The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors

Neuropharmacology

Volumn 97, Issue , 2015, Pages 75-85

  Chatzidaki, Anna ^a   D'Oyley, Jarryl M ^a   Gill Thind, JasKiran K ^a   Sheppard, Tom D ^a   Millar, Neil S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Allosteric modulation; Ion channel; Nicotinic acetylcholine receptor; Pharmacology

Indexed keywords

1 (5 CHLORO 2 HYDROXY PHENYL) 3 (2 CHLORO 5 TRIFLUOROMETHYL PHENYL)UREA; 4 (4 BROMOPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (NAPTHALEN 1 YL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 [3 (4 BROMOPHENYL) 5 (4 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 1 YL]BENZENESULFONAMIDE; 4 [3 (4 BROMOPHENYL) 5 PHENETHYL 1H 1,2,4 TRIAZOL 1 YL]BENZENESULFONAMIDE; 4 [3 (4 BROMOPHENYL) 5 PHENYL 1H 1,2,4 TRIAZOL 1 YL]BENZENESULFONAMIDE; 4 [3 (4 BROMOPHENYL) 5 PROPYL 1H 1,2,4 TRIAZOL 1 YL]BENZENESULFONAMIDE; 4 [5 BENZYL 3 (4 BROMOPHENYL) 1H 1,2,4 TRIAZOL 1 YL]BENZENESULFONAMIDE; BUNGAROTOXIN RECEPTOR; NICOTINIC AGENT; UNCLASSIFIED DRUG; ACETYLCHOLINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; SEROTONIN 3 RECEPTOR;

ADULT; ALLOSTERIC MODULATION; ALLOSTERISM; ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG POTENTIATION; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR DOWN REGULATION; XENOPUS LAEVIS; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; MEMBRANE POTENTIAL; METABOLISM; MOUSE; PHYSIOLOGY; RADIOASSAY; RAT;

ACETYLCHOLINE; ALLOSTERIC SITE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; CHOLINERGIC AGENTS; HEK293 CELLS; HUMANS; MEMBRANE POTENTIALS; MICE; MOLECULAR STRUCTURE; MUTATION; OOCYTES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN, 5-HT3; XENOPUS LAEVIS;

EID: 84930655498     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.05.006     Document Type: Article

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