-
1
-
-
84861963413
-
Structure and pharmacology of pentameric receptor channels: From bacteria to brain
-
Corringer, P. J., Poitevin, F., Prevost, M. S., Sauguet, L., Delarue, M., and Changeux, J. P. (2012) Structure and pharmacology of pentameric receptor channels: from bacteria to brain. Structure 20, 941-956
-
(2012)
Structure
, vol.20
, pp. 941-956
-
-
Corringer, P.J.1
Poitevin, F.2
Prevost, M.S.3
Sauguet, L.4
Delarue, M.5
Changeux, J.P.6
-
3
-
-
0013854436
-
Affinity labeling of antibodies to the p-azophenyltrimethylammonium hapten and a structural relationship among antibody active sites of different specificities
-
Fenton, J. W., 2nd, and Singer, S. J. (1965) Affinity labeling of antibodies to the p-azophenyltrimethylammonium hapten and a structural relationship among antibody active sites of different specificities. Biochem. Biophys. Res. Commun. 20, 315-320
-
(1965)
Biochem. Biophys. Res. Commun.
, vol.20
, pp. 315-320
-
-
Fenton II, J.W.1
Singer, S.J.2
-
4
-
-
0014149278
-
Affinity labeling of the acetylcholine receptor
-
Changeux, J. P., Podleski, T. R., and Wofsy, L. (1967) Affinity labeling of the acetylcholine receptor. Proc. Natl. Acad. Sci. U.S.A. 58, 2063-2070
-
(1967)
Proc. Natl. Acad. Sci. U.S.A.
, vol.58
, pp. 2063-2070
-
-
Changeux, J.P.1
Podleski, T.R.2
Wofsy, L.3
-
5
-
-
0014295433
-
Reduction and specific alkylation of the receptor for acetylcholine
-
Karlin, A., and Winnik, M. (1968) Reduction and specific alkylation of the receptor for acetylcholine. Proc. Natl. Acad. Sci. U.S.A. 60, 668-674
-
(1968)
Proc. Natl. Acad. Sci. U.S.A.
, vol.60
, pp. 668-674
-
-
Karlin, A.1
Winnik, M.2
-
6
-
-
0014662844
-
Separation of excitable membranes from the electric organ of Electrophorus electricus
-
Changeux, J. P., Gautron, J., Israël, M., and Podleski, T. (1969) Separation of excitable membranes from the electric organ of Electrophorus electricus. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D 269, 1788-1791
-
(1969)
C. R. Acad. Sci. Hebd. Seances Acad. Sci. D
, vol.269
, pp. 1788-1791
-
-
Changeux, J.P.1
Gautron, J.2
Israël, M.3
Podleski, T.4
-
8
-
-
0014937852
-
Demonstration of the excitation by cholinergic agonists from fractions of purified membranes in vitro
-
Kasai, M., and Changeux, J. P. (1970) Demonstration of the excitation by cholinergic agonists from fractions of purified membranes in vitro. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D 270, 1400-1403
-
(1970)
C. R. Acad. Sci. Hebd. Seances Acad. Sci. D
, vol.270
, pp. 1400-1403
-
-
Kasai, M.1
Changeux, J.P.2
-
10
-
-
0014936960
-
Extraction from electric tissue of Electrophorus of a protein presenting several typical properties characteristic of the physiological receptor of acetylcholine
-
Changeux, J. P., Kasai, M., Huchet, M., and Meunier, J. C. (1970) Extraction from electric tissue of Electrophorus of a protein presenting several typical properties characteristic of the physiological receptor of acetylcholine. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D 270, 2864-2867
-
(1970)
C. R. Acad. Sci. Hebd. Seances Acad. Sci. D
, vol.270
, pp. 2864-2867
-
-
Changeux, J.P.1
Kasai, M.2
Huchet, M.3
Meunier, J.C.4
-
11
-
-
84883837027
-
Isolation of neurotoxins from the venom of Bungarus multicinctus and their modes of neuromuscular blocking action
-
Chang, C. C., and Lee, C. Y. (1963) Isolation of neurotoxins from the venom of Bungarus multicinctus and their modes of neuromuscular blocking action. Arch. Int. Pharmacodyn. Ther. 144, 241-257
-
(1963)
Arch. Int. Pharmacodyn. Ther.
, vol.144
, pp. 241-257
-
-
Chang, C.C.1
Lee, C.Y.2
-
12
-
-
0014877189
-
Use of a snake venom toxin to characterize the cholinergic receptor protein
-
Changeux, J. P., Kasai, M., and Lee, C. Y. (1970) Use of a snake venom toxin to characterize the cholinergic receptor protein. Proc. Natl. Acad. Sci. U.S.A. 67, 1241-1247
-
(1970)
Proc. Natl. Acad. Sci. U.S.A.
, vol.67
, pp. 1241-1247
-
-
Changeux, J.P.1
Kasai, M.2
Lee, C.Y.3
-
13
-
-
0015209843
-
Separation of the receptor protein of acetylcholine and acetylcholinesterase
-
Meunier, J. C., Huchet, M., Boquet, P., and Changeux, J. P. (1971) Separation of the receptor protein of acetylcholine and acetylcholinesterase. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D 272, 117-120
-
(1971)
C. R. Acad. Sci. Hebd. Seances Acad. Sci. D
, vol.272
, pp. 117-120
-
-
Meunier, J.C.1
Huchet, M.2
Boquet, P.3
Changeux, J.P.4
-
14
-
-
0015511492
-
Isolation of the nicotinic acetylcholine receptor by biospecific chromatography on insolubilized Naja naja neurotoxin
-
Karlsson, E., Heilbronn, E., and Widlund, L. (1972) Isolation of the nicotinic acetylcholine receptor by biospecific chromatography on insolubilized Naja naja neurotoxin. FEBS Lett. 28, 107-111
-
(1972)
FEBS Lett.
, vol.28
, pp. 107-111
-
-
Karlsson, E.1
Heilbronn, E.2
Widlund, L.3
-
15
-
-
0015867163
-
The acetylcholine receptor. I. Purification and characterization of a macromolecule isolated from Electrophorus electricus
-
Klett, R. P., Fulpius, B. W., Cooper, D., Smith, M., Reich, E., and Possani, L. D. (1973) The acetylcholine receptor. I. Purification and characterization of a macromolecule isolated from Electrophorus electricus. J. Biol. Chem. 248, 6841-6853
-
(1973)
J. Biol. Chem.
, vol.248
, pp. 6841-6853
-
-
Klett, R.P.1
Fulpius, B.W.2
Cooper, D.3
Smith, M.4
Reich, E.5
Possani, L.D.6
-
16
-
-
84870026067
-
-
Bennett, M. V. L., ed Raven Press, New York
-
Lindstrom, J., and Patrick, J. (1974) in Synaptic Transmission and Neuronal Interaction (Bennett, M. V. L., ed) pp. 191-216, Raven Press, New York
-
(1974)
Synaptic Transmission and Neuronal Interaction
, pp. 191-216
-
-
Lindstrom, J.1
Patrick, J.2
-
17
-
-
0015511406
-
Progress in purification of the cholinergic receptor protein from Electrophorus electricus by affinity chromatography
-
Olsen, R. W., Meunier, J. C., and Changeux, J. P. (1972) Progress in purification of the cholinergic receptor protein from Electrophorus electricus by affinity chromatography. FEBS Lett. 28, 96-100
-
(1972)
FEBS Lett.
