Monomerized Cu,Zn-superoxide dismutase induces oxidative stress through aberrant Cu binding

Free Radical Biology and Medicine

Volumn 48, Issue 7, 2010, Pages 945-952

  Kishigami, Hitoshi ^a   Nagano, Seiichi ^a   Bush, Ashley I ^b   Sakoda, Saburo ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

ALS; Copper; Free radicals; Monomer; SOD1; Thiol oxidation

Indexed keywords

COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; CUPRIC ION; CYSTEINE; DIMER; MONOMER; THIOL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME MODIFICATION; FEMALE; GENE MUTATION; GENETIC TRANSFECTION; MOUSE; MUTATIONAL ANALYSIS; NERVE CELL; NONHUMAN; OXIDATION KINETICS; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; TOXICITY; WILD TYPE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL LINE, TUMOR; CHROMATOGRAPHY, AFFINITY; CROSS-LINKING REAGENTS; FEMALE; HAPLORHINI; HUMANS; HYDROGEN PEROXIDE; MALEIMIDES; MASS SPECTROMETRY; MICE; NEURONS; OVARY; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SUPEROXIDE DISMUTASE;

MUS;

EID: 77249126861     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.01.008     Document Type: Article

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