Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation

Oncogene

Volumn 27, Issue 11, 2008, Pages 1572-1579

  Julian, L M ^a   Palander, O ^a   Seifried, L A ^a   Foster, J E G ^a   Dick, F A ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Apoptosis; Cell cycle; E2F; Retinoblastoma; Transcription

Indexed keywords

RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE CONTROL; GENE INTERACTION; HUMAN; HUMAN CELL; MUTAGENESIS; MUTANT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN;

APOPTOSIS; BINDING SITES; BONE NEOPLASMS; E2F1 TRANSCRIPTION FACTOR; FLOW CYTOMETRY; G1 PHASE; HUMANS; LUCIFERASES; MUTATION; OSTEOSARCOMA; RETINOBLASTOMA PROTEIN; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 40449096674     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210803     Document Type: Article

References (16)

1. Dick FA, Dyson N. (2002). Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins. J Virol 76: 6224-6234.
2. Dick FA, Dyson N. (2003). pRB Contains an E2F1 specific binding domain that allows E2F1 induced apoptosis to be regulated separately from other E2F activities. Mol Cell 12: 639-649.
3. Dick FA, Sailhamer E, Dyson NJ. (2000). Mutagenesis of the pRB pocket domain reveals that cell cycle arrest functions are separable from binding to viral oncoproteins. Mol Cell Biol 20: 3715-3727.
4. Dyson N. (1998). The regulation of E2F by pRB-family proteins. Genes Dev 12: 2245-2262.
5. Field SJ, Tsai F-Y, Kuo F, Zubiaga AM, Kaelin WG, Livingston DM et al. (1996). E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85: 549-561.
6. Ginsberg D. (2002). E2F1 pathways to apoptosis. FEBS Lett 529: 122-125.
7. Johnson DG, Degregori J. (2006). Putting the oncogenic and tumor suppressive activities of E2F into context. Curr Mol Med 6: 731-738.
8. Muller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E et al. (2001). E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev 15: 267-285.
9. Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA et al. (2002). E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 16: 245-256.
10. Rubin SM, Gall AL, Zheng N, Pavletich NP. (2005). Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123: 1093-1106.
11. Stevens C, La Thangue NB. (2003). A new role for E2F-1 in checkpoint control. Cell Cycle 2: 435-437.
12. Strobeck MW, Fribourg AF, Puga A, Knudsen ES. (2000). Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest. Oncogene 19: 1857-1867.
13. Takahashi Y, Rayman J, Dynlacht B. (2000). Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev 14: 804-816.
14. Trimarchi JM, Lees JA. (2002). Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 3: 11-20.
15. Urist M, Tanaka T, Poyurovsky MV, Prives C. (2004). p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev 18: 3041-3054.
16. Wells J, Boyd K, Fry C, Bartley S, Farnham P. (2000). Target gene specificity of E2F and pocket protein family members in living cells. Mol Cell Biol 20: 5797-5807.