-
1
-
-
0021346853
-
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
-
Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984;36:93-99.
-
(1984)
Cell
, vol.36
, pp. 93-99
-
-
Groffen, J.1
Stephenson, J.R.2
Heisterkamp, N.3
de Klein, A.4
Bartram, C.R.5
Grosveld, G.6
-
2
-
-
0015694748
-
Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
Rowley JD. Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973;243:290-293.
-
(1973)
Nature
, vol.243
, pp. 290-293
-
-
Rowley, J.D.1
-
3
-
-
0034670036
-
The molecular biology of chronic myeloid leukemia
-
Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood 2000;96:3343-3356.
-
(2000)
Blood
, vol.96
, pp. 3343-3356
-
-
Deininger, M.W.1
Goldman, J.M.2
Melo, J.V.3
-
4
-
-
0027972308
-
Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987
-
Preston DL, et al. Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat Res 1994;137(2 Suppl):S68-S97.
-
(1994)
Radiat Res
, vol.137
, Issue.2 SUPPL
, pp. S68-S97
-
-
Preston, D.L.1
-
5
-
-
0000902023
-
Leukemia in atomic bomb survivors. I. General observations
-
Lange RD, Moloney WC, Yamawaki T. Leukemia in atomic bomb survivors. I. General observations. Blood 1954;9:574-585.
-
(1954)
Blood
, vol.9
, pp. 574-585
-
-
Lange, R.D.1
Moloney, W.C.2
Yamawaki, T.3
-
6
-
-
84881017449
-
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells
-
Bolton-Gillespie E, et al. Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells. Blood 2013;121:4175-4183.
-
(2013)
Blood
, vol.121
, pp. 4175-4183
-
-
Bolton-Gillespie, E.1
-
7
-
-
84860819704
-
Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors
-
Nieborowska-Skorska M, et al. Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood 2012;119:4253-4263.
-
(2012)
Blood
, vol.119
, pp. 4253-4263
-
-
Nieborowska-Skorska, M.1
-
8
-
-
0028786297
-
Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals
-
wBiernaux C, Loos M, Sels A, Huez G, Stryckmans P. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood 1995;86:3118-3122.
-
(1995)
Blood
, vol.86
, pp. 3118-3122
-
-
wBiernaux, C.1
Loos, M.2
Sels, A.3
Huez, G.4
Stryckmans, P.5
-
9
-
-
0032211172
-
The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease
-
Bose S, Deininger M, Gora-Tybor J, Goldman JM, Melo JV. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood 1998;92:3362-3367.
-
(1998)
Blood
, vol.92
, pp. 3362-3367
-
-
Bose, S.1
Deininger, M.2
Gora-Tybor, J.3
Goldman, J.M.4
Melo, J.V.5
-
10
-
-
84992361009
-
Detection of BCR-ABL positive cells in an asymptomatic patient: a case report and literature review
-
Bayraktar S, Goodman M. Detection of BCR-ABL positive cells in an asymptomatic patient: a case report and literature review. Case Rep Med 2010;2010:939706.
-
(2010)
Case Rep Med
, vol.2010
, pp. 939706
-
-
Bayraktar, S.1
Goodman, M.2
-
11
-
-
0025117392
-
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
-
Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990;247:824-830.
-
(1990)
Science
, vol.247
, pp. 824-830
-
-
Daley, G.Q.1
Van Etten, R.A.2
Baltimore, D.3
-
12
-
-
19944426030
-
Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis
-
Koschmieder S, et al. Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis. Blood 2005;105:324-334.
-
(2005)
Blood
, vol.105
, pp. 324-334
-
-
Koschmieder, S.1
-
13
-
-
0142183447
-
Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome
-
Huettner CS, et al. Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome. Blood 2003;102:3363-3370.
-
(2003)
Blood
, vol.102
, pp. 3363-3370
-
-
Huettner, C.S.1
-
14
-
-
84885846261
-
Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia
-
Foley SB, et al. Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia. Cell Rep 2013;5:51-60.
-
(2013)
Cell Rep
, vol.5
, pp. 51-60
-
-
Foley, S.B.1
-
15
-
-
19944385935
-
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
-
Huntly BJ, et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 2004;6:587-596.
-
(2004)
Cancer Cell
, vol.6
, pp. 587-596
-
-
Huntly, B.J.1
-
16
-
-
0037441629
-
Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis
-
Kantarjian HM, et al. Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis. Cancer 2003;97:1033-1041.
-
(2003)
Cancer
, vol.97
, pp. 1033-1041
-
-
Kantarjian, H.M.1
-
17
-
-
3242808935
-
Natural history and staging of chronic myelogenous leukemia
-
viii.
-
Cortes J. Natural history and staging of chronic myelogenous leukemia. Hematol Oncol Clin North Am 2004;18:569-584, viii.
-
(2004)
Hematol Oncol Clin North Am
, vol.18
, pp. 569-584
-
-
Cortes, J.1
-
18
-
-
30144445384
-
Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML
-
Yong AS, Szydlo RM, Goldman JM, Apperley JF, Melo JV. Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML. Blood 2006;107:205-212.
-
(2006)
Blood
, vol.107
, pp. 205-212
-
-
Yong, A.S.1
Szydlo, R.M.2
Goldman, J.M.3
Apperley, J.F.4
Melo, J.V.5
-
19
-
-
51649102491
-
Multiple sub-microscopic genomic lesions are a universal feature of chronic myeloid leukaemia at diagnosis
-
Khorashad JS, et al. Multiple sub-microscopic genomic lesions are a universal feature of chronic myeloid leukaemia at diagnosis. Leukemia 2008;22:1806-1807.
