-
1
-
-
84857894346
-
-
Center for Disease Control and Prevention CDC, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion Accessed October 27, 2010
-
Center for Disease Control and Prevention CDC, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, http://www.cdc.gov/aging/aginginfo/alzheimers.htm, Accessed October 27, 2010.
-
-
-
-
2
-
-
0035159785
-
Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease
-
DOI 10.1385/JMN:17:2:137
-
Glabe C (2001) Intracellular mechanisms of amyloid accu-mulation and pathogenesis in Alzheimer's disease. J Mol Neurosci 17, 137-145. (Pubitemid 33063518)
-
(2001)
Journal of Molecular Neuroscience
, vol.17
, Issue.2
, pp. 137-145
-
-
Glabe, C.1
-
3
-
-
43049150678
-
Metals in Alzheimer's and Parkinson's diseases
-
Barnham KJ, Bush AI (2008) Metals in Alzheimer's and Parkinson's diseases. Curr Opin Chem Biol 12, 222-228.
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 222-228
-
-
Barnham, K.J.1
Bush, A.I.2
-
4
-
-
0344824654
-
Amyloid β-peptide [1-42]-assosiated free radical-induced oxidative stress and neurodegeneration in Alzheimer's disease brain: Mechanisms and consequences
-
DOI 10.2174/0929867033456422
-
Butterfield DA (2003) Amyloid beta-peptide [1-42]-associated free radical-induced oxidative stress and neurode-generation in Alzheimer's disease brain: mechanisms and consequences. Curr Med Chem 10, 2651-2659. (Pubitemid 37456035)
-
(2003)
Current Medicinal Chemistry
, vol.10
, Issue.24
, pp. 2651-2659
-
-
Butterfield, D.A.1
-
5
-
-
0345602771
-
Amyloid β Protein Toxicity Mediated by the Formation of Amyloid-β Protein Precursor Complexes
-
DOI 10.1002/ana.10761
-
Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo EH (2003) Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann Neurol 54, 781-789. (Pubitemid 37504953)
-
(2003)
Annals of Neurology
, vol.54
, Issue.6
, pp. 781-789
-
-
Lu, D.C.1
Shaked, G.M.2
Masliah, E.3
Bredesen, D.E.4
Koo, E.H.5
-
6
-
-
33646480747
-
Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664
-
Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE (2006) Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci USA 103, 7130-7135.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 7130-7135
-
-
Galvan, V.1
Gorostiza, O.F.2
Banwait, S.3
Ataie, M.4
Logvinova, A.V.5
Sitaraman, S.6
Carlson, E.7
Sagi, S.A.8
Chevallier, N.9
Jin, K.10
Greenberg, D.A.11
Bredesen, D.E.12
-
7
-
-
0034730639
-
Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death
-
Coulson EJ, Reid K, Baca M, Shipham KA, Hulett SM, Kilpatrick TJ, Bartlett PF (2000) Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death. J Biol Chem 275, 30537-30545.
-
(2000)
J Biol Chem
, vol.275
, pp. 30537-30545
-
-
Coulson, E.J.1
Reid, K.2
Baca, M.3
Shipham, K.A.4
Hulett, S.M.5
Kilpatrick, T.J.6
Bartlett, P.F.7
-
8
-
-
0037452773
-
JNK-interacting protein-1 promotes transcription of Aβ protein precursor but not Aβ precursor-like proteins, mechanistically different than Fe65
-
DOI 10.1073/pnas.0437908100
-
Scheinfeld MH, Matsuda S, D'Adamio L (2003) JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanis-tically different than Fe65. Proc Natl Acad Sci USA 100, 1729-1734. (Pubitemid 36254516)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.4
, pp. 1729-1734
-
-
Scheinfeld, M.H.1
Matsuda, S.2
D'Adamio, L.3
-
9
-
-
0031470093
-
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice
-
DOI 10.1016/S0197-4580(97)00151-6, PII S0197458097001516
-
von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, Sisodia SS (1997) Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging 18, 661-669. (Pubitemid 28046419)
-
(1997)
Neurobiology of Aging
, vol.18
, Issue.6
, pp. 661-669
-
-
Von Koch, C.S.1
Zheng, H.2
Chen, H.3
Trumbauer, M.4
Thinakaran, G.5
Van Der Ploeg, L.H.T.6
Price, D.L.7
Sisodia, S.S.8
-
10
-
-
0034329291
-
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members
-
Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Muller U (2000) Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci 20, 7951-7963.
