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Volumn 10, Issue 5, 2015, Pages

TSC1 promotes B cell maturation but is dispensable for germinal center formation

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G2C; IMMUNOGLOBULIN G3; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; T LYMPHOCYTE ANTIGEN; TUBEROUS SCLEROSIS COMPLEX 1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN;

EID: 84930647059     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127527     Document Type: Article
Times cited : (19)

References (55)
  • 1
    • 0035056376 scopus 로고    scopus 로고
    • B cell development pathways
    • Epub 2001/03/13. PMID: 11244048
    • Hardy RR, Hayakawa K. B cell development pathways. Annu Rev Immunol. 2001; 19:595-621. Epub 2001/03/13. doi: 10.1146/annurev.immunol.19.1.595 PMID: 11244048.
    • (2001) Annu Rev Immunol , vol.19 , pp. 595-621
    • Hardy, R.R.1    Hayakawa, K.2
  • 2
    • 0033526816 scopus 로고    scopus 로고
    • B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    • Epub 1999/08/03. PMID: 10429672; PubMed Central PMCID: PMC2195560
    • Loder F, Mutschler B, Ray RJ, Paige CJ, Sideras P, Torres R, et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J Exp Med. 1999; 190(1):75-89. Epub 1999/08/03. PMID: 10429672; PubMed Central PMCID: PMC2195560.
    • (1999) J Exp Med , vol.190 , Issue.1 , pp. 75-89
    • Loder, F.1    Mutschler, B.2    Ray, R.J.3    Paige, C.J.4    Sideras, P.5    Torres, R.6
  • 3
    • 0036580887 scopus 로고    scopus 로고
    • Marginal-zone B cells
    • Epub 2002/05/30. PMID: 12033738
    • Martin F, Kearney JF. Marginal-zone B cells. Nat Rev Immunol. 2002; 2(5):323-35. Epub 2002/05/30. doi: 10.1038/nri799 PMID: 12033738.
    • (2002) Nat Rev Immunol , vol.2 , Issue.5 , pp. 323-335
    • Martin, F.1    Kearney, J.F.2
  • 4
    • 44749092181 scopus 로고    scopus 로고
    • Peripheral B cell subsets
    • Epub 2008/04/25. PMID: 18434123; PubMed Central PMCID: PMC2532490
    • Allman D, Pillai S. Peripheral B cell subsets. Curr Opin Immunol. 2008; 20(2):149-57. Epub 2008/04/25. doi: 10.1016/j.coi.2008.03.014 PMID: 18434123; PubMed Central PMCID: PMC2532490.
    • (2008) Curr Opin Immunol , vol.20 , Issue.2 , pp. 149-157
    • Allman, D.1    Pillai, S.2
  • 5
    • 0942290441 scopus 로고    scopus 로고
    • Alternative routes to maturity: Branch points and pathways for generating follicular and marginal zone B cells
    • Epub 2004/02/14. PMID: 14962193
    • Allman D, Srivastava B, Lindsley RC. Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells. Immunol Rev. 2004; 197:147-60. Epub 2004/02/14. PMID: 14962193.
    • (2004) Immunol Rev , vol.197 , pp. 147-160
    • Allman, D.1    Srivastava, B.2    Lindsley, R.C.3
  • 6
    • 37549015263 scopus 로고    scopus 로고
    • Germinal centres: Role in B-cell physiology and malignancy
    • Epub 2007/12/22. PMID: 18097447
    • Klein U, Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol. 2008; 8(1):22-33. Epub 2007/12/22. doi: 10.1038/nri2217 PMID: 18097447.
    • (2008) Nat Rev Immunol , vol.8 , Issue.1 , pp. 22-33
    • Klein, U.1    Dalla-Favera, R.2
  • 7
    • 0019491424 scopus 로고
    • IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts
    • Epub 1981/05/07. PMID: 7231520
    • Gearhart PJ, Johnson ND, Douglas R, Hood L. IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature. 1981; 291(5810):29-34. Epub 1981/05/07. PMID: 7231520.