-
(2008)
Leukemia
, vol.22
, pp. 1806-1807
-
-
Khorashad, J.S.1
-
20
-
-
12844254396
-
Additional clonal abnormalities in Philadelphia-positive ALL and CML demonstrate a different cytogenetic pattern at diagnosis and follow different pathways at progression
-
Bacher U, Haferlach T, Hiddemann W, Schnittger S, Kern W, Schoch C. Additional clonal abnormalities in Philadelphia-positive ALL and CML demonstrate a different cytogenetic pattern at diagnosis and follow different pathways at progression. Cancer Genet Cytogenet 2005;157:53-61.
-
(2005)
Cancer Genet Cytogenet
, vol.157
, pp. 53-61
-
-
Bacher, U.1
Haferlach, T.2
Hiddemann, W.3
Schnittger, S.4
Kern, W.5
Schoch, C.6
-
21
-
-
77954977940
-
Chronic myeloid leukemia: mechanisms of blastic transformation
-
Perrotti D, Jamieson C, Goldman J, Skorski T. Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest 2010;120:2254-2264.
-
(2010)
J Clin Invest
, vol.120
, pp. 2254-2264
-
-
Perrotti, D.1
Jamieson, C.2
Goldman, J.3
Skorski, T.4
-
22
-
-
24744443720
-
High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy
-
Willis SG, et al. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood 2005;106:2128-2137.
-
(2005)
Blood
, vol.106
, pp. 2128-2137
-
-
Willis, S.G.1
-
23
-
-
23044458596
-
ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia
-
Soverini S, et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005;23:4100-4109.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4100-4109
-
-
Soverini, S.1
-
24
-
-
34848897224
-
Genomic profile of chronic myelogenous leukemia: imbalances associated with disease progression
-
Brazma D, et al. Genomic profile of chronic myelogenous leukemia: imbalances associated with disease progression. Genes Chromosom Cancer 2007;46:1039-1050.
-
(2007)
Genes Chromosom Cancer
, vol.46
, pp. 1039-1050
-
-
Brazma, D.1
-
25
-
-
79952451556
-
A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases
-
Grossmann V, et al. A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases. Leukemia 2011;25:557-560.
-
(2011)
Leukemia
, vol.25
, pp. 557-560
-
-
Grossmann, V.1
-
26
-
-
77949423503
-
Similar patterns of chromosome abnormalities in CML occur in addition to the Philadelphia chromosome with or without tyrosine kinase inhibitor treatment
-
Haferlach C, Bacher U, Schnittger S, Weiss T, Kern W, Haferlach T. Similar patterns of chromosome abnormalities in CML occur in addition to the Philadelphia chromosome with or without tyrosine kinase inhibitor treatment. Leukemia 2010;24:638-640.
-
(2010)
Leukemia
, vol.24
, pp. 638-640
-
-
Haferlach, C.1
Bacher, U.2
Schnittger, S.3
Weiss, T.4
Kern, W.5
Haferlach, T.6
-
27
-
-
77649222741
-
SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations
-
Nowak D, et al. SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations. Blood 2010;115:1049-1053.
-
(2010)
Blood
, vol.115
, pp. 1049-1053
-
-
Nowak, D.1
-
28
-
-
77955949422
-
Rapid clonal shifts in response to kinase inhibitor therapy in chronic myelogenous leukemia are identified by quantitation mutation assays
-
Yin CC, et al. Rapid clonal shifts in response to kinase inhibitor therapy in chronic myelogenous leukemia are identified by quantitation mutation assays. Cancer Sci 2010;101:2005-2010.
-
(2010)
Cancer Sci
, vol.101
, pp. 2005-2010
-
-
Yin, C.C.1
-
29
-
-
34249693090
-
Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells
-
Jiang X, Saw KM, Eaves A, Eaves C. Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells. J Natl Cancer Inst 2007;99:680-693.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 680-693
-
-
Jiang, X.1
Saw, K.M.2
Eaves, A.3
Eaves, C.4
-
30
-
-
84855203185
-
Genome-wide high density single-nucleotide polymorphism array-based karyotyping improves detection of clonal aberrations including der deletion, but does not predict treatment outcomes after imatinib therapy in chronic myeloid leukemia
-
Huh J, et al. Genome-wide high density single-nucleotide polymorphism array-based karyotyping improves detection of clonal aberrations including der deletion, but does not predict treatment outcomes after imatinib therapy in chronic myeloid leukemia. Ann Hematol 2011;90:1255-1264.
-
(2011)
Ann Hematol
, vol.90
, pp. 1255-1264
-
-
Huh, J.1
-
31
-
-
34648833625
-
The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells
-
Deininger MW, et al. The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells. Cancer 2007;110:1509-1519.
-
(2007)
Cancer
, vol.110
, pp. 1509-1519
-
-
Deininger, M.W.1
-
32
-
-
84869437107
-
The long-term clinical implications of clonal chromosomal abnormalities in newly diagnosed chronic phase chronic myeloid leukemia patients treated with imatinib mesylate
-
Lee SE, et al. The long-term clinical implications of clonal chromosomal abnormalities in newly diagnosed chronic phase chronic myeloid leukemia patients treated with imatinib mesylate. Cancer Genet 2012;205:563-571.
