente M, Egia A, et al. (2009). Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 119: 1359-1372.
    • (2009) J Clin Invest , vol.119 , pp. 1359-1372
    • Salazar, M.1    Carracedo, A.2    Salanueva, I.J.3    Hernandez-Tiedra, S.4    Lorente, M.5    Egia, A.6
  • 41
    • 0030425575 scopus 로고    scopus 로고
    • Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
    • Showalter VM, Compton DR, Martin BR, Abood ME, (1996). Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278: 989-999.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 989-999
    • Showalter, V.M.1    Compton, D.R.2    Martin, B.R.3    Abood, M.E.4
  • 42
    • 79960115996 scopus 로고    scopus 로고
    • Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
    • Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A, (2011). Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther 10: 1161-1172.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1161-1172
    • Shrivastava, A.1    Kuzontkoski, P.M.2    Groopman, J.E.3    Prasad, A.4
  • 43
    • 44449084242 scopus 로고    scopus 로고
    • Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response
    • Swarbrick A, Roy E, Allen T, Bishop JM, (2008). Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. Proc Natl Acad Sci U S A 105: 5402-5407.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5402-5407
    • Swarbrick, A.1    Roy, E.2    Allen, T.3    Bishop, J.M.4
  • 45
    • 17844388088 scopus 로고    scopus 로고
    • Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
    • Vaccani A, Massi P, Colombo A, Rubino T, Parolaro D, (2005). Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 144: 1032-1036.
    • (2005) Br J Pharmacol , vol.144 , pp. 1032-1036
    • Vaccani, A.1    Massi, P.2    Colombo, A.3    Rubino, T.4    Parolaro, D.5
  • 46
    • 84861530762 scopus 로고    scopus 로고
    • Towards the use of cannabinoids as antitumour agents
    • Velasco G, Sanchez C, Guzman M, (2012). Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 12: 436-444.
    • (2012) Nat Rev Cancer , vol.12 , pp. 436-444
    • Velasco, G.1    Sanchez, C.2    Guzman, M.3
  • 47
    • 0036226664 scopus 로고    scopus 로고
    • Resorcinol derivatives: A novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists
    • Wiley JL, Beletskaya ID, Ng EW, Dai Z, Crocker PJ, Mahadevan A, et al. (2002). Resorcinol derivatives: a novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists. J Pharmacol Exp Ther 301: 679-689.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 679-689
    • Wiley, J.L.1    Beletskaya, I.D.2    Ng, E.W.3    Dai, Z.4    Crocker, P.J.5    Mahadevan, A.6
  • 48
    • 54249156391 scopus 로고    scopus 로고
    • Cannabidiol: From an inactive cannabinoid to a drug with wide spectrum of action
    • Zuardi AW, (2008). Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Rev Bras Psiquiatr 30: 271-280.
    • (2008) Rev Bras Psiquiatr , vol.30 , pp. 271-280
    • Zuardi, A.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.