Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus

Journal of Comparative Neurology

Volumn 523, Issue 11, 2015, Pages 1717-1729

  Vnencak, Matej ^a   Paul, Mandy H ^a   Hick, Meike ^b   Schwarzacher, Stephan W ^a   Del Turco, Domenico ^a   Müller, Ulrike C ^b   Deller, Thomas ^a   Jedlicka, Peter ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

AB_514497; Alzheimer's disease; Amyloid precursor protein (APP); Granule cell; Long term potentiation; MGI_MGI:2154545; Paired pulse inhibition; Perforant path

Indexed keywords

AMYLOID PRECURSOR LIKE PROTEIN 1; AMYLOID PRECURSOR PROTEIN; UNCLASSIFIED DRUG; APLP1 PROTEIN, MOUSE; MESSENGER RNA;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENTATE GYRUS; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; EXCITATORY SYNAPTIC TRANSMISSION; GENE EXPRESSION; GRANULE CELL; GRANULE CELL FIRING; HIPPOCAMPUS; IN VIVO STUDY; INTERNEURON; LONG TERM POTENTIATION; MALE; MOUSE; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NETWORK INHIBITION; NONHUMAN; PAIRED PULSE INHIBITON; PERFORANT NERVE TRACT; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SHORT TERM PRESYNAPTIC PLASTICITY; SPIKE; SYNAPSE; SYNAPTIC TRANSMISSION; ACTION POTENTIAL; ANIMAL; C57BL MOUSE; ELECTROSTIMULATION; GENETICS; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; METABOLISM; MICRODISSECTION; MICROELECTRODE; NERVE CELL; NERVE CELL INHIBITION; PHYSIOLOGY; PREPULSE INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME FACTOR;

ACTION POTENTIALS; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DENTATE GYRUS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; IN SITU HYBRIDIZATION; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRODISSECTION; MICROELECTRODES; NEURAL INHIBITION; NEURONAL PLASTICITY; NEURONS; PERFORANT PATHWAY; PREPULSE INHIBITION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 84930375907     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.23766     Document Type: Article

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