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Volumn 156, Issue 3, 2010, Pages 180-187

Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CELL MARKER; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 77956234910     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2010.06.003     Document Type: Review
Times cited : (82)

References (58)
  • 1
    • 77956242900 scopus 로고    scopus 로고
    • Small intestine: Anatomy and structural anomalies
    • D.C. Rubin Small intestine: anatomy and structural anomalies T. Yamada, Textbook of gastroenterology 2009 Wiley-Blackwell Chichester, West Sussex, UK 1085 1107
    • (2009) Textbook of Gastroenterology , pp. 1085-1107
    • Rubin, D.C.1
  • 2
    • 0035940437 scopus 로고    scopus 로고
    • The intestinal stem cell niche: There grows the neighborhood
    • J.C. Mills, and J.I. Gordon The intestinal stem cell niche: there grows the neighborhood Proc Natl Acad Sci U S A 98 2001 12334 12336
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12334-12336
    • Mills, J.C.1    Gordon, J.I.2
  • 3
    • 0344413420 scopus 로고    scopus 로고
    • Live and let die in the intestinal epithelium
    • E. Sancho, E. Batlle, and H. Clevers Live and let die in the intestinal epithelium Curr Opin Cell Biol 15 2003 763 770
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 763-770
    • Sancho, E.1    Batlle, E.2    Clevers, H.3
  • 4
    • 33751439705 scopus 로고    scopus 로고
    • Intestinal epithelial stem cells and progenitors
    • M. Bjerknes, and H. Cheng Intestinal epithelial stem cells and progenitors Methods Enzymol 419 2006 337 383
    • (2006) Methods Enzymol , vol.419 , pp. 337-383
    • Bjerknes, M.1    Cheng, H.2
  • 5
    • 12344299675 scopus 로고    scopus 로고
    • Growth of intestinal epithelium in organ culture is dependent on EGF signalling
    • H.E. Abud, N. Watson, and J.K. Heath Growth of intestinal epithelium in organ culture is dependent on EGF signalling Exp Cell Res 303 2005 252 262
    • (2005) Exp Cell Res , vol.303 , pp. 252-262
    • Abud, H.E.1    Watson, N.2    Heath, J.K.3
  • 6
    • 75749146169 scopus 로고    scopus 로고
    • Coexistence of quiescent and active adult stem cells in mammals
    • L. Li, and H. Clevers Coexistence of quiescent and active adult stem cells in mammals Science 327 2010 542 545
    • (2010) Science , vol.327 , pp. 542-545
    • Li, L.1    Clevers, H.2
  • 7
    • 39749092525 scopus 로고    scopus 로고
    • Current view: Intestinal stem cells and signaling
    • D.H. Scoville, T. Sato, X.C. He, and L. Li Current view: intestinal stem cells and signaling Gastroenterology 134 2008 849 864
    • (2008) Gastroenterology , vol.134 , pp. 849-864
    • Scoville, D.H.1    Sato, T.2    He, X.C.3    Li, L.4
  • 8
    • 0019509229 scopus 로고
    • The stem-cell zone of the small intestinal epithelium. IV. Effects of resecting 30% of the small intestine
    • M. Bjerknes, and H. Cheng The stem-cell zone of the small intestinal epithelium. IV. Effects of resecting 30% of the small intestine Am J Anat 160 1981 93 103
    • (1981) Am J Anat , vol.160 , pp. 93-103
    • Bjerknes, M.1    Cheng, H.2
  • 9
    • 62549118631 scopus 로고    scopus 로고
    • Wnt signaling, lgr5, and stem cells in the intestine and skin
    • A. Haegebarth, and H. Clevers Wnt signaling, lgr5, and stem cells in the intestine and skin Am J Pathol 174 2009 715 721
    • (2009) Am J Pathol , vol.174 , pp. 715-721
    • Haegebarth, A.1    Clevers, H.2
  • 10
    • 70350239859 scopus 로고    scopus 로고
    • Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively
    • R. May, S.M. Sureban, and N. Hoang Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively Stem Cells 27 2009 2571 2579
    • (2009) Stem Cells , vol.27 , pp. 2571-2579
    • May, R.1    Sureban, S.M.2    Hoang, N.3
  • 11
    • 0030987665 scopus 로고    scopus 로고
    • The intestinal epithelial stem cell: The mucosal governor
    • C.S. Potten, C. Booth, and D.M. Pritchard The intestinal epithelial stem cell: the mucosal governor Int J Exp Pathol 78 1997 219 243