, vol.28
, pp. 96-100
-
-
Olsen, R.W.1
Meunier, J.C.2
Changeux, J.P.3
-
18
-
-
0016150992
-
Purification and properties of the cholinergic receptor protein from Electrophorus electricus electroplax
-
Meunier, J. C., Sealock, R., Olsen, R., and Changeux, J. P. (1974) Purification and properties of the cholinergic receptor protein from Electrophorus electricus electroplax. Eur. J. Biochem. 45, 371-394
-
(1974)
Eur. J. Biochem.
, vol.45
, pp. 371-394
-
-
Meunier, J.C.1
Sealock, R.2
Olsen, R.3
Changeux, J.P.4
-
19
-
-
0015514163
-
Use of affinity chromatography for acetylcholine receptor purification
-
Schmidt, J., and Raftery, M. A. (1972) Use of affinity chromatography for acetylcholine receptor purification. Biochem. Biophys. Res. Commun. 49, 572-578
-
(1972)
Biochem. Biophys. Res. Commun.
, vol.49
, pp. 572-578
-
-
Schmidt, J.1
Raftery, M.A.2
-
20
-
-
0015231923
-
Isolation of the cholinergic receptor protein of Torpedo electric tissue
-
Miledi, R., Molinoff, P., and Potter, L. T. (1971) Isolation of the cholinergic receptor protein of Torpedo electric tissue. Nature 229, 554-557
-
(1971)
Nature
, vol.229
, pp. 554-557
-
-
Miledi, R.1
Molinoff, P.2
Potter, L.T.3
-
21
-
-
0015408598
-
Purification from Torpedo marmorata electric tissue of membrane fragments particularly rich in cholinergic receptor
-
Cohen, J. B., Weber, M., Huchet, M., and Changeux, J. P. (1972) Purification from Torpedo marmorata electric tissue of membrane fragments particularly rich in cholinergic receptor. FEBS Lett. 26, 43-47
-
(1972)
FEBS Lett.
, vol.26
, pp. 43-47
-
-
Cohen, J.B.1
Weber, M.2
Huchet, M.3
Changeux, J.P.4
-
22
-
-
0017708049
-
Large-scale purification of the acetylcholine-receptor protein in its membrane-bound and detergent-extracted forms from Torpedo marmorata electric organ
-
DOI 10.1111/j.1432-1033.1977.tb11874.x
-
Sobel, A., Weber, M., Changeux, J. P. (1977) Large-scale purification of the acetylcholine receptor protein in its membrane-bound and detergent-extracted forms from Torpedo marmorata electric organ. Eur. J. Biochem. 80, 215-224 (Pubitemid 8210000)
-
(1977)
European Journal of Biochemistry
, vol.80
, Issue.1
, pp. 215-224
-
-
Sobel, A.1
Weber, M.2
Changeux, J.P.3
-
23
-
-
0015896618
-
Interaction of a fluorescent ligand with membrane-bound cholinergic receptor from Torpedo marmorata
-
Cohen, J. B., and Changeux, J. P. (1973) Interaction of a fluorescent ligand with membrane-bound cholinergic receptor from Torpedo marmorata. Biochemistry 12, 4855-4864
-
(1973)
Biochemistry
, vol.12
, pp. 4855-4864
-
-
Cohen, J.B.1
Changeux, J.P.2
-
24
-
-
0016785952
-
Interaction of a spin-labeled long chain acylcholine with the cholinergic receptor protein in its membrane environment
-
Brisson, A. D., Scandella, C. J., Bienvenüe, A., Devaux, P. F., Cohen, J. B., and Changeux, J. P. (1975) Interaction of a spin-labeled long chain acylcholine with the cholinergic receptor protein in its membrane environment. Proc. Natl. Acad. Sci. U.S.A. 72, 1087-1091
-
(1975)
Proc. Natl. Acad. Sci. U.S.A.
, vol.72
, pp. 1087-1091
-
-
Brisson, A.D.1
Scandella, C.J.2
Bienvenüe, A.3
Devaux, P.F.4
Cohen, J.B.5
Changeux, J.P.6
-
25
-
-
0015986009
-
X-ray diffraction study of membrane fragments rich in acetylcholine receptor protein prepared from the electric organ of Torpedo marmorata
-
Dupont, Y., Cohen, J. B., and Changeux, J. P. (1974) X-ray diffraction study of membrane fragments rich in acetylcholine receptor protein prepared from the electric organ of Torpedo marmorata. FEBS Lett. 40, 130-133
-
(1974)
FEBS Lett.
, vol.40
, pp. 130-133
-
-
Dupont, Y.1
Cohen, J.B.2
Changeux, J.P.3
-
26
-
-
0015788764
-
Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata
-
Cartaud, J., Benedetti, E. L., Cohen, J. B., Meunier, J. C., and Changeux, J. P. (1973) Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata. FEBS Lett. 33, 109-13
-
(1973)
FEBS Lett.
, vol.33
, pp. 109-113
-
-
Cartaud, J.1
Benedetti, E.L.2
Cohen, J.B.3
Meunier, J.C.4
Changeux, J.P.5
-
27
-
-
0015850997
-
Ultrastructure of isolated membranes of Torpedo electric tissue
-
Nickel, E., and Potter, L. T. (1973) Ultrastructure of isolated membranes of Torpedo electric tissue. Brain Res. 57, 508-517
-
(1973)
Brain Res.
, vol.57
, pp. 508-517
-
-
Nickel, E.1
Potter, L.T.2
-
28
-
-
13444271681
-
Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution
-
Unwin, N. (2005) Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution. J. Mol. Biol. 346, 967-989
-
(2005)
J. Mol. Biol.
, vol.346
, pp. 967-989
-
-
Unwin, N.1
-
29
-
-
0015720965
-
Molecular weight and quaternary structure of the cholinergic receptor protein extracted by detergents from Electrophorus electricus electric tissue
-
Hucho, F., and Changeux, J. P. (1973) Molecular weight and quaternary structure of the cholinergic receptor protein extracted by detergents from Electrophorus electricus electric tissue. FEBS Lett. 38, 11-15
-
(1973)
FEBS Lett.
