Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular β4 amino acids that are implicated in the coupling of binding to channel gating

Molecular Pharmacology

Volumn 71, Issue 2, 2007, Pages 389-397

  Young, Gareth T ^a   Broad, Lisa M ^b   Zwart, Ruud ^b   Astles, Peter C ^b   Bodkin, Michael ^b   Sher, Emanuele ^b   Millar, Neil S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCIUM; EPIBATIDINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR SUBUNIT ALPHA2BETA4; NICOTINIC RECEPTOR SUBUNIT ALPHA3BETA4; NICOTINIC RECEPTOR SUBUNIT ALPHA4BETA2; NICOTINIC RECEPTOR SUBUNIT ALPHA4BETA4; NICOTINIC RECEPTOR SUBUNIT ALPHA7; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CHANNEL GATING; CHIMERA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SENSITIVITY; ELECTROPHYSIOLOGY; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; WILD TYPE; XENOPUS LAEVIS;

AMINO ACIDS; ANIMALS; ANTHRAQUINONES; HUMANS; ION CHANNEL GATING; MUTATION; NICOTINIC AGONISTS; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN SUBUNITS; RATS; RECEPTORS, NICOTINIC; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846433512     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.030809     Document Type: Article

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