Pyridine induction of cytochrome P450 1A1, iNOS and metallothionein in Syrian hamsters and protective effects of silymarin

Experimental and Toxicologic Pathology

Volumn 61, Issue 3, 2009, Pages 243-255

  Tunca, Recai ^a   Sozmen, Mahmut ^b   Citil, Mehmet ^c   Karapehlivan, Mahmut ^b   Erginsoy, Serpil ^b   Yapar, Kursad ^b  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

^b KAFKAS UNIVERSITY   (Turkey)

^c KAFKAS UNIVERSITY   (Turkey)

Author keywords

Cytochrome P450 1A1; Immunohistochemistry; Inducible nitric oxide synthase; Kidney; Liver; Metallothionein; Pathology; Pyridine; Silymarin; Syrian hamster

Indexed keywords

CYTOCHROME P450 1A1; INDUCIBLE NITRIC OXIDE SYNTHASE; METALLOTHIONEIN; METALLOTHIONEIN I; METALLOTHIONEIN II; NITRIC OXIDE; OXYGEN RADICAL; PYRIDINE; S 0292; SILYMARIN; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CELL SWELLING; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; HEART; HEART MUSCLE DEGENERATION; KIDNEY; KIDNEY TUBULE NECROSIS; LIVER; MALE; METABOLISM; MYOCARDIAL DISEASE; NONHUMAN; OXIDATIVE STRESS; PROTECTION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SYRIAN HAMSTER;

ANIMALS; ANTIOXIDANTS; CRICETINAE; CYTOCHROME P-450 CYP1A1; HEART; KIDNEY; LIVER; MESOCRICETUS; METALLOTHIONEIN; NITRIC OXIDE SYNTHASE TYPE II; PYRIDINES; SILYMARIN;

MESOCRICETUS AURATUS;

EID: 64749101022     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2008.05.011     Document Type: Article

References (56)

