Large uptake of titania and iron oxide nanoparticles in the nucleus of lung epithelial cells as measured by Raman imaging and multivariate classification

Biophysical Journal

Volumn 105, Issue 2, 2013, Pages 310-319

  Ahlinder, Linnea ^a,b   Ekstrand Hammarström, Barbro ^b   Geladi, Paul ^c   Österlund, Lars ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC ION; FERRIC OXIDE; METAL NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

ARTICLE; CELL NUCLEUS; CYTOLOGY; EPITHELIUM CELL; HUMAN; LUNG; METABOLISM; MULTIVARIATE ANALYSIS; RAMAN SPECTROMETRY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; ULTRASTRUCTURE;

BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL NUCLEUS; EPITHELIAL CELLS; FERRIC COMPOUNDS; HUMANS; LUNG; METAL NANOPARTICLES; MULTIVARIATE ANALYSIS; SPECTRUM ANALYSIS, RAMAN; TITANIUM;

EID: 84880390282     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2013.06.017     Document Type: Article

References (62)

1. Committee for Review of the Federal Strategy to Address Environmental, Health, and Safety Research Needs for Engineered Nanoscale Materials, Committee on Toxicology, National Research Council Review of Federal Strategy for Nanotechnology-Related Environmental, Health, and Safety Research 2009 National Academies Press Washington, DC
2. 2009. Risk Assessment of Products of Nanotechnologies. Scientific Committee on Emerging and Newly Identified Health Risks. http://ec.europa.eu/ health/ph-risk/committees/04-scenihr/docs/scenihr-o-023.pdf.
3. M.-T. Zhu, and W.-Y. Feng Z.F. Chai Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment Toxicol. Sci. 107 2009 342 351
4. G. Oberdörster, E. Oberdörster, and J. Oberdörster Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles Environ. Health Perspect. 113 2005 823 839
5. S. Hussain, J.A.J. Vanoirbeek, and P.H.M. Hoet Interactions of nanomaterials with the immune system Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 4 2012 169 183
6. Å. Gustafsson, and E. Lindstedt A. Bucht Lung exposure of titanium dioxide nanoparticles induces innate immune activation and long-lasting lymphocyte response in the Dark Agouti rat J. Immunotoxicol. 8 2011 111 121
7. J.H. Shannahan, U.P. Kodavanti, and J.M. Brown Manufactured and airborne nanoparticle cardiopulmonary interactions: a review of mechanisms and the possible contribution of mast cells Inhal. Toxicol. 24 2012 320 339
8. W. Jiang, and B.Y.S. Kim W.C.W. Chan Nanoparticle-mediated cellular response is size-dependent Nat. Nanotechnol. 3 2008 145 150
9. P. Borm, and F.C. Klaessig S. Wood Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particles Toxicol. Sci. 90 2006 23 32
10. K.W. Powers, and S.C. Brown S.M. Roberts Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation Toxicol. Sci. 90 2006 296 303
11. J. Jiang, G. Oberdörster, and P. Biswas Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies J. Nanopart. Res. 11 2008 77 89
12. B.J. Marquis, and S.A. Love C.L. Haynes Analytical methods to assess nanoparticle toxicity Analyst (Lond.) 134 2009 425 439
13. H.J. Johnston, and G.R. Hutchison V. Stone Identification of the mechanisms that drive the toxicity of TiO(2)particulates: the contribution of physicochemical characteristics Part. Fibre Toxicol. 6 2009 33
14. L. Gonzalez, D. Lison, and M. Kirsch-Volders Genotoxicity of engineered nanomaterials: a critical review Nanotoxicology 2 2008 252 273
15. J.M. Wörle-Knirsch, K. Pulskamp, and H.F. Krug Oops they did it again! Carbon nanotubes hoax scientists in viability assays Nano Lett. 6 2006 1261 1268
