Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness

Cell Metabolism

Volumn 19, Issue 3, 2014, Pages 393-406

  Yue, Shuhua ^a   Li, Junjie ^b   Lee, Seung Young ^a   Lee, Hyeon Jeong ^c   Shao, Tian ^d   Song, Bing ^b   Cheng, Liang ^e   Masterson, Timothy A ^e   Liu, Xiaoqi ^d,f   Ratliff, Timothy L ^c,f   Cheng, Ji Xin ^a,f  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d PURDUE UNIVERSITY   (United States)

^e INDIANA UNIVERSITY   (United States)

^f Purdue University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; ESSENTIAL FATTY ACID; FAT DROPLET; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; STEROL REGULATORY ELEMENT BINDING PROTEIN; AVASIMIBE; POLYUNSATURATED FATTY ACID;

ARTICLE; CELL LEVEL; CHOLESTEROL ESTERIFICATION; CHOLESTEROL METABOLISM; CONTROLLED STUDY; ESTERIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPOGENESIS; MALE; METASTASIS; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATITIS; TUMOR GROWTH; TUMOR INVASION; UPREGULATION; ANDROGEN SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CANCER AGGRESSIVENESS; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CHOLESTEROL SYNTHESIS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INDUCTION; GLEASON SCORE; IN VIVO STUDY; LIPID COMPOSITION; LIPID STORAGE; LNCAP CELL LINE; MOUSE; NONHUMAN; ONCOLOGICAL PARAMETERS; PROTEIN DEPLETION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RAMAN SPECTROMETRY; SINGLE CELL ANALYSIS; TUMOR XENOGRAFT;

ACETYL-COA C-ACETYLTRANSFERASE; ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CHOLESTEROL; CHOLESTEROL ESTERS; HUMANS; MALE; MICE; MICE, NUDE; PHOSPHATIDYLINOSITOL 3-KINASE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTORS, ANDROGEN; RECEPTORS, LDL; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84895741045     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.01.019     Document Type: Article

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