    • (1981) Nature , vol.291 , Issue.5810 , pp. 29-34
    • Gearhart, P.J.1    Johnson, N.D.2    Douglas, R.3    Hood, L.4
  • 8
    • 70349260308 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: Insights into hyper-IgM syndrome
    • Epub 2009/08/12. PMID: 19667096; PubMed Central PMCID: PMC2779701
    • Kuraoka M, Liao D, Yang K, Allgood SD, Levesque MC, Kelsoe G, et al. Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. J Immunol. 2009; 183(5):3237-48. Epub 2009/08/12. doi: 10.4049/jimmunol.0901548 PMID: 19667096; PubMed Central PMCID: PMC2779701.
    • (2009) J Immunol , vol.183 , Issue.5 , pp. 3237-3248
    • Kuraoka, M.1    Liao, D.2    Yang, K.3    Allgood, S.D.4    Levesque, M.C.5    Kelsoe, G.6
  • 9
    • 84859381450 scopus 로고    scopus 로고
    • Germinal centers
    • Epub 2012/01/10. PMID: 22224772
    • Victora GD, Nussenzweig MC. Germinal centers. Annu Rev Immunol. 2012; 30:429-57. Epub 2012/01/10. doi: 10.1146/annurev-immunol-020711-075032 PMID: 22224772.
    • (2012) Annu Rev Immunol , vol.30 , pp. 429-457
    • Victora, G.D.1    Nussenzweig, M.C.2
  • 10
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Epub 2012/04/17. PMID: 22500797; PubMed Central PMCID: PMC3331679
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012; 149(2):274-93. Epub 2012/04/17. doi: 10.1016/j.cell.2012.03.017 PMID: 22500797; PubMed Central PMCID: PMC3331679.
    • (2012) Cell , vol.149 , Issue.2 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 11
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Epub 2007/07/07. PMID: 17613433
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 2007; 12(1):9-22. Epub 2007/07/07. doi: 10.1016/j.ccr.2007.05.008 PMID: 17613433.
    • (2007) Cancer Cell , vol.12 , Issue.1 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 12
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • Epub 2007/08/08. PMID: 17680028
    • Yang Q, Guan KL. Expanding mTOR signaling. Cell Res. 2007; 17(8):666-81. Epub 2007/08/08. doi: 10.1038/cr.2007.64 PMID: 17680028.
    • (2007) Cell Res , vol.17 , Issue.8 , pp. 666-681
    • Yang, Q.1    Guan, K.L.2
  • 13
    • 0037028305 scopus 로고    scopus 로고
    • Tuberin, The tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration
    • Epub 2002/12/06. PMID: 12466966
    • Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, Henske EP. Tuberin, The tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene. 2002; 21(55):8470-6. Epub 2002/12/06. doi: 10.1038/sj.onc.1205962 PMID: 12466966.
    • (2002) Oncogene , vol.21 , Issue.55 , pp. 8470-8476
    • Astrinidis, A.1    Cash, T.P.2    Hunter, D.S.3    Walker, C.L.4    Chernoff, J.5    Henske, E.P.6
  • 14
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Epub 2004/07/23. PMID: 15268862
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004; 14(14):1296-302. Epub 2004/07/23. doi: 10.1016/j.cub.2004.06.054 PMID: 15268862.
    • (2004) Curr Biol , vol.14 , Issue.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 15
    • 84863654925 scopus 로고    scopus 로고
    • The role and regulation of mTOR in T-lymphocyte function
    • Epub 2012/04/10. PMID: 22484804
    • O'Brien TF, Zhong XP. The role and regulation of mTOR in T-lymphocyte function. Archivum immunologiae et therapiae experimentalis. 2012; 60(3):173-81. Epub 2012/04/10. doi: 10.1007/s00005-012-0171-4 PMID: 22484804.
    • (2012) Archivum Immunologiae et Therapiae Experimentalis , vol.60 , Issue.3 , pp. 173-181
    • O'Brien, T.F.1    Zhong, X.P.2
  • 16
    • 65449135649 scopus 로고    scopus 로고
    • The multiple facets of mTOR in immunity
    • Epub 2009/04/14. PMID: 19362054
    • Weichhart T, Saemann MD. The multiple facets of mTOR in immunity. Trends Immunol. 2009; 30(5):218-26. Epub 2009/04/14. doi: 10.1016/j.it.2009.02.002 PMID: 19362054.
