Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS

Journal of Neurochemistry

Volumn 113, Issue 5, 2010, Pages 1188-1199

  Gros Louis, Francois ^a   Soucy, Geneviève ^a   Larivière, Roxanne ^a   Julien, Jean Pierre ^a  

^a Université Laval   (Canada)

Author keywords

Amyotrophic lateral sclerosis; Immunotherapy; Misfolded SOD1; Monoclonal antibody; Passive immunization; Superoxide dismutase 1

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A5C3; MONOCLONAL ANTIBODY B8H10; MONOCLONAL ANTIBODY D3H5; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; GENE MUTATION; GENETIC ASSOCIATION; IMMUNOGENICITY; IMMUNOTHERAPY; LIFESPAN; MOLECULAR SIZE; MORTALITY; MOUSE; NEUROPROTECTION; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; SPINAL CORD; TRANSGENIC MOUSE; TREATMENT DURATION; WILD TYPE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; DISEASE PROGRESSION; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IMMUNOTHERAPY; INJECTIONS, INTRAVENTRICULAR; METALS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PROTEIN FOLDING; SUPEROXIDE DISMUTASE;

MUS;

EID: 77951924183     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06683.x     Document Type: Article

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