16. N.A. Monteiro-Riviere, A.O. Inman, and L.W. Zhang Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line Toxicol. Appl. Pharmacol. 234 2009 222 235
17. N. Lewinski, V. Colvin, and R. Drezek Cytotoxicity of nanoparticles Small 4 2008 26 49
18. J. Dorney, and F. Bonnier H.J. Byrne Identifying and localizing intracellular nanoparticles using Raman spectroscopy Analyst (Lond.) 137 2012 1111 1119
19. 2 nanoparticles in living lung epithelial cells Small 7 2011 514 523
20. C. Kendall, and M. Isabelle N. Stone Vibrational spectroscopy: a clinical tool for cancer diagnostics Analyst (Lond.) 134 2009 1029 1045
21. N. Gierlinger, T. Keplinger, and M. Harrington Imaging of plant cell walls by confocal Raman microscopy Nat. Protoc. 7 2012 1694 1708
22. J. Lindgren, and P. Uvdal V. Thiel Molecular preservation of the pigment melanin in fossil melanosomes Nat Commun 3 2012 824
23. P. Knief, and C. Clarke H.J. Byrne Raman spectroscopy - a potential platform for the rapid measurement of carbon nanotube-induced cytotoxicity Analyst (Lond.) 134 2009 1182 1191
24. C. Krafft, and T. Knetschke R. Salzer Identification of organelles and vesicles in single cells by Raman microspectroscopic mapping Vib. Spectrosc. 38 2005 85 93
25. C. Matthäus, and T. Chernenko M. Diem Label-free detection of mitochondrial distribution in cells by nonresonant Raman microspectroscopy Biophys. J. 93 2007 668 673
26. C. Krafft, B. Dietzek, and J. Popp Raman and CARS microspectroscopy of cells and tissues Analyst (Lond.) 134 2009 1046 1057
27. N.J. Everall Confocal Raman microscopy: common errors and artefacts Analyst (Lond.) 135 2010 2512 2522
28. I. Notingher, and S. Verrier L.L. Hench Spectroscopic study of human lung epithelial cells (A549) in culture: living cells versus dead cells Biopolymers 72 2003 230 240
29. B. Ekstrand-Hammarström, and C.M. Akfur A. Bucht Human primary bronchial epithelial cells respond differently to titanium dioxide nanoparticles than the lung epithelial cell lines A549 and BEAS-2B Nanotoxicology 6 2012 623 634
30. Y. Wang, and M.-T. Zhu W.Y. Feng In vitro cytotoxicity of transparent yellow iron oxide nanoparticles on human glioma cells J. Nanosci. Nanotechnol. 10 2010 8550 8555
31. M.L. Shelley, and A.J. Wagner C. Bleckmann Modeling the in vivo case with in vitro nanotoxicity data Int. J. Toxicol. 27 2008 359 367
32. Z. Li, and L. Mi J.-Y. Chen Study on the visible-light-induced photokilling effect of nitrogen-doped TiO2 nanoparticles on cancer cells Nanoscale Res. Lett. 6 2011 356
33. S. Hackenberg, and G. Friehs N. Kleinsasser Nanosized titanium dioxide particles do not induce DNA damage in human peripheral blood lymphocytes Environ. Mol. Mutagen. 52 2011 264 268
34. M. Chen, and A. von Mikecz Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles Exp. Cell Res. 305 2005 51 62
35. J.-F. Boily, and J. Lützenkirchen S. Sjöberg Modeling proton binding at the goethite (α-FeOOH)-water interface Colloids Surf. A Physicochem. Eng. Asp. 179 2001 11 27
36. P. Mäkie, and G. Westin L. Österlund Adsorption of trimethyl phosphate on maghemite, hematite, and goethite nanoparticles J. Phys. Chem. A 115 2011 8948 8959
37. M. Kosmulski, and E. Maczka J.B. Rosenholm Synthesis and characterization of goethite and goethite-hematite composite: experimental study and literature survey Adv. Colloid Interface Sci. 103 2003 57 76
38. W. Rasband ImageJ 1.44 p 1997 National Institutes of Health Bethesda, Maryland