    • (2009) Trends Immunol , vol.30 , Issue.5 , pp. 218-226
    • Weichhart, T.1    Saemann, M.D.2
  • 17
    • 84860237060 scopus 로고    scopus 로고
    • Regulation and function of mTOR signalling in T cell fate decisions
    • Epub 2012/04/21. PMID: 22517423; PubMed Central PMCID: PMC3417069
    • Chi H. Regulation and function of mTOR signalling in T cell fate decisions. Nat Rev Immunol. 2012; 12(5):325-38. Epub 2012/04/21. doi: 10.1038/nri3198 PMID: 22517423; PubMed Central PMCID: PMC3417069.
    • (2012) Nat Rev Immunol , vol.12 , Issue.5 , pp. 325-338
    • Chi, H.1
  • 18
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Epub 2009/06/23. PMID: 19538929; PubMed Central PMCID: PMC2768135
    • Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009; 30(6):832-44. Epub 2009/06/23. doi: 10.1016/j.immuni.2009.04.014 PMID: 19538929; PubMed Central PMCID: PMC2768135.
    • (2009) Immunity , vol.30 , Issue.6 , pp. 832-844
    • Delgoffe, G.M.1    Kole, T.P.2    Zheng, Y.3    Zarek, P.E.4    Matthews, K.L.5    Xiao, B.6
  • 19
    • 77953897189 scopus 로고    scopus 로고
    • Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
    • Epub 2010/07/14. PMID: 20620941; PubMed Central PMCID: PMC2911434
    • Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 2010; 32(6):743-53. Epub 2010/07/14. doi: 10.1016/j.immuni.2010.06.002 PMID: 20620941; PubMed Central PMCID: PMC2911434.
    • (2010) Immunity , vol.32 , Issue.6 , pp. 743-753
    • Lee, K.1    Gudapati, P.2    Dragovic, S.3    Spencer, C.4    Joyce, S.5    Killeen, N.6
  • 20
    • 67650074206 scopus 로고    scopus 로고
    • mTOR regulates memory CD8 T-cell differentiation
    • Epub 2009/06/23. PMID: 19543266; PubMed Central PMCID: PMC2710807
    • Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, et al. mTOR regulates memory CD8 T-cell differentiation. Nature. 2009; 460(7251):108-12. Epub 2009/06/23. doi: 10.1038/nature08155 PMID: 19543266; PubMed Central PMCID: PMC2710807.
    • (2009) Nature , vol.460 , Issue.7251 , pp. 108-112
    • Araki, K.1    Turner, A.P.2    Shaffer, V.O.3    Gangappa, S.4    Keller, S.A.5    Bachmann, M.F.6
  • 21
    • 74649085700 scopus 로고    scopus 로고
    • + T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
    • Epub 2010/01/12. PMID: 20060330
    • + T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity. 2010; 32(1):67-78. Epub 2010/01/12. doi: 10.1016/j.immuni.2009.10.010 PMID: 20060330.
    • (2010) Immunity , vol.32 , Issue.1 , pp. 67-78
    • Rao, R.R.1    Li, Q.2    Odunsi, K.3    Shrikant, P.A.4
  • 22
    • 42449110816 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
    • Epub 2008/04/09. PMID: 18391955; PubMed Central PMCID: PMC2857321
    • Sinclair LV, Finlay D, Feijoo C, Cornish GH, Gray A, Ager A, et al. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol. 2008; 9(5):513-21. Epub 2008/04/09. doi: 10.1038/ni.1603 PMID: 18391955; PubMed Central PMCID: PMC2857321.
