Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Geraets, Liesbeth ^a   Oomen, Agnes G ^a   Krystek, Petra ^b   Jacobsen, Nicklas R ^c   Wallin, Håkan ^c   Laurentie, Michel ^d   Verharen, Henny W ^a   Brandon, Esther F A ^a   de Jong, Wim H ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b PHILIPS RESEARCH LABORATORIES   (Germany)

^c NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^d FRENCH AGENCY FOR FOOD   (France)

Author keywords

Kinetics; Nanoparticles; Tissue distribution; Titanium dioxide

Indexed keywords

TITANIUM DIOXIDE NANOPARTICLE; NM 100; NM 102; NM 103; NM 104; TITANIUM DIOXIDE; UNCLASSIFIED DRUG; METAL NANOPARTICLE; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; CONTROLLED STUDY; CRYSTALLIZATION; ELIMINATION REACTION; FEMALE; GASTROINTESTINAL ABSORPTION; HALF LIFE TIME; HEART; HYDROPHOBICITY; INTRAVENOUS ADMINISTRATION; KIDNEY; LIMIT OF DETECTION; LIVER; LUNG; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; OVARY; PARTICLE SIZE; POPULATION EXPOSURE; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SPLEEN; THYMUS; TISSUE DISTRIBUTION; TOXICOKINETICS; ABSORPTION; BIOAVAILABILITY; BLOOD LEVEL; BRAIN TISSUE; GENDER; KIDNEY PARENCHYMA; LUNG PARENCHYMA; MESENTERY LYMPH NODE; SYSTEMIC CIRCULATION; TESTIS; TISSUE ELIMINATION; ANIMAL; CHEMICAL PHENOMENA; COMPARATIVE STUDY; INTRAVENOUS DRUG ADMINISTRATION; LYMPH NODE; METABOLISM; WISTAR RAT;

ANIMALIA; RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CRYSTALLIZATION; FEMALE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INJECTIONS, INTRAVENOUS; LIVER; LUNG; LYMPH NODES; MALE; METAL NANOPARTICLES; PARTICLE SIZE; RATS, WISTAR; RISK ASSESSMENT; SPLEEN; TISSUE DISTRIBUTION; TITANIUM;

EID: 84910016017     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-11-30     Document Type: Article

References (40)

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