-
1
-
-
33750731675
-
100 years and counting: Prospects for defeating Alzheimer's disease
-
Roberson ED, Mucke L. 100 years and counting: prospects for defeating Alzheimer's disease. Science 2006; 314(5800):781-4
-
(2006)
Science
, vol.314
, Issue.5800
, pp. 781-784
-
-
Roberson, E.D.1
Mucke, L.2
-
2
-
-
84886600387
-
Therapeutics of Alzheimer's disease: Past, present and future
-
Anand R, Gill KD, Mahdi AA. Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology 2014;76(Part A):27-50
-
(2014)
Neuropharmacology
, vol.76
, pp. 27-50
-
-
Anand, R.1
Gill, K.D.2
Mahdi, A.A.3
-
3
-
-
84862806815
-
Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors
-
Tayeb HO, Yang HD, Price BH, et al. Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors. Pharmacol Ther 2012;134(1):8-25
-
(2012)
Pharmacol Ther
, vol.134
, Issue.1
, pp. 8-25
-
-
Tayeb, H.O.1
Yang, H.D.2
Price, B.H.3
-
4
-
-
3943092621
-
Pathways towards and away from Alzheimer's disease
-
Mattson MP. Pathways towards and away from Alzheimer's disease. Nature 2004; 430(7000):631-9
-
(2004)
Nature
, vol.430
, Issue.7000
, pp. 631-639
-
-
Mattson, M.P.1
-
6
-
-
79958252464
-
The cholinergic hypothesis of cognitive aging revisited again: Cholinergic functional compensation
-
Dumas JA, Newhouse PA. The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation. Pharmacol Biochem Behav 2011;99(2): 254-61
-
(2011)
Pharmacol Biochem Behav
, vol.99
, Issue.2
, pp. 254-261
-
-
Dumas, J.A.1
Newhouse, P.A.2
-
7
-
-
84871660406
-
Pathogenesis and disease-modifying therapy in Alzheimer's disease: The flat line of progress
-
Castellani RJ, Perry G. Pathogenesis and disease-modifying therapy in Alzheimer's disease: the flat line of progress. Arch Med Res 2012;43(8):694-8
-
(2012)
Arch Med Res
, vol.43
, Issue.8
, pp. 694-698
-
-
Castellani, R.J.1
Perry, G.2
-
8
-
-
84880702377
-
Amyloid b, glutamate, excitotoxicity in Alzheimer's disease: Are we on the right track?
-
Esposito Z, Belli L, Toniolo S, et al. Amyloid b, glutamate, excitotoxicity in Alzheimer's disease: are we on the right track? CNS Neurosci Ther 2013;19(8): 549-55
-
(2013)
CNS Neurosci Ther
, vol.19
, Issue.8
, pp. 549-555
-
-
Esposito, Z.1
Belli, L.2
Toniolo, S.3
-
9
-
-
79957803165
-
Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: A randomised, placebo-controlled phase 2 trial
-
Piette F, Belmin J, Vincent H, et al. Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial. Alzheimers. Res Ther 2011; 3(2):16
-
(2011)
Alzheimers. Res Ther
, vol.3
, Issue.2
, pp. 16
-
-
Piette, F.1
Belmin, J.2
Vincent, H.3
-
10
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991;12(10):383-8
-
(1991)
Trends Pharmacol Sci
, vol.12
, Issue.10
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
11
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992;256(5054):184-5
-
(1992)
Science
, vol.256
, Issue.5054
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
12
-
-
84907512825
-
A critical analysis of the amyloid cascade hypothesis
-
Armstrong RA. A critical analysis of the "amyloid cascade hypothesis". Folia Neuropathol 2014;52(3):211-25
-
(2014)
Folia Neuropathol
, vol.52
, Issue.3
, pp. 211-225
-
-
Armstrong, R.A.1
-
13
-
-
84872730067
-
Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis-But what lies beyond?