    • (2008) Nat Immunol , vol.9 , Issue.5 , pp. 513-521
    • Sinclair, L.V.1    Finlay, D.2    Feijoo, C.3    Cornish, G.H.4    Gray, A.5    Ager, A.6
  • 23
    • 84881192927 scopus 로고    scopus 로고
    • mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
    • Epub 2013/07/03. PMID: 23812589; PubMed Central PMCID: PMC3759242
    • Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature. 2013; 499(7459):485-90. Epub 2013/07/03. doi: 10.1038/nature12297 PMID: 23812589; PubMed Central PMCID: PMC3759242.
    • (2013) Nature , vol.499 , Issue.7459 , pp. 485-490
    • Zeng, H.1    Yang, K.2    Cloer, C.3    Neale, G.4    Vogel, P.5    Chi, H.6
  • 24
    • 84896869317 scopus 로고    scopus 로고
    • Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function
    • Epub 2014/02/12. PMID: 24516149
    • Shin J, Wang S, Deng W, Wu J, Gao J, Zhong XP. Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. Proc Natl Acad Sci U S A. 2014; 111(8):E776-83. Epub 2014/02/12. doi: 10.1073/pnas.1315435111 PMID: 24516149.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.8 , pp. E776-E783
    • Shin, J.1    Wang, S.2    Deng, W.3    Wu, J.4    Gao, J.5    Zhong, X.P.6
  • 25
    • 79251569252 scopus 로고    scopus 로고
    • Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production
    • Epub 2010/11/17. PMID: 21079150; PubMed Central PMCID: PMC3056471
    • Zhang S, Readinger JA, DuBois W, Janka-Junttila M, Robinson R, Pruitt M, et al. Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood. 2011; 117(4):1228-38. Epub 2010/11/17. doi: 10.1182/blood-2010-05-287821 PMID: 21079150; PubMed Central PMCID: PMC3056471.
    • (2011) Blood , vol.117 , Issue.4 , pp. 1228-1238
    • Zhang, S.1    Readinger, J.A.2    DuBois, W.3    Janka-Junttila, M.4    Robinson, R.5    Pruitt, M.6
  • 26
    • 84887729393 scopus 로고    scopus 로고
    • Requirement for Rictor in homeostasis and function of mature B lymphoid cells
    • Epub 2013/08/21. PMID: 23958952; PubMed Central PMCID: PMC3790507
    • Lee K, Heffington L, Jellusova J, Nam KT, Raybuck A, Cho SH, et al. Requirement for Rictor in homeostasis and function of mature B lymphoid cells. Blood. 2013; 122(14):2369-79. Epub 2013/08/21. doi: 10.1182/blood-2013-01-477505 PMID: 23958952; PubMed Central PMCID: PMC3790507.
    • (2013) Blood , vol.122 , Issue.14 , pp. 2369-2379
    • Lee, K.1    Heffington, L.2    Jellusova, J.3    Nam, K.T.4    Raybuck, A.5    Cho, S.H.6
  • 27
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Epub 2002/08/13. PMID: 12172553
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002; 4(9):648-57. Epub 2002/08/13. doi: 10.1038/ncb839 PMID: 12172553.
    • (2002) Nat Cell Biol , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 28
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Epub 2003/08/09. PMID: 12906785
    • Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol. 2003; 13(15):1259-68. Epub 2003/08/09. PMID: 12906785.
    • (2003) Curr Biol , vol.13 , Issue.15 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 29
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Epub 2002/09/25. PMID: 12271141; PubMed Central PMCID: PMC129715
    • Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA. 2002; 99(21):13571-6. Epub 2002/09/25. doi: 10.1073/pnas.202476899 PMID: 12271141; PubMed Central PMCID: PMC129715.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.21 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5    Blenis, J.6
  • 30
    • 79952696874 scopus 로고    scopus 로고
    • Receptor signaling in immune cell development and function
    • Epub 2010/12/04. PMID: 21128010; PubMed Central PMCID: PMC3193797
    • Zhong XP, Shin J, Gorentla BK, O'Brien T, Srivatsan S, Xu L, et al. Receptor signaling in immune cell development and function. Immunol Res. 2011; 49(1-3):109-23. Epub 2010/12/04. doi: 10.1007/s12026-010-8175-9 PMID: 21128010; PubMed Central PMCID: PMC3193797.
