Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function

Journal of Biological Chemistry

Volumn 287, Issue 50, 2012, Pages 41835-41843

  Raj, Nitin ^b   Zhang, Liang ^b   Wei, Yiliang ^a   Arnosti, David N ^a   Henry, R William ^a  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CELL CYCLE; CELL SIGNALING; CELL-CYCLE PROGRESSION; CELLULAR PROCESS; POST-TRANSLATIONAL MODIFICATIONS; RETINOBLASTOMA; RETINOBLASTOMA TUMORS; TARGET GENES; TRANSCRIPTIONAL REPRESSION; UBIQUITINATION;

ACTIVATION ANALYSIS; CELL DEATH; MACHINERY; PROTEINS;

GENES;

RETINOBLASTOMA FAMILY PROTEIN 1; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CONTROLLED STUDY; DROSOPHILA; GENE REPRESSION; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UBIQUITINATION;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 84868033012     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.422428     Document Type: Article

References (42)

1. Burkhart, D. L., and Sage, J. (2008) Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev. Cancer 8, 671-682
2. Hanahan, D., and Weinberg, R. A. (2011) Hallmarks of cancer: the next generation. Cell 144, 646-674
3. Nguyen, D. X., and McCance, D. J. (2005) Role of the retinoblastoma tumor suppressor protein in cellular differentiation. J. Cell Biochem. 94, 870-879 (Pubitemid 41420250)
4. Skapek, S. X., Pan, Y. R., and Lee, E. Y. (2006) Regulation of cell lineage specification by the retinoblastoma tumor suppressor. Oncogene 25, 5268-5276 (Pubitemid 44299087)
5. Wikenheiser-Brokamp, K. A. (2006) Retinoblastoma family proteins: insights gained through genetic manipulation of mice. Cell. Mol. Life Sci. 63, 767-780
6. Genovese, C., Trani, D., Caputi, M., and Claudio, P. P. (2006) Cell cycle control and beyond: emerging roles for the retinoblastoma gene family. Oncogene 25, 5201-5209 (Pubitemid 44299078)
7. Morris, E. J., and Dyson, N. J. (2001) Retinoblastoma protein partners. Adv. Cancer Res. 82, 1-54 (Pubitemid 32613381)
8. Delston, R. B., and Harbour, J. W. (2006) Rb at the interface between cell cycle and apoptotic decisions. Curr. Mol. Med. 6, 713-718 (Pubitemid 44725564)
9. Chen, P. L., Scully, P., Shew, J. Y., Wang, J. Y., and Lee, W. H. (1989) Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58, 1193-1198 (Pubitemid 19238195)
10. Hinds, P. W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S. I., and Weinberg, R. A. (1992) Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70, 993-1006
11. Kato, J., Matsushime, H., Hiebert, S. W., Ewen, M. E., and Sherr, C. J. (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7, 331-342 (Pubitemid 23139228)
12. Lin, B. T., and Wang, J. Y. (1992) Cell cycle regulation of retinoblastoma protein phosphorylation. Ciba Found. Symp. 170, 227-241; discussion 241-223
13. Knudsen, E. S., Buckmaster, C., Chen, T. T., Feramisco, J. R., and Wang, J. Y. (1998) Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev. 12, 2278-2292 (Pubitemid 28371349)
14. Wells, J., Boyd, K. E., Fry, C. J., Bartley, S. M., and Farnham, P. J. (2000) Target gene specificity of E2F and pocket protein family members in living cells. Mol. Cell Biol. 20, 5797-5807 (Pubitemid 30613029)
15. Wells, J., Yan, P. S., Cechvala, M., Huang, T., and Farnham, P. J. (2003) Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase. Oncogene 22, 1445-1460 (Pubitemid 36390594)
16. Delston, R. B., Matatall, K. A., Sun, Y., Onken, M. D., and Harbour, J. W. (2011) p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis. Oncogene 30, 588-599
17. Du, W., Vidal, M., Xie, J. E., and Dyson, N. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10, 1206-1218 (Pubitemid 26171102)
18. Du, W., Xie, J. E., and Dyson, N. (1996) Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15, 3684-3692 (Pubitemid 26239781)
19. 1 regulation during Drosophila embryogenesis. EMBO J. 18, 916-925