-
(2012)
Cancer Genet
, vol.205
, pp. 563-571
-
-
Lee, S.E.1
-
33
-
-
0032478962
-
A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Writing Committee for the Collaborative CML Prognostic Factors Project Group
-
Hasford J, et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Writing Committee for the Collaborative CML Prognostic Factors Project Group. J Natl Cancer Inst 1998;90:850-858.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 850-858
-
-
Hasford, J.1
-
34
-
-
67349233062
-
Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
-
Hochhaus A, et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009;23:1054-1061.
-
(2009)
Leukemia
, vol.23
, pp. 1054-1061
-
-
Hochhaus, A.1
-
35
-
-
84881298446
-
European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
-
Baccarani M, et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 2013;122:872-884.
-
(2013)
Blood
, vol.122
, pp. 872-884
-
-
Baccarani, M.1
-
36
-
-
19944428353
-
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
Lombardo LJ, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004;47:6658-6661.
-
(2004)
J Med Chem
, vol.47
, pp. 6658-6661
-
-
Lombardo, L.J.1
-
37
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
Weisberg E, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005;7:129-141.
-
(2005)
Cancer Cell
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
-
38
-
-
0037439689
-
SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
-
Golas JM, Arndt K, Etienne C, Lucas J, Nardin D, Gibbons J, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res 2003;63:375-381.
-
(2003)
Cancer Res
, vol.63
, pp. 375-381
-
-
Golas, J.M.1
Arndt, K.2
Etienne, C.3
Lucas, J.4
Nardin, D.5
Gibbons, J.6
-
39
-
-
80052578274
-
Restricted access to second generation tyrosine kinase inhibitors in the UK could result in suboptimal treatment for almost half of chronic myeloid leukaemia patients: results from a West of Scotland and Lothian population study
-
Gallipoli P, Shepherd P, Irvine D, Drummond M, Holyoake T. Restricted access to second generation tyrosine kinase inhibitors in the UK could result in suboptimal treatment for almost half of chronic myeloid leukaemia patients: results from a West of Scotland and Lothian population study. Br J Haematol 2011;155:128-130.
-
(2011)
Br J Haematol
, vol.155
, pp. 128-130
-
-
Gallipoli, P.1
Shepherd, P.2
Irvine, D.3
Drummond, M.4
Holyoake, T.5
-
40
-
-
49149111543
-
Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis
-
de Lavallade H, et al. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. J Clin Oncol 2008;26:3358-3363.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3358-3363
-
-
de Lavallade, H.1
-
41
-
-
54049130762
-
A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials
-
Lucas CM, et al. A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials. Leukemia 2008;22:1963-1966.
-
(2008)
Leukemia
, vol.22
, pp. 1963-1966
-
-
Lucas, C.M.1
-
42
-
-
33846023983
-
Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years
-
Rousselot P, et al. Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years. Blood 2007;109:58-60.
-
(2007)
Blood
, vol.109
, pp. 58-60
-
-
Rousselot, P.1
-
43
-
-
84886917643
-
Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study
-
Ross DM, et al. Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study. Blood 2013;122:515-522.
-
(2013)
Blood
, vol.122
, pp. 515-522
-
-
Ross, D.M.1
-
44
-
-
84886914746
-
TWIST it but don't spin it
-
Apperley JF. TWIST it but don't spin it. Blood 2013;122:470-471.
-
(2013)
Blood
, vol.122
, pp. 470-471
-
-
Apperley, J.F.1
-
45
-
-
84886781746
-
Discontinuation of second generation (2G) tyrosine kinase inhibitors (TKI) in chronic phase (CP)-chronic myeloid leukemia (CML) patients with stable undetectable BCR-ABL transcripts
-
Rea D, et al. Discontinuation of second generation (2G) tyrosine kinase inhibitors (TKI) in chronic phase (CP)-chronic myeloid leukemia (CML) patients with stable undetectable BCR-ABL transcripts. ASH Annu Meet Abstr 2012;120:916.
-
(2012)
ASH Annu Meet Abstr
, vol.120
, pp. 916
-
-
Rea, D.1
-
46
-
-
84860840888
-
Discontinuation of dasatinib or nilotinib in chronic myeloid leukemia (CML) patients (pts) with stable undetectable bcr-abl transcripts: results from the French CML group (FILMC)
-
Rea D, et al. Discontinuation of dasatinib or nilotinib in chronic myeloid leukemia (CML) patients (pts) with stable undetectable bcr-abl transcripts: results from the French CML group (FILMC). ASH Annu Meet Abstr 2011;118:604.
-
(2011)
ASH Annu Meet Abstr
, vol.118
, pp. 604
-
-
Rea, D.1
-
47
-
-
84897573995
-
Loss of major molecular response as a trigger for restarting tyrosine kinase inhibitor therapy in patients with chronic-phase chronic myelogenous leukemia who have stopped imatinib after durable undetectable disease
-
Rousselot P, et al. Loss of major molecular response as a trigger for restarting tyrosine kinase inhibitor therapy in patients with chronic-phase chronic myelogenous leukemia who have stopped imatinib after durable undetectable disease. J Clin Oncol 2014;32:424-430.
-
(2014)
J Clin Oncol
, vol.32
, pp. 424-430
-
-
Rousselot, P.1
-
48
-
-
84865776165
-
Second attempt to discontinue imatinib in CP-CML patients with a second sustained complete molecular response
-
Legros L, et al. Second attempt to discontinue imatinib in CP-CML patients with a second sustained complete molecular response. Blood 2012;120:1959-1960.
-
(2012)
Blood
, vol.120
, pp. 1959-1960
-
-
Legros, L.1
-
49
-
-
78049528573
-
Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial
-
Mahon FX, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol 2010;11:1029-1035.