    • (2011) Immunol Res , vol.49 , Issue.1-3 , pp. 109-123
    • Zhong, X.P.1    Shin, J.2    Gorentla, B.K.3    O'Brien, T.4    Srivatsan, S.5    Xu, L.6
  • 31
    • 84860333507 scopus 로고    scopus 로고
    • The role of tuberous sclerosis complex 1 in regulating innate immunity
    • Epub 2012/03/14. PMID: 22412198; PubMed Central PMCID: PMC3324625
    • Pan H, O'Brien TF, Zhang P, Zhong XP. The role of tuberous sclerosis complex 1 in regulating innate immunity. J Immunol. 2012; 188(8):3658-66. Epub 2012/03/14. doi: 10.4049/jimmunol.1102187 PMID: 22412198; PubMed Central PMCID: PMC3324625.
    • (2012) J Immunol , vol.188 , Issue.8 , pp. 3658-3666
    • Pan, H.1    O'Brien, T.F.2    Zhang, P.3    Zhong, X.P.4
  • 32
    • 84859592965 scopus 로고    scopus 로고
    • Regulation of mast cell survival and function by tuberous sclerosis complex 1
    • Epub 2012/03/01. PMID: 22362037; PubMed Central PMCID: PMC3321856
    • Shin J, Pan H, Zhong XP. Regulation of mast cell survival and function by tuberous sclerosis complex 1. Blood. 2012; 119(14):3306-14. Epub 2012/03/01. doi: 10.1182/blood-2011-05-353342 PMID: 22362037; PubMed Central PMCID: PMC3321856.
    • (2012) Blood , vol.119 , Issue.14 , pp. 3306-3314
    • Shin, J.1    Pan, H.2    Zhong, X.P.3
  • 33
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Epub 2008/04/16. PMID: 18411301; PubMed Central PMCID: PMC2423120
    • Huang J, Dibble CC, Matsuzaki M, Manning BD. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol. 2008; 28(12):4104-15. Epub 2008/04/16. doi: 10.1128/MCB.00289-08 PMID: 18411301; PubMed Central PMCID: PMC2423120.
    • (2008) Mol Cell Biol , vol.28 , Issue.12 , pp. 4104-4115
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 34
    • 80051997049 scopus 로고    scopus 로고
    • The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
    • Epub 2011/07/19. PMID: 21765414; PubMed Central PMCID: PMC3158818
    • Yang K, Neale G, Green DR, He W, Chi H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol. 2011; 12(9):888-97. Epub 2011/07/19. doi: 10.1038/ni.2068 PMID: 21765414; PubMed Central PMCID: PMC3158818.
    • (2011) Nat Immunol , vol.12 , Issue.9 , pp. 888-897
    • Yang, K.1    Neale, G.2    Green, D.R.3    He, W.4    Chi, H.5
  • 35
    • 84857398190 scopus 로고    scopus 로고
    • + T cell survival and homeostasis in mice
    • Epub 2012/03/01. PMID: 22363451; PubMed Central PMCID: PMC3283604
    • + T cell survival and homeostasis in mice. PLoS One. 2012; 7(2):e30592. Epub 2012/03/01. doi: 10.1371/journal.pone.0030592 PMID: 22363451; PubMed Central PMCID: PMC3283604.
    • (2012) PLoS One , vol.7 , Issue.2
    • Zhang, L.1    Zhang, H.2    Li, L.3    Xiao, Y.4    Rao, E.5    Miao, Z.6
  • 36
    • 80051617288 scopus 로고    scopus 로고
    • The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells
    • Epub 2011/06/29. PMID: 21709159; PubMed Central PMCID: PMC3151493
    • Wu Q, Liu Y, Chen C, Ikenoue T, Qiao Y, Li CS, et al. The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J Immunol. 2011; 187(3):1106-12. Epub 2011/06/29. doi: 10.4049/jimmunol.1003968 PMID: 21709159; PubMed Central PMCID: PMC3151493.
