Mapping dynamic epithelial cell proliferative activity within the oral cavity of man: A new insight into carcinogenesis?

British Journal of Oral and Maxillofacial Surgery

Volumn 37, Issue 5, 1999, Pages 377-383

  Thomson, P J ^a   Potten, C S ^b   Appleton, D R ^c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; DNA; THYMIDINE; TRITIUM;

ARTICLE; CARCINOGENESIS; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LABELING INDEX; MAJOR CLINICAL STUDY; MOUTH CAVITY; MOUTH MUCOSA; PALATE; TONGUE;

EID: 0032709289     PISSN: 02664356     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjom.1999.0130     Document Type: Article

References (19)

1. Brown A E, Langdon J D. Management of oral cancer. Ann R Coll Surg Engl 1995; 77: 404-408.
2. Mashberg A. Clinical features of oral malignancy in relation to prognosis. In: Mackenzie I C, Dabelsteen E, Squier C A, eds. Oral Premalignancy. Iowa, USA: University of Iowa Press, 1980: 292-303.
3. Cawson R A, Langdon J D, Eveson J W. Surgical Pathology of the Mouth and Jaws. Oxford: Butterworth-Heinemann, 1996.
4. Hume W J. Changing concepts of oral epithelium: discussion paper. J R Soc Med 1991; 84: 92-94.
5. Thomson P J. An investigation into oral epithelial cell activity and the pathogenesis of oral squamous cell carcinoma. PhD Thesis, University of Manchester, 1997.
6. Hume W J, Thompson J. Double labelling of cells with tritiated thymidine and bromodeoxyuridine reveals a circadian rhythm-dependent variation in duration of DNA synthesis and S phase flux rates in rodent oral epithelium. Cell Tissue Kinet 1990; 23: 313-323.
7. Hill M W. Cell renewal in oral epithelia. In: Meyer J, Squier C A, Gerson S J, eds. Structure and Function of Oral Mucosa. Oxford: Pergamon Press, 1984: 53-81.
8. Kellett M, Hume W J, Potten C S. A topographical study of the circadian rhythm in labelling index of mouse gingival and floor of mouth epithelium, including changes in labelling activity with individual cell position on the epithelial ridges. Arch Oral Biol 1989; 34: 321-328.
9. Caffesse R G, Nasjlet C E, Kowalski C J. Carrageenan-induced inflammation and its effects on mitotic activity and keratinisation of gingival epithelium. A histological and autoradiographic study. J Periodontol 1984; 56: 132-138.
10. Meyer J, Marwah A S, Weinmann J P. Mitotic rate of gingival epithelium in two age groups. J Invest Dermatol 1956; 27: 237-247.
11. Soni N N, Silberkweit M, Stricker E. Pattern of mitotic activity and cell densities in human gingival epithelium. J Periodontol 1965; 36: 15-21.
12. Kaidbey K H, Kurban A K. Mitotic behaviour of the buccal mucosal epithelium in psoriasis. Br J Dermatol 1971; 85: 162-166.
13. Alvares O, Skougaard M R, Pindborg J J, Roed-Peterson B. In vitro incorporation of tritiated thymidine in oral homogeneous leukoplakias. Scand J Dent Res 1972; 80: 510-514.
14. Maidhof R, Hornstein O P. Autoradiographic study on some proliferative properties of human buccal mucosa. Arch Dermatol Res 1979; 265: 165-172.
15. Warnakulasuriya K A A S, MacDonald D G. Diurnal variation in labelling index in human buccal epithelium. Arch Oral Biol 1993; 38: 1107-1111.
16. Warnakulasuriya K A A S, MacDonald D G. The influence of rate of cell entry to S phase of the labelling index of human buccal epithelium. Arch Oral Biol 1995; 40: 107-110.
17. Mashberg A, Meyers H. Anatomical site and size of 222 early asymptomatic oral squamous cell carcinomas. Cancer 1976; 37:2149-2157.
18. Wright N, Alison M. The Biology of Epithelial Cell Populations, Vol 1. Oxford: Clarendon Press, 1984.
19. Wardley A M, Booth D, Roberts S A, Scarffe J, Potten C S. A quantitative histometric murine in vivo model of radiation-induced oral mucositis. Arch Oral Biol 1998; 43: 567-577.