-
(2010)
Lancet Oncol
, vol.11
, pp. 1029-1035
-
-
Mahon, F.X.1
-
50
-
-
84872462658
-
BCR-ABL1 compound mutations in tyrosine kinase inhibitor-resistant CML: frequency and clonal relationships
-
Khorashad JS, et al. BCR-ABL1 compound mutations in tyrosine kinase inhibitor-resistant CML: frequency and clonal relationships. Blood 2013;121:489-498.
-
(2013)
Blood
, vol.121
, pp. 489-498
-
-
Khorashad, J.S.1
-
51
-
-
84897510743
-
Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations
-
Traer E, et al. Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations. Blood 2014;123:1516-1524.
-
(2014)
Blood
, vol.123
, pp. 1516-1524
-
-
Traer, E.1
-
52
-
-
0037438640
-
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
-
Donato NJ, et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 2003;101:690-698.
-
(2003)
Blood
, vol.101
, pp. 690-698
-
-
Donato, N.J.1
-
53
-
-
57149098598
-
Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression
-
Mahon FX, et al. Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression. Cancer Res 2008;68:9809-9816.
-
(2008)
Cancer Res
, vol.68
, pp. 9809-9816
-
-
Mahon, F.X.1
-
54
-
-
4544343214
-
A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2
-
Dai Y, Rahmani M, Corey SJ, Dent P, Grant S. A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. J Biol Chem 2004;279:34227-34239.
-
(2004)
J Biol Chem
, vol.279
, pp. 34227-34239
-
-
Dai, Y.1
Rahmani, M.2
Corey, S.J.3
Dent, P.4
Grant, S.5
-
55
-
-
77954377279
-
Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner
-
Pene-Dumitrescu T, Smithgall TE. Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner. J Biol Chem 2010;285:21446-21457.
-
(2010)
J Biol Chem
, vol.285
, pp. 21446-21457
-
-
Pene-Dumitrescu, T.1
Smithgall, T.E.2
-
56
-
-
46849114097
-
Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase
-
Wu J, et al. Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. J Natl Cancer Inst 2008;100:926-939.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 926-939
-
-
Wu, J.1
-
57
-
-
67651174451
-
Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors
-
Grosso S, et al. Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors. Mol Cancer Ther 2009;8:1924-1933.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1924-1933
-
-
Grosso, S.1
-
58
-
-
70350507997
-
AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
-
O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell 2009;16:401-412.
-
(2009)
Cancer Cell
, vol.16
, pp. 401-412
-
-
O'Hare, T.1
-
59
-
-
84874715679
-
All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to ponatinib
-
Cassuto O, et al. All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to ponatinib. Oncotarget 2012;3:1557-1565.
-
(2012)
Oncotarget
, vol.3
, pp. 1557-1565
-
-
Cassuto, O.1
-
60
-
-
84887127701
-
A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias
-
Cortes JE, et al. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med 2013;369:1783-1796.
-
(2013)
N Engl J Med
, vol.369
, pp. 1783-1796
-
-
Cortes, J.E.1
-
61
-
-
80055086681
-
Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general population
-
Efficace F, et al. Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general population. Blood 2011;118:4554-4560.
-
(2011)
Blood
, vol.118
, pp. 4554-4560
-
-
Efficace, F.1
-
62
-
-
67049087117
-
Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study
-
Noens L, et al. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study. Blood 2009;113:5401-5411.
-
(2009)
Blood
, vol.113
, pp. 5401-5411
-
-
Noens, L.1
-
63
-
-
77952467377
-
Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
-
Marin D, et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol 2010;28:2381-2388.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2381-2388
-
-
Marin, D.1
-
64
-
-
84893578349
-
Ponatinib in Philadelphia chromosome-positive leukemias
-
Cortes JE, Talpaz M, Kantarjian H. Ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med 2014;370:577.
-
(2014)
N Engl J Med
, vol.370
, pp. 577
-
-
Cortes, J.E.1
Talpaz, M.2
Kantarjian, H.3
-
65
-
-
84893541741
-
Ponatinib in Philadelphia chromosome-positive leukemias
-
Quintas-Cardama A. Ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med 2014;370:577.
-
(2014)
N Engl J Med
, vol.370
, pp. 577
-
-
Quintas-Cardama, A.1
-
66
-
-
3943088431
-
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
-
Jamieson CH, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 2004;351:657-667.
-
(2004)
N Engl J Med
, vol.351
, pp. 657-667
-
-
Jamieson, C.H.1
-
67
-
-
56649114489
-
BCR-ABL-transformed GMP as myeloid leukemic stem cells
-
Minami Y, et al. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci USA 2008;105:17967-17972.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17967-17972
-
-
Minami, Y.1
-
68
-
-
65949096301
-
The CML stem cell: evolution of the progenitor
-
Stuart SA, Minami Y, Wang JY. The CML stem cell: evolution of the progenitor. Cell Cycle 2009;8:1338-1343.
-
(2009)
Cell Cycle
, vol.8
, pp. 1338-1343
-
-
Stuart, S.A.1
Minami, Y.2
Wang, J.Y.3
-
69
-
-
84863124648
-
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
-
Hamilton A, et al. Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood 2012;119:1501-1510.
-
(2012)
Blood
, vol.119
, pp. 1501-1510
-
-
Hamilton, A.1
-
70
-
-
78650949272
-
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
-
Corbin AS, Agarwal A, Loriaux M, Cortes J, Deininger MW, Druker BJ. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest 2011;121:396-409.
