A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: Relevance to the pathogenesis of ALS

Human Molecular Genetics

Volumn 24, Issue 12, 2015, Pages 3427-3439

  Nagano, Seiichi ^a   Takahashi, Yoko ^a   Yamamoto, Kazuhiro ^a   Masutani, Hiroshi ^b   Fujiwara, Noriko ^c   Urushitani, Makoto ^d   Araki, Toshiyuki ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

^d KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; THIOREDOXIN; COPPER ZINC SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL ANALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CU ZN SUPEROXIDE DISMUTASE GENE; DISEASE COURSE; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; HUMAN; IN VIVO STUDY; MOLECULAR WEIGHT; MOTONEURON; MOUSE; MSOD1 MOUSE; MUTATOR GENE; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; SPINAL CORD; TRANSGENE; TRANSGENIC MOUSE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; DISEASE MODEL; EXERCISE; GENE DOSAGE; GENETICS; METABOLISM; MORTALITY; MUTATION; OXIDATION REDUCTION REACTION; PATHOLOGY; PROTEIN FOLDING; PROTEINOSIS;

MUS; MUS MUSCULUS;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CYSTEINE; DISEASE MODELS, ANIMAL; GENE DOSAGE; HUMANS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; OXIDATION-REDUCTION; PHENOTYPE; PHYSICAL EXERTION; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN CONFORMATION; PROTEIN FOLDING; SPINAL CORD; SUPEROXIDE DISMUTASE; TRANSGENES;

EID: 84930466683     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv093     Document Type: Article

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