1. Agarwal R., Agarwal C., Ichikawa H., Singh R.P., and Aggarwal B.B. Anticancer potential of silymarin: from bench to bed side. Anticancer Res 26 (2006) 4457-4498
2. Al-Shabanah O.A., Alam K., Nagi M.N., Al-Rikabi A.C., and Al- Bekairi A.M. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci 66 (2000) 265-270
3. Anderson RC. 90-Day subchronic oral toxicity in rats. Test material: Pyridine. Vol. I. Report to Dynamac Corporation, Rockville, MD, by Arthur D. Little, Inc., Cambridge, MA. EPA/530/SW-88/016A. NTIS No. PB88-176136, 1987.
4. ATSDR (Agency for Toxic Substances and Disease Registry): Toxicological Profile for Pyridine (TP-91/24), 1992.
5. Bauman J.W., Liu J., Liu Y.P., and Klaassen C.D. Increase in metallothionein produced by chemicals that induce oxidative stress. Toxicol Appl Pharmacol 110 (1991) 347-354
6. Baxter J.H., and Mason M.F. Studies of the mechanisms of liver and kidney injury. IV. A comparison of the effects of pyridine and methyl pyridinium chloride in the rat. J Pharmacol Exp Ther 91 (1947) 350-356
7. Beutler E., Duran O., and Kelley B.M. Improved method for determination of blood glutathione. J Lab Clin Med 61 (1963) 882-888
8. Carlson G.P. Comparison of the effects of pyridine and its metabolites on rat liver and kidney. Toxicol Lett 85 (1996) 173-178
9. Chen R.M., Chou M.W., and Ueng T.H. Induction of cytochrome P450 1A in hamster liver and lung by 6-nitrochrysene. Arch Toxicol 72 (1998) 395-401
10. Chen R.M., and Ueng T.H. Induction of cytochromes P450 1A, 2B and 2E in hamster tissues by acetone. Arch Toxicol 71 (1997) 489-495
11. Davis S.R., and Cousins R.J. Metallothionein expression in animals: a physiological perspective on function. J Nutr 130 (2000) 1085-1088
12. Deneke S.M. Thiol-based antioxidants. Curr Top Cell Reg 36 (2000) 151-180
13. Denissenko M.F., Pao A., Tang M., and Pfeifer G.P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 274 (1996) 430-432
14. Dvorak Z., Vrzal R., and Ulrichova J. Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells. Cell Biol Toxicol 22 (2006) 81-90
15. Groves J.T., and Wang C. Nitric oxide synthase: models and mechanisms. Curr Opin Chem Biol 4 (2000) 687-695
16. Hamer D. Metallothionein. Annu Rev Biochem 55 (1986) 913-951
17. Hammond D.K., Zhu B.T., Wang M.Y., Ricci M.J., and Liehr J.G. Cytochrome P450 metabolism of estradiol in hamster liver and kidney. Toxicol Appl Pharmacol 145 (1997) 54-60
18. Hotchkiss J.A., Kim S.G., Novak R.F., and Dahl A.R. Enhanced hepatic expression of P450IIE1 following inhalation exposure to pyridine. Toxicol Appl Pharmacol 118 (1993) 98-104
19. IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. IARC Monographs, vol. 38. Tobacco Smoking (1986), IARC, Lyon, France
20. Iba M.M., Nguyen T., and Fung J. CYP1A1 induction by pyridine and its metabolites in HepG2 cells. Arch Biochem Biophys 404 (2002) 326-334
21. Ioannides C., and Parke D.V. The cytochrome P450I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab Rev 22 (1990) 1-85
22. Jimenez I., Gotteland M., Zarzuelo A., Uauy R., and Speisky H. Loss of the metal binding properties of metallothionein induced by hydrogen peroxide and free radicals. Toxicology 120 (1997) 37-46
23. Kanazawa K., Yamashita T., Ashida H., and Danno G. Antimutagenicity of flavones and flavonols to heterocyclic amines by specific and strong inhibition of the cytochrome P450 1A family. Biosci Biotechnol Biochem 62 (1998) 970-977
24. Kang J.S., Jeon Y.J., Kim H.M., Han S.H., and Yang K.H. Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. J. Pharmacol Exp Ther 302 (2002) 138-144
25. Kleman M., Overvik E., Mason G., and Gustafsson J.A. Effects of the food mutagens MeIQx and PhIP on the expression of cytochrome P450IA proteins in various tissues of male and female rats. Carcinogenesis 11 (1990) 2185-2189
26. Kondoh M., Imada N., Kamada K., Tsukahara R., Higashimoto M., Takiguchi M., et al. Property of metallothionein as a Zn pool differs depending on the induced condition of metallothionein. Toxicol Lett 142 (2003) 11-18
27. Landers J.P., and Bunce N.J. The Ah receptor and the mechanism of dioxin toxicity. Biochem J 276 (1991) 273-287
28. Lazo J.S., Kondo Y., Dellapiazza D., Michalska A.E., Choo K.H., and Pitt B.R. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J Biol Chem 270 (1995) 5506-5510
29. Lee T.Y., Mai L.M., Wang G.J., Chiu J.H., Lin Y.L., and Lin H.C. Protective mechanism of salvia miltiorrhiza on carbon tetrachloride-induced acute hepatotoxicity in rats. J Pharmacol Sci 91 (2003) 202-210