-
(2011)
J Clin Invest
, vol.121
, pp. 396-409
-
-
Corbin, A.S.1
Agarwal, A.2
Loriaux, M.3
Cortes, J.4
Deininger, M.W.5
Druker, B.J.6
-
71
-
-
81555214617
-
Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment
-
Chu S, et al. Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment. Blood 2011;118:5565-5572.
-
(2011)
Blood
, vol.118
, pp. 5565-5572
-
-
Chu, S.1
-
72
-
-
84055179140
-
Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy
-
Chomel JC, Turhan AG. Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy. Oncotarget 2011;2:713-727.
-
(2011)
Oncotarget
, vol.2
, pp. 713-727
-
-
Chomel, J.C.1
Turhan, A.G.2
-
73
-
-
80053361301
-
Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease
-
Chomel JC, et al. Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease. Blood 2011;118:3657-3660.
-
(2011)
Blood
, vol.118
, pp. 3657-3660
-
-
Chomel, J.C.1
-
74
-
-
84860752177
-
BCR-ABL1 doubling times more reliably assess the dynamics of CML relapse compared with the BCR-ABL1 fold rise: implications for monitoring and management
-
Branford S, et al. BCR-ABL1 doubling times more reliably assess the dynamics of CML relapse compared with the BCR-ABL1 fold rise: implications for monitoring and management. Blood 2012;119:4264-4271.
-
(2012)
Blood
, vol.119
, pp. 4264-4271
-
-
Branford, S.1
-
75
-
-
21744462100
-
Dynamics of chronic myeloid leukaemia
-
Michor F, et al. Dynamics of chronic myeloid leukaemia. Nature 2005;435:1267-1270.
-
(2005)
Nature
, vol.435
, pp. 1267-1270
-
-
Michor, F.1
-
76
-
-
33749524667
-
Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications
-
Roeder I, Horn M, Glauche I, Hochhaus A, Mueller MC, Loeffler M. Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nat Med 2006;12:1181-1184.
-
(2006)
Nat Med
, vol.12
, pp. 1181-1184
-
-
Roeder, I.1
Horn, M.2
Glauche, I.3
Hochhaus, A.4
Mueller, M.C.5
Loeffler, M.6
-
77
-
-
84855842631
-
Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib
-
Kumari A, Brendel C, Hochhaus A, Neubauer A, Burchert A. Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib. Blood 2012;119:530-539.
-
(2012)
Blood
, vol.119
, pp. 530-539
-
-
Kumari, A.1
Brendel, C.2
Hochhaus, A.3
Neubauer, A.4
Burchert, A.5
-
78
-
-
84860767803
-
Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib
-
Weisberg E, et al. Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib. Leukemia 2012;26:985-990.
-
(2012)
Leukemia
, vol.26
, pp. 985-990
-
-
Weisberg, E.1
-
79
-
-
38349086394
-
CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
-
Jin L, et al. CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol Cancer Ther 2008;7:48-58.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 48-58
-
-
Jin, L.1
-
80
-
-
84859832491
-
Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia
-
Zhang B, et al. Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell 2012;21:577-592.
-
(2012)
Cancer Cell
, vol.21
, pp. 577-592
-
-
Zhang, B.1
-
81
-
-
83455201579
-
TNFalpha facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms
-
Fleischman AG, et al. TNFalpha facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms. Blood 2011;118:6392-6398.
-
(2011)
Blood
, vol.118
, pp. 6392-6398
-
-
Fleischman, A.G.1
-
82
-
-
84891689915
-
Autocrine TNF-alpha production supports CML stem and progenitor cell survival and enhances their proliferation
-
Gallipoli P, et al. Autocrine TNF-alpha production supports CML stem and progenitor cell survival and enhances their proliferation. Blood 2013;122:3335-3339.
-
(2013)
Blood
, vol.122
, pp. 3335-3339
-
-
Gallipoli, P.1
-
83
-
-
79958732559
-
Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia
-
Schmidt T, et al. Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. Cancer Cell 2011;19:740-753.
-
(2011)
Cancer Cell
, vol.19
, pp. 740-753
-
-
Schmidt, T.1
-
84
-
-
84876543495
-
Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-beta-catenin signaling
-
Zhang B, et al. Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-beta-catenin signaling. Blood 2013;121:1824-1838.
-
(2013)
Blood
, vol.121
, pp. 1824-1838
-
-
Zhang, B.1
-
85
-
-
84880790088
-
The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts
-
Experts in Chronic Myeloid L.
-
Experts in Chronic Myeloid L. The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts. Blood 2013;121:4439-4442.
-
(2013)
Blood
, vol.121
, pp. 4439-4442
-
-
-
86
-
-
84876100195
-
Re-emergence of interferon-alpha in the treatment of chronic myeloid leukemia
-
Talpaz M, Hehlmann R, Quintas-Cardama A, Mercer J, Cortes J. Re-emergence of interferon-alpha in the treatment of chronic myeloid leukemia. Leukemia 2013;27:803-812.
-
(2013)
Leukemia
, vol.27
, pp. 803-812
-
-
Talpaz, M.1
Hehlmann, R.2
Quintas-Cardama, A.3
Mercer, J.4
Cortes, J.5
-
88
-
-
44349166602
-
PML targeting eradicates quiescent leukaemia-initiating cells
-
Ito K, et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008;453:1072-1078.
-
(2008)
Nature
, vol.453
, pp. 1072-1078
-
-
Ito, K.1
-
89
-
-
67649861052
-
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
-
Chen Y, Hu Y, Zhang H, Peng C, Li S. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet 2009;41:783-792.
