Primary cultures of human hepatocytes as a tool in cytotoxicity studies: Cell protection against model toxins by flavonolignans obtained from Silybum marianum

Toxicology Letters

Volumn 137, Issue 3, 2003, Pages 201-212

  Dvořák, Zdeněk ^a   Kosina, Pavel ^a   Walterová, Daniela ^a   Šimánek, Vilím ^a   Bachleda, Petr ^b   Ulrichová, Jitka ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b UNIVERSITY HOSPITAL OLOMOUC   (Czech Republic)

Author keywords

Cytoprotectivity; Cytotoxicity; Flavonolignans; Human hepatocyte; Silymarin

Indexed keywords

ALLYL ALCOHOL; ANTIOXIDANT; CARBON TETRACHLORIDE; FLAVONOLIGNAN; GALACTOSAMINE; ISOSILYBIN; LIGNAN DERIVATIVE; PARACETAMOL; SILIBININ; SILICRISTIN; SILIDIANIN; SILYMARIN; TOXIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL MEMBRANE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; LIVER CELL; MEMBRANE STABILIZATION; PRIORITY JOURNAL; SILYBUM MARIANUM;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANTIOXIDANTS; ASTERACEAE; CELL SEPARATION; CELL SURVIVAL; CELLS, CULTURED; FLAVONOIDS; FREE RADICAL SCAVENGERS; GALACTOSAMINE; HEPATOCYTES; HUMANS; L-LACTATE DEHYDROGENASE; LIGNANS; PICRATES; PLANT EXTRACTS; PROPANOLS; PROTEIN BIOSYNTHESIS; TERT-BUTYLHYDROPEROXIDE; TOXINS, BIOLOGICAL;

SILYBUM MARIANUM;

EID: 0037415383     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00406-X     Document Type: Article

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