Mechanisms for consideration for intervention in the development of organophosphorus-induced delayed neuropathy

Chemico-Biological Interactions

Volumn 199, Issue 3, 2012, Pages 177-184

  Emerick, Guilherme L ^a,c   Deoliveira, Georgino H ^a   Dos Santos, Antonio C ^c   Ehrich, Marion ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Calcium; Calcium channel blockers; NTE inhibitors; Organophosphorus induced delayed neuropathy; Treatment of intoxication

Indexed keywords

BENZYLSULFONYL FLUORIDE; CALCICOL; CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM CHANNEL BLOCKING AGENT; CALPAIN; CARBAMIC ACID DERIVATIVE; CHLORPYRIFOS; CYTOSKELETON PROTEIN; DICHLORVOS; DITHIOCARBAMIC ACID DERIVATIVE; ESTERASE INHIBITOR; GLUCONATE CALCIUM; METHAMIDOPHOS; METRIFONATE; NEUROTOXIC ESTERASE; NEUROTOXIC ESTERASE INHIBITOR; NIFEDIPINE; NIMODIPINE; ORGANOPHOSPHATE INSECTICIDE; PHOSPHINIC ACID DERIVATIVE; SULFONIC ACID DERIVATIVE; SULFONYL HALIDE; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CLINICAL PRACTICE; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; GENE MUTATION; HUMAN; NERVE CELL EXCITABILITY; NERVE DEGENERATION; NERVE ENDING; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; ORGANOPHOSPHORUS INDUCED DELAYED NEUROPATHY; PARALYSIS; PROTEIN PHOSPHORYLATION; REPEATED DRUG DOSE; SINGLE DRUG DOSE;

WALLERIA;

EID: 84865994169     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.07.002     Document Type: Review

References (83)

