Disulfide Scrambling in Superoxide Dismutase 1 Reduces Its Cytotoxic Effect in Cultured Cells and Promotes Protein Aggregation

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Leinartaite, Lina ^a   Johansson, Ann Sofi ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; DISULFIDE; ENZYME VARIANT; OLIGOMER; ZINC ION;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CELL DEATH; CONTROLLED STUDY; COPPER METABOLISM; CYTOTOXICITY; DEGENERATIVE DISEASE; DISULFIDE BOND; DISULFIDE SCRAMBLING; ENZYME STABILITY; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; NEUROBLASTOMA CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MISFOLDING; PROTEIN POLYMORPHISM; WILD TYPE;

ACETAMIDES; APOENZYMES; CELL LINE, TUMOR; CELL SURVIVAL; CYSTEINE; CYTOTOXINS; DISULFIDES; ENZYME STABILITY; HUMANS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SESQUITERPENES; SOLUBILITY; SUPEROXIDE DISMUTASE; THIAZOLES;

EID: 84885443699     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078060     Document Type: Article

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