-
Mullane K, Williams M. Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis-But what lies beyond? Biochem Pharmacol 2014;85(3):289-305
-
(2014)
Biochem Pharmacol
, vol.85
, Issue.3
, pp. 289-305
-
-
Mullane, K.1
Williams, M.2
-
14
-
-
77953518555
-
Alzheimer's disease: Clinical trials and drug development
-
Mangialasche F, Solomon A, Winblad B, et al. Alzheimer's disease: clinical trials and drug development. Lancet Neurol 2010; 9(7):702-16
-
(2010)
Lancet Neurol
, vol.9
, Issue.7
, pp. 702-716
-
-
Mangialasche, F.1
Solomon, A.2
Winblad, B.3
-
15
-
-
84895729886
-
Clinical trials and late-stage drug development for Alzheimer's disease: An appraisal from 1984 to 2014
-
Schneider LS, Mangialasche F, Andreasen N, et al. Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014. J Intern Med 2014;275(3):251-83
-
(2014)
J Intern Med
, vol.275
, Issue.3
, pp. 251-283
-
-
Schneider, L.S.1
Mangialasche, F.2
Andreasen, N.3
-
16
-
-
84876925888
-
The case for soluble A oligomers as a drug target in Alzheimer's disease
-
Hefti F, Goure WF, Jerecic J, et al. The case for soluble A oligomers as a drug target in Alzheimer's disease. Trends Pharmacol Sci 2013;34(5):261-6
-
(2013)
Trends Pharmacol Sci
, vol.34
, Issue.5
, pp. 261-266
-
-
Hefti, F.1
Goure, W.F.2
Jerecic, J.3
-
17
-
-
0030758647
-
Mother's legacy: Mitochondrial DNA mutations and Alzheimer's disease
-
Mattson MP. Mother's legacy: mitochondrial DNA mutations and Alzheimer's disease. Trends Neurosci 1997; 20(9):373-5
-
(1997)
Trends Neurosci
, vol.20
, Issue.9
, pp. 373-375
-
-
Mattson, M.P.1
-
18
-
-
84860210262
-
Mitochondria and cell bioenergetics: Increasingly recognized components and a possible etiologic cause of Alzheimer's disease
-
Swerdlow RH. Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease. Antioxid Redox Signal 2012;16(12):1434-55
-
(2012)
Antioxid Redox Signal
, vol.16
, Issue.12
, pp. 1434-1455
-
-
Swerdlow, R.H.1
-
19
-
-
77957898888
-
How does diabetes accelerate Alzheimer disease pathology?
-
Sims-Robinson C, Kim B, Rosko A, et al. How does diabetes accelerate Alzheimer disease pathology? Nat Rev Neurol 2010; 6(10):551-9
-
(2010)
Nat Rev Neurol
, vol.6
, Issue.10
, pp. 551-559
-
-
Sims-Robinson, C.1
Kim, B.2
Rosko, A.3
-
20
-
-
62349114515
-
Screening of innate immune receptors in neurodegenerative diseases: A similar pattern
-
Letiembre M, Liu Y, Walter S, et al. Screening of innate immune receptors in neurodegenerative diseases: a similar pattern. Neurobiol Aging 2009;30(5):759-68
-
(2009)
Neurobiol Aging
, vol.30
, Issue.5
, pp. 759-768
-
-
Letiembre, M.1
Liu, Y.2
Walter, S.3
-
21
-
-
84883766647
-
Mast cells on the mind: New insights and opportunities
-
Silver R, Curley JP. Mast cells on the mind: New insights and opportunities. Trends Neurosci 2013;36(9):513-21
-
(2013)
Trends Neurosci
, vol.36
, Issue.9
, pp. 513-521
-
-
Silver, R.1
Curley, J.P.2
-
22
-
-
84921868191
-
Mast cells in human health and disease
-
Debruin EJ, Gold M, Lo BC, et al. Mast cells in human health and disease. Methods Mol Biol 2015;1220:93-119
-
(2015)
Methods Mol Biol
, vol.1220
, pp. 93-119
-
-
Debruin, E.J.1
Gold, M.2
Lo, B.C.3
-
23
-
-
0036789977
-
Mast cells: New targets for multiple sclerosis therapy?
