Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner

Journal of Biological Chemistry

Volumn 285, Issue 28, 2010, Pages 21446-21457

  Pene Dumitrescu, Teodora ^a   Smithgall, Thomas E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC MYELOGENOUS LEUKEMIA; COLONY FORMATION; DRUG RESISTANCE; IMATINIB; IN-CELL; INDUCED APOPTOSIS; KINASE ACTIVITY; KINASE INHIBITORS; OVER-EXPRESSION; SRC-FAMILY KINASE; WILD TYPES;

CELL DEATH; ENZYME INHIBITION;

PHOSPHORYLATION;

AGAR; ALANINE; BCR ABL PROTEIN; HEMATOPOIETIC CELL KINASE; IMATINIB; MUTANT PROTEIN; NAPHTHYLPYRAZOLOPYRIMIDINE 1; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; COLONY FORMATION; CONTROLLED STUDY; DRUG BINDING SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WILD TYPE;

ANIMALS; APOPTOSIS; DRUG RESISTANCE, NEOPLASM; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MODELS, GENETIC; MUTATION; PHOSPHORYLATION; PIPERAZINES; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; PYRIMIDINES; SRC-FAMILY KINASES;

EID: 77954377279     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.090043     Document Type: Article

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