Oral exposure to titanium dioxide (TiO2) nanoparticles: From translocation through oral and intestinal epithelia to fate and effects in the organism;Exposition orale aux nanoparticules de dioxyde de titane (TiO2) : du franchissement de l'épithélium buccal et intestinal au devenir et aux effets dans l'organisme

Biologie Aujourd'hui

Volumn 208, Issue 2, 2014, Pages 167-175

  Bettini, Sarah ^a   Houdeau, Eric ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

Author keywords

Buccal mucosa; Immune system; Intestinal barrier; Nanoparticles; White food pigment E171

Indexed keywords

METAL NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

ADVERSE EFFECTS; ANIMAL; BIOAVAILABILITY; DRUG EFFECTS; HUMAN; IMMUNE SYSTEM; INTESTINE MUCOSA; METABOLISM; MOUTH MUCOSA; OCCUPATIONAL EXPOSURE; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; HUMANS; IMMUNE SYSTEM; INTESTINAL MUCOSA; METAL NANOPARTICLES; MOUTH MUCOSA; OCCUPATIONAL EXPOSURE; TITANIUM;

EID: 84930515964     PISSN: 21050678     EISSN: 21050686     Source Type: Journal    
DOI: 10.1051/jbio/20140022     Document Type: Article

References (44)