, vol.38
, pp. 11-15
-
-
Hucho, F.1
Changeux, J.P.2
-
30
-
-
0016345688
-
Affinity labeling of purified acetylcholine receptor from Torpedo californica
-
Weill, C. L., McNamee, M. G., and Karlin, A. (1974) Affinity labeling of purified acetylcholine receptor from Torpedo californica. Biochem. Biophys. Res. Commun. 61, 997-1003
-
(1974)
Biochem. Biophys. Res. Commun.
, vol.61
, pp. 997-1003
-
-
Weill, C.L.1
McNamee, M.G.2
Karlin, A.3
-
31
-
-
0016332514
-
The biochemistry of an acetylcholine receptor
-
Raftery, M. A., Vandlen, R., Michaelson, D., Bode, J., Moody, T., Chao, Y., Reed, K., Deutsch, J., and Duguid, J. (1974) The biochemistry of an acetylcholine receptor. J. Supramol. Struct. 2, 582-592
-
(1974)
J. Supramol. Struct.
, vol.2
, pp. 582-592
-
-
Raftery, M.A.1
Vandlen, R.2
Michaelson, D.3
Bode, J.4
Moody, T.5
Chao, Y.6
Reed, K.7
Deutsch, J.8
Duguid, J.9
-
32
-
-
0018665657
-
Immunochemical similarities between subunits of acetylcholine receptors from Torpedo, Electrophorus, and mammalian muscle
-
DOI 10.1021/bi00588a004
-
Lindstrom, J., Walter, B., and Einarson, B. (1979) Immunochemical similarities between subunits of acetylcholine receptors from Torpedo, Electrophorus, and mammalian muscle. Biochemistry 18, 4470-4480 (Pubitemid 10209036)
-
(1979)
Biochemistry
, vol.18
, Issue.21
, pp. 4470-4480
-
-
Lindstrom, J.1
Walter, B.2
Einarson, B.3
-
33
-
-
0019156330
-
3H]trimethisoquin
-
DOI 10.1016/0014-5793(80)80522-9
-
Saitoh, T., Oswald, R., Wennogle, L. P., and Changeux, J. P. (1980) Conditions for the selective labelling of the 66,000 Dalton chain of the acetylcholine receptor by the covalent noncompetitive blocker 5-azido- [3H]trimethisoquin. FEBS Lett. 116, 30-36 (Pubitemid 11227324)
-
(1980)
FEBS Letters
, vol.116
, Issue.1
, pp. 30-36
-
-
Saitoh, T.1
Oswald, R.2
Wennogle, L.P.3
Changeux, J.P.4
-
34
-
-
0018508120
-
The amino-terminal sequence of the 40,000 molecular weight subunit of the acetylcholine receptor protein from Torpedo marmorata
-
Devillers-Thiéry, A., Changeux, J. P., Paroutaud, P., and Strosberg, A. D. (1979) The amino-terminal sequence of the 40,000 molecular weight subunit of the acetylcholine receptor protein from Torpedo marmorata. FEBS Lett. 104, 99-105
-
(1979)
FEBS Lett.
, vol.104
, pp. 99-105
-
-
Devillers-Thiéry, A.1
Changeux, J.P.2
Paroutaud, P.3
Strosberg, A.D.4
-
35
-
-
0018611551
-
Amino terminal amino acid sequence of the major polypeptide subunit of Torpedo californica acetylcholine receptor
-
DOI 10.1016/0006-291X(79)90598-9
-
Hunkapiller, M. W., Strader, C. D., Hood, L., and Raftery, M. A. (1979) Amino-terminal amino acid sequence of the major polypeptide subunit of Torpedo californica acetylcholine receptor. Biochem. Biophys. Res. Commun. 91, 164-169 (Pubitemid 10183356)
-
(1979)
Biochemical and Biophysical Research Communications
, vol.91
, Issue.1
, pp. 164-169
-
-
Hunkapiller, M.W.1
Strader, C.D.2
Hood, L.3
Raftery, M.A.4
-
36
-
-
0019311334
-
Acetylcholine receptor: Complex of homologous subunits
-
Raftery, M. A., Hunkapiller, M. W., Strader, C. D., and Hood, L. E. (1980) Acetylcholine receptor: complex of homologous subunits. Science 208, 1454-1456
-
(1980)
Science
, vol.208
, pp. 1454-1456
-
-
Raftery, M.A.1
Hunkapiller, M.W.2
Strader, C.D.3
Hood, L.E.4
-
37
-
-
78651189765
-
On the nature of allosteric transitions: A plausible model
-
Monod, J., Wyman, J., and Changeux, J. P. (1965) On the nature of allosteric transitions: a plausible model. J. Mol. Biol. 12, 88-118
-
(1965)
J. Mol. Biol.
, vol.12
, pp. 88-118
-
-
Monod, J.1
Wyman, J.2
Changeux, J.P.3
-
38
-
-
0019904425
-
Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence
-
DOI 10.1038/299793a0
-
Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Furutani, Y., Hirose, T., Asai, M., Inayama, S., Miyata, T., and Numa, S. (1982) Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature 299, 793-797 (Pubitemid 12003297)
-
(1982)
Nature
, vol.299
, Issue.5886
, pp. 793-797
-
-
Noda, M.1
Takahashi, H.2
Tanabe, T.3
-
39
-
-
0020687145
-
Primary structures of β- and δ-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences
-
Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Kikyotani, S., Hirose, T., Asai, M., Takashima, H., Inayama, S., Miyata, T., and Numa, S. (1983) Primary structures of β- and δ-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Nature 301, 251-255 (Pubitemid 13142227)
-
(1983)
Nature
, vol.301
, Issue.5897
, pp. 251-255
-
-
Noda, M.1
Takahashi, H.2
Tanabe, T.3
-
40
-
-
0020583289
-
Structural homology of Torpedo californica acetylcholine receptor subunits
-
Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Kikyotani, S., Furutani, Y., Hirose, T., Takashima, H., Inayama, S., Miyata, T., and Numa, S. (1983) Structural homology of Torpedo californica acetylcholine receptor subunits. Nature 302, 528-532 (Pubitemid 13111136)
-
(1983)
Nature
, vol.302
, Issue.5908
, pp. 528-532
-
-
Noda, M.1
Takahashi, H.2
Tanabe, T.3
-
41
-
-
0019988962
-
Molecular cloning of cDNA coding for the γ subunit of Torpedo acetylcholine receptor
-
DOI 10.1073/pnas.79.14.4466
-
Ballivet, M., Patrick, J., Lee, J., and Heinemann, S. (1982) Molecular cloning of cDNA coding for the γ-subunit of Torpedo acetylcholine receptor. Proc. Natl. Acad. Sci. U.S.A. 79, 4466-4470 (Pubitemid 12052895)
-
(1982)
Proceedings of the National Academy of Sciences of the United States of America
, vol.79
, Issue.14 I
, pp. 4466-4470
-
-
Ballivet, M.1
Patrick, J.2
Lee, J.3
Heinemann, S.4
-
42
-
-
0010665535
-
Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor γ subunit
-
Claudio, T., Ballivet, M., Patrick, J., and Heinemann, S. (1983) Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor γ-subunit. Proc. Natl. Acad. Sci. U.S.A. 80, 1111-1115 (Pubitemid 13118096)
-
(1983)
Proceedings of the National Academy of Sciences of the United States of America
, vol.80
, Issue.4 I
, pp. 1111-1115
-
-
Claudio, T.1
Ballivet, M.2
Patrick, J.3
Heinemann, S.4
-
43
-
-
0020480613
-
The molecular cloning and characterisation of cDNA coding for the γ-subunit of the acetylcholine receptor
-
Sumikawa, K., Houghton, M., Smith, J. C., Bell, L., Richards, B. M., and Barnard, E. A. (1982) The molecular cloning and characterisation of cDNA coding for the γ-subunit of the acetylcholine receptor. Nucleic Acids Res. 10, 5809-5822
-
(1982)
Nucleic Acids Res
, vol.10
, pp. 5809-5822
-
-
Sumikawa, K.1
Houghton, M.2
Smith, J.C.3
Bell, L.4
Richards, B.M.5
Barnard, E.A.6
-
44
-
-
0020338409
-
Identification of a cDNA clone coding for the acetylcholine binding subunit of Torpedo marmorata acetylcholine receptor
-
Giraudat, J., Devillers-Thiéry, A., Auffray, C., Rougeon, F., and Changeux, J. P. (1982) Identification of a cDNA clone coding for the acetylcholine binding subunit of Torpedo marmorata acetylcholine receptor. EMBO J. 1, 713-717
-
(1982)
EMBO J.