    • (1997) Int J Exp Pathol , vol.78 , pp. 219-243
    • Potten, C.S.1    Booth, C.2    Pritchard, D.M.3
  • 12
    • 46249108437 scopus 로고    scopus 로고
    • A new identity for the elusive intestinal stem cell
    • E. Batlle A new identity for the elusive intestinal stem cell Nat Genet 40 2008 818 819
    • (2008) Nat Genet , vol.40 , pp. 818-819
    • Batlle, E.1
  • 13
    • 0036591968 scopus 로고    scopus 로고
    • Intestinal stem cells protect their genome by selective segregation of template DNA strands
    • C.S. Potten, G. Owen, and D. Booth Intestinal stem cells protect their genome by selective segregation of template DNA strands J Cell Sci 115 2002 2381 2388
    • (2002) J Cell Sci , vol.115 , pp. 2381-2388
    • Potten, C.S.1    Owen, G.2    Booth, D.3
  • 14
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • N. Barker, J.H. van Es, and J. Kuipers Identification of stem cells in small intestine and colon by marker gene Lgr5 Nature 449 2007 1003 1007
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1    Van Es, J.H.2    Kuipers, J.3
  • 15
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • E. Sangiorgi, and M.R. Capecchi Bmi1 is expressed in vivo in intestinal stem cells Nat Genet 40 2008 915 920
    • (2008) Nat Genet , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 16
    • 75049085557 scopus 로고    scopus 로고
    • Stem cells in gastroenterology and hepatology
    • M. Quante, and T.C. Wang Stem cells in gastroenterology and hepatology Nat Rev Gastroenterol Hepatol 6 2009 724 737
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 724-737
    • Quante, M.1    Wang, T.C.2
  • 17
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • L.G. van der Flier, and H. Clevers Stem cells, self-renewal, and differentiation in the intestinal epithelium Annu Rev Physiol 71 2009 241 260
    • (2009) Annu Rev Physiol , vol.71 , pp. 241-260
    • Van Der Flier, L.G.1    Clevers, H.2
  • 18
    • 67649240439 scopus 로고    scopus 로고
    • OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells
    • L.G. van der Flier, A. Haegebarth, D.E. Stange, M. van de Wetering, and H. Clevers OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells Gastroenterology 137 2009 15 17
    • (2009) Gastroenterology , vol.137 , pp. 15-17
    • Van Der Flier, L.G.1    Haegebarth, A.2    Stange, D.E.3    Van De Wetering, M.4    Clevers, H.5
  • 19
    • 61349150537 scopus 로고    scopus 로고
    • Transcription factor achaete scute-like 2 controls intestinal stem cell fate
    • L.G. van der Flier, M.E. van Gijn, and P. Hatzis Transcription factor achaete scute-like 2 controls intestinal stem cell fate Cell 136 2009 903 912
    • (2009) Cell , vol.136 , pp. 903-912
    • Van Der Flier, L.G.1    Van Gijn, M.E.2    Hatzis, P.3
  • 20
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • T. Sato, R.G. Vries, and H.J. Snippert Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Nature 459 2009 262 265
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3
  • 21
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • N. Barker, R.A. Ridgway, and J.H. van Es Crypt stem cells as the cells-of-origin of intestinal cancer Nature 457 2009 608 611
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1    Ridgway, R.A.2    Van Es, J.H.3
  • 23
    • 67349157318 scopus 로고    scopus 로고
    • Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
    • A. Ootani, X. Li, and E. Sangiorgi Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche Nat Med 15 2009 701 706
    • (2009) Nat Med , vol.15 , pp. 701-706
    • Ootani, A.1    Li, X.2    Sangiorgi, E.3
  • 24
    • 34250206996 scopus 로고    scopus 로고
    • A ROCK inhibitor permits survival of dissociated human embryonic stem cells
    • K. Watanabe, M. Ueno, and D. Kamiya A ROCK inhibitor permits survival of dissociated human embryonic stem cells Nat Biotechnol 25 2007 681 686
    • (2007) Nat Biotechnol , vol.25 , pp. 681-686
    • Watanabe, K.1    Ueno, M.2    Kamiya, D.3
  • 26
    • 28444486367 scopus 로고    scopus 로고
