The evolutionary conserved C-terminal domains in the mammalian retinoblastoma tumor suppressor family serve as dual regulators of protein stability and transcriptional potency

Journal of Biological Chemistry

Volumn 290, Issue 23, 2015, Pages 14462-14475

  Sengupta, Satyaki ^a,b   Lingnurkar, Raj ^a   Carey, Timothy S ^a   Pomaville, Monica ^a   Kar, Parimal ^a   Feig, Michael ^a   Wilson, Catherine A ^b   Knott, Jason G ^a,b   Arnosti, David N ^a   Henry, R William ^a  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; MAMMALS; PLANTS (BOTANY); STEM CELLS; TRANSCRIPTION; TUMORS;

C-TERMINAL DOMAINS; CYCLIN-DEPENDENT KINASE; EMBRYONIC STEM CELLS; REGULATORY DOMAIN; REGULATORY PATHWAY; REPRESSOR ACTIVITY; RETINOBLASTOMA TUMORS; UBIQUITIN-PROTEASOME SYSTEM;

PROTEINS;

CYCLIN DEPENDENT KINASE 4; PROTEASOME; PROTEIN P107; PROTEIN P130; REPRESSOR PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DP; TRANSCRIPTION FACTOR E2F; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; GENE CONTROL; GENE TARGETING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REPRESSOR GENE; STEADY STATE; TRANSCRIPTION REGULATION; UBIQUITINATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CYTOLOGY; GENETIC TRANSCRIPTION; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CONSERVED SEQUENCE; EMBRYONIC STEM CELLS; EVOLUTION, MOLECULAR; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RETINOBLASTOMA PROTEIN; SEQUENCE ALIGNMENT; TRANSCRIPTION, GENETIC;

EID: 84930619807     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.599993     Document Type: Article

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