, vol.1
, pp. 713-717
-
-
Giraudat, J.1
Devillers-Thiéry, A.2
Auffray, C.3
Rougeon, F.4
Changeux, J.P.5
-
45
-
-
0000631357
-
Complete mRNA coding sequence of the acetylcholine binding α-subunit of Torpedo marmorata acetylcholine receptor: A model for the transmembrane organization of the polypeptide chain
-
Devillers-Thiéry, A., Giraudat, J., Bentaboulet, M., and Changeux, J. P. (1983) Complete mRNA coding sequence of the acetylcholine binding α-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain. Proc. Natl. Acad. Sci. U.S.A. 80, 2067-2071 (Pubitemid 13079233)
-
(1983)
Proceedings of the National Academy of Sciences of the United States of America
, vol.80
, Issue.7 I
, pp. 2067-2071
-
-
Devillers, T.A.1
Giraudat, J.2
Bentaboulet, M.3
Changeux, J.P.4
-
46
-
-
0019954796
-
Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes
-
Barnard, E. A., Miledi, R., and Sumikawa, K. (1982) Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes. Proc. R. Soc. Lond. B Biol. Sci. 215, 241-246 (Pubitemid 12024157)
-
(1982)
Proceedings of the Royal Society of London - Biological Sciences
, vol.215
, Issue.1199
, pp. 241-246
-
-
Barnard, E.A.1
Miledi, R.2
Sumikawa, K.3
-
47
-
-
0021155082
-
Expression of functional acetylcholine receptor from cloned cDNAs
-
Mishina, M., Kurosaki, T., Tobimatsu, T., Morimoto, Y., Noda, M., Yamamoto, T., Terao, M., Lindstrom, J., Takahashi, T., Kuno, M., and Numa, S. (1984) Expression of functional acetylcholine receptor from cloned cDNAs. Nature 307, 604-608 (Pubitemid 14129672)
-
(1984)
Nature
, vol.307
, Issue.5952
, pp. 604-608
-
-
Mishina, M.1
Kurosaki, T.2
Tobimatsu, T.3
-
49
-
-
0018120101
-
Reconstitution of carbamylcholine-dependent sodium ion flux and desensitization of the acetylcholine receptor from Torpedo californica
-
Epstein, M., and Racker, E. (1978) Reconstitution of carbamylcholine- dependent sodium ion flux and desensitization of the acetylcholine receptor from Torpedo californica. J. Biol. Chem. 253, 6660-6662 (Pubitemid 9060474)
-
(1978)
Journal of Biological Chemistry
, vol.253
, Issue.19
, pp. 6660-6662
-
-
Epstein, M.1
Racker, E.2
-
50
-
-
0022636117
-
Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit
-
DOI 10.1038/319368a0
-
Boulter, J., Evans, K., Goldman, D., Martin, G., Treco, D., Heinemann, S., and Patrick, J. (1986) Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit. Nature 319, 368-374 (Pubitemid 16163895)
-
(1986)
Nature
, vol.319
, Issue.6052
, pp. 368-374
-
-
Boulter, J.1
Evans, K.2
Goldman, D.3
-
52
-
-
26944443142
-
Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys loop ion channels
-
Tasneem, A., Iyer, L. M., Jakobsson, E., and Aravind, L. (2004) Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys loop ion channels. Genome Biol. 6, R4
-
(2004)
Genome Biol.