    • Stem cell niche: Structure and function
    • L. Li, and T. Xie Stem cell niche: structure and function Annu Rev Cell Dev Biol 21 2005 605 631
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 605-631
    • Li, L.1    Xie, T.2
  • 28
    • 0034644602 scopus 로고    scopus 로고
    • A niche maintaining germ line stem cells in the Drosophila ovary
    • T. Xie, and A.C. Spradling A niche maintaining germ line stem cells in the Drosophila ovary Science 290 2000 328 330
    • (2000) Science , vol.290 , pp. 328-330
    • Xie, T.1    Spradling, A.C.2
  • 29
    • 34848868159 scopus 로고    scopus 로고
    • Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors
    • C. Kosinski, V.S. Li, and A.S. Chan Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors Proc Natl Acad Sci U S A 104 2007 15418 15423
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15418-15423
    • Kosinski, C.1    Li, V.S.2    Chan, A.S.3
  • 30
    • 6944224156 scopus 로고    scopus 로고
    • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    • X.C. He, J. Zhang, and W.G. Tong BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling Nat Genet 36 2004 1117 1121
    • (2004) Nat Genet , vol.36 , pp. 1117-1121
    • He, X.C.1    Zhang, J.2    Tong, W.G.3
  • 31
    • 74249099740 scopus 로고    scopus 로고
    • A transient niche regulates the specification of Drosophila intestinal stem cells
    • D. Mathur, A. Bost, I. Driver, and B. Ohlstein A transient niche regulates the specification of Drosophila intestinal stem cells Science 327 2010 210 213
    • (2010) Science , vol.327 , pp. 210-213
    • Mathur, D.1    Bost, A.2    Driver, I.3    Ohlstein, B.4
  • 32
    • 67649988997 scopus 로고    scopus 로고
    • The role of stromal stem cells in tissue regeneration and wound repair
    • T.S. Stappenbeck, and H. Miyoshi The role of stromal stem cells in tissue regeneration and wound repair Science 324 2009 1666 1669
    • (2009) Science , vol.324 , pp. 1666-1669
    • Stappenbeck, T.S.1    Miyoshi, H.2
  • 33
    • 0032857527 scopus 로고    scopus 로고
    • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development
    • M. Weaver, J.M. Yingling, N.R. Dunn, S. Bellusci, and B.L. Hogan Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development Development 126 1999 4005 4015
    • (1999) Development , vol.126 , pp. 4005-4015
    • Weaver, M.1    Yingling, J.M.2    Dunn, N.R.3    Bellusci, S.4    Hogan, B.L.5
  • 34
    • 1542618115 scopus 로고    scopus 로고
    • De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine
    • A.P. Haramis, H. Begthel, and M. van den Born De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine Science 303 2004 1684 1686
    • (2004) Science , vol.303 , pp. 1684-1686
    • Haramis, A.P.1    Begthel, H.2    Van Den Born, M.3
  • 36
    • 33745205659 scopus 로고    scopus 로고
    • Epimorphin(-/-) mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis
    • Y. Wang, L. Wang, and H. Iordanov Epimorphin(-/-) mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis J Clin Invest 116 2006 1535 1546
    • (2006) J Clin Invest , vol.116 , pp. 1535-1546
    • Wang, Y.1    Wang, L.2    Iordanov, H.3
  • 37
    • 77953209234 scopus 로고    scopus 로고
    • Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion
    • A. Shaker, E.A. Swietlicki, and L. Wang Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion J Clin Invest 120 2010 2081 2093
    • (2010) J Clin Invest , vol.120 , pp. 2081-2093
    • Shaker, A.1    Swietlicki, E.A.2    Wang, L.3
  • 38
    • 77952745877 scopus 로고    scopus 로고
    • Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria
    • W.J. Zacharias, X. Li, and B.B. Madison Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria Gastroenterology 138 2010 2368 2377
    • (2010) Gastroenterology , vol.138 , pp. 2368-2377
    • Zacharias, W.J.1    Li, X.2    Madison, B.B.3
  • 39
    • 33646856627 scopus 로고    scopus 로고
    • Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection
    • Y. Tang, E.A. Swietlicki, and S. Jiang Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection Am J Physiol Gastrointest Liver Physiol 290 2006 G1280 G1288
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Tang, Y.1    Swietlicki, E.A.2    Jiang, S.3
  • 40
    • 7944220210 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling protects adult mice from diet-induced weight gain
    • K.K. Buhman, L.C. Wang, and Y. Tang Inhibition of Hedgehog signaling protects adult mice from diet-induced weight gain J Nutr 134 2004 2979 2984
    • (2004) J Nutr , vol.134 , pp. 2979-2984
    • Buhman, K.K.1    Wang, L.C.2    Tang, Y.3
  • 41
    • 10744233571 scopus 로고    scopus 로고
    • Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
    • G.R. van den Brink, S.A. Bleuming, and J.C. Hardwick Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation Nat Genet 36 2004 277 282
    • (2004) Nat Genet , vol.36 , pp. 277-282
    • Van Den Brink, G.R.1    Bleuming, S.A.2    Hardwick, J.C.3
  • 42
    • 33745498412 scopus 로고    scopus 로고
    • Hedgehog Wnteraction in colorectal cancer
    • G.R. van den Brink, and J.C. Hardwick Hedgehog Wnteraction in colorectal cancer Gut 55 2006 912 914
    • (2006) Gut , vol.55 , pp. 912-914
    • Van Den Brink, G.R.1    Hardwick, J.C.2
  • 43
    • 66149103193 scopus 로고    scopus 로고
    • Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the Hedgehog pathway
    • W.A. van Dop, A. Uhmann, and M. Wijgerde Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the Hedgehog pathway Gastroenterology 2009
    • (2009) Gastroenterology
    • Van Dop, W.A.1    Uhmann, A.2    Wijgerde, M.3
  • 44
    • 0037829660 scopus 로고    scopus 로고
    • Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    • D. Pinto, A. Gregorieff, H. Begthel, and H. Clevers Canonical Wnt signals are essential for homeostasis of the intestinal epithelium Genes Dev 17 2003 1709 1713
    • (2003) Genes Dev , vol.17 , pp. 1709-1713
    • Pinto, D.1    Gregorieff, A.2    Begthel, H.3    Clevers, H.4
  • 45
    • 0346458662 scopus 로고    scopus 로고
    • Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    • F. Kuhnert, C.R. Davis, and H.T. Wang Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1 Proc Natl Acad Sci U S A 101 2004 266 271
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 266-271
    • Kuhnert, F.1    Davis, C.R.2    Wang, H.T.3
  • 46
    • 0038350648 scopus 로고    scopus 로고
    • Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation
    • M. Ditschkowski, H. Einsele, and R. Schwerdtfeger Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation Transplantation 75 2003 1745 1747
    • (2003) Transplantation , vol.75 , pp. 1745-1747
    • Ditschkowski, M.1    Einsele, H.2    Schwerdtfeger, R.3
  • 47
    • 0042669939 scopus 로고    scopus 로고
    • Complete remission of Crohn's disease after high-dose cyclophosphamide and autologous stem cell transplantation
    • W. Kreisel, K. Potthoff, and H. Bertz Complete remission of Crohn's disease after high-dose cyclophosphamide and autologous stem cell transplantation Bone Marrow Transplant 32 2003 337 340
    • (2003) Bone Marrow Transplant , vol.32 , pp. 337-340
    • Kreisel, W.1    Potthoff, K.2    Bertz, H.3
  • 48
    • 0042412496 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation for severe Crohn's disease
    • R.M. Craig, A. Traynor, Y. Oyama, and R.K. Burt Hematopoietic stem cell transplantation for severe Crohn's disease Bone Marrow Transplant 32 suppl 1 2003 S57 S59
    • (2003) Bone Marrow Transplant , vol.32 , Issue.SUPPL. 1
    • Craig, R.M.1    Traynor, A.2    Oyama, Y.3    Burt, R.K.4
  • 49
    • 15744405106 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    • Y. Oyama, R.M. Craig, and A.E. Traynor Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease Gastroenterology 128 2005 552 563
    • (2005) Gastroenterology , vol.128 , pp. 552-563
    • Oyama, Y.1    Craig, R.M.2    Traynor, A.E.3
  • 50
    • 33947304185 scopus 로고    scopus 로고
    • Bone marrow stem cell-mediated regeneration in IBD: Where do we go from here?