-
Zappulla JP, Arock M, Mars LT, et al. Mast cells: new targets for multiple sclerosis therapy? J Neuroimmunol 2002;131(1-2): 5-20
-
(2002)
J Neuroimmunol
, vol.131
, Issue.1-2
, pp. 5-20
-
-
Zappulla, J.P.1
Arock, M.2
Mars, L.T.3
-
24
-
-
84875544697
-
Mast cells and inflammation
-
Frenzel L, Hermine O. Mast cells and inflammation. Jt Bone Spine 2013;80(2): 141-5
-
(2013)
Jt Bone Spine
, vol.80
, Issue.2
, pp. 141-145
-
-
Frenzel, L.1
Hermine, O.2
-
25
-
-
82955198480
-
New insights into the role of mast cells in autoimmunity: Evidence for a common mechanism of action?
-
Walker ME, Hatfield JK, Brown MA. New insights into the role of mast cells in autoimmunity: Evidence for a common mechanism of action? Biochim Biophys Acta Mol Basis Dis 2012;1822(1):57-65
-
(2012)
Biochim Biophys Acta Mol Basis Dis
, vol.1822
, Issue.1
, pp. 57-65
-
-
Walker, M.E.1
Hatfield, J.K.2
Brown, M.A.3
-
26
-
-
84864765533
-
Microglia and mast cells: Two tracks on the road to neuroinflammation
-
Skaper SD, Giusti P, Facci L. Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J 2012;26(8): 3103-17
-
(2012)
FASEB J
, vol.26
, Issue.8
, pp. 3103-3117
-
-
Skaper, S.D.1
Giusti, P.2
Facci, L.3
-
27
-
-
0030047921
-
Mast cell activation causes delayed neurodegeneration in mixed hippocampal cultures via the nitric oxide pathway
-
Skaper SD, Facci L, Romanello S, et al. Mast cell activation causes delayed neurodegeneration in mixed hippocampal cultures via the nitric oxide pathway. J Neurochem 1996;66(3):1157-66
-
(1996)
J Neurochem
, vol.66
, Issue.3
, pp. 1157-1166
-
-
Skaper, S.D.1
Facci, L.2
Romanello, S.3
-
28
-
-
84910621430
-
Targeting TNF: A therapeutic strategy for Alzheimer's disease
-
Cheng X, Shen Y, Li R. Targeting TNF: a therapeutic strategy for Alzheimer's disease. Drug Discov Today 2014;19(11): 1822-7
-
(2014)
Drug Discov Today
, vol.19
, Issue.11
, pp. 1822-1827
-
-
Cheng, X.1
Shen, Y.2
Li, R.3
-
30
-
-
84859917147
-
IL-33/ST2 axis in inflammation and immunopathology
-
Milovanovic M, Volarevic V, Radosavljevic G, et al. IL-33/ST2 axis in inflammation and immunopathology. Immunol Res 2012;52(1-2):89-99
-
(2012)
Immunol Res
, vol.52
, Issue.1-2
, pp. 89-99
-
-
Milovanovic, M.1
Volarevic, V.2
Radosavljevic, G.3
-
31
-
-
28444497136
-
The majority of brain mast cells in B10.PL mice is present in the hippocampal formation
-
Hendrix S, Warnke K, Siebenhaar F, et al. The majority of brain mast cells in B10.PL mice is present in the hippocampal formation. Neurosci Lett 2006;392(3):174-7
-
(2006)
Neurosci Lett
, vol.392
, Issue.3
, pp. 174-177
-
-
Hendrix, S.1
Warnke, K.2
Siebenhaar, F.3
-
34
-
-
84864472777
-
Targeting c-kit in the therapy of mast cell disorders: Current update
-
El-Agamy DS. Targeting c-kit in the therapy of mast cell disorders: Current update. Eur J Pharmacol 2012;690(1-3):1-3
-
(2012)
Eur J Pharmacol
, vol.690
, Issue.1-3
, pp. 1-3
-
-
El-Agamy, D.S.1
-
35
-
-
84867718489
-
Stem cell factor receptor/c-Kit: From basic science to clinical implications
-
Lennartsson J, Ronnstrand L. Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev 2012; 92(4):1619-49
-
(2012)
Physiol Rev
, vol.92
, Issue.4
, pp. 1619-1649
-
-
Lennartsson, J.1
Ronnstrand, L.2
-
37
-
-
34447531743
-
Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor
-
Yuzawa S, Opatowsky Y, Zhang Z, et al. Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor. Cell 2007;130(2):323-34