-
(2000)
J Neurosci
, vol.20
, pp. 7951-7963
-
-
Heber, S.1
Herms, J.2
Gajic, V.3
Hainfellner, J.4
Aguzzi, A.5
Rulicke, T.6
Von Kretzschmar, H.7
Von Koch, C.8
Sisodia, S.9
Tremml, P.10
Lipp, H.P.11
Wolfer, D.P.12
Muller, U.13
-
11
-
-
72449201115
-
Novel mediators of amyloid precursor protein signaling
-
Swistowski A, Zhang Q, Orcholski ME, Crippen D, Vitelli C, Kurakin A, Bredesen DE (2009) Novel mediators of amyloid precursor protein signaling. J Neurosci 29, 15703-15712.
-
(2009)
J Neurosci
, vol.29
, pp. 15703-15712
-
-
Swistowski, A.1
Zhang, Q.2
Orcholski, M.E.3
Crippen, D.4
Vitelli, C.5
Kurakin, A.6
Bredesen, D.E.7
-
12
-
-
0034671933
-
Modulation of amyloid precursor protein metabolism by X11α/Mint-1: A deletion analysis of protein-protein interaction domains
-
DOI 10.1074/jbc.M008453200
-
Mueller HT, Borg JP, Margolis B, Turner RS (2000) Modulation of amyloid precursor protein metabolism by X11alpha/Mint-1. A deletion analysis of protein-protein interaction domains. J Biol Chem 275, 39302-39306. (Pubitemid 32058950)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.50
, pp. 39302-39306
-
-
Mueller, H.T.1
Borg, J.-P.2
Margolis, B.3
Turner, R.S.4
-
13
-
-
0035816661
-
A transcriptivety active complex of APP with Fe65 and histone acetyltransferase Tip60
-
DOI 10.1126/science.1058783
-
Cao X, Sudhof TC (2001) A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115-120. (Pubitemid 32625507)
-
(2001)
Science
, vol.293
, Issue.5527
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
14
-
-
0037114010
-
Processing of β-amyloid precursor-like protein-1 and -2 by γ-secretase regulates transcription
-
DOI 10.1074/jbc.M208110200
-
Scheinfeld MH, Ghersi E, Laky K, Fowlkes BJ, D'Adamio L (2002) Processing of beta-amyloid precursor-like protein-1 and-2 by gamma-secretase regulates transcription. J Biol Chem 277, 44195-44201. (Pubitemid 36157850)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.46
, pp. 44195-44201
-
-
Scheinfeld, M.H.1
Ghersi, E.2
Laky, K.3
Fowlkes, B.J.4
D'Adamio, L.5
-
15
-
-
2442592973
-
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves α-, β-, γ-, and ε-Like cleavages: Modulation of APLP-1 processing by N-glycosylation
-
DOI 10.1074/jbc.M311601200
-
Eggert S, Paliga K, Soba P, Evin G, Masters CL, Weidemann A, Beyreuther K (2004) The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation. J Biol Chem 279, 18146-18156. (Pubitemid 38623227)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.18
, pp. 18146-18156
-
-
Eggert, S.1
Paliga, K.2
Soba, P.3
Evin, G.4
Masters, C.L.5
Weidemann, A.6
Beyreuther, K.7
-
16
-
-
38449120482
-
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664
-
DOI 10.1111/j.1471-4159.2007.05031.x
-
Nguyen TV, Galvan V, Huang W, Banwait S, Tang H, Zhang J, Bredesen DE (2008) Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem 104, 1065-1080. (Pubitemid 351143641)
-
(2008)
Journal of Neurochemistry
, vol.104
, Issue.4
, pp. 1065-1080
-
-
Nguyen, T.-V.V.1
Galvan, V.2
Huang, W.3
Banwait, S.4
Tang, H.5
Zhang, J.6
Bredesen, D.E.7
-
17
-
-
60549089207
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
-
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457, 981-989.