, vol.6
-
-
Tasneem, A.1
Iyer, L.M.2
Jakobsson, E.3
Aravind, L.4
-
53
-
-
33846106078
-
A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family
-
DOI 10.1038/nature05371, PII NATURE05371
-
Bocquet, N., Prado de Carvalho, L., Cartaud, J., Neyton, J., Le Poupon, C., Taly, A., Grutter, T., Changeux, J. P., and Corringer, P. J. (2007) A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature 445, 116-119 (Pubitemid 46067312)
-
(2007)
Nature
, vol.445
, Issue.7123
, pp. 116-119
-
-
Bocquet, N.1
Prado, D.C.L.2
Cartaud, J.3
Neyton, J.4
Le, P.C.5
Taly, A.6
Grutter, T.7
Changeux, J.-P.8
Corringer, P.-J.9
-
54
-
-
0021132711
-
Identification of the α subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site
-
Kao, P. N., Dwork, A. J., Kaldany, R. R., Silver, M. L., Wideman, J., Stein, S., and Karlin, A. (1984) Identification of the α-subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site. J. Biol. Chem. 259, 11662-11665 (Pubitemid 14022079)
-
(1984)
Journal of Biological Chemistry
, vol.259
, Issue.19
, pp. 11662-11665
-
-
Kao, P.N.1
Dwork, A.J.2
Kaldany, R.R.J.3
-
55
-
-
0020033955
-
Crosslinking of α-bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation
-
DOI 10.1016/0014-5793(82)80857-0
-
Oswald, R. E., and Changeux, J. P. (1982) Cross-linking of α-bungarotoxin to the acetylcholine receptor from Torpedo marmorata by UV light irradiation. FEBS Lett. 139, 225-229 (Pubitemid 12130858)
-
(1982)
FEBS Letters
, vol.139
, Issue.2
, pp. 225-229
-
-
Oswald, R.E.1
Changeux, J.P.2
-
56
-
-
0023001421
-
A photoaffinity ligand of the acetylcholine-binding site predominantly labels the region 179-207 of the α-subunit on native acetylcholine receptor from Torpedo marmorata
-
DOI 10.1016/0014-5793(86)81497-1
-
Dennis, M., Giraudat, J., Kotzyba-Hibert, F., Goeldner, M., Hirth, C., Chang, J. Y., and Changeux, J. P. (1986) A photoaffinity ligand of the acetylcholine binding site predominantly labels the region 179-207 of the α-subunit on native acetylcholine receptor from Torpedo marmorata. FEBS Lett. 207, 243-249 (Pubitemid 17176185)
-
(1986)
FEBS Letters
, vol.207
, Issue.2
, pp. 243-249
-
-
Dennis, M.1
Giraudat, J.2
Kotzyba-Hibert, F.3
-
57
-
-
0024278367
-
Amino acids of the Torpedo marmorata acetylcholine receptor subunit labeled by a photoaffinity ligand for the acetylcholine binding site
-
Dennis, M., Giraudat, J., Kotzyba-Hibert, F., Goeldner, M., Hirth, C., Chang, J. Y., Lazure, C., Chrétien, M., and Changeux, J. P. (1988) Amino acids of the Torpedo marmorata acetylcholine receptor subunit labeled by a photoaffinity ligand for the acetylcholine binding site. Biochemistry 27, 2346-2357
-
(1988)
Biochemistry
, vol.27
, pp. 2346-2357
-
-
Dennis, M.1
Giraudat, J.2
Kotzyba-Hibert, F.3
Goeldner, M.4
Hirth, C.5
Chang, J.Y.6
Lazure, C.7
Chrétien, M.8
Changeux, J.P.9
-
58
-
-
0025346780
-
Identification of a novel amino acid α-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites
-
Galzi, J. L., Revah, F., Black, D., Goeldner, M., Hirth, C., and Changeux, J. P. (1990) Identification of a novel amino acid α-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites. J. Biol. Chem. 265, 10430-10437
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 10430-10437
-
-
Galzi, J.L.1
Revah, F.2
Black, D.3
Goeldner, M.4
Hirth, C.5
Changeux, J.P.6
-
59
-
-
0036480194
-
Emerging structure of the nicotinic acetylcholine receptors
-
Karlin, A. (2002) Emerging structure of the nicotinic acetylcholine receptors. Nat. Rev. Neurosci. 3, 102-114
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 102-114
-
-
Karlin, A.1
-
60
-
-
0035902009
-
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
-
DOI 10.1038/35077011
-
Brejc, K., van Dijk, W. J., Klaassen, R. V., Schuurmans, M., van Der Oost, J., Smit, A. B., and Sixma, T. K. (2001) Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature 411, 269-276 (Pubitemid 32467026)
-
(2001)
Nature
, vol.411
, Issue.6835
, pp. 269-276
-
-
Brejc, K.1
Van Dijk, W.J.2
Klaassen, R.V.3
Schuurmans, M.4
Van Der, O.J.5
Smit, A.B.6
Sixma, T.K.7
-
61
-
-
79957953215
-
Principles of activation and permeation in an anion-selective Cys loop receptor
-
Hibbs, R. E., and Gouaux, E. (2011) Principles of activation and permeation in an anion-selective Cys loop receptor. Nature 474, 54-60
-
(2011)
Nature
, vol.474
, pp. 54-60
-
-
Hibbs, R.E.1
Gouaux, E.2
-
62
-
-
79959775185
-
Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC
-
Zimmermann, I., and Dutzler, R. (2011) Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC. PLoS Biol. 9, e1001101
-
(2011)
PLoS Biol.
, vol.9
-
-
Zimmermann, I.1
Dutzler, R.2
-
63
-
-
84859173541
-
Structure of the pentameric ligand-gated ion channel ELIC co-crystallized with its competitive antagonist acetylcholine
-
Pan, J., Chen, Q., Willenbring, D., Yoshida, K., Tillman, T., Kashlan, O. B., Cohen, A., Kong, X. P., Xu, Y., and Tang, P. (2012) Structure of the pentameric ligand-gated ion channel ELIC co-crystallized with its competitive antagonist acetylcholine. Nat. Commun. 3, 714
-
(2012)
Nat. Commun.
, vol.3
, pp. 714
-
-
Pan, J.1
Chen, Q.2
Willenbring, D.3
Yoshida, K.4
Tillman, T.5
Kashlan, O.B.6
Cohen, A.7
Kong, X.P.8
Xu, Y.9
Tang, P.10
-
64
-
-
0002224681
-
-
Changeux, J. P., Llinas, R. R., Purves, D., and Bloom, F. F., eds Raven Press, New York
-
Changeux, J. P. (1990) in Fidia Research Foundation Neuroscience Award Lectures (Changeux, J. P., Llinas, R. R., Purves, D., and Bloom, F. F., eds) Vol. 4, pp. 17-168, Raven Press, New York
-
(1990)
Fidia Research Foundation Neuroscience Award Lectures
, vol.4
, pp. 17-168
-
-
Changeux, J.P.1
-
65
-
-
0015980334
-
3H]α-toxin to membrane fragments from Electrophorus and Torpedo electric organs. III. Effect of local anaesthetics on the binding of the tritiated α-neurotoxin
-
3H]α-toxin to membrane fragments from Electrophorus and Torpedo electric organs. III. Effect of local anaesthetics on the binding of the tritiated α-neurotoxin. Mol. Pharmacol. 10, 35-40
-
(1974)
Mol. Pharmacol.
, vol.10
, pp. 35-40
-
-
Weber, M.1
Changeux, J.P.2
-
66
-
-
0016246242
-
Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata
-
Cohen, J. B., Weber, M., and Changeux, J. P. (1974) Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata. Mol. Pharmacol. 10, 904-932
-
(1974)
Mol. Pharmacol.