-
(2007)
Cell
, vol.130
, Issue.2
, pp. 323-334
-
-
Yuzawa, S.1
Opatowsky, Y.2
Zhang, Z.3
-
38
-
-
70349326733
-
Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain
-
Paulhe F, Wehrle-Haller M, Jacquier MC, et al. Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain. FASEB J 2009; 23(9):3037-48
-
(2009)
FASEB J
, vol.23
, Issue.9
, pp. 3037-3048
-
-
Paulhe, F.1
Wehrle-Haller, M.2
Jacquier, M.C.3
-
39
-
-
0042357240
-
Structure of a c-Kit product complex reveals the basis for kinase transactivation
-
Mol CD, Lim KB, Sridhar V, et al. Structure of a c-Kit product complex reveals the basis for kinase transactivation. J Biol Chem 2003;278(34):31461-4
-
(2003)
J Biol Chem
, vol.278
, Issue.34
, pp. 31461-31464
-
-
Mol, C.D.1
Lim, K.B.2
Sridhar, V.3
-
40
-
-
25844507795
-
Signaling by Kit protein - Tyrosine kinase - The stem cell factor receptor
-
Roskoski R. Signaling by Kit protein-tyrosine kinase - The stem cell factor receptor. Biochem Biophys Res Commun 2005;337(1):1-13
-
(2005)
Biochem Biophys Res Commun
, vol.337
, Issue.1
, pp. 1-13
-
-
Roskoski, R.1
-
41
-
-
27744551009
-
Structure and regulation of Kit protein - Tyrosine kinase - The stem cell factor receptor
-
Roskoski R. Structure and regulation of Kit protein-tyrosine kinase-the stem cell factor receptor. Biochem Biophys Res Commun 2005;338(3):1307-15
-
(2005)
Biochem Biophys Res Commun
, vol.338
, Issue.3
, pp. 1307-1315
-
-
Roskoski, R.1
-
42
-
-
84907046660
-
Tyrosine kinase inhibitors in the treatment of unresectable or metastatic gastrointestinal stromal tumors
-
Nishida T, Doi T, Naito Y. Tyrosine kinase inhibitors in the treatment of unresectable or metastatic gastrointestinal stromal tumors. Expert Opin Pharmacother 2014; 15(14):1979-89
-
(2014)
Expert Opin Pharmacother
, vol.15
, Issue.14
, pp. 1979-1989
-
-
Nishida, T.1
Doi, T.2
Naito, Y.3
-
43
-
-
84908371590
-
Advances in kinase targeting: Current clinical use and clinical trials
-
Rask-Andersen M, Zhang J, Fabbro D, et al. Advances in kinase targeting: current clinical use and clinical trials. Trends Pharmacol Sci 2014;35(11):604-20
-
(2014)
Trends Pharmacol Sci
, vol.35
, Issue.11
, pp. 604-620
-
-
Rask-Andersen, M.1
Zhang, J.2
Fabbro, D.3
-
44
-
-
84888246576
-
Imatinib mesylate: An innovation in treatment of autoimmune diseases
-
Azizi G, Mirshafiey A. Imatinib mesylate: an innovation in treatment of autoimmune diseases. Recent Pat Inflamm Allergy Drug Discov 2013;7(3):259-67
-
(2013)
Recent Pat Inflamm Allergy Drug Discov
, vol.7
, Issue.3
, pp. 259-267
-
-
Azizi, G.1
Mirshafiey, A.2
-
45
-
-
80755125565
-
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
-
Anastassiadis T, Deacon SW, Devarajan K, et al. Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol 2011; 29(11):1039-45
-
(2011)
Nat Biotechnol
, vol.29
, Issue.11
, pp. 1039-1045
-
-
Anastassiadis, T.1
Deacon, S.W.2
Devarajan, K.3
-
46
-
-
70349658639
-
Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
-
Dubreuil P, Letard S, Ciufolini M, et al. Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT. PLoS ONE 2009;4(9):e7258
-
(2009)
PLoS ONE
, vol.4
, Issue.9
, pp. e7258
-
-
Dubreuil, P.1
Letard, S.2
Ciufolini, M.3
-
47
-
-
84901627239
-
Masitinib (AB1010), from canine tumor model to human clinical development: Where we are?