    • (2011) J Immunol , vol.187 , Issue.3 , pp. 1106-1112
    • Wu, Q.1    Liu, Y.2    Chen, C.3    Ikenoue, T.4    Qiao, Y.5    Li, C.S.6
  • 37
    • 84865570428 scopus 로고    scopus 로고
    • Tumor suppressor TSC1 is critical for T-cell anergy
    • Epub 2012/08/15. PMID: 22891340; PubMed Central PMCID: PMC3435231
    • Xie DL, Wu J, Lou YL, Zhong XP. Tumor suppressor TSC1 is critical for T-cell anergy. Proc Natl Acad Sci USA. 2012; 109(35):14152-7. Epub 2012/08/15. doi: 10.1073/pnas.1119744109 PMID: 22891340; PubMed Central PMCID: PMC3435231.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.35 , pp. 14152-14157
    • Xie, D.L.1    Wu, J.2    Lou, Y.L.3    Zhong, X.P.4
  • 38
    • 84869457286 scopus 로고    scopus 로고
    • An expanded role of the tumor suppressor TSC1 in T cell tolerance
    • Epub 2012/10/04. PMID: 23032259; PubMed Central PMCID: PMC3507479
    • Zhong XP. An expanded role of the tumor suppressor TSC1 in T cell tolerance. Cell Cycle. 2012; 11 (21):3909-10. Epub 2012/10/04. doi: 10.4161/cc.22235 PMID: 23032259; PubMed Central PMCID: PMC3507479.
    • (2012) Cell Cycle , vol.11 , Issue.21 , pp. 3909-3910
    • Zhong, X.P.1
  • 39
    • 84897518164 scopus 로고    scopus 로고
    • Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity
    • Epub 2014/02/18. PMID: 24532578; PubMed Central PMCID: PMC3965184
    • Wu J, Shin J, Xie D, Wang H, Gao J, Zhong XP. Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity. J Immunol. 2014; 192(6):2643-50. Epub 2014/02/18. doi: 10.4049/jimmunol.1302076 PMID: 24532578; PubMed Central PMCID: PMC3965184.
    • (2014) J Immunol , vol.192 , Issue.6 , pp. 2643-2650
    • Wu, J.1    Shin, J.2    Xie, D.3    Wang, H.4    Gao, J.5    Zhong, X.P.6
  • 40
    • 84903136755 scopus 로고    scopus 로고
    • Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection
    • Epub 2014/05/14. PMID: 24818661; PubMed Central PMCID: PMC4097607
    • Krishna S, Yang J, Wang H, Qiu Y, Zhong XP. Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection. Infect Immun. 2014; 82(7):3045-57. Epub 2014/05/14. doi: 10.1128/IAI.01816-14 PMID: 24818661; PubMed Central PMCID: PMC4097607.
    • (2014) Infect Immun , vol.82 , Issue.7 , pp. 3045-3057
    • Krishna, S.1    Yang, J.2    Wang, H.3    Qiu, Y.4    Zhong, X.P.5
  • 41
    • 84897490986 scopus 로고    scopus 로고
    • iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions
    • Epub 2014/03/13. PMID: 24614103
    • Wu J, Yang J, Yang K, Wang H, Gorentla B, Shin J, et al. iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. J Clin Invest. 2014. Epub 2014/03/13. doi: 10.1172/JCI69780 PMID: 24614103.
    • (2014) J Clin Invest
    • Wu, J.1    Yang, J.2    Yang, K.3    Wang, H.4    Gorentla, B.5    Shin, J.6
  • 42
    • 84890040690 scopus 로고    scopus 로고
    • TSC1 regulates the balance between effector and regulatory T cells
    • Epub 2013/11/26. PMID: 24270422; PubMed Central PMCID: PMC3859395
    • Park Y, Jin HS, Lopez J, Elly C, Kim G, Murai M, et al. TSC1 regulates the balance between effector and regulatory T cells. J Clin Invest. 2013; 123(12):5165-78. Epub 2013/11/26. doi: 10.1172/JCI69751 PMID: 24270422; PubMed Central PMCID: PMC3859395.