-
(2009)
Nature
, vol.457
, pp. 981-989
-
-
Nikolaev, A.1
McLaughlin, T.2
O'Leary, D.D.3
Tessier-Lavigne, M.4
-
18
-
-
0034107524
-
A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor
-
DOI 10.1038/74656
-
Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE (2000) A second cyto-toxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med 6, 397-404. (Pubitemid 30208156)
-
(2000)
Nature Medicine
, vol.6
, Issue.4
, pp. 397-404
-
-
Lu, D.C.1
Rabizadeh, S.2
Chandra, S.3
Shayya, R.F.4
Ellerby, L.M.5
Ye, X.6
Salvesen, G.S.7
Koo, E.H.8
Bredesen, D.E.9
-
19
-
-
0035652138
-
A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo
-
DOI 10.1006/mcne.2001.1030
-
Bertrand E, Brouillet E, Caille I, Bouillot C, Cole GM, Prochiantz A, Allinquant B (2001) A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo. Mol Cell Neurosci 18, 503-511. (Pubitemid 34008390)
-
(2001)
Molecular and Cellular Neuroscience
, vol.18
, Issue.5
, pp. 503-511
-
-
Bertrand, E.1
Brouillet, E.2
Caille, I.3
Bouillot, C.4
Cole, G.M.5
Prochiantz, A.6
Allinquant, B.7
-
20
-
-
0030068094
-
+ channels and suppression of neuronal activity by secreted β-amyloid-precursor protein
-
DOI 10.1038/379074a0
-
+ channels and suppression of neuronal activ-ity by secreted beta-amyloid-precursor protein. Nature 379, 74-78. (Pubitemid 26008138)
-
(1996)
Nature
, vol.379
, Issue.6560
, pp. 74-78
-
-
Furukawa, K.1
Barger, S.W.2
Blalock, E.M.3
Mattson, M.P.4
-
21
-
-
0034488295
-
Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid β protein precursor
-
Passer B, Pellegrini L, Russo C, Siegel RM, Lenardo MJ, Schettini G, Bachmann M, Tabaton M, D'Adamio L (2000) Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor. J Alzheimers Dis 2, 289-301. (Pubitemid 32095613)
-
(2000)
Journal of Alzheimer's Disease
, vol.2
, Issue.3-4
, pp. 289-301
-
-
Passer, B.1
Pellegrini, L.2
Russo, C.3
Siegel, R.M.4
Lenardo, M.J.5
Schettini, G.6
Bachmann, M.7
Tabaton, M.8
D'Adamio, L.9
-
22
-
-
0142179222
-
Caspase cleavage of the amyloid precursor protein modulates amyloid β-protein toxicity
-
DOI 10.1046/j.1471-4159.2003.02059.x
-
Lu DC, Soriano S, Bredesen DE, Koo EH (2003) Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem 87, 733-741. (Pubitemid 37310638)
-
(2003)
Journal of Neurochemistry
, vol.87
, Issue.3
, pp. 733-741
-
-
Lu, D.C.1
Soriano, S.2
Bredesen, D.E.3
Koo, E.H.4
-
23
-
-
69249212154
-
Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein
-
Park SA, Shaked GM, Bredesen DE, Koo EH (2009) Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun 388, 450-455.
-
(2009)
Biochem Biophys Res Commun
, vol.388
, pp. 450-455
-
-
Park, S.A.1
Shaked, G.M.2
Bredesen, D.E.3
Koo, E.H.4
-
24
-
-
40549095365
-
C-terminal cleavage of the amyloid-β protein precursor at Asp664: A switch associated with Alzheimer's disease
-
Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE (2008) C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis 13, 1-16. (Pubitemid 351365623)
-
(2008)
Journal of Alzheimer's Disease
, vol.13
, Issue.1
, pp. 1-16
-
-
Banwait, S.1
Galvan, V.2
Zhang, J.3
Gorostiza, O.F.4
Ataie, M.5
Huang, W.6
Crippen, D.7
Koo, E.H.8
Bredesen, D.E.9
-
25
-
-
43849090364
-
Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664
-
Galvan V, Zhang J, Gorostiza OF, Banwait S, Huang W, Ataie M, Tang H, Bredesen DE (2008) Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664. Behav Brain Res 191, 246-255.