-
Marech I, Patruno R, Zizzo N, et al. Masitinib (AB1010), from canine tumor model to human clinical development: Where we are? Crit Rev Oncol Hematol 2014;91(1):98-111
-
(2014)
Crit Rev Oncol Hematol
, vol.91
, Issue.1
, pp. 98-111
-
-
Marech, I.1
Patruno, R.2
Zizzo, N.3
-
48
-
-
79952763618
-
Differential properties of current tyrosine kinase inhibitors in gastrointestinal stromal tumors
-
Demetri GD. Differential properties of current tyrosine kinase inhibitors in gastrointestinal stromal tumors. Semin Oncol 2011;38:S10-19
-
(2011)
Semin Oncol
, vol.38
, pp. S10-19
-
-
Demetri, G.D.1
-
49
-
-
77953048032
-
Safety and activity of masitinib in combination with gemcitabine in patients with advanced pancreatic cancer
-
Mitry E, Hammel P, Deplanque G, et al. Safety and activity of masitinib in combination with gemcitabine in patients with advanced pancreatic cancer. Cancer Chemother Pharmacol 2010;66(2):394-403
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, Issue.2
, pp. 394-403
-
-
Mitry, E.1
Hammel, P.2
Deplanque, G.3
-
50
-
-
84908396110
-
Impact of mast cells on multiple sclerosis: Inhibitory effect of natalizumab
-
Kritas SK, Saggini A, Cerulli G, et al. Impact of mast cells on multiple sclerosis: inhibitory effect of natalizumab. Int J Immunopathol Pharmacol 2014;27(3):331-5
-
(2014)
Int J Immunopathol Pharmacol
, vol.27
, Issue.3
, pp. 331-335
-
-
Kritas, S.K.1
Saggini, A.2
Cerulli, G.3
-
52
-
-
67650468281
-
Amyloid beta peptides trigger CD47-dependent mast cell secretory and phagocytic responses
-
Niederhoffer N, Levy R, Sick E, et al. Amyloid beta peptides trigger CD47-dependent mast cell secretory and phagocytic responses. Int J Immunopathol Pharmacol 2009;22(2):473-83
-
(2009)
Int J Immunopathol Pharmacol
, vol.22
, Issue.2
, pp. 473-483
-
-
Niederhoffer, N.1
Levy, R.2
Sick, E.3
-
53
-
-
34548299902
-
Distribution of tryptase-containing mast cells and metallothionein reactive astrocytes in human brains with amyloid deposits
-
Maslinska D, Laure-Kamionowska M, Maslinski KT, et al. Distribution of tryptase-containing mast cells and metallothionein reactive astrocytes in human brains with amyloid deposits. Inflamm Res 2007;56(Suppl 1):S17-18
-
(2007)
Inflamm Res
, vol.56
, pp. S17-18
-
-
Maslinska, D.1
Laure-Kamionowska, M.2
Maslinski, K.T.3
-
54
-
-
0027447602
-
The protein tyrosine kinase, fyn, in Alzheimer's disease pathology
-
Shirazi SK, Wood JG. The protein tyrosine kinase, fyn, in Alzheimer's disease pathology. Neuroreport 1993;4(4):435-7
-
(1993)
Neuroreport
, vol.4
, Issue.4
, pp. 435-437
-
-
Shirazi, S.K.1
Wood, J.G.2
-
55
-
-
12144288564
-
Phosphorylation of tau by fyn: Implications for Alzheimer's disease
-
Lee G, Thangavel R, Sharma VM, et al. Phosphorylation of tau by fyn: implications for Alzheimer's disease. J Neurosci 2004; 24(9):2304-12
-
(2004)
J Neurosci
, vol.24
, Issue.9
, pp. 2304-2312
-
-
Lee, G.1
Thangavel, R.2
Sharma, V.M.3
-
56
-
-
84861980282
-
Masitinib treatment in patients with progressive multiple sclerosis: A randomized pilot study
-
Vermersch P, Benrabah R, Schmidt N, et al. Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study. BMC Neurol 2012;12:36
-
(2012)
BMC Neurol
, vol.12
, pp. 36
-
-
Vermersch, P.1
Benrabah, R.2
Schmidt, N.3
-
57
-
-
77951878436
-
Phase II study of oral masitinib mesilate in imatinib-näve patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST)
-