    • (2013) J Clin Invest , vol.123 , Issue.12 , pp. 5165-5178
    • Park, Y.1    Jin, H.S.2    Lopez, J.3    Elly, C.4    Kim, G.5    Murai, M.6
  • 43
    • 84885101700 scopus 로고    scopus 로고
    • Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4+ CD25+ Foxp3+ regulatory T-cell development in mice
    • Epub 2013/07/25. PMID: 23882125
    • Chen H, Zhang L, Zhang H, Xiao Y, Shao L, Li H, et al. Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4+ CD25+ Foxp3+ regulatory T-cell development in mice. FASEB J. 2013; 27(10):3979-90. Epub 2013/07/25. doi: 10.1096/fj.13-235408 PMID: 23882125.
    • (2013) FASEB J , vol.27 , Issue.10 , pp. 3979-3990
    • Chen, H.1    Zhang, L.2    Zhang, H.3    Xiao, Y.4    Shao, L.5    Li, H.6
  • 44
    • 84880103374 scopus 로고    scopus 로고
    • Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA
    • Epub 2013/06/19. PMID: 23776173; PubMed Central PMCID: PMC3702379
    • Pan H, O'Brien TF, Wright G, Yang J, Shin J, Wright KL, et al. Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. J Immunol. 2013; 191(2):699-707. Epub 2013/06/19. doi: 10.4049/jimmunol.1201443 PMID: 23776173; PubMed Central PMCID: PMC3702379.
    • (2013) J Immunol , vol.191 , Issue.2 , pp. 699-707
    • Pan, H.1    O'Brien, T.F.2    Wright, G.3    Yang, J.4    Shin, J.5    Wright, K.L.6
  • 45
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Epub 2008/09/24. PMID: 18809716; PubMed Central PMCID: PMC2556783
    • Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, et al. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. 2008; 205(10):2397-408. Epub 2008/09/24. doi: 10.1084/jem.20081297 PMID: 18809716; PubMed Central PMCID: PMC2556783.
    • (2008) J Exp Med , vol.205 , Issue.10 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Liu, Y.6
  • 46
    • 79960724234 scopus 로고    scopus 로고
    • Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells
    • Epub 2011/06/16. PMID: 21674478
    • Benhamron S, Tirosh B. Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells. Eur J Immunol. 2011; 41(8):2390-6. Epub 2011/06/16. doi: 10.1002/eji.201041336 PMID: 21674478.
    • (2011) Eur J Immunol , vol.41 , Issue.8 , pp. 2390-2396
    • Benhamron, S.1    Tirosh, B.2
  • 47
    • 0036501277 scopus 로고    scopus 로고
    • A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
    • Epub 2002/03/05. PMID: 11875047
    • Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N, et al. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet. 2002; 11(5):525-34. Epub 2002/03/05. PMID: 11875047.
    • (2002) Hum Mol Genet , vol.11 , Issue.5 , pp. 525-534
    • Kwiatkowski, D.J.1    Zhang, H.2    Bandura, J.L.3    Heiberger, K.M.4    Glogauer, M.5    El-Hashemite, N.6
  • 48
    • 0030818183 scopus 로고    scopus 로고
    • B lymphocyte-specific, Cre-mediated mutagenesis in mice
    • Epub 1997/03/15. PMID: 9092650; PubMed Central PMCID: PMC146582
    • Rickert RC, Roes J, Rajewsky K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 1997; 25(6):1317-8. Epub 1997/03/15. PMID: 9092650; PubMed Central PMCID: PMC146582.
    • (1997) Nucleic Acids Res , vol.25 , Issue.6 , pp. 1317-1318
    • Rickert, R.C.1    Roes, J.2    Rajewsky, K.3
  • 49
    • 28544444025 scopus 로고    scopus 로고
    • Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
    • Epub 2005/11/30. PMID: 16314438; PubMed Central PMCID: PMC2213334
    • Shapiro-Shelef M, Lin KI, Savitsky D, Liao J, Calame K. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med. 2005; 202(11):1471-6. Epub 2005/11/30. doi: 10.1084/jem.20051611 PMID: 16314438; PubMed Central PMCID: PMC2213334.