1. Afssa mars 2009. http://www.afssa.fr/Documents/RCCPRa-NanoAlimentation.pdf.
2. Ahlinder L., Ekstrand-Hammarström B., Geladi P., Osterlund L., Large uptake of titania and iron. Oxide nanoparticules in the nucleus of lung epithelial cells as measured by Raman Imaging and multivariate classification. Biophys J, 2013, 105, 310-319.
3. Becker H.M., Bertschinger M.M., Rogler G., Microparticles and their impact on intestinal immunity. Dig Dis, 2012, 30, 47-54.
4. Brun E., Carrière M., Mabondzo A., In vitro evidence of dysregulation of blood-brain barrier function after acute and repeated/long-term exposure to TiO(2) nanoparticles. Biomaterials, 2012, 333, 886-896.
5. Brun E., Barreau F., Veronesi G., Fayard B., Sorieul S., Chanéac C., Carapito C., Rabilloud T., Mabondzo A., Herlin-Boime N., Carrière M., Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia. Part Fibre Toxicol, 2014, 11, 13.
6. Chen X.X., Cheng B., Yang Y.X., Cao A., Liu J.H., Du L.J., Liu Y., Zhao Y., Wang H.,Characterization and preliminary toxicity assay of nano-titanium dioxide additive in sugar-coated chewing gum. Small, 2013, 9, 1765-1774.
7. Cho W.S., Kang B.C., Lee J.K., Jeong J., Che J.H., Seok S.H., Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration. Part Fibre Toxicol, 2013, 10, 9.
8. Duan Y., Liu J., Ma L., Li N., Liu H., Wang J., Zheng L., Liu C., Wang X., Zhao X., Yan J., Wang S.,Wang H., Zhang X., Hong F., Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials, 2010, 31, 894-899.
9. Geraets L., Oomen A.G., Krystek P., Jacobsen N.R., Wallin H., Laurentie M., Verharen H.W., Brandon E.F., de Jong W.H., Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Part Fibre Toxicol, 2014, 11, 30.
10. Giovanni M., Tay C.Y., Setyawati M.I., Xie J., Ong C.N., Fan R., Yue J., Zhang L., Leong D.T., Toxicity profiling of water contextual zinc oxide, silver, and titanium dioxide nanoparticles in human oral and gastrointestinal cell systems. Environ Toxicol, 2014 [doi: 10.1002/tox.22015].
11. Gottschalk F., Sonderer T., Scholz R.W., Nowack B., Modeled environmental concentrations of engineered nanomaterials (TiO(2), ZnO, Ag, CNT, Fullerenes) for different regions. Environ Sci Technol, 2009, 43, 9216-9222.
12. Harris D., Robinson JR., Drug delivery via the mucous membranes of the oral cavity. J Pharm Sci, 1992, 81, 1-10.
13. Houdeau E., Nanoparticules et barrière intestinale : comprendre les mécanismes de franchissement. Innov Agro, 2012, 24, 105-112.
14. Janer G., Mas del Molino E., Fernández-Rosas E., Fernández A., Vázquez-Campos S., Cell uptake and oral absorption of titanium dioxide nanoparticles. Toxicol Lett, 2014, 228, 103-110.
15. Jin C., Tang Y., Fan X.Y., Ye X.T., Li X.L., Tang K., Zhang Y.F., Li A.G., Yang Y.J., In vivo evaluation of the interaction between titanium dioxide nanoparticle and rat liver DNA. Toxicol Ind Health, 2013, 29, 235-244.
16. JOUE no L275-20.10.2011 : http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2011:275:0038: 0040:FR:PDF.
17. Kang S.J., Kim B.M., Lee Y.J., Chung H.W., Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Environ Mol Mutagen, 2008, 49, 399-405.
18. Koeneman B.A., Zhang Y., Westerhoff P., Chen Y., Crittenden J.C., Capco D.G.,Toxicity and cellular responses of intestinal cells exposed to titanium dioxide. Cell Biol Toxicol, 2010, 26, 225-238.
19. Larue C., Veronesi G., Flank A.M., Surble S., Herlin-Boime N., Carrière M., Comparative uptake and impact of TiO2 nanoparticles in wheat and rapeseed. J Toxicol Environ Health A, 2012a, 75, 722-734.
20. Larue C., Laurette J., Herlin-Boime N., Khodja H., Fayard B., Flank A.M., Brisset F., Carrière M., Accumulation, translocation and impact of TiO2 nanoparticles in wheat (Triticum aestivum spp.): influence of diameter and crystal phase. Sci Total Environ, 2012b, 431, 197-208.
21. Li N., Ma L.L, Wang J., Zheng L., Liu J., Duan Y.M., Liu H., Zhao X., Wang H., Hong F., Xie Y., Interaction between nano-anatase TiO2 and liver DNA from mice in vivo. Nanoscale Res Lett, 2010, 5, 108-115.
22. Lomer M.C.E., Thompson R.P.H., Commisso J., Keen C.L., Powell J.J., Determination of titanium dioxide in foods using inductively coupled plasma optical emission spectrometry. Analyst, 2000, 125, 2339-2343.
23. Lomer M.C., Hutchinson C., Volkert S., Greenfield S.M., Catterall A., Thompson R.P., Powell J.J., Dietary sources of inorganic microparticles and their intake in healthy subjects and patients with Crohn's disease. Br J Nutr, 2004, 92, 947-955.