Le Cesne A, Blay JY, Bui BN, et al. Phase II study of oral masitinib mesilate in imatinib-näve patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST). Eur J Cancer 2010;46(8):1344-51
-
(2010)
Eur J Cancer
, vol.46
, Issue.8
, pp. 1344-1351
-
-
Le Cesne, A.1
Blay, J.Y.2
Bui, B.N.3
-
58
-
-
84906847643
-
Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: A randomized controlled open-label trial
-
Adenis A, Blay JY, Bui-Nguyen B, et al. Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: a randomized controlled open-label trial. Ann Oncol 2014;25(9): 1762-9
-
(2014)
Ann Oncol
, vol.25
, Issue.9
, pp. 1762-1769
-
-
Adenis, A.1
Blay, J.Y.2
Bui-Nguyen, B.3
-
59
-
-
84908015088
-
TNF and. TNF-receptors: From mediators of cell death and inflammation to therapeutic giants-past, present and future
-
Sedger LM, McDermott MF. TNF and. TNF-receptors: From mediators of cell death and inflammation to therapeutic giants-past, present and future. Cytokine Growth Factor Rev 2014;25(4):453-72
-
(2014)
Cytokine Growth Factor Rev
, vol.25
, Issue.4
, pp. 453-472
-
-
Sedger, L.M.1
McDermott, M.F.2
-
60
-
-
67649890634
-
Masitinib in the treatment of active rheumatoid arthritis: Results of a multicentre, open-label, dose-ranging, phase 2a study
-
Tebib J, Mariette X, Bourgeois P, et al. Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study. Arthritis Res Ther 2009; 11(3):R95
-
(2009)
Arthritis Res Ther
, vol.11
, Issue.3
, pp. R95
-
-
Tebib, J.1
Mariette, X.2
Bourgeois, P.3
-
63
-
-
67650314629
-
Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics
-
Humbert M, De Blay F, Garcia G, et al. Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics. Allergy Eur J Allergy Clin Immunol 2009; 64(8):1194-201
-
(2009)
Allergy Eur J Allergy Clin Immunol
, vol.64
, Issue.8
, pp. 1194-1201
-
-
Humbert, M.1
De Blay, F.2
Garcia, G.3
-
64
-
-
78649504351
-
Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: A phase 2a study
-
Paul C, Sans B, Suarez F, et al. Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: A phase 2a study. Am J Hematol 2010;85(12):921-5
-
(2010)
Am J Hematol
, vol.85
, Issue.12
, pp. 921-925
-
-
Paul, C.1
Sans, B.2
Suarez, F.3
-
65
-
-
84883238548
-
Overview and management of cardiac adverse events associated with tyrosine kinase inhibitors
-
Lenihan DJ, Kowey PR. Overview and management of cardiac adverse events associated with tyrosine kinase inhibitors. Oncologist 2013;18(8):900-8
-
(2013)
Oncologist
, vol.18
, Issue.8
, pp. 900-908
-
-
Lenihan, D.J.1
Kowey, P.R.2
-
66
-
-
68949166379
-
Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers
-
Soria JC, Massard C, Magne N, et al. Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers. Eur J Cancer 2009;45(13):2333-41
-
(2009)
Eur J Cancer
, vol.45
, Issue.13
, pp. 2333-2341
-
-
Soria, J.C.1
Massard, C.2
Magne, N.3
-
67
-
-
0036138048
-
Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: Involvement of Src family protein kinases
-
Williamson R, Scales T, Clark BR, et al. Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases. J Neurosci 2002;22(1):10-20
-
(2002)
J Neurosci
, vol.22
, Issue.1
, pp. 10-20
-
-
Williamson, R.1
Scales, T.2
Clark, B.R.3
-
68
-
-
0030060636
-
Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor
-
Yasunaga M, Yagi T, Hanzawa N, et al. Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor. J Cell Biol 1996;132(1-2):91-9
-
(1996)
J Cell Biol
, vol.132
, Issue.1-2
