Threonine-for-leucine mutation within domain M2 of the neuronal α 7 nicotinic receptor converts 5-hydroxytryptamine from antagonist to agonist

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 20, 1996, Pages 11231-11235

  Palma, E ^a   Mileo, A M ^b   Eusebi, F ^a,b   Miledi, R ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

acetylcholine receptors; neurotransmitter interactions; Xenopus oocytes

Indexed keywords

NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; SEROTONIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; DRUG RECEPTOR BINDING; MEMBRANE CURRENT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SEROTONINERGIC SYSTEM; XENOPUS;

ANIMALS; CHICKENS; ION CHANNEL GATING; LEUCINE; MEMBRANE POTENTIALS; NEURONS; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; OOCYTES; RECEPTORS, NICOTINIC; SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE; XENOPUS LAEVIS;

ANIMALIA; GALLUS GALLUS;

EID: 0029763194     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.20.11231     Document Type: Article

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