, vol.10
, pp. 904-932
-
-
Cohen, J.B.1
Weber, M.2
Changeux, J.P.3
-
68
-
-
0020434877
-
LE SITE DE LIAISON DE HAUTE AFFINITE DE LA CHLORPROMAZINE N'EST PRESENT QU'A UN SEUL EXEMPLAIRE PAR MOLECULE DE RECEPTEUR CHOLINERGIQUE ET EST COMMUN AUX QUATRE CHAINES POLYPEPTIDIQUES
-
Heidmann, T., Oswald, R., and Changeux, J. P. (1982) The high affinity binding site for chlorpromazine is present only as a single copy per cholinergic receptor molecule and is shared by four polypeptide chains. C. R. Seances Acad. Sci. III 295, 345-349 (Pubitemid 13176602)
-
(1982)
Comptes Rendus des Seances de l'Academie des Sciences - Series III
, vol.295
, Issue.5
, pp. 345-349
-
-
Heidmann, T.1
Oswald, R.2
Changeux, J.P.3
-
69
-
-
0345363642
-
Time-resolved photolabeling by the noncompetitive blocker chlorpromazine of the acetylcholine receptor in its transiently open and closed ion channel conformations
-
Heidmann, T., and Changeux, J. P. (1984) Time-resolved photolabeling by the noncompetitive blocker chlorpromazine of the acetylcholine receptor in its transiently open and closed ion channel conformations. Proc. Natl. Acad. Sci. U.S.A. 81, 1897-1901 (Pubitemid 14149573)
-
(1984)
Proceedings of the National Academy of Sciences of the United States of America
, vol.81
, Issue.6 I
, pp. 1897-1901
-
-
Heidmann, T.1
Changeux, J.P.2
-
70
-
-
0022998659
-
3H]chlorpromazine: Additional evidence for the open channel conformation
-
3H]chlorpromazine: additional evidence for the open channel conformation. Biochemistry 25, 6109-6113
-
(1986)
Biochemistry
, vol.25
, pp. 6109-6113
-
-
Heidmann, T.1
Changeux, J.P.2
-
71
-
-
0000791015
-
3H]chlorpromazine
-
Giraudat, J., Dennis, M., Heidmann, T., Chang, J. Y., and Changeux, J. P. (1986) Structure of the high affinity site for noncompetitive blockers of the acetylcholine receptor: serine 262 of the δ-subunit is labeled by [3H]chlorpromazine. Proc. Natl. Acad. Sci. U.S.A. 83, 2719-2723 (Pubitemid 16026955)
-
(1986)
Proceedings of the National Academy of Sciences of the United States of America
, vol.83
, Issue.8
, pp. 2719-2723
-
-
Giraudat, J.1
Dennis, M.2
Heidmann, T.3
-
72
-
-
0022758905
-
The reaction site of a noncompetitive antagonist in the δ-subunit of the nicotinic acetylcholine receptor
-
Oberthür, W., Muhn, P., Baumann, H., Lottspeich, F., Wittmann-Liebold, B., and Hucho, F. (1986) The reaction site of a noncompetitive antagonist in the δ-subunit of the nicotinic acetylcholine receptor. EMBO J. 5, 1815-1819
-
(1986)
EMBO J.
, vol.5
, pp. 1815-1819
-
-
Oberthür, W.1
Muhn, P.2
Baumann, H.3
Lottspeich, F.4
Wittmann-Liebold, B.5
Hucho, F.6
-
73
-
-
0022458822
-
The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits
-
DOI 10.1016/0014-5793(86)80881-X
-
Hucho, F., Oberthür, W., and Lottspeich, F. (1986) The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helicesM II of the receptor subunits. FEBS Lett. 205, 137-142 (Pubitemid 16031360)
-
(1986)
FEBS Letters
, vol.205
, Issue.1
, pp. 137-142
-
-
Hucho, F.1
Oberthur, W.2
Lottspeich, F.3
-
75
-
-
0022975736
-
Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel
-
DOI 10.1038/324670a0
-
Imoto, K., Methfessel, C., Sakmann, B., Mishina, M., Mori, Y., Konno, T., Fukuda, K., Kurasaki, M., Bujo, H., Fujita, Y., and Numa, S. (1986) Location of a β-subunit region determining ion transport through the acetylcholine receptor channel. Nature 324, 670-674 (Pubitemid 17206357)
-
(1986)
Nature
, vol.324
, Issue.6098
, pp. 670-674
-
-
Imoto, K.1
Methfessel, C.2
Sakmann, B.3
-
76
-
-
0023748825
-
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
-
Imoto, K., Busch, C., Sakmann, B., Mishina, M., Konno, T., Nakai, J., Bujo, H., Mori, Y., Fukuda, K., and Numa, S. (1988) Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature 335, 645-648
-
(1988)
Nature
, vol.335
, pp. 645-648
-
-
Imoto, K.1
Busch, C.2
Sakmann, B.3
Mishina, M.4
Konno, T.5
Nakai, J.6
Bujo, H.7
Mori, Y.8
Fukuda, K.9
Numa, S.10
-
77
-
-
0024213680
-
Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor
-
Leonard, R. J., Labarca, C. G., Charnet, P., Davidson, N., and Lester, H. A. (1988) Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science 242, 1578-1581 (Pubitemid 19023704)
-
(1988)
Science
, vol.242
, Issue.4885
, pp. 1578-1581
-
-
Leonard, R.J.1
Labarca, C.G.2
Charnet, P.3
Davidson, N.4
Lester, H.A.5
-
78
-
-
0026082583
-
Location of a threonine residue in the α-subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel
-
Villarroel, A., Herlitze, S., Koenen, M., and Sakmann, B. (1991) Location of a threonine residue in the α-subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel. Proc. Biol. Sci. 243, 69-74
-
(1991)
Proc. Biol. Sci.
, vol.243
, pp. 69-74
-
-
Villarroel, A.1
Herlitze, S.2
Koenen, M.3
Sakmann, B.4
-
79
-
-
0026656037
-
Mutations in the ion channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic
-
Galzi, J. L., Devillers-Thiéry, A., Hussy, N., Bertrand, S., Changeux, J. P., and Bertrand, D. (1992) Mutations in the ion channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature 359, 500-505
-
(1992)
Nature
, vol.359
, pp. 500-505
-
-
Galzi, J.L.1
Devillers-Thiéry, A.2
Hussy, N.3
Bertrand, S.4
Changeux, J.P.5
Bertrand, D.6
-
80
-
-
0033119869
-
Mutational analysis of the charge selectivity filter of the α7 nicotinic acetylcholine receptor
-
DOI 10.1016/S0896-6273(00)80741-2
-
Corringer, P. J., Bertrand, S., Galzi, J. L., Devillers-Thiéry, A., Changeux, J. P., and Bertrand, D. (1999) Mutational analysis of the charge selectivity filter of the α7 nicotinic acetylcholine receptor. Neuron 22, 831-843 (Pubitemid 29203505)
-
(1999)
Neuron
, vol.22
, Issue.4
, pp. 831-843
-
-
Corringer, P.-J.1
Bertrand, S.2
Galzi, J.-L.3
Devillers-Thiery, A.4
Changeux, J.-P.5
Bertrand, D.6
-
81
-
-
0027772476
-
Chimeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities
-
Eiselé, J. L., Bertrand, S., Galzi, J. L., Devillers- Thiéry, A., Changeux, J. P., and Bertrand, D. (1993) Chimeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature 366, 479-483
-
(1993)
Nature
, vol.366
, pp. 479-483
-
-
Eiselé, J.L.1
Bertrand, S.2
Galzi, J.L.3
Devillers-Thiéry, A.4
Changeux, J.P.5
Bertrand, D.6
-
82
-
-
79961044901
-
Functional prokaryotic- Eukaryotic chimera from the pentameric ligand-gated ion channel family
-
Duret, G., Van Renterghem, C., Weng, Y., Prevost, M., Moraga-Cid, G., Huon, C., Sonner, J. M., and Corringer, P. J. (2011) Functional prokaryotic- eukaryotic chimera from the pentameric ligand-gated ion channel family. Proc. Natl. Acad. Sci. U.S.A. 108, 12143-12148
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 12143-12148
-
-
Duret, G.1
Van Renterghem, C.2
Weng, Y.3
Prevost, M.4
Moraga-Cid, G.5
Huon, C.6
Sonner, J.M.7
Corringer, P.J.8
-
83
-
-
58149267953
-
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
-
Bocquet, N., Nury, H., Baaden, M., Le Poupon, C., Changeux, J. P., Delarue, M., and Corringer, P. J. (2009) X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature 457, 111-114
-
(2009)
Nature
, vol.457
, pp. 111-114
-
-
Bocquet, N.1
Nury, H.2
Baaden, M.3
Le Poupon, C.4
Changeux, J.P.5
Delarue, M.6
Corringer, P.J.7
-
84
-
-
41149168686
-
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
-
DOI 10.1038/nature06717, PII NATURE06717
-
Hilf, R. J., and Dutzler, R. (2008) X-ray structure of a prokaryotic pentameric ligand-gated ion channel. Nature 452, 375-379 (Pubitemid 351430790)
-
(2008)
Nature
, vol.452
, Issue.7185
, pp. 375-379
-
-
Hilf, R.J.C.1
Dutzler, R.2
-
85
-
-
58149242730
-
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel
-
Hilf, R. J., and Dutzler, R. (2009) Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel. Nature 457, 115-118
-
(2009)
Nature
, vol.457
, pp. 115-118
-
-
Hilf, R.J.1
Dutzler, R.2
-
86
-
-
84861219631
-
Allostery and the Monod-Wyman-Changeux model after 50 years
-
Changeux, J. P. (2012) Allostery and the Monod-Wyman-Changeux model after 50 years. Annu. Rev. Biophys. 41, 103-133
-
(2012)
Annu. Rev. Biophys.