, pp. 91-99
-
-
Yasunaga, M.1
Yagi, T.2
Hanzawa, N.3
-
69
-
-
0037107424
-
Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase
-
Sette C, Paronetto MP, Barchi M, et al. Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase. EMBO J 2002;21(20): 5386-95
-
(2002)
EMBO J
, vol.21
, Issue.20
, pp. 5386-5395
-
-
Sette, C.1
Paronetto, M.P.2
Barchi, M.3
-
70
-
-
84865403573
-
Role of cell cycle re-entry in neurons: A common apoptotic mechanism of neuronal cell death
-
Folch J, Junyent F, Verdaguer E, et al. Role of cell cycle re-entry in neurons: A common apoptotic mechanism of neuronal cell death. Neurotox Res 2012;22(3):195-207
-
(2012)
Neurotox Res
, vol.22
, Issue.3
, pp. 195-207
-
-
Folch, J.1
Junyent, F.2
Verdaguer, E.3
-
71
-
-
84877879701
-
Amyloid-b signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease
-
Seward ME, Swanson E, Norambuena A, et al. Amyloid-b signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease. J Cell Sci 2013; 126(Pt 5):1278-86
-
(2013)
J Cell Sci
, vol.126
, pp. 1278-1286
-
-
Seward, M.E.1
Swanson, E.2
Norambuena, A.3
-
72
-
-
78650914558
-
Tubulin-independent tau in Alzheimer's disease and cancer: Implications for disease pathogenesis and treatment
-
Souter S, Lee G. Tubulin-independent tau in Alzheimer's disease and cancer: implications for disease pathogenesis and treatment. Curr Alzheimer Res 2010;7(8): 697-707
-
(2010)
Curr Alzheimer Res
, vol.7
, Issue.8
, pp. 697-707
-
-
Souter, S.1
Lee, G.2
-
73
-
-
27144489060
-
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease
-
Chin J, Palop JJ, Puoliväli J, et al. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci 2005; 25(42):9694-703
-
(2005)
J Neurosci
, vol.25
, Issue.42
, pp. 9694-9703
-
-
Chin, J.1
Palop, J.J.2
Puoliväli, J.3
-
74
-
-
84866065959
-
Alzheimer amyloid-b oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
-
Um JW, Nygaard HB, Heiss JK, et al. Alzheimer amyloid-b oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat Neurosci 2012;15(9): 1227-35
-
(2012)
Nat Neurosci
, vol.15
, Issue.9
, pp. 1227-1235
-
-
Um, J.W.1
Nygaard, H.B.2
Heiss, J.K.3
-
75
-
-
77955322042
-
Dendritic function of tau mediates amyloid-b toxicity in alzheimer's disease mouse models
-
Ittner LM, Ke YD, Delerue F, et al. Dendritic function of tau mediates amyloid-b toxicity in alzheimer's disease mouse models. Cell 2010;142(3):387-97
-
(2010)
Cell
, vol.142
, Issue.3
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
-
76
-
-
2442711560
-
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice
-
Chin J, Palop JJ, Yu GQ, et al. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Neurosci 2004; 24(19):4692-7
-
(2004)
J Neurosci
, vol.24
, Issue.19
, pp. 4692-4697
-
-
Chin, J.1
Palop, J.J.2
Yu, G.Q.3
-
77
-
-
75149170925
-
Beta-amyloid protein (25-35) disrupts hippocampal network activity: Role of Fyn-kinase
-
Penã F, Ordaz B, Balleza-Tapia H, et al. Beta-amyloid protein (25-35) disrupts hippocampal network activity: Role of Fyn-kinase. Hippocampus 2010;20(1):78-96
-
(2010)
Hippocampus
, vol.20
, Issue.1
, pp. 78-96
-
-
Penã, F.1
Ordaz, B.2
Balleza-Tapia, H.3
-
78
-
-
84884200967
-
Metabotropic glutamate receptor 5 Is a coreceptor for Alzheimer Ab oligomer bound to cellular prion protein
-
Um J, Kaufman A, Kostylev M, et al. Metabotropic glutamate receptor 5 Is a coreceptor for Alzheimer Ab oligomer bound to cellular prion protein. Neuron 2013;79(5):887-902