30. Lin H.L., Kent U.M., Zhang H., Waskell L., and Hollenberg P.F. Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite. Chem Res Toxicol 16 (2003) 129-136
31. Lock E.A., and Reed C.J. Xenobiotic metabolizing enzymes of the kidney. Toxicol Pathol 26 (1998) 18-25
32. 1. Toxicol Appl Pharmacol 141 (1996) 185-194
33. Miles A.T., Hawksworth G.M., Beattie J.H., and Rodilla V. Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Crit Rev Biochem Mol Biol 35 (2000) 35-70
34. Miranda K.M., Espey M.G., and Wink D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5 (2001) 62-71
35. Munday R., and Manns E. 2,3,6-Triaminopyridine, a metabolite of the urinary tract analgesic phenazopyridine, causes muscle necrosis and renal damage in rats. J Appl Toxicol 18 (1998) 161-165
36. Nakagawa I., Suzuki M., Imura N., and Naganuma A. Involvement of oxidative stress in paraquat-induced metallothionein synthesis under glutathione depletion. Free Radic Biol Med 24 (1998) 1390-1395
37. National Toxicology Program. Toxicology and carcinogenesis studies of pyridine (CAS no. 110-86-1) in F344/N rats, Wistar rats, and B6C3F1 mice (drinking water studies). Natl Toxicol Program Tech Rep Ser 470 (2000) 1-330
38. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., et al. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6 (1996) 1-42
39. Nishimura N., Yonemoto J., Nishimura H., and Tohyama C. Localization of cytochrome P450 1A1 in a specific region of hydronephrotic kidney of rat neonates lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology 227 (2006) 117-126
40. Pearce L.L., Gandley R.E., Han W., Wasserloos K., Stitt M., Kanai A.J., et al. Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein. Proc Natl Acad Sci USA 97 (2000) 477-482
41. Puntarulo S., and Cederbaum A.I. Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes. Free Radic Biol Med 24 (1998) 1324-1330
42. Rastogi R., Srivastava A.K., Srivastava M., and Rastogi A.K. Hepatocurative effect of picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in rats. Planta Med 66 (2000) 709-713
43. Saller R., Meier R., and Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs 61 (2001) 2035-2063
44. Sato M., Apostolova M.D., Hamaya M., Yamaki J., Choo K.H.A., Michalska A.E., et al. Susceptibility of metallothionein-null mice to paraquat. Environ Toxicol Pharmacol 1 (1996) 221-225
45. Sato R., and Omura T. Cytochrome P-450 (1978), Academic Press, New York and London p. 1-233
46. Schumacher J.N., Green C.R., Best F.W., and Newell M.P. Smoke composition: an extensive investigation of the water-soluble portion of cigarette smoke. J Agric Food Chem 25 (1977) 310-320
47. Schumann J., Prockl J., Kiemer A.K., Vollmar A.M., Bang R., and Tiegs G. Silibinin protects mice from T cell-dependent liver injury. J Hepatol 39 (2003) 333-340
48. Sun M., Sakakibara H., Ashida H., Danno G., and Kanazawa K. Cytochrome P4501A1-inhibitory action of antimutagenic anthraquinones in medicinal plants and the structure-activity relationship. Biosci Biotechnol Biochem 64 (2000) 1373-1378
49. Sydow G. A simplified quick method for determination of sialic acid in serum. Biomed Biochem Acta 44 (1985) 1721-1723
50. Tang Z.L., Wasserloos K.J., Liu X., Stitt M.S., Reynolds I.J., Pitt B.R., et al. Nitric oxide decreases the sensitivity of pulmonary endothelial cells to LPS-induced apoptosis in a zinc-dependent fashion. Mol Cell Biochem 234-235 (2002) 211-217
51. Tsutsumi M., Lasker J.M., Shimizu M., Rosman A.S., and Lieber C.S. The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology 10 (1989) 437-446
52. Valenzuela A., and Garrido A. Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin. Biol Res 27 (1994) 105-112
53. Yoshoiko T., Kawada K., and Shimada T. Lipid peroxidation in maternal and cord blood and protective mechanism against actived-oxygen toxicity in the blood. Am J Obstet Gynecol 135 (1979) 372-376
54. Zangger K., Oz G., Haslinger E., Kunert O., and Armitage I.M. Nitric oxide selectively releases metals from the amino-terminal domain of metallothioneins: potential role at inflammatory sites. FASEB J 15 (2001) 1303-1305
55. Zhao H., Barger M.W., Ma J.K., Castranova V., and Ma J.Y. Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. Environ Health Perspect 114 (2006) 1253-1258
56. Zhou B., Wu L.J., Tashiro S., Onodera S., Uchiumi F., and Ikejima T. Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle. Biol Pharm Bull 29 (2006) 1900-1905