1. C. Pope, S. Karanth, and J. Liu Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action Environ. Toxicol. Pharmacol. 19 2005 433 446
2. M.K. Johnson Organophosphates and delayed neuropathy - Is NTE alive and well? Toxicol. Appl. Pharmacol. 102 1990 385 399
3. W.Y. Hou, D.X. Long, H.P. Wang, Q. Wang, and Y.J. Wu The homeostasis of phosphatidylcholine and lysophosphatidylcholine was not disrupted during tri-o-cresyl phosphate-induced delayed neurotoxicity in hens Toxicology 252 2008 56 63
4. A.J. Araújo, J.S. Lima, J.C. Moreira, S.C. Jacob, M.O. Soares, M.C.M. Monteiro, A.M. Amaral, A. Kubota, A. Meyer, C.A.N. Cosenza, C. Neves, and S. Markowitz Exposição múltipla a agrotóxicos e efeitos à saúde: estudo transversal em amostra de 102 trabalhadores rurais, Nova Friburgo, RJ Ciênc. Saúde. Col. 12 2007 115 130
5. J.R. Chrismana, S. Koifmanb, P.N. Sarcinellia, J.C. Moreira, R.J. Koifman, and A. Meyer Pesticide sales and adult male cancer mortality in Brazil Int. J. Hyg. Environ. Health 212 2009 310 321
6. C. Wesseling, M. Corriolsb, and V. Bravo Acute pesticide poisoning and pesticide registration in Central America Toxicol. Appl. Pharmacol. 207 2005 s697 s705
7. M.K. Johnson, D. Jacobsen, T.J. Meredith, P. Eyer, A.J. Heath, D.A. Ligtenstein, T.C. Marrs, L. Szinicz, J.A. Vale, and J.A. Haines Evaluation of antidotes for poisoning by organophosphorus pesticides Emerg. Med. 12 2000 22 37
8. R.M. Salvi, D.R. Lara, E.S. Ghisolfi, L.V. Portela, R.D. Dias, and D.O. Souza Neuropsychiatric evaluation in subjects chronically exposed to organophosphate pesticides Toxicol. Sci. 72 2003 267 271
9. S.J. Wijeyesakere, and R.J. Richardson Neuropathy target esterase R. Krieger, Hayes' Handbook of Pesticide Toxicology 3rd ed. 2010 Academic Press San Diego 1435 1455
10. M.K. Johnson Organophosphorus esters causing delayed neurotoxic effects: mechanism of action and structure/activity studies Arch. Toxicol. 34 1975 259 288
11. X.L. Zhao, Z.P. Zhu, T.L. Zhang, C.L. Zhang, L.H. Yu, and K.Q. Xie Tri-ortho-cresyl phosphate (TOCP) decreases the levels of cytoskeletal proteins in hen sciatic nerve Toxicol. Lett. 152 2004 139 147
12. B.S. Jortner Mechanisms of toxic injury in the peripheral nervous system: neuropathologic considerations Toxicol. Pathol. 28 2000 54 69
13. T.V. Damodaran, R.P. Gupta, M.K. Attia, and M.B. Abou-Donia DFP initiated early alterations of PKA/p-CREB pathway and differential persistence of β-tubulin subtypes in the CNS of hens contributes to OPIDN Toxicol. Appl. Pharmacol. 240 2009 132 142
14. P. Glynn Neural development and neurodegeneration: two faces of neuropathy target esterase Prog. Neurobiol. 61 2000 61 74
15. M. Ehrich, L. Correll, and B. Veronesi Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity Fund. Appl. Toxicol. 38 1997 55 63
16. G.L. Emerick, G.H. DeOliveira, R.V. Oliveira, and M. Ehrich Comparative in vitro study of the inhibition of human and hen esterases by methamidophos enantiomers Toxicology 292 2012 145 150
17. P.H. Craig, and M.L. Barth Evaluation of the hazards of industrial exposure to tricresyl phosphate: a review and interpretation of the literature J. Toxicol. Environ. Health, Part B: Critical Reviews 2 1999 281 300
18. A. Moretto Promoters and promotion of axonopathies Toxicol. Lett. 112-113 2000 17 21
19. M. Bertolazzi, S. Caroldi, A. Moretto, and M. Lotti Interaction of methamidophos with hen and human acetylcholinesterase and neuropathy target esterase Arch. Toxicol. 65 1991 580 585
20. M. Lotti, A. Moretto, M. Bertolazzi, and M. Peraica Organophosphate polyneuropathy and neuropathy target esterase: studies with methamidophos and its resolved optical isomers Arch. Toxicol. 69 1995 330 336
21. J.M. Battershill, P.M. Edwards, and M.K. Johnson Toxicological assessment of isomeric pesticides: a strategy for testing of chiral organophosphorus (OP) compounds for delayed polyneuropathy in a regulatory setting Food Chem. Toxicol. 42 2004 1279 1285