-
(2013)
Neuron
, vol.79
, Issue.5
, pp. 887-902
-
-
Um, J.1
Kaufman, A.2
Kostylev, M.3
-
79
-
-
84869992747
-
The Complex PrPc-Fyn Couples Human Oligomeric A with Pathological Tau Changes in Alzheimer's Disease
-
Larson M, Sherman MA, Amar F, et al. The Complex PrPc-Fyn Couples Human Oligomeric A with Pathological Tau Changes in Alzheimer's Disease. J Neurosci 2012;32(47):16857-71
-
(2012)
J Neurosci
, vol.32
, Issue.47
, pp. 16857-16871
-
-
Larson, M.1
Sherman, M.A.2
Amar, F.3
-
82
-
-
84897886749
-
Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
-
Ferreira ST, Clarke JR, Bomfim TR, et al. Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease. Alzheimer's Dement 2014; 10(Suppl 1):S76-83
-
(2014)
Alzheimer's Dement
, vol.10
, pp. S76-83
-
-
Ferreira, S.T.1
Clarke, J.R.2
Bomfim, T.R.3
-
83
-
-
84897976299
-
Microglial priming in neurodegenerative disease
-
Perry VH, Holmes C. Microglial priming in neurodegenerative disease. Nat Rev Neurol 2014;10(4):217-24
-
(2014)
Nat Rev Neurol
, vol.10
, Issue.4
, pp. 217-224
-
-
Perry, V.H.1
Holmes, C.2
-
84
-
-
84896324370
-
The role of inflammasome in Alzheimer's disease
-
Liu L, Chan C. The role of inflammasome in Alzheimer's disease. Ageing Res Rev 2014;15(1):6-15
-
(2014)
Ageing Res Rev
, vol.15
, Issue.1
, pp. 6-15
-
-
Liu, L.1
Chan, C.2
-
85
-
-
84924862476
-
Targeting microglia for the treatment of Alzheimer's disease
-
McGeer PL, McGeer EG. Targeting microglia for the treatment of Alzheimer's disease. Expert Opin Ther Targets 2015; 19(4):497-506
-
(2015)
Expert Opin Ther Targets
, vol.19
, Issue.4
, pp. 497-506
-
-
McGeer, P.L.1
McGeer, E.G.2
-
86
-
-
33847339301
-
NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
-
McGeer PL, McGeer EG. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiol Aging 2007;28(5):639-47
-
(2007)
Neurobiol Aging
, vol.28
, Issue.5
, pp. 639-647
-
-
McGeer, P.L.1
McGeer, E.G.2
-
87
-
-
84885456046
-
The amyloid cascade-inflammatory hypothesis of Alzheimer disease: Implications for therapy
-
McGeer PL, McGeer EG. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: Implications for therapy. Acta Neuropathol 2013;126(4):479-97
-
(2013)
Acta Neuropathol
, vol.126
, Issue.4
, pp. 479-497
-
-
McGeer, P.L.1
McGeer, E.G.2
-
88
-
-
0035936004
-
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
-
in t' Veld BA, Ruitenberg A, Hofman A, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001;345(21):1515-21
-
(2001)
N Engl J Med
, vol.345
, Issue.21
, pp. 1515-1521
-
-
Int'Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
-
89
-
-
0038375640
-
Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies
-
Etminan M, Gill S, Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 2003;327(7407):128
-
(2003)
BMJ
, vol.327
, Issue.7407
, pp. 128
-
-
Etminan, M.1
Gill, S.2
Samii, A.3
-
90
-
-
84861805073
-
Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease
-
Dhawan G, Combs CK. Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease. J Neuroinflammation 2012;9(1):117
-
(2012)
J Neuroinflammation
, vol.9
, Issue.1
, pp. 117
-
-
Dhawan, G.1
Combs, C.K.2
-
91
-
-
84898459097
-
The dendritic hypothesis for Alzheimer's disease pathophysiology
-
Cochran JN, Hall AM, Roberson ED. The dendritic hypothesis for Alzheimer's disease pathophysiology. Brain Res Bull 2013;103: 18-28
-
(2013)
Brain Res Bull
, vol.103
, pp. 18-28
-
-
Cochran, J.N.1
Hall, A.M.2
Roberson, E.D.3
|