Silymarin prevents benzo(a)pyrene-induced toxicity in Wistar rats by modulating xenobiotic-metabolizing enzymes

Toxicology and Industrial Health

Volumn 31, Issue 6, 2015, Pages 523-541

  Kiruthiga, Pv ^a   Karthikeyan, K ^b   Archunan, G ^b   Pandian, S Karutha ^a   Devi, K Pandima ^a  

^a ALAGAPPA UNIVERSITY   (India)

^b BHARATHIDASAN UNIVERSITY   (India)

Author keywords

benzo(a)pyrene; CYP1A1; histopathology; phase II enzymes; Silymarin

Indexed keywords

BENZO[A]PYRENE; CYTOCHROME P450 1A1; ENZYME; EPOXIDE HYDROLASE; ETHOXYRESORUFIN DEETHYLASE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE; OXYGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SILYMARIN; SULFOTRANSFERASE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLUCURONIDATION; HISTOPATHOLOGY; LIVER BIOPSY; LIVER PROTECTION; LIVER TOXICITY; METABOLIC ACTIVATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; ANIMAL; DOSE RESPONSE; DRUG-INDUCED LIVER INJURY; ENZYME ACTIVATION; ENZYME REPRESSION; ENZYMOLOGY; LIVER; METABOLISM; PATHOLOGY; WISTAR RAT;

RATTUS NORVEGICUS;

ANIMALS; BENZO(A)PYRENE; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ENZYME ACTIVATION; ENZYME REPRESSION; FEMALE; LIVER; PROTECTIVE AGENTS; RATS; RATS, WISTAR; SILYMARIN;

EID: 84930434310     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233713475524     Document Type: Article

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