24. Ménard S., Cerf-Bensussan N., Heyman M., Multiple facets of intestinal permeability and epithelial handling of dietary antigens. Mucosal Immunol, 2010, 3, 247-259
25. Moussaoui N., Braniste V., Ait-Belgnaoui A., Gabanou M., Sekkal S., Olier M., Théodorou V., Martin P.G., Houdeau E., Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial defect in maternal-deprived rats. PloS One, 2014, 9, e88382.
26. Myers W.D., Ludden P.A., Nayigihugu V., Hess B.W., Technical note: a procedure for the preparation and quantitative analysis of samples for titanium dioxide. J Anim Sci, 2004, 82, 179-183.
27. Peters R.J., van Bemmel G., Herrera-Rivera Z., Helsper H.P., Marvin H.J., Weigel S., Tromp P.C., Oomen A.G., Rietveld A.G., Bouwmeester H., Characterization of titanium dioxide nanoparticles in food products: analytical methods to define nanoparticles. J Agric Food Chem, 2014, 9, 6285-6293.
28. Powell J.J., Faria N., Thomas-McKay E., Pele L.C., Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun, 2010, 34, J226-J233.
29. Principato M., Gastrointestinal Immunoregulation and the Challenges of Nanotechnology in Foods. In Innocenzo Muzzalupo (Ed.), Agricultural and Biological Sciences "Food Industry", 2013, 491-517.
30. Roblegg E., Fröhlich E., Meindl C., Teubl B., Zaversky M., Zimmer A., Evaluation of a physiological in vitro system to study the transport of nanoparticles through the buccal mucosa. Nanotoxicology, 2012, 6, 399-413.
31. Servin A.D., Morales M.I., Castillo-Michel H., Hernandez-Viezcas J.A., Munoz B., Zhao L., Nunez J.E., Peralta-Videa J.R., Gardea-Torresdey J.L., Synchrotron verification of TiO2 accumulation in cucumber fruit: a possible pathway of TiO2 nanoparticle transfer from soil into the food chain. Environ Sci Technol, 2013, 47, 11592-11598.
32. Shrivastava R., Raza S., Yadav A., Kushwaha P., Flora S.J., Effects of sub-acute exposure to TiO2, ZnO and Al2O3 nanoparticles on oxidative stress and histological changes in mouse liver and brain. Drug Chem Toxicol, 2014, 37, 336-347.
33. Squier C.A., The permeability of oral mucosa. Crit Rev Oral Biol Med, 1991, 2, 13-32.
34. Sycheva L.P., Zhurkov V.S., Iurchenko V.V., Daugel-Dauge N.O., Kovalenko M.A., Krivtsova E.K., Durnev A.D., Investigation of genotoxic and cytotoxic effects of micro-and nanosized titanium dioxide in six organs of mice in vivo. Mutat Res, 2011, 726, 8-14.
35. Tassinari R., Cubadda F., Moracci G., Aureli F., D'Amato M., Valeri M., De Berardis B., Raggi A., Mantovani A., Passeri D., Rossi M., Maranghi F., Oral, shortterm exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen. Nanotoxicology, 2014, 8, 654-662.
36. Tay C.Y., Fang W., Setyawati M.I., Chia S.L., Tan K.S., Hong C.H., Leong D.T., Nano-hydroxyapatite and nano-titanium dioxide exhibit different subcellular distribution and apoptotic profile in human oral epithelium. ACS Appl Mater Interfaces, 2014, 6, 6248-6256.
37. Teubl B.J., Absenger M., Fröhlich E., Leitinger G., Zimmer A., Roblegg E., The oral cavity as a biological barrier system : design of an advanced buccal in vitro permeability model. Eur J Pharm Ther, 2013, 84, 386-393.
38. Teubl B.J., Leitinger G., Schneider M., Lehr C.M., Fröhlich E., Zimmer A., Roblegg E., The buccal mucosa as a route for TiO2 nanoparticle uptake. Nanotoxicology, 2014, 29, 1-9.
39. Thomson P.J., Potten C.S., Appleton D.R., Mapping dynamic epithelial cell proliferative activity within the oral cavity of man: a new insight into carcinogenesis? Br J Oral Maxillofac Surg, 1999, 37, 377-383.
40. Turner J.R. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol, 2009, 9, 799-809.
41. Weir A., Westerhoff P., Fabricius L., Hristovski K., von Goetz N., Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol, 2012, 46, 2242-2250.
42. Winter M., Beer H.D., Hornung V., Krämer U., Schins R.P., Förster I., Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells. Nanotoxicology, 2011, 5, 326-40.
43. Yang Y., Doudrick K,. Bi X., Hristovski K., Herckes P., Westerhoff P., Kaegi R., Characterization of foodgrade titanium dioxide: the presence of nanosized particles. Environ Sci Technol, 2014, 48, 6391-6400.
44. Yu B., Leung K.M., Guo Q., Lau W.M., Yang J., Synthesis of Ag-TiO2 composite nano thin film for antimicrobial application. Nanotechnology, 2011, 22, 115603.