22. C.D. Carrington, and M.B. Abou-Donia The time course of protection from delayed neurotoxicity induced by tri-o-cresyl phosphate and o, o-diisopropyl phosphorofluoridate by phenyl methyl sulfonyl fluoride in chickens Toxicol. Lett. 18 1983 251 256
23. A. Moretto, E. Capodicasa, and M. Lotti Clinical expression of organophosphate-induced delayed polyneuropathy in rats Toxicol. Lett. 63 1992 97 102
24. K. Xie, R.P. Gupta, and M.B. Abou-Donia Protein levels of neurofilament subunits in the hen central nervous system following prevention and potentiation of diisopropyl phosphorofluoridate (DFP)-induced delayed neurotoxicity Toxicol. Lett. 63 2002 11 19
25. G.A. Muzardo, R.G.P. Machado, and G.H. DeOliveira Effects of calcium gluconate and PMSF in the treatment of acute intoxication of chicken by TOCP Human Exp. Toxicol. 27 2008 247 252
26. D. Milatovic, and M.K. Johnson Reactivation of phosphorodiamidated acetylcholinesterase and neuropathy target esterase by treatment of inhibited enzyme with potassium fluoride Chem. Biol. Interact 87 1993 425 430
27. M. Jokanovic, R.M. Stepanovic, M. Maksimovic, M. Kosanovic, and M.P. Stojiljkovic Modification of the rate of aging of diisopropylfluorophosphate- inhibited neuropathy target esterase of hen brain Toxicol. Lett. 95 1998 93 101
28. B.P. Schimmer, and J.W. Funder ACTH, adrenal steroids, and pharmacology of the adrenal cortex L. Brunton, B. Chabner, B. Knollman, Goodman & Gilman's: The Pharmacological Basis of Therapeutics 12th ed. 2011 McGraw Hill Medical Publishers New York 1209 1235
29. M. Ehrich, and B.S. Jortner Organophosphorus-induced delayed neuropathy R.I. Krieger, Hayes' Handbook of Pesticide Toxicology 3rd ed. 2010 Elsevier Academic Press San Diego 1479 1504
30. M. Ehrich, B.S. Jortner, and W.B. Gross Absence of a protective effect of corticosterone on O-O-diisopropyl phosphorofluoridate (DFP) induced delayed neurotoxicity in chickens Neurotoxicology 6 1985 87 92
31. M. Ehrich, R.W. Briles, W.E. Briles, E.A. Dunnington, A. Martin, P.B. Siegel, and W.B. Gross Neurotoxicity of tri-ortho-tolyl phosphate in chickens of different genotypes in the presence and absence of deoxycorticosterone Poult. Sci. 65 1986 375 379
32. M. Ehrich, B.S. Jortner, and W.B. Gross Dose-related beneficial and adverse effects of dietary corticosterone on organophosphorus-induced delayed neuropathy in chickens Toxicol. Appl. Pharmacol. 83 1986 250 260
33. M. Ehrich, B.S. Jortner, and W.B. Gross Types of adrenocorticoids and their effect on organophosphorus-induced delayed neuropathy in chickens Toxicol. Appl. Pharmacol. 92 1988 214 223
34. P.R.M. Stepanovic, M. Jokanovic, M. Maksimovic, N. Ugresic, and B. Boskovic The treatment of delayed polyneuropathy induced with diisopropylfluorophosphate in hens Die Pharmazie 55 2000 454 455
35. M. Jokanovic, M. Kosanovic, D. Brkic, and P. Vukomanovic Organophosphate induced delayed polyneuropathy in man: an overview Clin. Neurol. Neurosurg. 113 2011 7 10
36. H.A.N. El-Fawal, B.S. Jortner, and M. Ehrich Effect of verapamil on organophosphorus-induced delayed neuropathy in hens Toxicol. Appl. Pharmacol. 97 1989 500 511
37. H.A.N. El-Fawal, L. Correll, L. Gay, and M. Ehrich Protease activity in brain, nerve and muscle of hens given neuropathy-inducing organophosphates and a calcium channel blocker Toxicol. Appl. Pharmacol. 103 1990 133 142
38. H.A.N. El-Fawal, B.S. Jortner, and M. Ehrich Modification of phenyl saligenin phosphate-induced delayed effects by calcium channel blockers: in vivo and in vitro electrophysiological assessment Neurotoxicology 11 1990 573 592
39. H.A.N. El-Fawal, and M. Ehrich Calpain activity in organophosphorus- induced delayed neuropathy (OPIDN): effects of a phenylalkylamine calcium channel blocker Ann. N. Y. Acad. Sci. 679 1993 325 329
40. Y.J. Wu, and X.F. Leng Effect of verapamil on changes in brain phosphorylation after oral administration of tri-o-cresyl phosphate to hens Pest. Biochem. Physiol. 58 1997 7 12