39. M. Barker, and W. Rayens Partial least squares for discrimination J. Chemometrics 17 2003 166 173
40. 2011. SIMCA-P+ 12.0.1. Umetrics, Umea, Sweden.
41. Z.-M. Zhang, and S. Chen H. Zhou An intelligent background-correction algorithm for highly fluorescent samples in Raman spectroscopy J. Raman. Spectrosc. 41 2009 659 669
42. 2011. R Development Core Team. R: A Language and Environment for Statistical Computing 2.13.0. R Foundation for Statistical Computing, Vienna, Austria.
43. S. Wold, M. Sjöström, and L. Eriksson PLS-regression: a basic tool of chemometrics Chemometr. Intell. Lab. 58 2001 109 130
44. C. Krafft, and M.A. Diderhoshan J. Popp Crisp and soft multivariate methods visualize individual cell nuclei in Raman images of liver tissue sections Vib. Spectrosc. 55 2011 90 100
45. K. Meister, and J. Niesel M. Havenith Label-free imaging of metal-carbonyl complexes in live cells by Raman microspectroscopy Angew. Chem. Int. Ed. Engl. 49 2010 3310 3312
46. N.B. Shah, J. Dong, and J.C. Bischof Cellular uptake and nanoscale localization of gold nanoparticles in cancer using label-free confocal Raman microscopy Mol. Pharm. 8 2011 176 184
47. C. Lamprecht, and N. Gierlinger A. Ebner Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique J. Phys. Condens. Matter 24 2012 164206
48. G.J. Puppels, and J.H.F. Olminkhof J. Greve Laser irradiation and Raman spectroscopy of single living cells and chromosomes: sample degradation occurs with 514.5 nm but not with 660 nm laser light Exp. Cell Res. 195 1991 361 367
49. L.-L. Kang, and Y.-X. Huang M. Luo Confocal Raman microscopy on single living young and old erythrocytes Biopolymers 89 2008 951 959
50. N. Panté, and M. Kann Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm Mol. Biol. Cell 13 2002 425 434
51. S. Singh, and T. Shi R.P. Schins Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles Toxicol. Appl. Pharmacol. 222 2007 141 151
52. D.H.M. Dam, and J.H. Lee T.W. Odom Direct observation of nanoparticle-cancer cell nucleus interactions ACS Nano 6 2012 3318 3326
53. H.N. Yehia, and R.K. Draper P. Pantano Single-walled carbon nanotube interactions with HeLa cells J. Nanobiotechnology 5 2007 8
54. Q. Mu, and N.S. Hondow M.N. Routledge Mechanism of cellular uptake of genotoxic silica nanoparticles Part. Fibre Toxicol. 9 2012 29
55. Z. Wang, and N. Li B. Xing CuO nanoparticle interaction with human epithelial cells: cellular uptake, location, export, and genotoxicity Chem. Res. Toxicol. 25 2012 1512 1521
56. L.J. Terry, E.B. Shows, and S.R. Wente Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport Science 318 2007 1412 1416
57. S. Linse, and C. Cabaleiro-Lago K.A. Dawson Nucleation of protein fibrillation by nanoparticles Proc. Natl. Acad. Sci. USA 104 2007 8691 8696
58. W.T. Godbey, K.K. Wu, and A.G. Mikos Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery Proc. Natl. Acad. Sci. USA 96 1999 5177 5181
59. P.V. AshaRani, and G. Low Kah Mun S. Valiyaveettil Cytotoxicity and genotoxicity of silver nanoparticles in human cells ACS Nano 3 2009 279 290
60. J.A. Kim, and C. Åberg K.A. Dawson Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population Nat. Nanotechnol. 7 2012 62 68
61. J. Moger, B.D. Johnston, and C.R. Tyler Imaging metal oxide nanoparticles in biological structures with CARS microscopy Opt. Express 16 2008 3408 3419
62. K. Kneipp, and A.S. Haka M.S. Feld Surface-enhanced Raman spectroscopy in single living cells using gold nanoparticles Appl. Spectrosc. 56 2002 150 154