-
(2009)
Nat Genet
, vol.41
, pp. 783-792
-
-
Chen, Y.1
Hu, Y.2
Zhang, H.3
Peng, C.4
Li, S.5
-
90
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003;348:994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
-
91
-
-
78650625238
-
Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia
-
Preudhomme C, et al. Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N Engl J Med 2010;363:2511-2521.
-
(2010)
N Engl J Med
, vol.363
, pp. 2511-2521
-
-
Preudhomme, C.1
-
92
-
-
80053130415
-
Combination of pegylated IFN-alpha2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia
-
Simonsson B, et al. Combination of pegylated IFN-alpha2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia. Blood 2011;118:3228-3235.
-
(2011)
Blood
, vol.118
, pp. 3228-3235
-
-
Simonsson, B.1
-
93
-
-
66149115277
-
IFNalpha activates dormant haematopoietic stem cells in vivo
-
Essers MA, et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 2009;458:904-908.
-
(2009)
Nature
, vol.458
, pp. 904-908
-
-
Essers, M.A.1
-
94
-
-
31544451592
-
Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate
-
Jorgensen HG, et al. Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clin Cancer Res 2006;12:626-633.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 626-633
-
-
Jorgensen, H.G.1
-
95
-
-
33847049119
-
Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment
-
Holtz M, Forman SJ, Bhatia R. Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment. Cancer Res 2007;67:1113-1120.
-
(2007)
Cancer Res
, vol.67
, pp. 1113-1120
-
-
Holtz, M.1
Forman, S.J.2
Bhatia, R.3
-
96
-
-
67349105601
-
A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response
-
Drummond MW, et al. A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response. Leukemia 2009;23:1199-1201.
-
(2009)
Leukemia
, vol.23
, pp. 1199-1201
-
-
Drummond, M.W.1
-
97
-
-
70349673335
-
Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib
-
Foo J, Drummond MW, Clarkson B, Holyoake T, Michor F. Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib. PLoS Comput Biol 2009;5:e1000503.
-
(2009)
PLoS Comput Biol
, vol.5
, pp. e1000503
-
-
Foo, J.1
Drummond, M.W.2
Clarkson, B.3
Holyoake, T.4
Michor, F.5
-
98
-
-
84887536827
-
Safety and efficacy of pulsed imatinib with or without G-CSF versus continuous imatinib in chronic phase chronic myeloid leukaemia patients at 5 years follow-up
-
Gallipoli P, et al. Safety and efficacy of pulsed imatinib with or without G-CSF versus continuous imatinib in chronic phase chronic myeloid leukaemia patients at 5 years follow-up. Br J Haematol 2013;163:674-676.
-
(2013)
Br J Haematol
, vol.163
, pp. 674-676
-
-
Gallipoli, P.1
-
99
-
-
66449122303
-
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
-
Bellodi C, et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009;119:1109-1123.
-
(2009)
J Clin Invest
, vol.119
, pp. 1109-1123
-
-
Bellodi, C.1
-
100
-
-
84888048568
-
Autophagy in chronic myeloid leukaemia: stem cell survival and implication in therapy
-
Helgason GV, Mukhopadhyay A, Karvela M, Salomoni P, Calabretta B, Holyoake TL. Autophagy in chronic myeloid leukaemia: stem cell survival and implication in therapy. Curr Cancer Drug Targets 2013;13:724-734.
-
(2013)
Curr Cancer Drug Targets
, vol.13
, pp. 724-734
-
-
Helgason, G.V.1
Mukhopadhyay, A.2
Karvela, M.3
Salomoni, P.4
Calabretta, B.5
Holyoake, T.L.6
-
101
-
-
80052164677
-
Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML
-
Helgason GV, Karvela M, Holyoake TL. Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML. Blood 2011;118:2035-2043.
-
(2011)
Blood
, vol.118
, pp. 2035-2043
-
-
Helgason, G.V.1
Karvela, M.2
Holyoake, T.L.3
-
102
-
-
80052643889
-
BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription
-
Sheng Z, Ma L, Sun JE, Zhu LJ, Green MR. BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood 2011;118:2840-2848.
-
(2011)
Blood
, vol.118
, pp. 2840-2848
-
-
Sheng, Z.1
Ma, L.2
Sun, J.E.3
Zhu, L.J.4
Green, M.R.5
-
103
-
-
84861385403
-
Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia
-
Zhang H, Li H, Ho N, Li D, Li S. Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia. Mol Cell Biol 2012;32:1776-1787.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 1776-1787
-
-
Zhang, H.1
Li, H.2
Ho, N.3
Li, D.4
Li, S.5
-
104
-
-
80055108071
-
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia
-
Hurtz C, et al. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med 2011;208:2163-2174.
-
(2011)
J Exp Med
, vol.208
, pp. 2163-2174
-
-
Hurtz, C.1
-
105
-
-
84863011183
-
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
-
Li L, et al. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell 2012;21:266-281.
-
(2012)
Cancer Cell
, vol.21
, pp. 266-281
-
-
Li, L.1
-
107
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995;378:206-208.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
108
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995;378:203-206.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes de Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
109
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant J, et al. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 2001;29:92-95.
-
(2001)
Nat Genet
, vol.29
, pp. 92-95
-
-
Parant, J.1
-
110
-
-
34547192721
-
Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development
-
Terzian T, Wang Y, Van Pelt CS, Box NF, Travis EL, Lozano G. Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development. Mol Cell Biol 2007;27:5479-5485.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 5479-5485
-
-
Terzian, T.1
Wang, Y.2
Van Pelt, C.S.3
Box, N.F.4
Travis, E.L.5
Lozano, G.6
-
111
-
-
84868203735
-
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
-
Ray-Coquard I, et al. Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study. Lancet Oncol 2012;13:1133-1140.