41. Y.J. Wu, M. Li, Y.X. Li, W. Li, Y.J. Dai, and X.F. Leng Verapamil abolished the enhancement of protein phosphorylation of brainstem mitochondria and synaptosomes from the hens dosed with tri-o-cresyl phosphate Environ. Toxicol. Pharmacol. 24 2007 67 71
42. S. Choudhary, and K.D. Gill Protective effect of nimodipine on dichlorvos-induced delayed neurotoxicity in rat brain Biochem. Pharmacol. 62 2001 1265 1272
43. S. Choudhary, S.K. Verma, G. Raheja, P. Kaur, K. Joshi, and K.D. Gill The L-type calcium channel blocker nimodipine mitigates cytoskeletal proteins phosphorylation in dichlorvos-induced delayed neurotoxicity in rats Basic Clin. Pharmacol. Toxicol. 98 2006 447 455
44. G.L. Emerick, R.G. Peccinini, and G.H. DeOliveira Organophosphorus- induced delayed neuropathy: a simple and efficient therapeutic strategy Toxicol. Lett. 192 2010 238 244
45. M. Jokanovic Medical treatment of acute poisoning with organophosphorus and carbamate pesticides Toxicol. Lett. 190 2009 107 115
46. D.A. Jett Neurotoxic pesticides and neurologic effects Neurol. Clin. 29 2011 667 677
47. G.A. Jamal, S. Hansen, and P.O.O. Julu Low level exposures to organophosphorus esters may cause neurotoxicity Toxicology 181-182 2002 23 33
48. L.G. Costa Current issues in organophosphate toxicology Clin. Chim. Acta 366 2006 1 13
49. R.J. Richardson, R.M. Worden, and G.F. Makhaeva Biomarkers and biosensors of delayed neuropathy agents R.C. Gupta, Handbook of Toxicology of Chemical Warfare Agents 2009 Academic Press San Diego 859 876
50. M.K. Johnson Structure-activity relationships for substrates and inhibitors of hen brain neurotoxic esterase Biochem. Pharmacol. 24 1975 797 805
51. B.S. Jortner Preparation and analysis of the peripheral nervous system Toxicol. Pathol. 39 2011 66 72
52. S.E. Patton, J.P. O'Callaghan, D.B. Miller, and M.B. Abou-Donia The effect of oral administration of tri-o-cresyl phosphate on in vitro phosphorylation of membrane and cytosolic proteins from chicken brain J. Neurochem. 41 1983 897 901
53. S.E. Patton, J.P. O'Callaghan, D.B. Miller, and M.B. Abou-Donia Changes in in vitro brain and spinal cord protein phosphorylation after a single oral administration of tri-o-cresyl phosphate to hens J. Neurochem. 45 1983 1567 1577
54. M.B. Abou-Donia The cytoskeleton as a target for organophosphorus ester-induced delayed neurotoxicity (OPIDN) Chem. Biol. Interact. 87 1993 383 393
55. 2+ calmodulin (CaM)-dependent phosphorylation by the brain supernatant of diisopropyl phosphorofluoridate DFP-treated hen: tau mutants indicate phosphorylation of more amino acids in tau by CaM kinase II Brain Res. 813 1998 32 43
56. 2+ /calmodulin-dependent protein kinase II α-subunit and its mRNA expression in diisopropyl phosphorofluoridate DFP-treated hen central nervous system Mol. Cell. Biochem. 181 1998 29 39
57. B.S. Jortner, S.K. Perkins, and M. Ehrich Immunohistochemical study of phosphorylated neurofilaments during the evolution of organophosphorus ester-induced delayed neuropathy (OPIDN) Neurotoxicology 20 1999 971 976
58. V.C. Moser, M. Aschner, R.J. Richardson, and M.A. Philbert Toxic responses of the nervous system C.D. Klaassen, Casarett and Doull's Toxicology: The Basic Science of Poisons 7th ed. 2007 McGraw-Hill New York 631 664
59. B.S. Jortner, S.K. Hancock, J. Hinckley, L. Flory, L. Colby, L. Tobias, L. Williams, and M. Ehrich Neuropathological studies of rats following multiple exposure to tri-ortho-tolyl phosphate, chlorpyrifos and stress Toxicol. Pathol. 33 2005 378 385
60. M. Inomata, M. Hayashi, M. Nakamura, K. Imahori, and S. Kawashima Purification and characterization of a calcium-activated neutral protease from rabbit skeletal muscle which requires calcium ions of μM order concentration J. Biochem. 93 1983 291 294
61. B.W. Schwab, and R.J. Richardson Lymphocyte and brain neurotoxic esterase: dose and time dependence of inhibition in the hen examined with three organophosphorus esters Toxicol. Appl. Pharmacol. 83 1986 1 9
