In vitro evidence of dysregulation of blood-brain barrier function after acute and repeated/long-term exposure to TiO2 nanoparticles

Biomaterials

Volumn 33, Issue 3, 2012, Pages 886-896

  Brun, Emilie ^a,b   Carrière, Marie ^b,c   Mabondzo, Aloïse ^a  

^a SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^b DIF   (France)

^c UNIV GRENOBLE ALPES   (France)

Author keywords

ABC transporters; Blood brain barrier; Inflammation; Nanoparticles; Nanotoxicology; Titanium dioxide

Indexed keywords

BLOOD; CYTOLOGY; ENDOTHELIAL CELLS; GLYCOPROTEINS; ION BEAMS; MONOLAYERS; NANOPARTICLES; OXIDES; POLYMERASE CHAIN REACTION;

ABC TRANSPORTER; BLOOD-BRAIN BARRIER; INFLAMMATION; INFLAMMATORY RESPONSE; NANOTOXICOLOGY; PARTICLE INDUCED X-RAY EMISSION; TITANIUM DIOXIDE NANOPARTICLES; TRANSCRIPTION PROFILES;

TITANIUM DIOXIDE;

ABC TRANSPORTER; CYTOKINE; GLYCOPROTEIN P; MEMBRANE PROTEIN; METAL NANOPARTICLE; SUCROSE; TITANIUM DIOXIDE; TITANIUM DIOXIDE NANOPARTICLE; UNCLASSIFIED DRUG; VINBLASTINE; NANOPARTICLE; TITANIUM;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; ENZYME ACTIVITY; GLIA CELL; IN VITRO STUDY; INFLAMMATION; NANOTOXICOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECT; GLIA; METABOLISM; PHYSIOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

RATTUS;

ANIMALS; BLOOD-BRAIN BARRIER; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NEUROGLIA; RATS; REAL-TIME POLYMERASE CHAIN REACTION; TITANIUM;

EID: 81155135018     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.10.025     Document Type: Article

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