, vol.41
, pp. 103-133
-
-
Changeux, J.P.1
-
87
-
-
0016760413
-
Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata
-
Weber, M., David-Pfeuty, T., and Changeux, J. P. (1975) Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata. Proc. Natl. Acad. Sci. U.S.A. 72, 3443-3447
-
(1975)
Proc. Natl. Acad. Sci. U.S.A.
, vol.72
, pp. 3443-3447
-
-
Weber, M.1
David-Pfeuty, T.2
Changeux, J.P.3
-
88
-
-
0017113789
-
Effects of inhibitors of the binding of iodinated α-bungarotoxin to acetylcholine receptors in rat muscle
-
Colquhoun, D., and Range, H. P. (1976) Effects of inhibitors of the binding of iodinated α-bungarotoxin to acetylcholine receptors in rat muscle. Mol. Pharmacol. 12, 519-535
-
(1976)
Mol. Pharmacol.
, vol.12
, pp. 519-535
-
-
Colquhoun, D.1
Range, H.P.2
-
89
-
-
0017109025
-
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. IV. Quinacrine: A fluorescent probe for the conformational transitions of the cholinergic receptor protein in its membrane bound state
-
Grünhagen, H. H., and Changeux, J. P. (1976) Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. IV. Quinacrine: a fluorescent probe for the conformational transitions of the cholinergic receptor protein in its membrane bound state. J. Mol. Biol. 106, 497-516
-
(1976)
J. Mol. Biol.
, vol.106
, pp. 497-516
-
-
Grünhagen, H.H.1
Changeux, J.P.2
-
90
-
-
0017717088
-
Kinetics of agonist-mediated transitions in state of the cholinergic receptor
-
Weiland, G., Georgia, B., Lappi, S., Chignell, C. F., and Taylor, P. (1977) Kinetics of agonist-mediated transitions in state of the cholinergic receptor. J. Biol. Chem. 252, 7648-7656 (Pubitemid 8211015)
-
(1977)
Journal of Biological Chemistry
, vol.252
, Issue.21
, pp. 7648-7656
-
-
Weiland, G.1
Georgia, B.2
Lappi, S.3
-
91
-
-
0018790793
-
Fast kinetic studies on the interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata
-
Heidmann, T., and Changeux, J. P. (1979) Fast kinetic studies on the interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata. Eur. J. Biochem. 94, 255-279
-
(1979)
Eur. J. Biochem.
, vol.94
, pp. 255-279
-
-
Heidmann, T.1
Changeux, J.P.2
-
92
-
-
0019327308
-
Interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata in the millisecond time range: Resolution of an "intermediate" conformational transition and evidence for positive cooperative effects
-
Heidmann, T., and Changeux, J. P. (1980) Interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata in the millisecond time range: resolution of an "intermediate" conformational transition and evidence for positive cooperative effects. Biochem. Biophys. Res. Comm. 97, 889-896
-
(1980)
Biochem. Biophys. Res. Comm.
, vol.97
, pp. 889-896
-
-
Heidmann, T.1
Changeux, J.P.2
-
93
-
-
0021041862
-
Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata
-
Heidmann, T., Bernhardt, J., Neumann, E., and Changeux, J. P. (1983) Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor-rich membranes from Torpedo marmorata. Biochemistry 22, 5452-5459 (Pubitemid 14240199)
-
(1983)
Biochemistry
, vol.22
, Issue.23
, pp. 5452-5459
-
-
Heidmann, T.1
Bernhardt, J.2
Neumann, E.3
Changeux, J.P.4
-
94
-
-
0010518490
-
Spontaneous openings of the acetylcholine receptor channel
-
Jackson, M. B. (1984) Spontaneous openings of the acetylcholine receptor channel. Proc. Natl. Acad. Sci. U.S.A. 81, 3901-3904
-
(1984)
Proc. Natl. Acad. Sci. U.S.A.