-
(2008)
Behav Brain Res
, vol.191
, pp. 246-255
-
-
Galvan, V.1
Zhang, J.2
Gorostiza, O.F.3
Banwait, S.4
Huang, W.5
Ataie, M.6
Tang, H.7
Bredesen, D.E.8
-
26
-
-
70350324313
-
Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: A role for early experience
-
Zhang J, Gorostiza OF, Tang H, Bredesen DE, Galvan V (2010) Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav Brain Res 206, 202-207.
-
(2010)
Behav Brain Res
, vol.206
, pp. 202-207
-
-
Zhang, J.1
Gorostiza, O.F.2
Tang, H.3
Bredesen, D.E.4
Galvan, V.5
-
27
-
-
78650662312
-
Importance of the caspase cleavage site in amyloid precursor protein
-
Bredesen DE, John V, Galvan V (2010) Importance of the caspase cleavage site in amyloid precursor protein. J Alzheimers Dis 22, 57-63.
-
(2010)
J Alzheimers Dis
, vol.22
, pp. 57-63
-
-
Bredesen, D.E.1
John, V.2
Galvan, V.3
-
28
-
-
74849103981
-
Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein
-
Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L (2010) Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein. J Neurosci 30, 372-381.
-
(2010)
J Neurosci
, vol.30
, pp. 372-381
-
-
Harris, J.A.1
Devidze, N.2
Halabisky, B.3
Lo, I.4
Thwin, M.T.5
Yu, G.Q.6
Bredesen, D.E.7
Masliah, E.8
Mucke, L.9
-
29
-
-
78650662312
-
Importance of the caspase cleavage site in amyloid-beta protein precursor
-
Bredesen DE, John V, Galvan V (2010) Importance of the caspase cleavage site in amyloid-beta protein precursor. J Alzheimers Dis 22, 57-63.
-
(2010)
J Alzheimers Dis
, vol.22
, pp. 57-63
-
-
Bredesen, D.E.1
John, V.2
Galvan, V.3
-
30
-
-
72749122106
-
The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system
-
YanagidaK, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M (2009) The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system. EMBO MolMed 1, 223-235.
-
(2009)
EMBO MolMed
, vol.1
, pp. 223-235
-
-
Yanagidak Okochi, M.1
Tagami, S.2
Nakayama, T.3
Kodama, T.S.4
Nishitomi, K.5
Jiang, J.6
Mori, K.7
Tatsumi, S.8
Arai, T.9
Ikeuchi, T.10
Kasuga, K.11
Tokuda, T.12
Kondo, M.13
Ikeda, M.14
Deguchi, K.15
Kazui, H.16
Tanaka, T.17
Morihara, T.18
Hashimoto, R.19
Kudo, T.20
Steiner, H.21
Haass, C.22
Tsuchiya, K.23
Akiyama, H.24
Kuwano, R.25
Takeda, M.26
more..
-
31
-
-
23644431709
-
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
-
DOI 10.1126/science.1110955
-
Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309, 1074-1078. (Pubitemid 41134465)
-
(2005)
Science
, vol.309
, Issue.5737
, pp. 1074-1078
-
-
Hong, J.-H.1
Hwang, E.S.2
McManus, M.T.3
Amsterdam, A.4
Tian, Y.5
Kalmukova, R.6
Mueller, E.7
Benjamin, T.8
Spiegelman, B.M.9
Sharp, P.A.10
Hopkins, N.11
Yaffe, M.B.12
-
32
-
-
48749127970
-
PPARs in Alzheimer's disease
-
Kummer MP, Heneka MT (2008) PPARs in Alzheimer's disease. PPAR Res 2008, 403-896.
-
(2008)
PPAR Res
, vol.2008
, pp. 403-896
-
-
Kummer, M.P.1
Heneka, M.T.2
|