62. N.D. Hein, S.R. Rainier, R.J. Richardson, and J.K. Fink Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis Toxicol. Lett. 199 2010 1 5
63. M. Lotti The pathogenesis of organophosphate polyneuropathy CRC Crit. Rev. Toxicol. 21 1992 465 487
64. C. Massicotte, K.D. Inzana, M. Ehrich, and B.S. Jortner Neuropathologic effects of phenylmethylsulfonyl fluoride (PMSF)-induced promotion and protection in organophosphorus ester-induced delayed neuropathy (OPIDN) in hens Neurotoxicology 20 1999 749 759
65. M. Lotti, A. Moretto, E. Capodicasa, M. Bertolazzi, M. Peraica, and M.L. Scapellato Interactions between neuropathy target esterase and its inhibitors and the development of polyneuropathy Toxicol. Appl. Pharmacol. 122 1993 165 171
66. M.K. Johnson, and D.J. Read Prophylaxis against and promotion of organophosphate-induced delayed neuropathy by phenyl di-n-pentylphosphinate Chem. Biol. Interact. 87 1993 449 455
67. M. Lotti Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitors Toxicology 181-182 2002 245 248
68. M.A. Escudero, M.V. Céspedes, and E. Vilanova Chromatographic discrimination of soluble neuropathy target esterase isoenzymes and related phenyl valerate esterases from chicken brain, spinal cord, and sciatic nerve J. Neurochem. 68 1997 2170 2176
69. A.J. Greiner, R.J. Richardson, R.M. Worden, and R.Y. Ofoli Influence of lysophospholipid hydrolysis by the catalytic domain of neuropathy target esterase on the fluidity of bilayer lipid membranes Biochem. Biophys. Acta 1798 2010 1533 1539
70. K. Akassoglou, B. Malester, J. Xu, L. Tessarollo, J. Rosenbluth, and M.V. Chao Brain-specific deletion of neuropathy target esterase/swiss cheese results in neurodegeneration Proc. Natl. Acad. Sci. USA 101 2004 5075 5080
71. R. Marcus Drugs affecting calcification and bone turnover J.G. Hardman, L.E. Limbird, Goodman & Gilman: The Pharmacological Basis of Therapeutics 10th ed. 2001 McGraw-Hill Rio de Janeiro 1715 1744
72. M. Murgia, C. Giorgi, P. Pinton, and R. Rizzuto Controlling metabolism and cell death: at the heart of mitochondrial calcium signaling J. Mol. Cell. Cardiol. 46 2009 781 788
73. 2+ signaling, mitochondria and cell death Curr. Mol. Med. 8 2008 119 130
74. F. Piao, T. Yamauchi, and N. Ma The effect of calcicol® as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds Toxicol. Lett. 143 2003 65 71
75. Y.J. Wu, P.A. Chang, M. Li, Y.X. Li, and W. Li Effect of tri-o-cresyl phosphate and methamidophos on 45Ca uptake by brain synaptsomes in hens Pest. Biochem. Physiol. 77 2003 18 23
76. F. Song, Y. Yan, X. Zhao, D. Dou, C. Zhang, and K. Xie Phenylmethylsulfonyl fluoride protects against the degradation of neurofilaments in tri-ortho-cresyl phosphate (TOCP) induced delayed neuropathy Toxicology 262 2009 258 264
77. R.M. Lopachin, and E.J. Lehning Mechanism of calcium entry during axon injury and degeneration Toxicol. Appl. Pharmacol. 143 1997 233 244
78. K. Haak, S.B. Narayan, H. Li, A. Warnock, L. Tan, and N.J. Bennett Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers Acta Biochim. Biophys. 2011 1810 186 191
79. M. Lotti, S. Caroldi, S. Capodicasa, and A. Moretto Promotion of organophosphate-induced delayed polyneuropathy by phenylmethanesulfonyl fluoride Toxicol. Appl. Pharmacol. 108 1991 234 241
80. B. Veronesi, and S. Padilla Phenylmethylsulfonyl fluoride protects rats from mipafox-induced delayed neuropathy Toxicol. Appl. Pharmacol. 81 1985 258 264
81. M. Lotti, and A. Moretto Clinical expression of organophosphate-induced delayed polyneuropathy in rats Toxicol. Lett. 63 1992 97 102
82. P. Harp, P. Tanaka Jr., and C. Pope Potentiation of organophosphorus- induced delayed neurotoxicity following phenyl saligenin phosphate exposures in 2-, 5-, and 8-week-old chickens Fund. Appl. Toxicol. 37 1997 64 70
83. H.A.N. El-Fawal, and W.C. McCain Antibodies to neural proteins in organophosphorus-induced delayed neuropathy (OPIDN) and its amelioration Neurotoxicol. Teratol. 30 2008 161 166