, vol.81
, pp. 3901-3904
-
-
Jackson, M.B.1
-
95
-
-
0038112088
-
Structure and gating mechanism of the acetylcholine receptor pore
-
DOI 10.1038/nature01748
-
Miyazawa, A., Fujiyoshi, Y., and Unwin, N. (2003) Structure and gating mechanism of the acetylcholine receptor pore. Nature 423, 949-955 (Pubitemid 36806903)
-
(2003)
Nature
, vol.423
, Issue.6943
, pp. 949-955
-
-
Miyazawa, A.1
Fujiyoshi, Y.2
Unwin, N.3
-
96
-
-
0037022640
-
2+-binding sites
-
DOI 10.1073/pnas.042699699
-
Le Novère, N., Grutter, T., and Changeux, J. P. (2002) Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+- binding sites. Proc. Natl. Acad. Sci. U.S.A. 99, 3210-3215 (Pubitemid 34240611)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.5
, pp. 3210-3215
-
-
Le, N.N.1
Grutter, T.2
Changeux, J.-P.3
-
97
-
-
22244438519
-
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism
-
DOI 10.1529/biophysj.104.050229
-
Taly, A., Delarue, M., Grutter, T., Nilges, M., Le Novère, N., Corringer, P. J., and Changeux, J. P. (2005) Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism. Biophys. J. 88, 3954-3965 (Pubitemid 40991108)
-
(2005)
Biophysical Journal
, vol.88
, Issue.6
, pp. 3954-3965
-
-
Taly, A.1
Delarue, M.2
Grutter, T.3
Nilges, M.4
Le, N.N.5
Corringer, P.-J.6
Changeux, J.-P.7
-
98
-
-
77950868175
-
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue
-
Nury, H., Poitevin, F., Van Renterghem, C., Changeux, J. P., Corringer, P. J., Delarue, M., and Baaden, M. (2010) One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue. Proc. Natl. Acad. Sci. U.S.A. 107, 6275-6280
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 6275-6280
-
-
Nury, H.1
Poitevin, F.2
Van Renterghem, C.3
Changeux, J.P.4
Corringer, P.J.5
Delarue, M.6
Baaden, M.7
-
99
-
-
0026716690
-
Potentiation of nicotinic receptor response by external calcium in rat central neurons
-
Mulle, C., Léna, C., and Changeux, J. P. (1992) Potentiation of nicotinic receptor response by external calcium in rat central neurons. Neuron 8, 937-945
-
(1992)
Neuron
, vol.8
, pp. 937-945
-
-
Mulle, C.1
Léna, C.2
Changeux, J.P.3
-
100
-
-
0026586188
-
Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors
-
Vernino, S., Amador, M., Luetje, C. W., Patrick, J., and Dani, J. A. (1992) Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron 8, 127-134
-
(1992)
Neuron
, vol.8
, pp. 127-134
-
-
Vernino, S.1
Amador, M.2
Luetje, C.W.3
Patrick, J.4
Dani, J.A.5
-
101
-
-
0031887759
-
Ivermectin: A positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor
-
Krause, R. M., Buisson, B., Bertrand, S., Corringer, P. J., Galzi, J. L., Changeux, J. P., and Bertrand, D. (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol. Pharmacol. 53, 283-294 (Pubitemid 28099739)
-
(1998)
Molecular Pharmacology
, vol.53
, Issue.2
, pp. 283-294
-
-
Krause, R.M.1
Buisson, B.2
Bertrand, S.3
Corringer, P.-J.4
Galzi, J.-L.5
Changeux, J.-P.6
Bertrand, D.7
-
102
-
-
78751673139
-
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
-
Nury, H., Van Renterghem, C., Weng, Y., Tran, A., Baaden, M., Dufresne, V., Changeux, J. P., Sonner, J. M., Delarue, M., and Corringer, P. J. (2011) X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature 469, 428-431
-
(2011)
Nature
, vol.469
, pp. 428-431
-
-
Nury, H.1
Van Renterghem, C.2
Weng, Y.3
Tran, A.4
Baaden, M.5
Dufresne, V.6
Changeux, J.P.7
Sonner, J.M.8
Delarue, M.9
Corringer, P.J.10
-
103
-
-
84859949261
-
A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties
-
Gill, J. K., Dhankher, P., Sheppard, T. D., Sher, E., and Millar, N. S. (2012) A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties. Mol. Pharmacol. 81, 710-718
-
(2012)
Mol. Pharmacol.
, vol.81
, pp. 710-718
-
-
Gill, J.K.1
Dhankher, P.2
Sheppard, T.D.3
Sher, E.4
Millar, N.S.5
-
104
-
-
0017368198
-
In vitro phosphorylation of the acetylcholine receptor
-
Teichberg, V. I., Sobel, A., and Changeux, J. P. (1977) In vitro phosphorylation of the acetylcholine receptor. Nature 267, 540-542
-
(1977)
Nature
, vol.267
, pp. 540-542
-
-
Teichberg, V.I.1
Sobel, A.2
Changeux, J.P.3
-
105
-
-
38049107601
-
Intracellular complexes of the β2-subunit of the nicotinic acetylcholine receptor in brain identified by proteomics
-
Kabbani, N., Woll, M. P., Levenson, R., Lindstrom, J. M., and Changeux, J. P. (2007) Intracellular complexes of the β2-subunit of the nicotinic acetylcholine receptor in brain identified by proteomics. Proc. Natl. Acad. Sci. U.S.A. 104, 20570-20575
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 20570-20575
-
-
Kabbani, N.1
Woll, M.P.2
Levenson, R.3
Lindstrom, J.M.4
Changeux, J.P.5
-
106
-
-
0343387854
-
In vitro excitation of purified membrane fragments by cholinergic agonists
-
Kasai, M., and Changeux, J. P. (1971) In vitro excitation of purified membrane fragments by cholinergic agonists. J. Memb. Biol. 6, 1-88
-
(1971)
J. Memb. Biol.
, vol.6
, pp. 1-88
-
-
Kasai, M.1
Changeux, J.P.2
-
107
-
-
0017110370
-
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. V. Qualitative correlation between pharmacological effects and equilibration processes of the cholinergic receptor protein as revealed by the structural probe quinacrine
-
Grünhagen, H. H., and Changeux, J. P. (1976) Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. V. Qualitative correlation between pharmacological effects and equilibration processes of the cholinergic receptor protein as revealed by the structural probe quinacrine. J. Mol. Biol. 106, 517-535
-
(1976)
J. Mol. Biol.
, vol.106
, pp. 517-535
-
-
Grünhagen, H.H.1
Changeux, J.P.2
-
108
-
-
0017742507
-
Fast kinetic studies on the interaction of cholinergic agonists with the membrane-bound acetylcholine receptor from Torpedo marmorata as revealed by quinacrine fluorescence
-
DOI 10.1111/j.1432-1033.1977.tb11875.x
-
Grünhagen, H. H., Iwatsubo, M., and Changeux, J. P. (1977) Fast kinetic studies on the interaction of cholinergic agonists with the membranebound acetylcholine receptor from Torpedo marmorata as revealed by quinacrine fluorescence. Eur. J. Biochem. 80, 225-242 (Pubitemid 8210001)
-
(1977)
European Journal of Biochemistry
, vol.80
, Issue.1
, pp. 225-242
-
-
Gruenhagen, H.H.1
Iwatsubo, M.2
Changeux, J.P.3
-
109
-
-
0018762233
-
Fast kinetic studies on the allosteric interactions between acetylcholine receptor and local anesthetic binding sites
-
DOI 10.1111/j.1432-1033.1979.tb12894.x
-
Heidmann, T., and Changeux, J. P. (1979) Fast kinetic studies on the allosteric interactions between acetylcholine receptor and local anesthetic binding sites. Eur. J. Biochem. 94, 281-296 (Pubitemid 9236200)
-
(1979)
European Journal of Biochemistry
, vol.94
, Issue.1
, pp. 281-296
-
-
Heidmann, T.1
Changeux, J.P.2
|