-
(2012)
Lancet Oncol
, vol.13
, pp. 1133-1140
-
-
Ray-Coquard, I.1
-
112
-
-
84876422526
-
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence
-
Takeishi S, Matsumoto A, Onoyama I, Naka K, Hirao A, Nakayama KI. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell 2013;23:347-361.
-
(2013)
Cancer Cell
, vol.23
, pp. 347-361
-
-
Takeishi, S.1
Matsumoto, A.2
Onoyama, I.3
Naka, K.4
Hirao, A.5
Nakayama, K.I.6
-
113
-
-
0026788001
-
Dominant negative MYC blocks transformation by ABL oncogenes
-
Sawyers CL, Callahan W, Witte ON. Dominant negative MYC blocks transformation by ABL oncogenes. Cell 1992;70:901-910.
-
(1992)
Cell
, vol.70
, pp. 901-910
-
-
Sawyers, C.L.1
Callahan, W.2
Witte, O.N.3
-
114
-
-
84867690864
-
Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML
-
Winter GE, et al. Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML. Nat Chem Biol 2012;8:905-912.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 905-912
-
-
Winter, G.E.1
-
115
-
-
84864403159
-
The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells
-
Zhang H, et al. The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet 2012;44:861-871.
-
(2012)
Nat Genet
, vol.44
, pp. 861-871
-
-
Zhang, H.1
-
116
-
-
84874835799
-
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
-
Soucek L, et al. Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. Genes Dev 2013;27:504-513.
-
(2013)
Genes Dev
, vol.27
, pp. 504-513
-
-
Soucek, L.1
-
117
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
Delmore JE, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011;146:904-917.
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
-
118
-
-
84876434253
-
Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression
-
Reavie L, et al. Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. Cancer Cell 2013;23:362-375.
-
(2013)
Cancer Cell
, vol.23
, pp. 362-375
-
-
Reavie, L.1
-
119
-
-
84857143671
-
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia
-
Hantschel O, et al. BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol 2012;8:285-293.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 285-293
-
-
Hantschel, O.1
-
120
-
-
84887392984
-
JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia
-
Warsch W, Walz C, Sexl V. JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia. Blood 2013;122:2167-2175.
-
(2013)
Blood
, vol.122
, pp. 2167-2175
-
-
Warsch, W.1
Walz, C.2
Sexl, V.3
-
121
-
-
84875611495
-
Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex
-
Chen M, et al. Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex. J Natl Cancer Inst 2013;105:405-423.
-
(2013)
J Natl Cancer Inst
, vol.105
, pp. 405-423
-
-
Chen, M.1
-
122
-
-
84885085996
-
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
-
Neviani P, et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest 2013;123:4144-4157.
-
(2013)
J Clin Invest
, vol.123
, pp. 4144-4157
-
-
Neviani, P.1
-
123
-
-
84906241089
-
The anti-proliferative activity of kinase inhibitors in chronic myeloid leukaemia cells is mediated by FOXO transcription factors
-
Pellicano F, et al. The anti-proliferative activity of kinase inhibitors in chronic myeloid leukaemia cells is mediated by FOXO transcription factors. Stem Cells 2014;32:2324-2337.
-
(2014)
Stem Cells
, vol.32
, pp. 2324-2337
-
-
Pellicano, F.1
-
124
-
-
76249087423
-
α-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
-
Naka K, et al. α-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 2010;463:676-680.
-
(2010)
Nature
, vol.463
, pp. 676-680
-
-
Naka, K.1
-
125
-
-
80055113098
-
Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks
-
Pellicano F, Holyoake TL. Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks. J Exp Med 2011;208:2155-2158.
-
(2011)
J Exp Med
, vol.208
, pp. 2155-2158
-
-
Pellicano, F.1
Holyoake, T.L.2
-
127
-
-
84859523707
-
Genetic and pharmacologic inhibition of beta-catenin targets imatinib-resistant leukemia stem cells in CML
-
Heidel FH, et al. Genetic and pharmacologic inhibition of beta-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell 2012;10:412-424.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 412-424
-
-
Heidel, F.H.1
-
128
-
-
77954299059
-
Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl
-
Gregory MA, et al. Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell 2010;18:74-87.
-
(2010)
Cancer Cell
, vol.18
, pp. 74-87
-
-
Gregory, M.A.1
-
129
-
-
36649002031
-
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
-
Zhao C, et al. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 2007;12:528-541.
-
(2007)
Cancer Cell
, vol.12
, pp. 528-541
-
-
Zhao, C.1
-
130
-
-
33748859509
-
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
-
Scheller M, et al. Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol 2006;7:1037-1047.
-
(2006)
Nat Immunol
, vol.7
, pp. 1037-1047
-
-
Scheller, M.1
-
131
-
-
30044444251
-
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
-
Trowbridge JJ, Xenocostas A, Moon RT, Bhatia M. Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat Med 2006;12:89-98.
-
(2006)
Nat Med
, vol.12
, pp. 89-98
-
-
Trowbridge, J.J.1
Xenocostas, A.2
Moon, R.T.3
Bhatia, M.4
-
132
-
-
84858032395
-
Targeting of GSK3beta promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells
-
Reddiconto G, et al. Targeting of GSK3beta promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells. Blood 2012;119:2335-2345.