    • (2005) J Exp Med , vol.202 , Issue.11 , pp. 1471-1476
    • Shapiro-Shelef, M.1    Lin, K.I.2    Savitsky, D.3    Liao, J.4    Calame, K.5
  • 50
    • 79956214676 scopus 로고    scopus 로고
    • Plexin-D1 is a novel regulator of germinal centers and humoral immune responses
    • Epub 2011/04/06. PMID: 21464091
    • Holl EK, O'Connor BP, Holl TM, Roney KE, Zimmermann AG, Jha S, et al. Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. J Immunol. 2011; 186(10):5603-11. Epub 2011/04/06. doi: 10.4049/jimmunol.1003464 PMID: 21464091.
    • (2011) J Immunol , vol.186 , Issue.10 , pp. 5603-5611
    • Holl, E.K.1    O'Connor, B.P.2    Holl, T.M.3    Roney, K.E.4    Zimmermann, A.G.5    Jha, S.6
  • 51
    • 0030764978 scopus 로고    scopus 로고
    • V(D)J recombinase activity in a subset of germinal center B lymphocytes
    • Epub 1997/10/10. PMID: 9323211
    • Han S, Dillon SR, Zheng B, Shimoda M, Schlissel MS, Kelsoe G. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science. 1997; 278(5336):301-5. Epub 1997/10/10. PMID: 9323211.
    • (1997) Science , vol.278 , Issue.5336 , pp. 301-305
    • Han, S.1    Dillon, S.R.2    Zheng, B.3    Shimoda, M.4    Schlissel, M.S.5    Kelsoe, G.6
  • 52
    • 33746574474 scopus 로고    scopus 로고
    • Targeting of somatic hypermutation
    • Epub 2006/07/27. PMID: 16868548
    • Odegard VH, Schatz DG. Targeting of somatic hypermutation. Nat Rev Immunol. 2006; 6(8):573-83. Epub 2006/07/27. doi: 10.1038/nri1896 PMID: 16868548.
    • (2006) Nat Rev Immunol , vol.6 , Issue.8 , pp. 573-583
    • Odegard, V.H.1    Schatz, D.G.2
  • 53
    • 77953247731 scopus 로고    scopus 로고
    • Akt1 and Akt2 promote peripheral B-cell maturation and survival
    • Epub 2010/01/01. PMID: 20042722; PubMed Central PMCID: PMC2875094
    • Calamito M, Juntilla MM, Thomas M, Northrup DL, Rathmell J, Birnbaum MJ, et al. Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood. 2010; 115(20):4043-50. Epub 2010/01/01. doi: 10.1182/blood-2009-09-241638 PMID: 20042722; PubMed Central PMCID: PMC2875094.
    • (2010) Blood , vol.115 , Issue.20 , pp. 4043-4050
    • Calamito, M.1    Juntilla, M.M.2    Thomas, M.3    Northrup, D.L.4    Rathmell, J.5    Birnbaum, M.J.6
  • 54
    • 0037342166 scopus 로고    scopus 로고
    • Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
    • Epub 2003/02/04. PMID: 12563260
    • Anzelon AN, Wu H, Rickert RC. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol. 2003; 4(3):287-94. Epub 2003/02/04. doi: 10.1038/ni892 PMID: 12563260.
    • (2003) Nat Immunol , vol.4 , Issue.3 , pp. 287-294
    • Anzelon, A.N.1    Wu, H.2    Rickert, R.C.3
  • 55
    • 77954125132 scopus 로고    scopus 로고
    • Foxo1 regulates marginal zone B-cell development
    • Epub 2010/05/08. PMID: 20449867; PubMed Central PMCID: PMC2926184
    • Chen J, Limon JJ, Blanc C, Peng SL, Fruman DA. Foxo1 regulates marginal zone B-cell development. Eur J Immunol. 2010; 40(7):1890-6. Epub 2010/05/08. doi: 10.1002/eji.200939817 PMID: 20449867; PubMed Central PMCID: PMC2926184.
    • (2010) Eur J Immunol , vol.40 , Issue.7 , pp. 1890-1896
    • Chen, J.1    Limon, J.J.2    Blanc, C.3    Peng, S.L.4    Fruman, D.A.5


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