    • M. Brittan, M.R. Alison, S. Schier, and N.A. Wright Bone marrow stem cell-mediated regeneration in IBD: where do we go from here? Gastroenterology 132 2007 1171 1173
    • (2007) Gastroenterology , vol.132 , pp. 1171-1173
    • Brittan, M.1    Alison, M.R.2    Schier, S.3    Wright, N.A.4
  • 51
    • 20444473689 scopus 로고    scopus 로고
    • A regenerative role for bone marrow following experimental colitis: Contribution to neovasculogenesis and myofibroblasts
    • M. Brittan, V. Chance, and G. Elia A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts Gastroenterology 128 2005 1984 1995
    • (2005) Gastroenterology , vol.128 , pp. 1984-1995
    • Brittan, M.1    Chance, V.2    Elia, G.3
  • 52
    • 13844270574 scopus 로고    scopus 로고
    • Involvement of bone marrow-derived cells in healing of experimental colitis in rats
    • M. Komori, S. Tsuji, and M. Tsujii Involvement of bone marrow-derived cells in healing of experimental colitis in rats Wound Repair Regen 13 2005 109 118
    • (2005) Wound Repair Regen , vol.13 , pp. 109-118
    • Komori, M.1    Tsuji, S.2    Tsujii, M.3
  • 53
    • 33947307177 scopus 로고    scopus 로고
    • Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease
    • P.N. Khalil, V. Weiler, and P.J. Nelson Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease Gastroenterology 132 2007 944 954
    • (2007) Gastroenterology , vol.132 , pp. 944-954
    • Khalil, P.N.1    Weiler, V.2    Nelson, P.J.3
  • 54
    • 35449007194 scopus 로고    scopus 로고
    • Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon
    • O. Ringden, M. Uzunel, and B. Sundberg Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon Leukemia 21 2007 2271 2276
    • (2007) Leukemia , vol.21 , pp. 2271-2276
    • Ringden, O.1    Uzunel, M.2    Sundberg, B.3
  • 55
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • K. Le Blanc, I. Rasmusson, and B. Sundberg Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells Lancet 363 2004 1439 1441
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3
  • 56
    • 60449100851 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses
    • M.A. Gonzalez, E. Gonzalez-Rey, L. Rico, D. Buscher, and M. Delgado Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses Gastroenterology 136 2009 978 989
    • (2009) Gastroenterology , vol.136 , pp. 978-989
    • Gonzalez, M.A.1    Gonzalez-Rey, E.2    Rico, L.3    Buscher, D.4    Delgado, M.5
  • 57
    • 77952243854 scopus 로고    scopus 로고
    • Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis
    • A. Semont, M. Mouiseddine, and A. Francois Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis Cell Death Differ 17 2010 952 961
    • (2010) Cell Death Differ , vol.17 , pp. 952-961
    • Semont, A.1    Mouiseddine, M.2    Francois, A.3
  • 58
    • 66149128792 scopus 로고    scopus 로고
    • Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders
    • M. Metzger, C. Caldwell, A.J. Barlow, A.J. Burns, and N. Thapar Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders Gastroenterology 136 2009 2055 2058
    • (2009) Gastroenterology , vol.136 , pp. 2055-2058
    • Metzger, M.1    Caldwell, C.2    Barlow, A.J.3    Burns, A.J.4    Thapar, N.5


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