-
(2012)
Blood
, vol.119
, pp. 2335-2345
-
-
Reddiconto, G.1
-
133
-
-
84930319760
-
Oncogene-induced DNA repair defects promote PARP1-mediated "dual synthetic lethality" to eradicate quiescent and proliferating leukemia stem and progenitor cells
-
Slupianek A, et al. Oncogene-induced DNA repair defects promote PARP1-mediated "dual synthetic lethality" to eradicate quiescent and proliferating leukemia stem and progenitor cells. Blood 2013;122:810.
-
(2013)
Blood
, vol.122
, pp. 810
-
-
Slupianek, A.1
-
134
-
-
79954443802
-
Improved outcome following allogeneic stem cell transplantation in chronic myeloid leukemia is associated with higher expression of BMI-1 and immune responses to BMI-1 protein
-
Yong AS, et al. Improved outcome following allogeneic stem cell transplantation in chronic myeloid leukemia is associated with higher expression of BMI-1 and immune responses to BMI-1 protein. Leukemia 2011;25:629-637.
-
(2011)
Leukemia
, vol.25
, pp. 629-637
-
-
Yong, A.S.1
-
135
-
-
84888037897
-
Advances in immunotherapy of chronic myeloid leukemia CML
-
Held SA, Heine A, Mayer KT, Kapelle M, Wolf DG, Brossart P. Advances in immunotherapy of chronic myeloid leukemia CML. Curr Cancer Drug Targets 2013;13:768-774.
-
(2013)
Curr Cancer Drug Targets
, vol.13
, pp. 768-774
-
-
Held, S.A.1
Heine, A.2
Mayer, K.T.3
Kapelle, M.4
Wolf, D.G.5
Brossart, P.6
-
136
-
-
59649118271
-
Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib
-
Yong AS, et al. Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib. Blood 2009;113:875-882.
-
(2009)
Blood
, vol.113
, pp. 875-882
-
-
Yong, A.S.1
-
137
-
-
51649108782
-
Hematopoietic stem cells and progenitors of chronic myeloid leukemia express leukemia-associated antigens: implications for the graft-versus-leukemia effect and peptide vaccine-based immunotherapy
-
Yong AS, et al. Hematopoietic stem cells and progenitors of chronic myeloid leukemia express leukemia-associated antigens: implications for the graft-versus-leukemia effect and peptide vaccine-based immunotherapy. Leukemia 2008;22:1721-1727.
-
(2008)
Leukemia
, vol.22
, pp. 1721-1727
-
-
Yong, A.S.1
-
138
-
-
77957560308
-
Complete molecular response in CML after p210 BCR-ABL1-derived peptide vaccination
-
Bocchia M, et al. Complete molecular response in CML after p210 BCR-ABL1-derived peptide vaccination. Nat Rev Clin Oncol 2010;7:600-603.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 600-603
-
-
Bocchia, M.1
-
139
-
-
0034161533
-
Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses
-
Pinilla-Ibarz J, et al. Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses. Blood 2000;95:1781-1787.
-
(2000)
Blood
, vol.95
, pp. 1781-1787
-
-
Pinilla-Ibarz, J.1
-
140
-
-
75149121612
-
K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate
-
Smith BD, et al. K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate. Clin Cancer Res 2010;16:338-347.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 338-347
-
-
Smith, B.D.1
-
141
-
-
84885336017
-
Induction of high-titer IgG antibodies against multiple leukemia-associated antigens in CML patients with clinical responses to K562/GVAX immunotherapy
-
Qin L, et al. Induction of high-titer IgG antibodies against multiple leukemia-associated antigens in CML patients with clinical responses to K562/GVAX immunotherapy. Blood Cancer J 2013;3:e145.
-
(2013)
Blood Cancer J
, vol.3
, pp. e145
-
-
Qin, L.1
-
142
-
-
84903174180
-
A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias
-
Dubrovsky L, et al. A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias. Blood 2014;123:3296-3304.
-
(2014)
Blood
, vol.123
, pp. 3296-3304
-
-
Dubrovsky, L.1
-
143
-
-
82355180964
-
Antigens in chronic myeloid leukemia: implications for vaccine development
-
Smahel M. Antigens in chronic myeloid leukemia: implications for vaccine development. Cancer Immunol Immunother 2011;60:1655-1668.
-
(2011)
Cancer Immunol Immunother
, vol.60
, pp. 1655-1668
-
-
Smahel, M.1
-
144
-
-
64049107901
-
Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia
-
Rezvani K, et al. Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia. Blood 2009;113:2245-2255.
-
(2009)
Blood
, vol.113
, pp. 2245-2255
-
-
Rezvani, K.1
-
145
-
-
77954635822
-
Immunotherapy prospects for acute myeloid leukaemia
-
Barrett AJ, Le Blanc K. Immunotherapy prospects for acute myeloid leukaemia. Clin Exp Immunol 2010;161:223-232.
-
(2010)
Clin Exp Immunol
, vol.161
, pp. 223-232
-
-
Barrett, A.J.1
Le Blanc, K.2
-
146
-
-
84871913379
-
Cancer vaccines and T cell therapy
-
Rezvani K, et al. Cancer vaccines and T cell therapy. Biol Blood Marrow Transplant 2013;19(Suppl):S97-S101.
-
(2013)
Biol Blood Marrow Transplant
, vol.19
, Issue.Suppl
, pp. S97-S101
-
-
Rezvani, K.1
-
147
-
-
84866876169
-
Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML
-
Agarwal A, et al. Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML. Blood 2012;120:2658-2668.
-
(2012)
Blood
, vol.120
, pp. 2658-2668
-
-
Agarwal, A.1
|