Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1

Oncotarget

Volumn 5, Issue 20, 2014, Pages 10017-10033

  Nambiar, Dhanya K ^a,b   Deep, Gagan ^a,c   Singh, Rana P ^b   Agarwal, Chapla ^a,c   Agarwal, Rajesh ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

^c UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

AMPK; Chemoprevention; Lipogenesis; Phytochemicals; Prostate cancer; SREBP1

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; ANDROGEN; CHOLESTEROL; CITRIC ACID; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPID; MESSENGER RNA; METRIBOLONE; SILIBININ; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; FATOSTATIN; PYRIDINE DERIVATIVE; SILYMARIN; SREBF1 PROTEIN, HUMAN; SREBF2 PROTEIN, HUMAN; THIAZOLE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG TARGETING; HUMAN; HUMAN CELL; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; PROSTATE CANCER CELL LINE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; DRUG EFFECTS; GENETIC TRANSFECTION; MALE; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; TUMOR CELL LINE;

CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LIPID METABOLISM; MALE; METRIBOLONE; MOLECULAR TARGETED THERAPY; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; PYRIDINES; SILYMARIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; THIAZOLES; TRANSFECTION;

EID: 84930445535     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2488     Document Type: Article

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