20. Acharya, P., Raj, N., Buckley, M. S., Zhang, L., Duperon, S., Williams, G., Henry, R. W., and Arnosti, D. N. (2010) Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins. Mol. Biol. Cell 21, 3890-3901
21. Stevaux, O., and Dyson, N. J. (2002) A revised picture of the E2F transcriptional network and RB function. Curr. Opin. Cell Biol. 14, 684-691 (Pubitemid 35449380)
22. Acharya, P., Negre, N., Johnston, J., Wei, Y., White, K. P., Henry, R. W., and Arnosti, D. N. (2012)Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein. Genes Genomes Genet., in press
23. Korenjak, M., Anderssen, E., Ramaswamy, S., Whetstine, J. R., and Dyson, N. J. (2012) RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Mol. Cell Biol. 32, 4375-4387
24. Ullah, Z., Buckley, M. S., Arnosti, D. N., and Henry, R. W. (2007) Retinoblastoma protein regulation by the COP9 signalosome. Mol. Biol. Cell 18, 1179-1186 (Pubitemid 46626614)
25. Bech-Otschir, D., Seeger, M., and Dubiel, W. (2002) The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis. J. Cell Sci. 115, 467-473 (Pubitemid 34182974)
26. Chamovitz, D. A., and Glickman, M. (2002) The COP9 signalosome. Curr. Biol. 12, R232
27. Ryu, J. R., and Arnosti, D. N. (2003) Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. Nucleic Acids Res. 31, 4654-4662
28. Keller, S. A., Ullah, Z., Buckley, M. S., Henry, R. W., and Arnosti, D. N. (2005) Distinct developmental expression of Drosophila retinoblastoma factors. Gene Expr. Patterns 5, 411-421 (Pubitemid 40124557)
29. Hammond-Martel, I., Yu, H., and Affar el, B. (2012) Roles of ubiquitin signaling in transcription regulation. Cell. Signal. 24, 410-421
30. Barbash, O., Lin, D. I., and Diehl, J. A. (2007) SCF Fbx4/αB- crystallin cyclin D1 ubiquitin ligase: a license to destroy. Cell Div. 2, 2
31. Sdek, P., Ying, H., Zheng, H., Margulis, A., Tang, X., Tian, K., and Xiao, Z. X. (2004) The central acidic domain ofMDM2is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J. Biol. Chem. 279, 53317-53322 (Pubitemid 40051836)
32. Uchida, C., Miwa, S., Kitagawa, K., Hattori, T., Isobe, T., Otani, S., Oda, T., Sugimura, H., Kamijo, T., Ookawa, K., Yasuda, H., and Kitagawa, M. (2005) Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J. 24, 160-169 (Pubitemid 40188473)
33. Ying, H., and Xiao, Z. X. (2006) Targeting retinoblastoma protein for degradation by proteasomes. Cell Cycle 5, 506-508 (Pubitemid 43340528)
34. Deroo, B. J., and Archer, T. K. (2002) Proteasome inhibitors reduce luciferase and β-galactosidase activity in tissue culture cells. J. Biol. Chem. 277, 20120-20123 (Pubitemid 34967299)
35. Rubin, S. M., Gall, A. L., Zheng, N., and Pavletich, N. P. (2005) Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123, 1093-1106 (Pubitemid 41785423)
36. Geng, F., Wenzel, S., and Tansey, W. P. (2012) Ubiquitin and proteasomes in transcription. Annu. Rev. Biochem. 81, 177-201
37. Salghetti, S. E., Caudy, A. A., Chenoweth, J. G., and Tansey, W. P. (2001) Regulation of transcriptional activation domain function by ubiquitin. Science 293, 1651-1653 (Pubitemid 32807843)
38. Salghetti, S. E., Kim, S. Y., and Tansey, W. P. (1999) Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J. 18, 717-726 (Pubitemid 29057256)
39. Salghetti, S. E., Muratani, M., Wijnen, H., Futcher, B., and Tansey, W. P. (2000) Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis. Proc. Natl. Acad. Sci. U.S.A. 97, 3118-3123 (Pubitemid 30183265)
40. Kurosu, T., and Peterlin, B. M. (2004) VP16 and ubiquitin; binding of P-TEFb via its activation domain and ubiquitin facilitates elongation of transcription of target genes. Curr. Biol. 14, 1112-1116 (Pubitemid 38791575)
41. Horwitz, A. A., Affar el, B., Heine, G. F., Shi, Y., and Parvin, J. D. (2007) A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A. 104, 6614-6619
42. Raj, N., Zhang, L., Wei, Y., Arnosti, D. N., and Henry, R. W. (2012) Rbf1 degron dysfunction enhances cellular DNA replication. Cell Cycle 11, 3731-3738